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公开(公告)号：KR100260302B1
公开(公告)日：2000-07-01
申请号：KR1019980015619
申请日：1998-04-30
IPC: C12N1/20
Abstract: PURPOSE: A microorganism Phellinus sp. that produces an active material to improve immunity is provided, thereby the immunity improving active material can be effectively produced and used in the treatment of cancer. CONSTITUTION: The immunity improving active material is produced from the Phellinus sp., especially Phellinus linteus Yoo (KCTC 0399BP) by the steps of: incubating 13 Phellinus sp. strains on potato dextrose agar; separating total DNA of grown Phellinus sp. strains by SDS-phenol; separating mitochondria DNA from the total DNA; treating the mitochondria DNA with endonuclease; developing the endonuclease treated DNA on agarose gel electrophoresis; calculating F value of developed fragment and determining P value based on F value to analyze the relation between 13 Phellinus sp. strains; selecting Phellinus linteus Yoo (KCTC 0399BP) based on the result; incubating Phellinus linteus Yoo (KCTC 0399BP); extracting and separating polysaccharide as an immunity improving active material; and analyzing its immunity improving activity.
Abstract translation: 目的：微生物桑黄 提供产生提高免疫力的活性物质，从而可以有效地制备免疫改善活性物质并用于治疗癌症。 构成：通过以下步骤从桑黄，特别是桑黄（KCTC 0399BP）生产提高免疫力的活性物质：培养13个桑黄 马铃薯葡萄糖琼脂上的菌株; 分离生长的桑黄总DNA 菌株用SDS-苯酚; 从总DNA中分离线粒体DNA; 用核酸内切酶处理线粒体DNA; 在琼脂糖凝胶电泳上开发内切核酸酶处理的DNA; 计算开发片段的F值，并根据F值确定P值，分析13种番茄属植物之间的关系。 株; 根据结果选择枸杞子（KCTC 0399BP）; 孵化桑黄（KCTC 0399BP）; 提取和分离多糖作为免疫改善活性物质; 并分析其免疫力改善活动。
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公开(公告)号：KR1019990081594A
公开(公告)日：1999-11-15
申请号：KR1019980015618
申请日：1998-04-30
IPC: A61K31/715
Abstract: 본 발명은 펠리누스속의 균주, 특히 펠리누스 린테우스 유(Phellinus linteus Yoo KCTC 0399BP)로부터 분리한 다당류 물질의 면역 항암치료제로서의 용도에 관한 것이다.
본 발명은 펠리누스 린테우스 유 균주로부터 분리한 다당류 물질이 생체내 면역기능을 매개로 하여 암전이를 억제하므로 암을 비롯한 AIDS 등 면역관련 질환의 예방, 치료 및 기초기전연구를 위한 약물로 사용할 수 있는 뛰어난 효과가 있다.
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