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    STENT WITH ELASTOMERIC ELEMENTS
    11.
    发明申请
    STENT WITH ELASTOMERIC ELEMENTS 审中-公开
    具有弹性元件的STENT

    公开(公告)号：WO2014081914A3

    公开(公告)日：2014-07-31

    申请号：PCT/US2013071161

    申请日：2013-11-21

    Applicant: 480 BIOMEDICAL INC ,  CORE LEE ,  CONCAGH DANNY ,  RUSK EMILY ,  WEBBER STEPHANIE ,  KNOX RAYMOND ,  HO KICHERL

    Inventor： CORE LEE ,  CONCAGH DANNY ,  RUSK EMILY ,  WEBBER STEPHANIE ,  KNOX RAYMOND ,  HO KICHERL

    IPC: A61F2/90 ,  A61F2/82 ,  A61F2/91

    CPC classification number: A61F2/915 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/825 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2250/0018 ,  A61F2250/004 ,  A61F2250/0042 ,  A61F2250/0048 ,  Y10T29/49925

    Abstract: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desirable mechanical properties. The implant comprises a plurality of open area (214) having a continuous outer boundary and one or more elements (310) spanning one or more open area of the implant and connecting proximal and distal boundary portions of said open area. The spanning element (310) due to its nature (for instance due to its material) applies a force to the implant that acts in favour of radial expansion and axial contraction, thus enhancing radial strength.

    Abstract translation: 公开了一种用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得其可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。 植入物包括具有连续外边界的多个开放区域（214）和跨越植入物的一个或多个开放区域并连接所述开放区域的近端和远端边界部分的一个或多个元件（310）。 跨越元件（310）由于其性质（例如由于其材料）而对植入物施加力，其有利于径向膨胀和轴向收缩，从而增强径向强度。

    EXPANDABLE SHEATH TUBING
    14.
    发明申请
    EXPANDABLE SHEATH TUBING 审中-公开
    可膨胀护套管

    公开(公告)号：WO2004037333A1

    公开(公告)日：2004-05-06

    申请号：PCT/US2003/034003

    申请日：2003-10-24

    Applicant: NMT MEDICAL, INC. ,  CORE, Lee, A.

    Inventor： CORE, Lee, A.

    IPC: A61M25/06

    CPC classification number: A61B17/3439 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61M25/0023 ,  A61M25/0662 ,  A61M2025/0024

    Abstract: An introducer sheath or catheter can be formed in two or more layers with an inner layer made of a higher durometer material and an outer layer made of a lowerdurometer material. The inner layer can have one or a combination of the following: one or more longitudinal slits, overlapping portions, monolithic hinges, or other formations to allow for radial expansion.

    Abstract translation: 导入鞘或导管可以形成为两层或更多层，内层由较高硬度材料制成，外层由较低硬度材料制成。 内层可具有以下中的一种或其组合：一个或多个纵向狭缝，重叠部分，整体式铰链或允许径向扩张的其他构造。

    HEMOSTASIS VALVE
    15.
    发明申请
    HEMOSTASIS VALVE 审中-公开
    HEMOSTASIS阀

    公开(公告)号：WO2004032993A2

    公开(公告)日：2004-04-22

    申请号：PCT/US2003/032133

    申请日：2003-10-10

    Applicant: NMT MEDICAL, INC. ,  CORE, Lee, A.

    Inventor： CORE, Lee, A.

    IPC: A61M

    CPC classification number: A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/064

    Abstract: A hemostasis valve includes a single gland with multiple offset longitudinal slits that do no extend through the gland completely. The multiple slits from a complex pathway for the guide dilator/catheter and thus a better seal. The offset slits are joined by a lateral cut in the gland. When a guide wire or dilator/catheter in introduced into the introducer, the gland deforms sufficiently to allow the guide wire or other device to move through the first slits, the lateral cut and the second slits. This complex pathway or slit provides a larger sealing surface thereby creating a better seal. As a result, effective seals may be formed around relatively large, as compared to the inner diameter of an introducer sheath, catheters.

    Abstract translation: 止血阀包括具有多个偏移纵向狭缝的单个腺体，其不完全延伸穿过腺体。 来自导向扩张器/导管的复合路径的多个狭缝，因此更好的密封。 偏移狭缝通过腺体中的横向切口连接。 当引导线或扩张器/导管引入引导器时，腺体足够变形以允许导丝或其它装置移动穿过第一狭缝，横切和第二狭缝。 这个复杂的路径或狭缝提供了更大的密封面，从而形成更好的密封。 结果，与引导器套管的内径相比，导管可以相对较大地形成有效的密封。

    HEMOSTASIS VALVE
    18.
    发明申请
    HEMOSTASIS VALVE 审中-公开
    HEMOSTASIS阀

    公开(公告)号：WO2004032993A3

    公开(公告)日：2004-07-01

    申请号：PCT/US0332133

    申请日：2003-10-10

    Applicant: NMT MEDICAL INC ,  CORE LEE A

    Inventor： CORE LEE A

    IPC: A61M20060101 ,  A61M1/00 ,  A61M5/00 ,  A61M5/14 ,  A61M5/178 ,  A61M39/06 ,  B29C33/40

    CPC classification number: A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/064

    Abstract: A hemostasis valve includes a single gland (16) with multiple offset longitudinal slits (32/34) that do no extend through the gland (16) completely. The multiple slits (32/34) from a complex pathway for the guide dilator/catheter (58) and thus a better seal. The offset slits (32/34) are joined by a lateral cut (36) in the gland. When a guide wire or dilator/catheter (58) is introduced into the introducer, the gland (16) deforms sufficiently to allow the guide wire or other device (58) to move through the first slits (32), the lateral cut (36) and the second slits (34). This complex pathway or slit provides a larger sealing surface thereby creating a better seal. As a result, effective seals may be formed around relatively large, as compared to the inner diameter of an introducer sheath, catheters.

    Abstract translation: 止血阀包括具有多个偏移纵向狭缝（32/34）的单个压盖（16），其不完全延伸穿过压盖（16）。 来自用于引导扩张器/导管（58）的复合路径的多个狭缝（32/34），因此更好的密封。 偏移狭缝（32/34）通过腺体中的横向切口（36）连接。 当引导线或扩张器/导管（58）被引入导引器时，压盖（16）充分变形，以允许引导线或其他装置（58）移动通过第一狭缝（32），横向切口（36） ）和第二狭缝（34）。 这个复杂的路径或狭缝提供了更大的密封面，从而形成更好的密封。 结果，与引导器套管的内径相比，导管可以相对较大地形成有效的密封。

    DRUG DELIVERY SYSTEMS AND RELATED METHODS
    19.
    发明申请
    DRUG DELIVERY SYSTEMS AND RELATED METHODS 审中-公开
    药物输送系统及相关方法

    公开(公告)号：WO2015035387A1

    公开(公告)日：2015-03-12

    申请号：PCT/US2014/054792

    申请日：2014-09-09

    Applicant: ARSENAL MEDICAL, INC. ,  PALASIS, Maria ,  CONCAGH, Danny ,  CORE, Lee ,  WEBBER, Stephanie ,  KUANG, Yina ,  NAIMARK, Wendy ,  KNOX, Raymond

    Inventor： PALASIS, Maria ,  CONCAGH, Danny ,  CORE, Lee ,  WEBBER, Stephanie ,  KUANG, Yina ,  NAIMARK, Wendy ,  KNOX, Raymond

    IPC: A61B17/12

    CPC classification number: A61M25/10 ,  A61F2/90 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/105 ,  A61M2025/1075 ,  C08L67/04

    Abstract: The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body.

    Abstract translation: 本发明提供了使用临时或永久地放置在体内的可扩展装置来靶向递送治疗剂的系统和方法。 这样的治疗剂可以作为涂层递送到可扩张装置的外表面上。 一旦定位在身体内的期望位置，则该装置被扩张，使得其药物涂覆的外表面与靶组织直接接触。 膨胀的装置在从身体取出之前保持与目标组织接触预定量的时间。 可以通过将第二可扩张装置递送到身体内的相同位置，或之前进行使用可扩张装置的治疗剂的递送。

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