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    MODULAR RESERVOIR SYSTEM
    181.
    发明申请
    MODULAR RESERVOIR SYSTEM 审中-公开
    MODULAR RESERVOIR系统

    公开(公告)号：WO1987005533A1

    公开(公告)日：1987-09-24

    申请号：PCT/US1987000519

    申请日：1987-03-11

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  MURRAY, Donald, Storrs ,  PFOST, Dale, R. ,  KELLER, Brent, Ward

    IPC: B01L03/00

    CPC classification number: B01L3/50855 ,  B01L3/5085 ,  B01L9/06

    Abstract: A modular reservoir system which has a plurality of interchangeable fluid containment receptacle modules (14, 16, 18, 100), secured within the perimeter of a base frame (12). The frame (12) provides support and positioning for a user selectable configuration of modules (14, 16, 18, 100) to allow the user to perform a scientific experiment where a number of different reagents may be contained in close proximity for use by a pipettor or bulk dispenser. The modules are (14, 16, 18, 100) stand-alone components; or, they may be user selectably configured within the base frame (12) to enhance the usage of an automated fluid transporting and measuring work station. In an alternative embodiment, the invention discloses test tube support rack (80) and microtiter plate (102) modules for use in conjunction with the fluid reservoir modules (14, 16, 18, 100). In still another alternate embodiment, the invention discloses a pipette tip support rack module (122) for use in conjunction with the fluid reservoir modules (14, 16, 18, 100).

    Abstract translation: 一种模块化储存器系统，其具有固定在基座框架（12）的周边内的多个可互换流体容纳容器模块（14,16,18，100）。 框架（12）为用户可选择地配置模块（14,16,18,100）提供支持和定位，以允许用户执行科学实验，其中可以紧密地包含多个不同的试剂以供 移液器或散装器。 这些模块是（14,16,18，100）独立组件; 或者，它们可以是用户可选择地构造在基架（12）内以增强自动化流体输送和测量工作站的使用。 在替代实施例中，本发明公开了与流体储存器模块（14,16,18，100）结合使用的试管支撑架（80）和微量滴定板（102）模块。 在又一替代实施例中，本发明公开了一种用于与流体储存器模块（14,16,18，100）结合使用的移液管末端支撑架模块（122）。

    AUTOMATIC IMMUNOCHEMISTRY ANALYZING APPARATUS AND METHOD
    182.
    发明申请
    AUTOMATIC IMMUNOCHEMISTRY ANALYZING APPARATUS AND METHOD 审中-公开
    自动免疫分析装置及方法

    公开(公告)号：WO1987003966A1

    公开(公告)日：1987-07-02

    申请号：PCT/US1986002777

    申请日：1986-12-22

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  PANG, Wing, S. ,  OKAWA, Dobson, M. ,  KAN, Peter ,  SHIBATA, George, K.

    IPC: G01N35/00

    CPC classification number: G01N21/0332 ,  G01N21/51 ,  G01N33/53 ,  G01N35/00 ,  G01N2201/122 ,  Y10S435/808 ,  Y10S436/808 ,  Y10S436/909

    Abstract: A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitive measurements of specific proteins and other immunochemistries in body fluids. The reaction occurs in a cuvette (48, 50) within a nephelometric optics module (44, 46). A sensor (246, 248) senses the temperatures of reaction buffer liquids as they flow into the cuvette (48, 50), and a heat exchanging device (250, 252) increases or decreases the temperatures of the buffer liquids. A control circuit (242) responsive to the temperature sensor (246, 248) controls the heat exchanging device (218) to maintain the temperature of the buffer liquids and the cuvette (48, 50) within a selected temperature range. The system may also include a sample pickup station (18), sample probe (22) means for withdrawing a selected sample from the sample pickup station (18), a sample preparation station, and sample transport (20) means for carrying said sample from the sample preparation station to the reaction cuvette (48, 50). The system may include an antibody pickup station (108), antibody probe (110) means for withdrawing an antibody from the antibody pickup station (108), an antibody preparation station, and antibody transport (106) means for carrying the antibody from the antibody preparation station to the reaction cuvette (48, 50).

    Abstract translation: 用于分析化学反应的系统提供对试剂的温度和体积的控制，以提高体液中特定蛋白质和其他免疫化学物质的定量测量的准确性和精确度。 反应发生在浊度计光学模块（44,46）内的比色皿（48,50）中。 当反应缓冲液流入比色皿（48,50）时，传感器（246,248）感测反应缓冲液体的温度，热交换装置（250,252）增加或减少缓冲液体的温度。 响应于温度传感器（246,248）的控制电路（242）控制热交换装置（218）以将缓冲液体和反应杯（48,50）的温度保持在所选择的温度范围内。 系统还可以包括样品拾取站（18），样品探针（22）用于从样品拾取站（18）中取出选定样品的装置，样品制备站和样品输送装置（20），用于将样品从 样品制备站到反应池（48,50）。 该系统可以包括抗体拾取站（108），抗体探针（110）用于从抗体拾取站（108）取出抗体的装置，抗体制备站和抗体转运（106）用于从抗体携带抗体的装置 准备站到反应池（48,50）。

    SPLIT TUBE CENTRIFUGE ROTOR ADAPTER
    184.
    发明申请
    SPLIT TUBE CENTRIFUGE ROTOR ADAPTER 审中-公开
    分体管中心转子适配器

    公开(公告)号：WO1986005718A1

    公开(公告)日：1986-10-09

    申请号：PCT/US1986000609

    申请日：1986-03-25

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  ANTHONY, Linda, Jean

    IPC: B04B05/04

    CPC classification number: B04B5/0414 ,  B04B2005/0435

    Abstract: A centrifuge adapter is formed in two sections (12, 14) divided by a plane that preferably extends through the longitudinal axis of the adapter. The two sections may be substantially identical in a first embodiment, each including a generally semicylindrical portion having a trough (20) therein and further including an end portion (18). In a second embodiment, the adapter may comprise a first section (42) including the entire bottom end portion for supporting the bottom of a centrifuge tube. The second section (44) is formed generally as a semicylinder or a cylinder. When the first and second portions are assembled in facing relationship the troughs (20, 22) form a cavity for receiving a centrifuge tube therein. The sections of the adapter may be separate pieces, or they may hingedly connected along a pair of adjacent edges. The sections may be connected by projections (36) extending from one section into corresponding cavities (30) in the other section. The sections are easily separated after the sample has been centrifuged to remove the centrifuge sample tube from the adapter.

    QUENCH, VOLUME AND ACTIVITY DETERMINATIONS IN A LIQUID SCINTILLATION FLOW SYSTEM
    185.
    发明申请
    QUENCH, VOLUME AND ACTIVITY DETERMINATIONS IN A LIQUID SCINTILLATION FLOW SYSTEM 审中-公开
    液体流动系统中的液滴，体积和活度测定

    公开(公告)号：WO1985005460A1

    公开(公告)日：1985-12-05

    申请号：PCT/US1985000916

    申请日：1985-05-15

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  HORROCKS, Donald, L.

    IPC: G01T01/204

    CPC classification number: G01F1/7042 ,  G01T1/2045

    Abstract: A method for use with liquid scintillation flow systems including flowing a mixture comprising a sample (12) and a liquid scintillation medium (20) through a flow detector (24), the liquid scintillation medium including a radionuclide marker having an energy distribution different from the sample. A pulse height distribution spectrum is determined and a unique point on the portion of the pulse height distribution spectrum representing the energy spectrum of the medium is found, a pulse height value related to such unique point providing a value related to the degree of quench present in the mixture. By comparing such pulse height value to a pulse height value obtained in a like manner for a calibration standard, a degree of quench present in the mixture is indicated. Furthermore, the counts detected for the liquid scintillation medium during a measurement period may be related to the specific activity of the liquid scintillation medium to determine the volume of liquid scintillation medium flowing during the measurement period. The volume of sample flowing during such period may also be determined by relating the liquid scintillation medium volume to a ratio of sample to liquid scintillation medium flowing through the flow detector. Sample count rate is corrected for quench and sample specific activity is determined.

    IMMUNOFIXATION ELECTROPHORESIS PROCESS
    187.
    发明申请
    IMMUNOFIXATION ELECTROPHORESIS PROCESS 审中-公开
    免疫组化电泳法

    公开(公告)号：WO1985004256A1

    公开(公告)日：1985-09-26

    申请号：PCT/US1985000409

    申请日：1985-03-13

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  GEBOTT, Michael, D. ,  GURSKE, William, A. ,  MACY, Joan, Ann

    IPC: G01N33/561

    CPC classification number: G01N27/44726 ,  G01N33/561

    Abstract: A method comprising (a) applying a sample to at least two application areas on an electrophoretic gel; (b) electrophoresing the gel; (c) aligning a template onto the electrophoresed gel, the template having a template slot corresponding to each electrophoresed area; (d) applying a composition capable of fixing proteins in situ to at least one template slot and applying an antisera capable of reacting with one protein to at least one of the remaining template slots; (e) incubating the resultant product of step (d); (f) removing the template from the incubated, electrophoresed gel; (g) washing the incubated electrophoresed gel of step (f); (h) drying the washed gel of step (g); (i) staining the dryed gel of step (h); (j) destaining the stained gel of step (i); (k) drying the destained gel of step (j); and (l) analyzing the dryed gel of step (k).

    OBJECT PROCESSING DEVICE
    188.
    发明申请
    OBJECT PROCESSING DEVICE 审中-公开
    对象处理设备

    公开(公告)号：WO1985000538A1

    公开(公告)日：1985-02-14

    申请号：PCT/US1984001167

    申请日：1984-07-23

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  COOK, William, E. ,  VODIAN, Morton, A. ,  HAUNOLD, Otto

    IPC: B01L09/06

    CPC classification number: B01L9/06 ,  B01J2219/00468 ,  B01L99/00 ,  G01N2035/00287

    Abstract: A device (18) for handling and washing beads (42). The device is attachable to a test tube rack (11) and includes a frame (24), a containing slide (22), and a capture slide (23). By manipulating the slides in various combinations of positions the beads may be added to, removed from, or separately washed apart from test tubes (12) in the rack. Complete and easy washing of the beads may thus be accomplished.

    Abstract translation: 一种用于处理和洗涤珠粒（42）的装置（18）。 该装置可附接到试管架（11）并且包括框架（24），容纳滑板（22）和捕获滑块（23）。 通过以各种位置的组合操作载玻片，珠子可以与机架中的试管（12）分开加入，除去或分开洗涤。 因此可以完成和容易地洗涤珠粒。

    DYNAMIC MIRROR ALIGNMENT CONTROL
    189.
    发明申请
    DYNAMIC MIRROR ALIGNMENT CONTROL 审中-公开
    动态镜像对准控制

    公开(公告)号：WO1984003560A1

    公开(公告)日：1984-09-13

    申请号：PCT/US1984000361

    申请日：1984-03-05

    Applicant: BECKMAN INSTRUMENTS, INC.

    Inventor： BECKMAN INSTRUMENTS, INC. ,  WIJNTJES, Geert ,  HERCHER, Michael

    IPC: G01J03/28

    CPC classification number: G01J3/4535

    Abstract: An improved mirror alignment control for dynamically aligning the reflecting mirrors bounding the optical path in an interferometer comprises a closed loop servo control which utilizes a two frequency laser beam (16) to provide phase comparison between beams traversing differing portions of the optical paths in the interferometer to determine alignment of the mirrors (12, 14), said phase comparison providing a correction signal to direct multi-axial alignment of at least one of the mirrors.

    Abstract translation: 用于在干涉仪中动态对准包围光路的反射镜的改进的反射镜对准控制器包括一个闭环伺服控制器，其使用两个频率激光束（16）来提供穿过干涉仪中的光路的不同部分的光束之间的相位比较 为了确定反射镜（12,14）的对准，所述相位比较提供校正信号以指导至少一个反射镜的多轴对准。

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