公开(公告)号：US802444A

公开(公告)日：1905-10-24

申请号：US1903186326

申请日：1903-12-23

Applicant: DATE DAVID BEEBE

Inventor： DATE DAVID BEEBE

CPC classification number: A22C9/008

公开(公告)号：US20130302817A1

公开(公告)日：2013-11-14

申请号：US13467544

申请日：2012-05-09

Applicant: Erwin Berthier ,  Eric Sackmann ,  Peter Cavnar ,  David Beebe ,  David John Guckenberger

Inventor： Erwin Berthier ,  Eric Sackmann ,  Peter Cavnar ,  David Beebe ,  David John Guckenberger

IPC: G01N33/53 ,  C12Q1/02 ,  B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/5023 ,  B01L3/50853 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  B01L2400/086

Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. The device includes a base having outer surface and a channel therethough for receiving fluid therein. The channel has input and output ports communicating with the outer surface. A lid is also provided. The lid has an outer surface, a first well having a port communicating with the outer surface of the lid, and a second well having a port communicating with the outer surface. The lid moveable between a first disengaged position and a second engaged position wherein the first port of the lid is adjacent the input port of the channel and the second port is adjacent the output port of the channel.

Abstract translation: 提供了用于手持诊断和测定的微流体装置和方法。 该装置包括具有外表面的基部和用于在其中接收流体的通道。 通道具有与外表面连通的输入和输出端口。 还提供盖子。 盖具有外表面，第一阱具有与盖的外表面连通的端口，以及具有与外表面连通的端口的第二阱。 所述盖可在第一脱离位置和第二接合位置之间移动，其中所述盖的第一端口邻近所述通道的输入端口，并且所述第二端口邻近所述通道的输出端口。

公开(公告)号：US20050282267A1

公开(公告)日：2005-12-22

申请号：US10872647

申请日：2004-06-21

Applicant: Justin Williams ,  David Beebe ,  Stephen Johnson

Inventor： Justin Williams ,  David Beebe ,  Stephen Johnson

IPC: C12M1/34 ,  C12M1/42 ,  G01F1/64

CPC classification number: C12M41/46 ,  C12M35/08

Abstract: A micro device and method are provided for examining and testing a slice of a biological object, such as brain tissue. The micro device includes a body defining a chamber and a channel in communication with the chamber. A stimulation fluid flows axially along a flow path in the channel and engages a user selectable region of the slice. An array of electrodes in the chamber engages the slice and allows for the multi-channel electrical recording and stimulation of the slice at each of the electrode sites.

Abstract translation: 提供了用于检查和测试诸如脑组织的生物体的切片的微装置和方法。 微型装置包括限定腔室的主体和与腔室连通的通道。 刺激流体沿着通道中的流动路径轴向流动并且接合切片的用户可选择区域。 腔室中的电极阵列接合切片并且允许在每个电极位置处的多通道电记录和切片的刺激。

公开(公告)号：US6148635A

公开(公告)日：2000-11-21

申请号：US174813

申请日：1998-10-19

Applicant: David Beebe ,  Clark Bullard ,  Michael Philpott ,  Mark Shannon

Inventor： David Beebe ,  Clark Bullard ,  Michael Philpott ,  Mark Shannon

IPC: F04B43/02 ,  F04B43/04 ,  F04B43/06 ,  F04B43/12 ,  F25B1/00 ,  F25B1/02 ,  F25B39/00 ,  F25B41/06 ,  F25B49/02 ,  F28D9/00 ,  F28B1/00

CPC classification number: F28F3/048 ,  F04B43/043 ,  F25B1/02 ,  F25B39/00 ,  F28D9/00 ,  F25B2400/15 ,  F28D2021/0068 ,  F28F2260/02

Abstract: A compact active vapor compression cycle heat transfer device. The device of the invention includes a flexible diaphragm serving as the compressive member in a layered compressor. The compressor is stimulated by capacitive electrical action and drives the relatively small refrigerant charge for the device through a closed loop defined by the compressor, an evaporator and a condenser. The evaporator and condenser include microchannel heat exchange elements to respectively draw heat from an atmosphere on a cool side of the device and expel heat into an atmosphere on a hot side of the device. The overall structure and size of the device is similar to microelectronic packages, and it may be combined to operate with similar devices in useful arrays.

Abstract translation: 一种紧凑的主动蒸气压缩循环传热装置。 本发明的装置包括在分层压缩机中用作压缩构件的柔性隔膜。 压缩机由电容性电动作用刺激，并通过由压缩机，蒸发器和冷凝器限定的闭合回路来驱动装置的相对较小的制冷剂装料。 蒸发器和冷凝器包括微通道热交换元件，以分别从装置的冷却侧的气氛中吸收热量，并将热量排放到装置的热侧上的气氛中。 器件的总体结构和尺寸与微电子封装类似，并且可以将其组合以与有用阵列中的类似器件一起工作。

公开(公告)号：US08993243B2

公开(公告)日：2015-03-31

申请号：US12987934

申请日：2011-01-10

Applicant: David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

Inventor： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

IPC: C12Q1/68 ,  G01N33/543

CPC classification number: G01N33/54326 ,  G01N33/543

Abstract: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

Abstract translation: 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。

公开(公告)号：US20060152377A1

公开(公告)日：2006-07-13

申请号：US11033370

申请日：2005-01-11

Applicant: David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

Inventor： David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

IPC: G08B21/00 ,  G01N3/56 ,  G01M19/00 ,  G08B19/00

CPC classification number: A43B3/001 ,  A43B3/0005 ,  A43B5/00 ,  A43B7/00 ,  G01N3/56

Abstract: A device and method are provided for determining the wear of a sole of a shoe. The device includes first and second sensors receivable in the sole of the shoe. The sensors are axially spaced and generate signals in response to corresponding impact forces acting thereon. A control circuit is connectable to the first and second sensors. The control circuit compares the difference between the first and second signals to a threshold and generates an alert signal in response to the difference between the first and second signal meeting the threshold.

Abstract translation: 提供了一种用于确定鞋底的磨损的装置和方法。 该装置包括可容纳在鞋底中的第一和第二传感器。 传感器轴向间隔开并响应于作用于其上的相应冲击力产生信号。 控制电路可连接到第一和第二传感器。 控制电路将第一和第二信号之间的差异与阈值进行比较，并且响应于满足阈值的第一和第二信号之间的差异而产生报警信号。

公开(公告)号：US20060002804A1

公开(公告)日：2006-01-05

申请号：US11133901

申请日：2005-05-20

Applicant: Hongrui Jiang ,  David Beebe ,  Abhishek Agarwal ,  Francisco Atencia-Fernandez

Inventor： Hongrui Jiang ,  David Beebe ,  Abhishek Agarwal ,  Francisco Atencia-Fernandez

IPC: F04B35/04 ,  F04B17/00

CPC classification number: B01F13/0059 ,  B01F13/0818 ,  F04B19/006

Abstract: A micro device is provided that includes a body defining a chamber for receiving fluid. A rotational element is disposed in the chamber for acting on the fluid. The rotational element is rotatable about an axis in response to a rotating magnetic field. The micro device further includes a clutch mechanism having a first disengaged configuration and a second engaged configuration wherein the clutch mechanism engages the rotational element and prevents rotation of the same.

公开(公告)号：US09186670B2

公开(公告)日：2015-11-17

申请号：US13467544

申请日：2012-05-09

Applicant: Erwin Berthier ,  Eric Sackmann ,  Peter Cavnar ,  David Beebe ,  David John Guckenberger

Inventor： Erwin Berthier ,  Eric Sackmann ,  Peter Cavnar ,  David Beebe ,  David John Guckenberger

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/5023 ,  B01L3/50853 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  B01L2400/086

Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. The device includes a base having outer surface and a channel therethough for receiving fluid therein. The channel has input and output ports communicating with the outer surface. A lid is also provided. The lid has an outer surface, a first well having a port communicating with the outer surface of the lid, and a second well having a port communicating with the outer surface. The lid moveable between a first disengaged position and a second engaged position wherein the first port of the lid is adjacent the input port of the channel and the second port is adjacent the output port of the channel.

Abstract translation: 提供了用于手持诊断和测定的微流体装置和方法。 该装置包括具有外表面的基部和用于在其中接收流体的通道。 通道具有与外表面连通的输入和输出端口。 还提供盖子。 盖具有外表面，第一阱具有与盖的外表面连通的端口，以及具有与外表面连通的端口的第二阱。 所述盖可在第一脱离位置和第二接合位置之间移动，其中所述盖的第一端口邻近所述通道的输入端口，并且所述第二端口邻近所述通道的输出端口。

公开(公告)号：US20060263241A1

公开(公告)日：2006-11-23

申请号：US11124936

申请日：2005-05-09

Applicant: David Beebe ,  Ivar Meyvantsson

Inventor： David Beebe ,  Ivar Meyvantsson

IPC: G01N31/22

CPC classification number: B01L3/502715 ,  B01L3/5025 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/0829 ,  B01L2400/0406 ,  B01L2400/0487 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: A device and method is provided for performing a high throughput assay. The device includes a plate structure having a plate and a plurality of microfluidic structures positioned thereon. Each microfluidic structure defines a channel having an input and an output. At least one of the input and the output of the channel of each of the plurality of mircofluidic structures includes a first plurality of ports. In operation, the channels are filled with fluid and pressure gradients are generated between the fluids at the inputs and the fluids at the outputs of the channels. As a result, fluid flows through the channels toward the outputs.

Abstract translation: 提供了用于执行高通量测定的装置和方法。 该装置包括具有板和位于其上的多个微流体结构的板结构。 每个微流体结构定义具有输入和输出的通道。 多个微流体结构中的每一个的通道的输入和输出中的至少一个包括第一多个端口。 在操作中，通道充满流体，并且在输入处的流体和通道的输出处的流体之间产生压力梯度。 结果，流体流过通道朝向输出。

公开(公告)号：US20060078462A1

公开(公告)日：2006-04-13

申请号：US11144723

申请日：2005-06-03

Applicant: Hongrui Jiang ,  David Beebe

Inventor： Hongrui Jiang ,  David Beebe

IPC: G01N33/00

CPC classification number: G01N33/48707 ,  B01L3/502738 ,  B01L2300/0645 ,  B01L2400/0677 ,  Y10T137/0329 ,  Y10T137/0396

Abstract: A detection device is provided for detecting the presence of an agent in a fluid. The device includes a body defining first and second chambers. It is intended for the first chamber accommodating the flow of fluid therein. A first valve is disposed in the body between in the first and second chambers. The first valve opens in response to the presence of the agent in the fluid. A first detection structure is disposed in the second chamber in order to generate a predetermined signal in response to exposure to the fluid.

Abstract translation: 提供了用于检测流体中的试剂的存在的检测装置。 该装置包括限定第一和第二腔室的主体。 适用于容纳流体流的第一腔室。 第一阀在第一和第二室之间设置在主体内。 响应于流体中存在的试剂，第一阀打开。 第一检测结构设置在第二室中，以便响应于暴露于流体而产生预定信号。