公开(公告)号：EP2994046A1

公开(公告)日：2016-03-16

申请号：EP13711478.1

申请日：2013-02-15

Applicant: Stichting VU-VUmc

Inventor： HUITINK, Johannes Martinus

IPC: A61B5/08 ,  A61M16/00 ,  G06F19/00

CPC classification number: A61M16/107 ,  A61B5/083 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/06 ,  A61M16/0816 ,  A61M2016/0027 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/584 ,  A61M2205/8206 ,  A61M2230/205 ,  A61M2230/432 ,  A61M2230/50 ,  A61M2230/63

Abstract: In a system and method of monitoring a respiration of a patient, an SpO2 signal and a CO2 signal are provided and processed to establish an output signal indicating a respiration status, being one of a "call for help" status, a "perform tracheotomy" status and a "normal situation" status, depending on conditions determined from the SpO2 signal and the CO2 signal over time, weight data, length data and age data of the patient.

公开(公告)号：EP2867200A1

公开(公告)日：2015-05-06

申请号：EP13739857.4

申请日：2013-07-04

Applicant: Stichting VU-VUmc

Inventor： CHRISTIAANS, Johannes Antonius Maria ,  WINDHORST, Albert Dirk ,  METAXAS, Athanasios ,  KLEIN, Pieter Jacob ,  KOOIJMAN, Esther Johanna Maria ,  VAN BERCKEL, Bart Nicolaas Maria

IPC: C07C217/56 ,  C07D213/24

CPC classification number: C07D213/74 ,  C07C213/02 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/24 ,  C07D213/38 ,  C07C215/74

Abstract: The invention is directed to a compound according to formula (1) wherein R
2 is fluorine, X is nitrogen or carbon and R
3 is an organic group. The invention is also directed to the use of this compound as a precursor for the preparation of a
11 C or
18 F-radio labelled compound. The radio labelled compound may be used in an in vivo diagnostic or imaging method.

Abstract translation: 本发明涉及式（1）的化合物，其中R 2是氟，X是氮或碳，R 3是有机基团。 本发明还涉及该化合物作为制备11C或18F-无线电标记化合物的前体的用途。 放射性标记的化合物可以用于体内诊断或成像方法。

公开(公告)号：EP2849719A1

公开(公告)日：2015-03-25

申请号：EP13720618.1

申请日：2013-04-26

Applicant: Stichting VU-VUmc

Inventor： BIKKER, Floris Jacob ,  VEERMAN, Engelmundus Cornelis Ignatius ,  VALENTIJN-BENZ, Marianne ,  VAN 'T HOF, Willem

IPC: A61K8/41 ,  A61Q11/00 ,  A61K8/68 ,  A61Q11/02

CPC classification number: A61K8/55 ,  A23L33/10 ,  A23V2002/00 ,  A61C13/08 ,  A61K8/24 ,  A61K8/41 ,  A61K8/42 ,  A61K8/68 ,  A61Q11/00 ,  A61Q11/02

Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.

Abstract translation: 本发明涉及基于鞘氨醇的化合物，特别是植物鞘氨醇化合物在保护含有羟基磷灰石的材料如牙齿和骨中的用途。 这些化合物在治疗和预防龋齿，牙齿侵蚀，牙本质过敏症和牙垢（牙结石）形成中特别有用。 还提供了使用鞘氨醇基化合物防止生物膜形成的方法和装置。 还提供了包含基于鞘氨醇的化合物的组合物。

公开(公告)号：EP2714651A1

公开(公告)日：2014-04-09

申请号：EP12726658.3

申请日：2012-05-30

Applicant: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschapelijk Onderzoek en Patientenzorg ,  STICHTING VU-VUMUC ,  Klein, Pieter Jacob ,  Metaxas, Athansios ,  Windhorst, Albert Dirk ,  Christiaans, Johannes Antonius Maria ,  Van Berckel, Bart Nicolaas Maria

Inventor： KLEIN, Pieter Jacob ,  METAXAS, Athansios ,  WINDHORST, Albert Dirk ,  CHRISTIAANS, Johannes Antonius Maria ,  VAN BERCKEL, Bart Nicolaas Maria

IPC: C07C279/18 ,  C07B59/00 ,  A61K31/155

CPC classification number: C07C279/18 ,  A61K31/155 ,  A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C277/08 ,  C07C319/20 ,  C07C323/44

Abstract: The invention is directed to a N, N-substituted guanidine compound or a salt or solvate thereof according to formula (1), R
1 RNC(NH)NR
2 R
3 , wherein R
1 is methyl and R
2 is hydrogen. R
3 is a organic group comprising a halogen and thiomethyl substituted phenyl group. R is an organic group comprising a substituted aryl group Z wherein the substituent group is -Y-R
4 , wherein Y is a heteroatom chosen from the group consisting of O, S and N and R
4 is a fluorinated organic group.

公开(公告)号：EP2593787A2

公开(公告)日：2013-05-22

申请号：EP11736199.8

申请日：2011-07-15

Applicant: Stichting VU-VUmc

Inventor： WÜRDINGER, Thomas ,  NILSSON, Rolf Jonas

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：GB202417753D0

公开(公告)日：2025-01-15

申请号：GB202417753

申请日：2024-12-03

Applicant: STICHTING VU

公开(公告)号：AU2019257105B2

公开(公告)日：2024-11-28

申请号：AU2019257105

申请日：2019-04-18

Applicant: STICHTING VU

Inventor： GROSSMANN TOM NORBERT ,  PELAY GIMENO MARTA ,  HENNIG SVEN ,  NEUBACHER SASKIA ANTONIE

IPC: C12N9/96 ,  C12N9/52 ,  C12N9/64

Abstract: The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.

公开(公告)号：CA2830461C

公开(公告)日：2021-06-29

申请号：CA2830461

申请日：2012-01-16

Applicant: VER VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU VUMC

Inventor： WURDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

公开(公告)号：NL2024478A

公开(公告)日：2020-01-09

申请号：NL2024478

申请日：2019-12-17

Applicant: UNIV AMSTERDAM ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INST ,  ASML NETHERLANDS BV ,  STICHTING VU

Inventor： ARIE JEFFREY DEN BOEF ,  VASCO TOMAS TENNER ,  NITESH PANDEY ,  JOHANNES FITZGERALD DE BOER ,  CHRISTOS MESSINIS

IPC: G03F7/20

Abstract: A dark field digital holographic microscope is disclosed which is configured to determine a characteristic of interest of a structure. The dark field digital holographic microscope comprises an illumination device configured to provide at least: a first beam pair comprising a first illumination beam of radiation and a first reference beam of radiation and a second beam pair comprising a second illumination beam of radiation and a second reference beam of radiation; and one or more optical elements operable to capture a first scattered radiation and to capture a second scattered radiation scattered by the structure resultant from the first and second illumination beams respectively. The beams of the first beam pair are mutually coherent and the beams of the second beam pair are mutually coherent. The illumination device is configured to impose incoherence between the first beam pair and second beam pair.

公开(公告)号：NL2020862B1

公开(公告)日：2019-11-12

申请号：NL2020862

申请日：2018-05-02

Applicant: LUMICKS TECH B V ,  STICHTING VU

Inventor： GIJS JAN LODEWIJK WUITE ,  RAYA SORKIN ,  DOUWE KAMSMA ,  GERRIT SITTERS ,  ERWIN JOHANNES GERARD PETERMAN ,  GIULIA BERGAMASCHI ,  MATTIJS DE GROOT

IPC: B01L3/00 ,  G01N29/06

Abstract: A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a 5 plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant 10 bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast 15 factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the 20 force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle. Fig. ZB