公开(公告)号：US06433197B1

公开(公告)日：2002-08-13

申请号：US09969681

申请日：2001-10-02

Applicant: Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

Inventor： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC: C07D30702

CPC classification number: C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

公开(公告)号：US06403814B1

公开(公告)日：2002-06-11

申请号：US09418637

申请日：1999-10-15

Applicant: Alla Venkata Rama Rao ,  Mukund S. Chorghade ,  Amin ul Islam ,  Vemuri Venkata Kiran Rao ,  Anegondi Sreenivasa Prasad ,  Batchu Venkateswara Rao ,  Ranga Reddy ,  Lalata Krishnakanth Reddy ,  Kotakonda Shailaja ,  Mukund Keshao Gurjar ,  Sunil Vyankatesh Mhaskar

Inventor： Alla Venkata Rama Rao ,  Mukund S. Chorghade ,  Amin ul Islam ,  Vemuri Venkata Kiran Rao ,  Anegondi Sreenivasa Prasad ,  Batchu Venkateswara Rao ,  Ranga Reddy ,  Lalata Krishnakanth Reddy ,  Kotakonda Shailaja ,  Mukund Keshao Gurjar ,  Sunil Vyankatesh Mhaskar

IPC: C07D30702

CPC classification number: C07D307/16 ,  C07C45/63 ,  C07C45/71 ,  C07C319/20 ,  C07C323/19 ,  C07D307/12 ,  C07D307/14 ,  C07C49/84

Abstract: A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N′-methyl-N′-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

Abstract translation: 提供了合成二芳基取代的杂环化合物，特别是2,5-二芳基取代的四氢呋喃和四氢噻吩的方法。 还提供合成起始原料和中间体的方法。 本发明的重要应用是合成CMI-392，（±）反式-2- [5-N'-甲基-N'-羟基脲基甲基）3-甲氧基-4-对氯苯硫基乙氧基苯基] -5- （3,4,5-三甲氧基苯基） - 四氢呋喃，一种治疗炎症和免疫疾病的高效药物。 本发明还包括可用作所公开的合成方法中的原料和中间体的新化合物。

公开(公告)号：US06306895B1

公开(公告)日：2001-10-23

申请号：US09347113

申请日：1999-07-02

Applicant: Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

Inventor： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC: A01N4302

CPC classification number: C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

Abstract translation: 本发明提供了制备环氧化合物的新方法，包括2,5-二取代的四氢呋喃，2,6-二取代的四氢吡喃，2,7-二取代氧杂环庚烷和2,8-氧代山梨糖醇。 本发明还提供新的环氧化合物和包含这些化合物的药物组合物和治疗方法。