公开(公告)号：WO2006040182A1

公开(公告)日：2006-04-20

申请号：PCT/EP2005/011106

申请日：2005-10-14

Applicant: ABBOTT GMBH & CO. KG ,  DRESCHER, Karla ,  HAUPT, Andreas ,  UNGER, Liliane ,  TURNER, Sean, C. ,  BRAJE, Wilfried ,  GRANDEL, Roland ,  HENRY, Christophe ,  BACKFISCH, Gisela ,  BEYERBACH, Armin ,  LUBISCH, Wilfried

Inventor： DRESCHER, Karla ,  HAUPT, Andreas ,  UNGER, Liliane ,  TURNER, Sean, C. ,  BRAJE, Wilfried ,  GRANDEL, Roland ,  HENRY, Christophe ,  BACKFISCH, Gisela ,  BEYERBACH, Armin ,  LUBISCH, Wilfried

IPC: C07D207/09 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/04 ,  C07D403/04 ,  C07D413/12 ,  C07D205/04 ,  C07D413/10 ,  C07D413/14 ,  C07D211/28 ,  A61K31/397 ,  A61K31/445 ,  A61P25/16

CPC classification number: C07D413/14 ,  C07D205/04 ,  C07D207/09 ,  C07D211/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12

Abstract: The invention relates to compounds of the formula (I) wherein n is 0, 1 or 2; G is CH 2 or CHR 3 ; R 1 is H, C,-C 6 -alkyl, C,-C 6 -alkyl substituted by C 3 -C 6 -cycloalkyl, C l -C 6 -hydroxyalkyl, fluorinated C,-C 6 -alkyl, C 3 -C 6 -cycloalkyl, fluorinated C 3 -C 6 -cycloalkyl, C 3 -C 6 ­ alkenyl, fluorinated C 3 -C 6 -alkenyl, formyl, acetyl or propionyl; R 2 , R 3 and R 4 are, independently of each other, H, methyl, fluoromethyl, difluoromethyl, or trifluoromethyl; A is phenylene, pyridylene, pyrimidylene, pyrazinylene, pyridazinylene or thiophenylene, which can be substituted by one ore more substituents selected from halogen, methyl, methoxy and CF 3 ; E is NR 5 or CH 2 , wherein R 5 is H or C 1 -C 3 -alkyl; Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6- ­membered heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms selected from N, O and S and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR 8 , where R 8 is H, C 1 -C 4 -alkyl, fluorinated C 1 -C 4 -alkyl, C 1 -C 4 ­alkylcarbonyl or fluorinated C 1 -C 4 -alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents R a , wherein the variable R a has the meanings given in the claims and in the description; and physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

Abstract translation: 本发明涉及式（I）化合物，其中n为0,1或2; G是CH