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    METHODS OF USING PD-L1 EXPRESSION IN TREATMENT DECISIONS FOR CANCER THERAPY
    17.
    发明申请
    METHODS OF USING PD-L1 EXPRESSION IN TREATMENT DECISIONS FOR CANCER THERAPY 审中-公开
    使用PD-L1表达治疗癌症治疗的方法

    公开(公告)号：WO2017181073A1

    公开(公告)日：2017-10-19

    申请号：PCT/US2017/027714

    申请日：2017-04-14

    Applicant: CREATV MICROTECH, INC.

    Inventor： ADAMS, Daniel ,  TANG, Cha-Mei

    IPC: C07K16/28 ,  C12N5/00 ,  G01N33/574

    Abstract: Methods of using detection of PD-L1 expression by circulating cancer cells in the screening, monitoring, treatment and diagnosis of cancer in subjects are disclosed. The methods are based on assaying one or more of circulating tumor cells (CTCs), epithelial to mesenchymal transition CTCs (EMTCTCs), cancer associated macrophage-like cells (CAMLs), and cancer associated vascular endothelial cells (CAVEs) isolated from a subject having cancer for PD-L1 expression.

    Abstract translation: 在受试者中筛选，监测，治疗和诊断癌症时，公开了通过使癌细胞循环检测PD-L1表达的方法。 该方法基于分析自患有以下疾病的受试者分离的循环肿瘤细胞（CTC），上皮细胞间质转化CTC（EMTCTC），癌症相关巨噬细胞样细胞（CAML）和癌症相关血管内皮细胞（CAVE）中的一种或多种： 癌症为PD-L1表达。

    METHOD OF FABRICATION OF MICRO AND NANOFILTERS
    18.
    发明申请
    METHOD OF FABRICATION OF MICRO AND NANOFILTERS 审中-公开
    微波和纳米薄膜的制备方法

    公开(公告)号：WO2010085337A1

    公开(公告)日：2010-07-29

    申请号：PCT/US2010/000144

    申请日：2010-01-21

    Applicant: CREATV MICROTECH, INC. ,  TANG, Cha-Mei ,  MAKAROVA, Olga ,  HOFFBAUER, Mark ,  WILLIAMSON, Todd ,  AMSTUTZ, Platte

    Inventor： TANG, Cha-Mei ,  MAKAROVA, Olga ,  HOFFBAUER, Mark ,  WILLIAMSON, Todd ,  AMSTUTZ, Platte

    IPC: B01D39/00

    CPC classification number: B01D67/0062 ,  B01D67/0034 ,  B01D67/0093 ,  B01D69/02 ,  B01D2323/38 ,  B01D2325/028 ,  B01D2325/26

    Abstract: Abstract of the Disclosure Micro- and nanofilters have a wide range of applications in many fields, including medical diagnostics, drug delivery, medical implants, and hemodialysis. Some issues that limit commercial application of current nanofilters in medicine are low pore density, non-uniform pore size, and the use of materials that are not biocompatible. A method is described to fabricate high porosity polymer and diamond micro- and nanofilters producing smooth, uniform and straight pores of high aspect ratio. Pore size, density, and shape can be predetermined with a high degree of precision by masks and controlled etch. The method combines energetic neutral atom beam lithography and a mask. This technology allows etching polymeric materials in a clean, well-controlled, and charge-free environment, making it very suitable for fabricating nanofilters and other components for biomedical applications.

    Abstract translation: 公开摘要微纳米过滤器在许多领域有广泛的应用，包括医疗诊断，药物输送，医疗植入物和血液透析。 限制当前纳米过滤器在医药中的商业应用的一些问题是低孔密度，不均匀孔径以及不能生物相容的材料的使用。 描述了一种制造高孔隙率聚合物和金刚石微米和纳米过滤器的方法，其产生高纵横比的光滑，均匀和直孔。 孔径，密度和形状可以通过掩模和受控蚀刻以高精确度预先确定。 该方法结合了高能中性原子束光刻和掩模。 该技术允许在干净，良好控制和无电荷环境中蚀刻聚合物材料，使其非常适合制造用于生物医学应用的纳米过滤器和其他部件。

    SENSITIVE EMISSION LIGHT GATHERING AND DETECTION SYSTEM
    19.
    发明申请
    SENSITIVE EMISSION LIGHT GATHERING AND DETECTION SYSTEM 审中-公开
    敏感发射光学和检测系统

    公开(公告)号：WO2007041507A3

    公开(公告)日：2007-07-12

    申请号：PCT/US2006038464

    申请日：2006-10-03

    Applicant: CREATV MICROTECH INC ,  TANG CHA-MEI ,  AMSTUTZ PLATTE

    Inventor： TANG CHA-MEI ,  AMSTUTZ PLATTE

    IPC: G02B6/02

    CPC classification number: G01N21/0303 ,  G01N21/255 ,  G01N21/645

    Abstract: A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample and can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light from the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, an one or more optical detectors. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light from the bottom of the waveguide sample holder.

    Abstract translation: 提供了一种发光计，其包括波导样本保持器和一个或多个检测器。 波导样品保持器可以包括用于保持样品的中空区域，并且可以由将发射光引导到波导样品保持器的底端的材料制成。 可以提供一个或多个检测器，其检测来自波导样品保持器的底部的发射光。 还提供了一种荧光计/光度计，其包括波导样品保持器，一个或多个激发光源，一个或多个光学检测器。 激发光以与波导样品保持器的一个表面成一定角度或垂直的方向引入。 波导样品架由能够将发射光引导到波导样品架的底端的材料制成。 存在一个或多个检测器，其检测来自波导样品保持器的底部的发射光。

    FLOW-THROUGH CHEMICAL AND BIOLOGICAL SENSOR
    20.
    发明申请
    FLOW-THROUGH CHEMICAL AND BIOLOGICAL SENSOR 审中-公开
    流通化学和生物传感器

    公开(公告)号：WO2005086703A2

    公开(公告)日：2005-09-22

    申请号：PCT/US2005/007121

    申请日：2005-03-04

    Applicant: CREATV MICROTECH, INC. ,  TANG, Cha-Mei ,  AMSTUTZ, Platte, T., III

    Inventor： TANG, Cha-Mei ,  AMSTUTZ, Platte, T., III

    IPC: B01F5/06 ,  B01F13/00 ,  G01N21/05

    CPC classification number: G01N21/05 ,  B01F5/0603 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/086 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/54373 ,  G01N2021/0346

    Abstract: The invention provides a mixing flow apparatus. The mixing flow apparatus consists of a waveguide and a mixing flow chamber; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal, and the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet. Also provided is a detection apparatus. The detection apparatus consists of a waveguide, a mixing flow chamber and a radiation detector; the waveguide having a higher index of refraction material than its surroundings for propagation of a signal; the mixing flow chamber having a body forming a flow chamber with an inlet, an outlet, a radiation transmissive wall and a surface positioned to disrupt flow regularity of a sample fluid, the body of the mixing flow chamber surrounding at least a portion of the waveguide, wherein constituents of a sample fluid entering the inlet are mixed by disruption of sample fluid flow regularity prior to discharge at the outlet, and the radiation detector being disposed facing the direction of oncoming propagated signal from the waveguide. The detection apparatus can include an illumination source.

    Abstract translation: 本发明提供一种混合流动装置。 混合流动装置由波导和混合流动室构成; 所述波导具有比其周围的更高的折射率折射材料以传播信号，并且所述混合流动室具有形成流动室的主体，所述主体具有入口，出口，辐射透射壁和定位成破坏流动规则性的表面 样品流体，混合流动室的主体围绕波导的至少一部分，其中进入入口的样品流体的组分通过在出口排放之前破坏样品流体流动规则性而混合。 还提供了检测装置。 检测装置由波导管，混合流室和放射线检测器构成， 波导具有比其周围更高的折射材料折射率以传播信号; 所述混合流动室具有形成具有入口，出口，辐射透射壁和定位成破坏样品流体的流动规则的流动室的主体，所述混合流动室的主体围绕所述波导的至少一部分 其中进入入口的样品流体的组分通过在出口处排出之前破坏样品流体流动规则性而被混合，并且辐射检测器被布置为面对来自波导的迎面传播信号的方向。 检测装置可以包括照明源。

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