公开(公告)号：WO1991011136A1

公开(公告)日：1991-08-08

申请号：PCT/US1991000702

申请日：1991-02-01

Applicant: BOSTON ADVANCED TECHNOLOGIES, INC.

Inventor： BOSTON ADVANCED TECHNOLOGIES, INC. ,  CLARKE, Richard, H.

IPC: A61B05/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/359

Abstract: Systems and methods for material analysis are disclosed in which a material is illuminated at a plurality of discrete wavelengths. Measurements of the intensity of reflected light at such wavelengths are taken, and an analysis of reflection ratios for various wavelengths is performed. The present invention permits non-invasive blood analysis by illumination through the skin and similar analyses of meats and other food materials by non-destructive illumination. Changes in the reflection ratios can be correlated with specific material properties such as the concentration of analytes (e.g., oxygen content, glucose levels, cholesterol or drugs) in a subject's circulatory system or the condition of the food material (e.g., oxidation, contamination, sugar content, ripeness, fermentation, degree of cooking, or other processing stages).

Abstract translation: 公开了用于材料分析的系统和方法，其中以多个离散波长照射材料。 对这些波长的反射光的强度进行测量，并进行各种波长的反射率分析。 本发明允许通过皮肤照射进行非侵入性血液分析，并通过非破坏性照明对肉类和其他食物材料进行类似的分析。 反射率的变化可以与特定材料性质相关，例如受试者的循环系统中的分析物浓度（例如氧含量，葡萄糖水平，胆固醇或药物）或食物材料的状况（例如氧化，污染， 糖含量，成熟度，发酵，烹饪程度或其他处理阶段）。

公开(公告)号：WO1991005508A1

公开(公告)日：1991-05-02

申请号：PCT/EP1990001795

申请日：1990-10-23

Applicant: ROSEBANK INVESTMENTS S.A.

Inventor： ROSEBANK INVESTMENTS S.A. ,  SACRISTAN, Emilio ,  SHAHNARIAN, Albert ,  PEURA, Robert, A.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/1491 ,  A61B5/42

Abstract: The pCO2 probe (10) has a miniaturized glass bulb pH sensor (14) concentrically arranged in a flexible, noncollapsible hollow tube (12). A silicone end cap (48) is expanded in a freon solvent and placed over the end of the tube while the freon evaporates, returning the end cap to its normal contracted size where it forms a tight elastic fit. The pH sensor (14) includes an internal electrode (26) and an outer electrode (30) which is concentrically wrapped about a glass bulb (20) so that the electrodes (26 and 30) are in close proximity. The glass bulb (20) and the chamber (18) defined by the tube walls (58) and silicone membrane (48) are both filled with suitable electrolytes of sufficient volume to minimize air bubbles. Without air bubbles, the electrodes (26 and 30) remain immersed in the respective electrolytes regardless of the physical orientation of the probe (10).

公开(公告)号：WO1990014791A1

公开(公告)日：1990-12-13

申请号：PCT/US1990002668

申请日：1990-05-11

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAPRIOLI, Richard, M.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/412

Abstract: The present invention combines microdialysis with mass spectrometry (22), for example continuous flow fast atom bombardment, to follow the pharmacokinetics of drugs or other compounds directly in the blood stream or tissues of a live animal (12). After intramuscular injection of the drug, the blood dialysate from a microdialysis probe (11) inserted into a blood vessel or tissue of the animal (12), is allowed to flow into the mass spectrometer (22) via the continuous flow fast atom bombardment interface (28). Tandem mass spectrometry allows for isolating and recording the ion fragments produced from the drug as the dialysate is exposed to the ionization process. The detected concentration of the drug or other compounds of interest can be used to adjust the rate of administration of the drug.

公开(公告)号：WO1990014790A1

公开(公告)日：1990-12-13

申请号：PCT/JP1990000723

申请日：1990-06-04

Applicant: OTSUKA PHARMACEUTICAL CO., LTD. ,  MASAKI, Kyosuke ,  MIWA, Sachiko ,  YOSHIOKA, Yasuyuki ,  KORI, Hideaki

Inventor： OTSUKA PHARMACEUTICAL CO., LTD.

IPC: A61B05/00

CPC classification number: A61F5/0006 ,  G06F15/025

Abstract: Excess or deficiency of nutrition can be judged based on actually ingested foods and behavior of an individual by inputting data on meals ingested by an individual and that on behavior of an individual such as sleeping hours, amount of exercise, etc. and comparing them with nutrition data by food and data of desired values of nutrition suitable to typical behavior and bodily characteristic of an individual stored in advance. Based on this, information on desirable nutrition ingestion and/or exercise can be prescribed.

公开(公告)号：WO1990006719A1

公开(公告)日：1990-06-28

申请号：PCT/US1989005619

申请日：1989-12-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  EDELL, David, J.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/1473

Abstract: Flexible measurement probes are described for the determination of oxygen partial pressure; temperature and perfusion; and combined measurement of oxygen partial pressure, temperature, and perfusion. The probes are fabricated by patterning a metal coated substrate to form a conductive pattern of ribbon leads (12), insulating the conductive ribbon leads except for contact openings (20), and then attaching sensors to the conductive ribbon leads through noble metal plated open contacts. The plated contacts may be used directly to measure oxygen partial pressure.

公开(公告)号：WO1990004941A1

公开(公告)日：1990-05-17

申请号：PCT/US1989003564

申请日：1989-08-18

Applicant: NIM, INCORPORATED

Inventor： NIM, INCORPORATED ,  CHANCE, Britton

IPC: A61B05/00

CPC classification number: A61B5/14551 ,  A61B5/0002 ,  A61B5/6828 ,  G01N21/49

Abstract: A system for non-invasively determining the oxygenation state of tissue located beneath the surface of the skin of a subject is disclosed. In a preferred embodiment, a user-wearable detector array and related circuitry (10) which use near-infrared radiation to collect oxygenation data are provided. The apparatus also includes displays (40) for information regarding the oxygenation state in several ways. In one embodiment, a user wearable wristband indicator connected to the detector array which is located at another location, such as on the leg, provides information directly to the user. A separate, user-wearable battery pack (30), which is preferably designed to provide power for the duration of the activity being monitored, is also provided.

Abstract translation: 公开了一种用于非侵入性地确定位于受试者皮肤表面下方的组织的氧合状态的系统。 在优选实施例中，提供了一种使用可穿戴式检测器阵列和使用近红外辐射来收集氧合数据的相关电路（10）。 该装置还包括用于以几种方式关于氧合状态的信息的显示器（40）。 在一个实施例中，连接到位于另一位置（例如腿上）的检测器阵列的用户可穿戴腕带指示器直接向用户提供信息。 还提供了独立的，用户可佩戴的电池组（30），其优选地被设计成在所监视的活动的持续时间内提供电力。

公开(公告)号：WO1990004351A1

公开(公告)日：1990-05-03

申请号：PCT/US1989004704

申请日：1989-10-19

Applicant: LINEBACK, Paul, I.

IPC: A61B05/00

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150251 ,  A61B5/150259

Abstract: Apparatus and methods for simultaneously obtaining clinical laboratory and arterial blood gas samples are disclosed. The apparatus includes a flow-through plunger (11) configured for being detachably secured to the tip of a standard arterial blood gas syringe (12). The flow-through plunger (11) has a conduit (24) through the center thereof which permits blood to flow through the plunger into the arterial blood gas syringe (12). The flow-through plunger (11) preferably has a diameter larger than the diameter of the arterial blood gas syringe (12). The combination of flow-through plunger (11) and arterial blood gas syringe (12) function as a plunger assembly for a larger syringe (16). Both a clinical laboratory blood sample and an arterial blood gas sample may be obtained by introducing arterial blood into the clinical laboratory syringe barrel (32) and passing the blood through the flow-through plunger (11) into the arterial blood gas syringe (12).

公开(公告)号：WO1990001893A1

公开(公告)日：1990-03-08

申请号：PCT/US1989003659

申请日：1989-08-24

Applicant: MOUNTPELIER INVESTMENTS S.A. ,  FIDDIAN-GREEN, Richard, G.

Inventor： MOUNTPELIER INVESTMENTS S.A.

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/42 ,  A61B5/4255 ,  A61B5/6853

Abstract: A remote sensing tonometric catheter apparatus (20) and method for sampling of a fluid or gas property of interest in a hollow internal organ. The tonometric catheter (20) assists in early detection of the problems of stress ulceration and/or intestinal ischemia. The tonometric catheter (20) has one or more sampling chambers (40) for introduction into a hollow internal organ or an area adjacent thereto. The tonometric catheter (20) has an electric sensor (42) for developing a signal indicative of the condition of the organ. Electric sensor (42) is in communication with the sampling chamber (40). The sensor (42) has a conductor (56) coupled therewith for conveying the signal to a location outside the organ such that the condition of the organ may be remotely determined. Preferably, the wall (36) of the sampling chamber (40) is freely permeable to the gas or fluid to be measured by the sensor (42), but is poorly permeable to other gases or fluids which may interfere with the sensor (42). The method is accomplished by introducing the catheter into the organ such that the sampling chamber is disposed at a portion of the wall of the organ. The sampling chamber is left in position at the wall of the organ for a time sufficient to allow the fluid or gas of interest to diffuse into the sampling chamber. The concentration of the fluid or gas of interest is analyzed. The pH of the wall of the organ may be calculated based on the concentration of the fluid or gas property of interest.

Abstract translation: 遥感测量导管装置（20）以及在中空内脏器官中对感兴趣的流体或气体属性取样的方法。 测量导管（20）有助于早期检测应激性溃疡和/或肠缺血的问题。 测量导管（20）具有一个或多个采样室（40），用于引入中空的内部器官或与其相邻的区域。 测量导管（20）具有用于产生指示器官状况的信号的电传感器（42）。 电传感器（42）与取样室（40）连通。 传感器（42）具有与其连接的导体（56），用于将信号传送到器官外部的位置，使得器官的状态可以被远程确定。 优选地，采样室（40）的壁（36）可自由地透过传感器（42）测量的气体或流体，但对可能与传感器（42）干扰的其它气体或流体的渗透性差， 。 该方法通过将导管引入器官来实现，使得采样室设置在器官壁的一部分处。 取样室留在器官壁上的时间足以使感兴趣的流体或气体扩散到取样室中。 分析感兴趣的流体或气体的浓度。 器官壁的pH可以根据感兴趣的流体或气体性质的浓度来计算。

公开(公告)号：WO1989011244A1

公开(公告)日：1989-11-30

申请号：PCT/US1989002132

申请日：1989-05-17

Applicant: DATA SCIENCES, INC.

Inventor： DATA SCIENCES, INC. ,  BROCKWAY, Brian, P. ,  MILLS, Perry, A. ,  MILLER, Jonathan, T.

IPC: A61B05/00

CPC classification number: G01L19/141 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/6882 ,  G01L19/0061 ,  G01L19/0084 ,  G01L19/147 ,  H01L2224/48091 ,  H01L2924/16152 ,  Y10S128/903 ,  H01L2924/00014

Abstract: Measurement of a physiological pressure is accomplished by placement of a pressure transmitting catheter (20) within a blood vessel or other structure within which pressure is to be measured. The catheter (20) is blood-compatible, capable of withstanding handling during distribution and implantation, and provides adequate pressure transmission frequency response in a variety of applications. The catheter (20), which includes a hollow tube filled with a low viscosity fluid (29) and having a plug (30) of a gel-like material at its distal end (22), transmits the pressure signal to a solid-state transducer (16) which is typically connected to amplifying electronics and an implantable radio-transmitter (18) capable of relaying the pressure information from within the body to a radio receiver external to the body.

公开(公告)号：WO1989009563A1

公开(公告)日：1989-10-19

申请号：PCT/US1989001420

申请日：1989-04-06

Applicant: POLLOCK, Richard, A. ,  MURPHY, R., Edward

IPC: A61B05/00

CPC classification number: A61M1/006 ,  A61B5/02042 ,  A61B50/37 ,  A61B90/90 ,  A61B2090/0805 ,  A61B2217/005 ,  A61B2217/007 ,  G06F19/00 ,  G06F19/3481 ,  G16H40/63 ,  Y02A90/26

Abstract: Apparatus for accurately and more safely monitoring blood and bodily fluids in a patient. In one embodiment, at least one load cell supports a container for receiving various sizes of sponges that hold such fluids. The sponges may be sorted into the container utilizing a sorting grip located above or forming a part of the container, and photoelectric or other sensors detect the number of sponges placed into the container via each opening in the grid. The load cells and sensors are connected to controller circuitry which counts, tracks and displays the number of each size of sponges in the container and the weight of fluid in the sponges. The weighing apparatus may be connected to a computer that is programed to read information from the weighing apparatus and from its own keyboard to calculate, update, store, display and print values corresponding to amounts of suction products, urine, crystalloids, irrigation, miscellaneous blood products including whole blood, fresh frozen plasma, packed red blood cells, platelets, cryoprecipitates and stimates introduced to or removed from the patient. The processor of the weighing apparatus may be adapted to perform the computer's functions in order to reduce the size of the apparatus. Alternatively, a computer without a weighing apparatus may be used to account for the values mentioned above, in which case the operator manually enters information relating to numbers and weights of sponges.