中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

86 records (took 0.023 seconds)

    Production of 1-desoxynojirimicin
    11.
    发明授权
    Production of 1-desoxynojirimicin 失效
    1-desoxynojirimicin的生产

    公开(公告)号：US4282320A

    公开(公告)日：1981-08-04

    申请号：US116174

    申请日：1980-01-28

    Applicant: Werner Frommer ,  Delf Schmidt

    Inventor： Werner Frommer ,  Delf Schmidt

    IPC: C07D211/46 ,  C12P17/12 ,  C12P19/26 ,  C12R1/07 ,  C12R1/12

    CPC classification number: C12P17/12 ,  Y10S435/832 ,  Y10S435/838 ,  Y10S435/839

    Abstract: The invention relates to a novel process for the production of 1-desoxynojirimycin which involves culturing an organism of the Bacillaceae family in a nutrient solution as a temperature of about 15.degree. to 80.degree. C. in a fermentation vessel, whilst aerating and then isolating the 1-desoxynojirimycin, said nutrient solution containing sorbitol as the source of carbon.

    Abstract translation: 本发明涉及一种生产1-脱氧野尻霉素的新方法，其包括在发酵容器中以约15-80℃的温度在营养液中培养芽孢杆菌科的生物体，同时通气，然后分离 所述营养液含有山梨醇作为碳源。

    Amino sugar derivatives
    12.
    发明授权
    Amino sugar derivatives 失效
    氨基糖衍生物

    公开(公告)号：US4062950A

    公开(公告)日：1977-12-13

    申请号：US654627

    申请日：1976-02-02

    Applicant: Werner Frommer ,  Bodo Junge ,  Uwe Keup ,  Lutz Muller ,  Walter Puls ,  Delf Schmidt

    Inventor： Werner Frommer ,  Bodo Junge ,  Uwe Keup ,  Lutz Muller ,  Walter Puls ,  Delf Schmidt

    IPC: C07H15/207 ,  C12P19/26 ,  C12P19/28 ,  A61K31/71 ,  C07H15/20

    CPC classification number: C07H15/207 ,  C12P19/26 ,  C12P19/28 ,  Y10S435/827

    Abstract: New amino sugars which are glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino)-.alpha.-D-glucopyranose inhibit glycoside hydrolases of the digestive tract. The compounds, of which O-{4,6-bisdesoxy-4-[1S-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-en-1-ylamino]-.alpha.-D-glucopyranosyl}-(1.fwdarw.4)-O-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-D-glucopyranose is a representative embodiment, demonstrate both saccharase and amylase inhibiting properties.

    Abstract translation: 作为4,6-双脱氧-4-（4,5,6-三羟基-3-羟甲基环己-2-烯-1-基） - 吡喃葡萄糖苷的吡喃葡萄糖基和低聚葡糖苷基衍生物的新型氨基糖抑制糖苷水解酶 消化道。 其中O- {4,6-双脱氧-4- [1S-（1,4,6 / 5）-4,5,6-三羟基-3-羟甲基环己-2-烯-1-基氨基] - α-D-吡喃葡萄糖基} - （1-> 4）-O-D-吡喃葡萄糖基 - （1-> 4）-D-吡喃葡萄糖是代表性的实施方案，证明了糖酶和淀粉酶抑制性质。

    Process for the production of a saccharase inhibitor
    14.
    发明授权
    Process for the production of a saccharase inhibitor 失效
    生产糖酶抑制剂的方法

    公开(公告)号：US4019960A

    公开(公告)日：1977-04-26

    申请号：US336741

    申请日：1973-02-28

    Applicant: Werner Frommer ,  Walter Puls ,  Delf Schmidt

    Inventor： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    IPC: C12N9/99 ,  A61K38/55 ,  C12P1/06 ,  C12R1/045 ,  C12D13/02

    CPC classification number: C12P1/06 ,  Y10S435/803 ,  Y10S435/822

    Abstract: The invention relates to a saccharase inhibitor derived from Actinoplanaceae Strain CBS 961.70, including mutants and variants thereof, means for the production of said saccharase inhibitors comprising cultivation of Actinoplanaceae Strain CBS 961.70, including mutants and variants thereof, in appropriate nutrient solutions which are characterized by being starch free under conditions most favorable to growth and production of said saccharase inhibitor and recovering a saccharase inhibitor from culture broths of said nutrient solutions, as well as the use of said inhibitor in pharmaceutically acceptable therapeutic compositions suitable for use in the treatment and relief of conditions indicative of adiposity, diabetes, pre-diabetes, hyperlipaemia (atherosclerosis), caries and the like.

    Abstract translation: 本发明涉及衍生自Actinoplanaceae菌株CBS 961.70的糖酶抑制剂，包括突变体及其变体，用于产生所述糖酶抑制剂的方法，该方法包括在合适的营养液中培养Actinoplanaceae菌株CBS 961.70（包括其突变体和变体），其特征在于 在最有利于生长和产生所述糖酶抑制剂的条件下淀粉，并从所述营养液的培养液中回收糖酶抑制剂，以及所述抑制剂在适用于治疗和缓解的药学上可接受的治疗组合物中的用途 指示肥胖，糖尿病，前期糖尿病，高脂血症（动脉粥样硬化），龋齿等的状况。

    Amylase inhibitor
    15.
    发明授权
    Amylase inhibitor 失效
    淀粉酶抑制剂

    公开(公告)号：US3995026A

    公开(公告)日：1976-11-30

    申请号：US482660

    申请日：1974-06-24

    Applicant: Werner Frommer ,  Walter Puls ,  Delf Schmidt

    Inventor： Werner Frommer ,  Walter Puls ,  Delf Schmidt

    IPC: C12N9/99 ,  A61K38/55 ,  C12N9/26 ,  C12P1/06 ,  C12R1/045 ,  A61K35/00

    CPC classification number: C12P1/06 ,  Y10S435/826 ,  Y10S435/827

    Abstract: The invention relates to an amylase inhibitor for glycoside-hydrolases derived from a new strain of microorganism, mutants and variants thereof, of the order Actinomycetales, means for their production comprising cultivation of the new strain of the order Actinomycetales, mutants and variants thereof, in appropriate nutrient solutions under conditions most favorable to growth and production of said amylase inhibitor and recovering an amylase inhibitor from culture broths of said nutrient solutions and said new strain of microorganism, mutants and variants thereof, of the order Actinomycetales as well as the use of said enzyme inhibitor in pharmaceutically acceptable therapeutic compositions suitable for use in the treatment and relief of conditions indicative of obesity, diabetes, pre-diabetes, gastritis, gastric and duodenal ulcers, hyperlippidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes, and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzyme in the presence of a glycoside-hydrolase enzyme derived from a new strain, mutants and variants thereof, of the order Actinomycetales. The invention further contemplates the provision of method for the treatment of indications of the group consisting of obesity, adipose, hyperlippidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer and dental caries induced by the action of glycoside-hydrolase enzymes and carbohydrates which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a new strain of microorganism of the order Actinomycetales of the family Actinoplanaceae.

    Abstract translation: 本发明涉及一种用于衍生自放线菌纲的微生物，突变体和变体的新菌株的糖苷 - 水解酶的淀粉酶抑制剂，其生产方法包括培养放线菌纲的新菌株，其突变体和变体， 在最有利于所述淀粉酶抑制剂的生长和产生的条件下，在所述营养液和所述新型放线菌纲的微生物，突变体和变体菌株的培养液中回收淀粉酶抑制剂以及使用所述淀粉酶抑制剂 适合用于治疗和缓解指示肥胖症，糖尿病，前期糖尿病，胃炎，胃和十二指肠溃疡，高脂血症（动脉硬化）等）的药物学上可接受的治疗组合物中的酶抑制剂。 本发明还考虑提供通过在存在下进行所述碳水化合物和糖苷 - 水解酶的所述反应来抑制碳水化合物和糖苷 - 水解酶的反应的方法，特别是消除道的碳水化合物 - 裂解糖苷 - 水解酶 的衍生自放线菌纲的新菌株，其突变体和变体的糖苷 - 水解酶。 本发明进一步考虑了提供治疗由糖苷类药物诱导的肥胖，脂肪，高脂血症（动脉粥样硬化），糖尿病，糖尿病前期，胃炎，胃溃疡，十二指肠溃疡和龋齿组成的组的适应症的方法， 水解酶和碳水化合物，其包括使用酶抑制剂用于通过科诺诺科科放线菌放线菌的新菌株产生的糖苷 - 水解酶。

    Glycoside-hydrolase enzyme inhibitors
    16.
    发明授权
    Glycoside-hydrolase enzyme inhibitors 失效
    糖苷 - 水解酶抑制剂

    公开(公告)号：US3951745A

    公开(公告)日：1976-04-20

    申请号：US493464

    申请日：1974-07-31

    Applicant: Werner Frommer ,  Walter Puls ,  Dietmar Schafer ,  Delf Schmidt

    Inventor： Werner Frommer ,  Walter Puls ,  Dietmar Schafer ,  Delf Schmidt

    IPC: C12P1/04 ,  C12P1/06 ,  C12D13/00

    CPC classification number: A61K31/70 ,  C12P1/04 ,  C12P1/06

    Abstract: This invention relates to inhibitors for glycoside-hydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (arteriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycoside-hydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, adipose, hyperlipidemia (arteriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.

    Abstract translation: 本发明涉及来源于放线菌纲的细菌的糖苷 - 水解酶的抑制剂，其生产方法包括在最有利于生长和产生酶抑制剂的条件下，在合适的营养溶液中培养放线菌纲的微生物， 来自培养物的新产品，糖苷 - 水解酶酶抑制剂以及所述酶抑制剂在药学上可接受的治疗组合物中用于治疗指示肥胖，糖尿病，前期糖尿病，胃炎，胃溃疡，高脂血症（动脉硬化） 等等。 本发明还考虑提供通过在所述碳水化合物和糖苷 - 水解酶的存在下进行所述碳水化合物和糖苷 - 水解酶的反应来抑制碳水化合物和糖苷 - 水解酶，特别是消化道的碳水化合物 - 裂解糖苷 - 水解酶的反应的方法 一种衍生自放线菌纲的微生物菌株的糖苷 - 水解酶的糖苷 - 水解酶抑制剂。 本发明进一步考虑了提供治疗由肥胖，脂肪，高脂血症（动脉硬化），糖尿病，前期糖尿病，胃炎，胃溃疡，十二指肠溃疡以及由糖苷 - 水解酶和碳水化合物，其改进包括使用由抑制放线菌的微生物菌株产生的糖苷 - 水解酶的酶抑制剂。

    Amylase inhibitor from wheat gluten using alcohol
    17.
    发明授权
    Amylase inhibitor from wheat gluten using alcohol 失效
    使用酒精的燕麦淀粉酶抑制剂

    公开(公告)号：US3950319A

    公开(公告)日：1976-04-13

    申请号：US435648

    申请日：1974-01-23

    Applicant: Delf Schmidt ,  Walter Puls

    Inventor： Delf Schmidt ,  Walter Puls

    IPC: A61K38/00 ,  C07K14/415 ,  C07G7/00

    CPC classification number: C07K14/415 ,  A61K38/00

    Abstract: An inhibitor for .alpha.-amylases, particularly pancreas amylase, is extracted from wheat, as for example, wheat flour or wheat gluten, by means of aqueous alcoholic solutions of lower alcohols of 1 to 3 carbon atoms, or dilute aqueous acid solutions having a pH of from 1 to 5, or of mixtures of the aqueous alcoholic solutions with dilute acids, and separating the desired amylase inhibitor contained in the aqueous phase from the extraction mixture by known methods. The amylase inhibitor thus obtained is particularly effective against pancreas amylase and is indicated as a therapeutic agent for the treatment of conditions resulting from alimentary hyperglycemia, such as adiposity, arteriosclerosis, diabetes and prediabetes.

    Masking background flourescence and luminescence in optical analysis of biomedical assays
    19.
    发明授权
    Masking background flourescence and luminescence in optical analysis of biomedical assays 有权

    公开(公告)号：US07063952B2

    公开(公告)日：2006-06-20

    申请号：US09966137

    申请日：2001-09-28

    Applicant: Thoams Krahn ,  Wolfgang Paffhausen ,  Andreas Schade ,  Martin Bechem ,  Delf Schmidt

    Inventor： Thoams Krahn ,  Wolfgang Paffhausen ,  Andreas Schade ,  Martin Bechem ,  Delf Schmidt

    IPC: G01N33/567

    CPC classification number: G01N33/542 ,  G01N33/5005 ,  G01N33/5306 ,  G01N33/54393 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/823 ,  Y10T436/13

    Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11. Analogously, these process principles can also be used in receptor studies for the masking of the interfering background radiation in the quantitative optical analysis of fluorescently or luminescently labelled reaction components. In this case, a receptor layer 12 at the bottom 2 of a reaction vessel 1 is in contact with a solution (supernatant 3) in which a fluorescent or luminescent ligand 13 is dissolved. The sensitivity and accuracy of the analytical detection can be considerably improved here if a masking dye 9 which absorbs the excitation light 6 for the fluorescent dye and/or its emission light or (in the case of luminescent ligands) the luminescent light is added to the supernatant 3. Instead of the masking dye in the solution 3 or optionally as an additional measure, a separating layer 10 permeable to the solution 3 and absorbing and/or reflecting the excitation light 6 and/or the emission light or the luminescent light can be applied to the cell or receptor layer 12 at the bottom 2.

Patent Agency Ranking