公开(公告)号：WO2008103992A3

公开(公告)日：2008-11-20

申请号：PCT/US2008054909

申请日：2008-02-25

Applicant: UNIV CLEMSON ,  MARCUS R KENNETH ,  CHRISTENSEN KENNETH A

Inventor： MARCUS R KENNETH ,  CHRISTENSEN KENNETH A

IPC: C12Q1/00 ,  C12M1/34 ,  G01N21/00 ,  G01N33/48

CPC classification number: G01N15/1484 ,  G01N15/147 ,  G01N2015/1486 ,  G01N2015/149

Abstract: The present invention relates to methods for counting, sorting, and manipulation of cells, organelles, and/or cellular material using capillary-channeled polymer films.

Abstract translation: 本发明涉及使用毛细管通道聚合物膜对细胞，细胞器和/或细胞材料进行计数，分选和操作的方法。

公开(公告)号：WO2006023332A2

公开(公告)日：2006-03-02

申请号：PCT/US2005/028296

申请日：2005-08-10

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION ,  FELLOWS OF HARVARD COLLEGE ,  ROGERS, Michael, S. ,  D'AMATO, Robert, J. ,  CHRISTENSEN, Kenneth

Inventor： ROGERS, Michael, S. ,  D'AMATO, Robert, J. ,  CHRISTENSEN, Kenneth

IPC: A61K39/00

CPC classification number: A61K38/164

Abstract: The present invention is based on the discovery that protective antigen related molecules (PARMs) without anthrax lethal factor have antiangiogenic or anticancer properties. The invention is directed to a method of inhibiting an angiogenic disease/disorder or cancer. Additionally, the invention can be applied to those at risk for developing cancer or an angiogenic disease/disorder comprising administering to a mammal an angiogenesis-inhibiting or cancer inhibiting amount of an PARM (including analogs, or derivative thereof having angiogenesis-inhibiting or anticancer activity, consisting of PA, PA fragment, analog, or derivative that is administered in a composition substantially free of anthrax lethal factor or other toxins).

Abstract translation: 本发明基于没有炭疽致死因子的保护性抗原相关分子（PARM）具有抗血管生成或抗癌特性的发现。 本发明涉及抑制血管生成疾病/病症或癌症的方法。 另外，本发明可以应用于处于发展中的癌症或血管发生疾病/病症的风险中，包括向哺乳动物施用血管生成抑制或癌抑制量的PARM（包括具有血管生成抑制或抗癌活性的类似物或其衍生物 由在基本上不含炭疽致死因子或其它毒素的组合物中施用的PA，PA片段，类似物或衍生物组成）。