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    Uses of alpha-conotoxin peptides
    12.
    发明申请
    Uses of alpha-conotoxin peptides 审中-公开
    α-芋螺毒素肽的使用

    公开(公告)号：US20040192610A1

    公开(公告)日：2004-09-30

    申请号：US10827369

    申请日：2004-04-20

    Applicant: The University of Utah Research Foundation ,  Cognetix, Inc.

    Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  Doju Yoshikami ,  G. Edward Cartier ,  Sigin Luo

    IPC: A61K038/10 ,  C07K014/435

    CPC classification number: A61K38/17 ,  A61K38/08 ,  C07K14/43504

    Abstract: The present invention relates to the use of null-conotoxin peptides having the general formula Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Pro-Xaa5-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Cys (SEQ ID NO:1) for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma. In this formula, Xaa1 is des-Xaa1, Tyr, mono-iodo-Tyr or di-iodo-Tyr, Xaa2 is any amino acid, Xaa3 is any amino acid, Xaa4 is any amino acid, Xaa5 is any amino acid; Xaa6 is any amino acid, Xaa7 is any amino acid, Xaa8 is any amino acid, Xaa9 is des-Xaa9 or any amino acid, Xaa10 is des-Xaa10 or any amino acid, Xaa11 is des-Xaa11 or any amino acid and Xaa12 is des-Xaa12 or any amino acid. Disulfide linkages exist between the first and third cysteines and the second and fourth cysteines. Pro may be replaced with hydroxy-Pro. The C-terminus may contain a hydroxyl or an amide group, preferably an amide group.

    Abstract translation: 本发明涉及具有通式Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Pro-Xaa5-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Cys的α-芋螺毒素肽 SEQ ID NO：1），用于治疗在神经元烟碱乙酰胆碱受体调节的病症。 这些病症包括但不限于心血管疾病，胃动力障碍，尿失禁，尼古丁成瘾，情绪障碍（例如双相情感障碍，单极抑郁，精神抑郁和季节性有效障碍）和小细胞肺癌，以及 小细胞肺癌的定位。 在该式中，Xaa1是des-Xaa1，Tyr，单碘-Tyr或二碘-Tyr，Xaa2是任何氨基酸，Xaa3是任何氨基酸，Xaa4是任何氨基酸，Xaa5是任何氨基酸; Xaa6是任何氨基酸，Xaa7是任何氨基酸，Xaa8是任何氨基酸，Xaa9是des-Xaa9或任何氨基酸，Xaa 10是des-Xaa 10或任何氨基酸，Xaa 11是des-Xaa 11或任何氨基酸，Xaa 12是 des-Xaa12或任何氨基酸。 第一和第三半胱氨酸与第二和第四半胱氨酸之间存在二硫键。 Pro可以用羟基替代。 C末端可以含有羟基或酰胺基，优选酰胺基。

    Conus gamma-carboxylase
    13.
    发明申请
    Conus gamma-carboxylase 审中-公开
    圆锥菌γ-羧化酶

    公开(公告)号：US20040163139A1

    公开(公告)日：2004-08-19

    申请号：US10788266

    申请日：2004-03-01

    Applicant: Cognetix, Inc. ,  University of Utah Research Foundation

    Inventor： James E. Garrett ,  Pradip K. Bandyopadhyay

    IPC: A01K067/033 ,  C07H021/04 ,  C12N009/48

    CPC classification number: C12N9/93

    Abstract: The present invention is relates to a null-carboxylase from Conus snails, a nucleic acid sequence encoding the Conus null-carboxylase and to a method for using the nucleic acid or protein sequences for preparing null-carboxylated proteins.

    Abstract translation: 本发明涉及来自锥螺旋体的γ-羧化酶，编码柯氏γ-羧化酶的核酸序列以及使用该核酸或蛋白质序列制备γ-羧化蛋白质的方法。

    Contulakin-G, analogs thereof and uses therefor
    14.
    发明申请
    Contulakin-G, analogs thereof and uses therefor 审中-公开
    Contulakin-G，其类似物和用途

    公开(公告)号：US20040072758A1

    公开(公告)日：2004-04-15

    申请号：US10695516

    申请日：2003-10-29

    Applicant: Cognetix, Inc.

    Inventor： John D. Wagstaff ,  Richard T. Layer ,  R. Tyler McCabe

    IPC: A61K038/14

    CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K9/001 ,  C07K14/575

    Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

    Abstract translation: 本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及 到前体肽。 本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍 焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍，以及神经系统，神经功能和 神经精神药理学障碍。

    MuO-conopeptides and their use as local anesthetics
    15.
    发明申请
    MuO-conopeptides and their use as local anesthetics 审中-公开
    MuO-肽和它们作为局部麻醉剂的用途

    公开(公告)号：US20020198145A1

    公开(公告)日：2002-12-26

    申请号：US09908739

    申请日：2001-07-20

    Applicant: COGNETIX, INC.

    Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  R. Tyler McCabe ,  James E. Garrett ,  Richard T. Layer ,  John D. Wagstaff ,  Robert M. Jones

    IPC: A61K038/17

    CPC classification number: C07K14/43504 ,  A61K38/17

    Abstract: The present invention is directed to the new nullO-conopeptides, their coding sequences and their propeptides and to the use of nullO-conopeptides as a local anesthetic for treating pain. The nullO-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operative pain or via an intrathecal pump for severe chronic pain situations or for treatment of pain in epithelial tissue.

    Abstract translation: 本发明涉及新的muO-肽，它们的编码序列及其前肽，以及使用muO-肽作为局部麻醉剂治疗疼痛。 muO-肽具有持久的麻醉活性，对于脊髓麻醉特别有用，无论是急性用于术后疼痛还是通过鞘内泵用于严重慢性疼痛情况或用于治疗上皮组织中的疼痛。

    USE OF CONANTOKINS
    18.
    发明申请
    USE OF CONANTOKINS 审中-公开
    使用组合

    公开(公告)号：WO1998003189A1

    公开(公告)日：1998-01-29

    申请号：PCT/US1997012652

    申请日：1997-07-21

    Applicant: COGNETIX, INC. ,  McCABE, R., Tyler ,  ZHOU, Li-Ming ,  LAYER, Richard, T.

    Inventor： COGNETIX, INC.

    IPC: A61K38/00

    CPC classification number: C07K14/43504 ,  A61K38/00

    Abstract: The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma -carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents. Neurologic disorders and psychiatric disorders include epilepsy, convulsions, neurotoxic injury (associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events), neurodegeneration (associated with Alzheimer's disease, senile dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's disease, Huntington's disease, Down's Syndrome, Korsakoff's disease, schizophrenia, AIDS dementia, multi-infarct dementia, Binswanger dementia and neuronal damage associated with uncontrolled seizures), chemical toxicity (such as addiction, morphine tolerance, opiate tolerance, opioid tolerance and barbiturate tolerance), pain (acute, chronic, migraine), anxiety, major depression, manic-depressive illness, obsessive-compulsive disorder, schizophrenia and mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and dystonia (movement disorder), sleep disorder, muscle relaxation and urinary incontinence. In addition, the conantokins are useful for treating HIV infection, ophthalmic indications and memory, learning or cognitive deficits.

    Abstract translation: 本发明涉及使用具有10-30个氨基酸（包括优选两个或更多个γ-羧基谷氨酸残基）的用于治疗神经系统和神经系统疾病的柯南多诺肽，柯南多肽衍生物和柯南多肽嵌合体 精神障碍，如抗惊厥剂，神经保护剂或止痛剂。 神经系统疾病和精神疾病包括癫痫，抽搐，神经毒性损伤（与缺氧，缺氧或局部缺血的症状相关，典型地是中风，脑血管意外，脑或脊髓创伤，心肌梗塞，身体创伤，溺水，窒息，围产期窒息或 低血糖事件），神经变性（与阿尔茨海默病，老年性痴呆，肌萎缩性侧索硬化，多发性硬化症，帕金森病，亨廷顿病，唐氏综合征，柯萨科夫病，精神分裂症，AIDS痴呆，多发性梗塞性痴呆，Binswanger痴呆和神经元损伤有关 不安全的癫痫发作），化学毒性（如成瘾，吗啡耐受，阿片剂耐受，阿片样物质耐受和巴比妥耐受），疼痛（急性，慢性，偏头痛），焦虑，主要抑郁症，躁狂抑郁症，强迫症，精神分裂症和 情绪障碍（如双相情感障碍，单极压抑 离子，心境恶劣和季节性有效障碍）和肌张力障碍（运动障碍），睡眠障碍，肌肉松弛和尿失禁。 此外，凝血因子可用于治疗艾滋病毒感染，眼科指征和记忆，学习或认知缺陷。

    A library of phylogenetically related sequences
    19.
    发明专利
    A library of phylogenetically related sequences 未知

    公开(公告)号：AU2004246009A1

    公开(公告)日：2004-12-16

    申请号：AU2004246009

    申请日：2004-06-04

    Applicant: COGNETIX INC

    Inventor： BULAJ GRZEGORZ ,  OLIVERA BALDOMERO M

    IPC: G01N33/53 ,  C12N20060101 ,  G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  G06F19/00

    Abstract: The invention includes a method of assaying phylogenetically related sequences and generating a set of possible nucleic acid or amino acid sequence combinations. Sequences are analyzed to create an alignment and a set of phylogenetically related sequences are selected. The observed residue(s) or indel(s) occupying each position in the alignment of the selected phylogenetically related sequences are identified and this information is used to generate a set of sequence combinations, wherein the set of possible sequence combinations (nucleic acid or polypeptide) is composed of the union of the observed residues or indels identified at each position.

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