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    Use of morphogenic protein for treating cartilage defect
    182.
    发明专利
    Use of morphogenic protein for treating cartilage defect 审中-公开
    使用形态蛋白进行处理缺陷

    公开(公告)号：JP2011189200A

    公开(公告)日：2011-09-29

    申请号：JP2011148712

    申请日：2011-07-04

    Applicant: Stryker Corp ,  ストライカー コーポレイションStryker Corporation

    Inventor： RUEGER DAVID C ,  KILDEY ROBYN

    IPC: A61L27/00 ,  A61K9/06 ,  A61K9/08 ,  A61K38/00 ,  A61K38/18 ,  A61P19/00 ,  C07K14/51

    CPC classification number: A61K38/1875 ,  A61L27/227 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/06

    Abstract: PROBLEM TO BE SOLVED: To provide compositions and methods for repairing and regenerating cartilage defects which overcome the problems associated with the currently available methods and compositions. SOLUTION: The present invention provides the methods of repairing and regenerating cartilage tissue by administering into the cartilage or into the area surrounding the cartilage a composition comprising a therapeutically effective amount of a morphogenic protein. In some embodiments, the present invention provides the method of repairing a cartilage defect in a patient comprising the step of administering into the cartilage or into the area surrounding the cartilage the composition comprising a therapeutically effective amount of the morphogenic protein. The present invention also provides the method of repairing or regenerating a cartilage defect in a patient comprising the step of administering into the cartilage or into the area surrounding the cartilage the composition comprising a therapeutically effective amount of the morphogenic protein. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供克服与当前可用的方法和组合物相关的问题的用于修复和再生软骨缺陷的组合物和方法。 解决方案：本发明提供了通过向软骨或软骨周围的区域施用包含治疗有效量的形态发生蛋白质的组合物来修复和再生软骨组织的方法。 在一些实施方案中，本发明提供了修复患者软骨缺损的方法，该方法包括将包含治疗有效量的形态发生蛋白的组合物施用于软骨或软骨周围区域的步骤。 本发明还提供了修复或再生患者软骨缺损的方法，包括向软骨中施用包含治疗有效量的形态发生蛋白的组合物的软骨或围绕软骨的区域的步骤。 版权所有（C）2011，JPO＆INPIT

    Cot bed for ambulances and hydraulic lifting mechanism for the same
    183.
    发明专利
    Cot bed for ambulances and hydraulic lifting mechanism for the same 有权
    用于甲醛和液压提升机构的COT床

    公开(公告)号：JP2011172958A

    公开(公告)日：2011-09-08

    申请号：JP2011098523

    申请日：2011-04-26

    Applicant: Stryker Corp ,  ストライカー コーポレイションStryker Corporation

    Inventor： LAMBARTH CLIFFORD E ,  SOUKE CHAD ,  GATTO TODD ,  COLVIN JOSHUA C ,  NAHAVANDI KUROSH ,  KNEEN JASON ,  STEFFLER MICHAEL W ,  WAY CHRISTOPHER B ,  MORTON GARY ,  REED DENNIS A ,  MCKEE MICHAEL ,  PUVOGEL THOMAS A ,  BARTLEY BRIAN ,  DYKEMA KURT ,  BOUWS BRENT

    IPC: A61G1/02

    CPC classification number: A61G1/0262 ,  A61G1/013 ,  A61G1/0212 ,  A61G1/0237 ,  A61G1/0293 ,  A61G1/04 ,  A61G1/048 ,  A61G1/052 ,  A61G1/0567 ,  A61G3/0816 ,  A61G7/0509 ,  A61G7/0513

    Abstract: PROBLEM TO BE SOLVED: To provide a cot bed for an ambulance which is equipped with lifting mechanism which makes the rise and fall of a stretcher easy. SOLUTION: There are provided a base which is supported by a wheel 14 as necessary and a stretcher which is moved up and down by power lifting mechanism which is arranged at a predetermined position between the base and the stretcher. A cot bed for an ambulance 10 also has radio communication capacity which makes communication easy between the cot bed for the ambulance and a loading system on the ambulance and makes wireless troubleshooting easy through a handheld wireless unit. The cot bed for the ambulance also has a head part 197 which stretches in a longitudinal direction. The cot bed for the ambulance also has some accessories such as an accessory hook which is placed on the lower side of a fowler and a foldable porch accessory which is fixed on the contractible head part and a stretcher frame 17. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：为救护车提供床床，该救护车配有提升机构，使担架的上升和下降变得容易。 解决方案：根据需要设置有由车轮14支撑的基座，以及通过布置在基部和担架之间的预定位置的动力提升机构上下移动的担架。 救护车10的婴儿床还具有无线电通信能力，使得救护车的婴儿床与救护车上的加载系统之间的通信变得容易，并且通过手持无线单元使得无线故障排除变得容易。 救护车的婴儿床还具有沿纵向延伸的头部197。 用于救护车的婴儿床还具有一些附件，例如放置在饲养器的下侧的附件钩和固定在收缩头部分和担架框架17上的可折叠门廊附件。版权所有（ C）2011，JPO＆INPIT

    Synergistic effect of op/bmp morphogen and gdnf/ngf neurotrophic factor
    188.
    发明专利
    Synergistic effect of op/bmp morphogen and gdnf/ngf neurotrophic factor 有权
    OP / BMP多态性和GDNF / NGF神经营养因子的协同作用

    公开(公告)号：JP2009209152A

    公开(公告)日：2009-09-17

    申请号：JP2009143767

    申请日：2009-06-16

    Applicant: Stryker Corp ,  ストライカー コーポレイションStryker Corporation

    Inventor： RUEGER DAVID C ,  CHARETTE MARC F ,  EBENDAL TED

    IPC: A61K38/00 ,  A61K38/22 ,  A61K38/18 ,  A61P9/02 ,  A61P9/10 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  C07K14/47

    CPC classification number: A61K38/1875 ,  A61K2300/00

    Abstract: PROBLEM TO BE SOLVED: To provide pharmaceuticals for promoting the survival or growth, or inhibiting the death or degeneration, of mammalian cells (particularly neural cells). SOLUTION: A synergistic effect of OP/BMP morphogens in combination with GDNF/NGF neurotrophic factors in promoting the survival or growth, or inhibiting the death or degeneration, of mammalian cells (particularly neural cells), which express OP/BMP-activated serine/threonine kinase receptors and GDNF/NGF-activated tyrosine kinase receptors, is disclosed. Also disclosed are new methods for the in vivo and in vitro treatments of such cells, including in vivo treatments for mammals afflicted with, or at imminent risk of, damage or injury to such cells, as well as new pharmaceutical preparations for such in vivo and in vitro treatments. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 待解决的问题：提供用于促进哺乳动物细胞（特别是神经细胞）的存活或生长或抑制死亡或变性的药物。 解决方案：OP / BMP形态发生与GDNF / NGF神经营养因子联合促进哺乳动物细胞（特别是神经细胞）的生存或生长或抑制死亡或退化的协同作用，其表达OP / BMP- 公开了活化的丝氨酸/苏氨酸激酶受体和GDNF / NGF-激活的酪氨酸激酶受体。 还公开了用于体内和体外治疗这些细胞的新方法，包括对这种细胞受到或者即将遭受损伤或损伤的哺乳动物的体内治疗，以及用于体内和/或细胞的新药物制剂 体外治疗。 版权所有（C）2009，JPO＆INPIT

    Osteogenic device and method of use thereof for repair of bones
    190.
    发明专利
    Osteogenic device and method of use thereof for repair of bones 审中-公开
    骨质疏松装置及其用于修复骨骼的方法

    公开(公告)号：JP2009131649A

    公开(公告)日：2009-06-18

    申请号：JP2009040036

    申请日：2009-02-23

    Applicant: Stryker Corp ,  ストライカー コーポレイションStryker Corporation

    Inventor： RUEGER DAVID C ,  TUCKER MARJORIE M ,  CHANG AN-CHENG

    IPC: A61L27/00 ,  A61K9/10 ,  A61K9/14 ,  A61K38/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/38 ,  A61K47/42 ,  A61L27/22 ,  A61L31/00 ,  A61L31/04 ,  A61P19/00 ,  A61P43/00 ,  C12N15/09

    CPC classification number: A61L31/047 ,  A61F2002/2817 ,  A61L27/227 ,  Y10S514/801 ,  Y10S514/944

    Abstract: PROBLEM TO BE SOLVED: To provide improved osteogenic devices and methods of use thereof for repair of bone defects, cartilage defects and/or osteochondral defects. SOLUTION: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dissecans. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供改进的成骨装置及其用于修复骨缺损，软骨缺陷和/或骨软骨缺陷的方法。 解决方案：本文公开了改进的成骨装置及其用于修复骨和软骨缺陷的方法。 与本领域中的装置相比，装置和方法促进了使用较少成骨蛋白的增强的稳定性的修复组织的形成。 本发明易于修复的缺陷包括但不限于临界尺寸缺陷，非临界尺寸缺陷，非联合骨折，骨折，骨软骨缺损，软骨下缺陷以及由退行性疾病如骨软骨炎所致的缺陷。 版权所有（C）2009，JPO＆INPIT

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