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11.发明申请
公开(公告)号：WO2011161609A8
公开(公告)日：2012-03-01
申请号：PCT/IB2011052676
申请日：2011-06-20
Applicant: EMD MILLIPORE CORP , WEISSENBACH JEAN-LOUIS , CIROU SEBASTIEN
Inventor： WEISSENBACH JEAN-LOUIS , CIROU SEBASTIEN
CPC classification number: B01D63/00 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/13 , B01D2313/18 , B01D2313/58 , B01D2313/90 , B01D2315/10 , Y10T137/6851 , Y10T137/8593
Abstract: The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (1 1 C) emerging on a first side (68) and a tangential filter connector (1 1 M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (1 1 B) emerging on said first side (68), and another tangential flow connector (1 1 N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (1 1 J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (1 1A), until it enters said second conduit (13B).
Abstract translation: 本发明涉及一种包括第一导管（13C）的袋子，该第一导管（13C）在出现在第一侧面（68）上的流动泵连接器（118）和在第二侧（69）上出现的切向过滤器连接器（110M）之间纵向延伸 ）; 第二导管（13B），其从所述导管（13C）的第一侧纵向延伸在出现在所述第一侧（68）上的供应容器连接器（11B）和另一切向流动连接器 所述第二面（69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。
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公开(公告)号：WO2015195452A4
公开(公告)日：2016-03-31
申请号：PCT/US2015035250
申请日：2015-06-11
Applicant: EMD MILLIPORE CORP
Inventor： LUTZ HERBERT , PARRELLA JOSEPH , RAGHUNATH BALA
CPC classification number: B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
Abstract translation: 本发明在各种实施例中提供了混合单通道切向流过滤组件，一次性单通道切向流过滤组件，可扩展单通道切向流过滤组件和可适应的模块化单通道切向流过滤组件。 在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜的表面回收蛋白质并用于清洗切向流过滤组件的方法。 在另外的实施例中，本发明提供了增加单通切向流过滤组件的处理能力的方法。
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公开(公告)号：WO2015195452A3
公开(公告)日：2016-02-11
申请号：PCT/US2015035250
申请日：2015-06-11
Applicant: EMD MILLIPORE CORP
Inventor： LUTZ HERBERT , PARRELLA JOSEPH , RAGHUNATH BALA
CPC classification number: B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
Abstract translation: 在各种实施例中，本发明提供了混合单程切向流过滤组件，一次性单程切向流过滤组件，可缩放单程切向流过滤组件和适应性模块化单程切向流过滤组件。 在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜表面回收蛋白质和清洁切向流过滤组件的方法。 在另外的实施例中，本发明提供了增加单程切向流过滤组件的处理能力的方法。
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公开(公告)号：WO2014088882A3
公开(公告)日：2015-08-20
申请号：PCT/US2013071861
申请日：2013-11-26
Applicant: EMD MILLIPORE CORP
Inventor： PERREAULT JEREMY , FOLEY SEAN , RAUTIO KEVIN
CPC classification number: B01D19/0031 , A61L2/0017 , B01D61/142 , B01D61/18 , B01D63/084 , B01D2313/16 , B01D2313/44 , B01D2315/08 , B01D2317/025 , B01D2317/06 , B01D2325/36 , B01D2325/38
Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.
Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，该阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器的网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络具有用于将液体原料引入流体工艺流中的一个或多个输入，以及用于将流体从流体工艺流中排出的一个或多个输出端口。 网络优选是基本上封闭的网络，并且优选地是无菌和/或无菌的。
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公开(公告)号：WO2012068263A3
公开(公告)日：2012-08-30
申请号：PCT/US2011061014
申请日：2011-11-16
Applicant: EMD MILLIPORE CORP , JOSEPH CIANCIOLO
Inventor： JOSEPH CIANCIOLO
CPC classification number: G01F11/20
Abstract: A bag construction is provided comprising a bag, a first conduit sealed to the feed bag, an impeller device secured within the bag and extending from the first conduit in the bag to a second end and a one piece cap that is removably mounted on the first conduit. Optionally, the bag has a second conduit sealed to the interior of the bag for supplying wash reagent such as gas or a liquid to the bag. The impeller device is driven to cause all material in the bag to flow out the first conduit.
Abstract translation: 提供了一种袋结构，其包括袋子，密封到供给袋上的第一导管，固定在袋子内并从袋子中的第一导管延伸到第二端部的叶轮装置以及可移除地安装在第一端部上的一体式帽盖 导管。 可选地，袋子具有密封到袋子内部的第二导管，用于向袋子供应洗涤剂例如气体或液体。 驱动叶轮装置以使袋中的所有物质流出第一导管。
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Patent Agency Ranking
公开(公告)号：JP2020089882A
公开(公告)日：2020-06-11
申请号：JP2020007673
申请日：2020-01-21
Applicant: EMD MILLIPORE CORP
Inventor： JOHN PAUL AMARA , JOHN BOYLE , DAVID YAVORSKY , BENJAMIN CACACE
IPC: B01D15/00 , B01D15/36 , B01D15/38 , B01J20/281 , C12N7/02
Abstract: 【課題】サンプル中の生体分子を精製する方法を提供すること。【解決手段】本発明の方法は、サンプルを多孔質の絡み合ったナノファイバーの床と接触させることを含み、前記多孔質の絡み合ったナノファイバーは、重合体とポロゲンとのブレンドを溶融押出し、押出生成物を目標直径まで延伸し、且つ高分子又は無機ポロゲンを抽出することによって製造され、前記床中の多孔質の絡み合ったナノファイバーの各々は、その断面全体にわたって細孔を有し、1ミクロン以下の直径を有し、前記多孔質の絡み合ったナノファイバーは、個別の多孔質の束の形に配置され、前記多孔質の絡み合ったナノファイバーは、クロマトグラフィーを可能にする官能基をその上に付与されている。【選択図】なし
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公开(公告)号：JP2013199327A
公开(公告)日：2013-10-03
申请号：JP2013117966
申请日：2013-06-04
Applicant: Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
Inventor： HOBSON JAMES , AUSTIN JAMES , PESAKOVICH BORIS , NOUKAS ELIAS G , JANKO THOMAS , MCMAHON SHAUN
CPC classification number: A61J1/10 , B65B69/0091 , B65D88/20 , B65D90/046 , B65D2203/10 , B65D2303/00 , B65F1/06 , Y10T29/49826
Abstract: PROBLEM TO BE SOLVED: To provide an alignment device for a bag containing one or more ports.SOLUTION: An alignment device is attached to a port such as by wire ties, clamps or cable ties or to a bag adjacent the port via adhesives or welding or molding such as overmolding. A plate has either an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a bag holder such as a carboy or tote bag to ensure proper alignment of the bag and its port in the holder. In one embodiment the plate formed of plastic, metal, wood or composite material has a series of holes equal to and in alignment with the one or more ports of the bag and the ports are extended through the holes of the plate and the plate is attached to the bag by retainers on the ports below the plate.
Abstract translation: 要解决的问题：提供一种用于包含一个或多个端口的袋的对准装置。解决方案：对准装置通过粘合剂或焊接方式附接到端口，例如通过扎带，夹具或扎带或邻近端口的袋 或模制如包覆成型。 板具有指示器或独特的外边缘形状，其被设计成适合于诸如卡通或手提袋的袋保持器中的相应的独特开口，以确保袋和其在支架中的端口的适当对准。 在一个实施例中，由塑料，金属，木材或复合材料形成的板具有与袋的一个或多个端口相等并且对准的一系列孔，并且端口延伸穿过板的孔并且板被附接 通过在板下面的端口上的保持器到袋子。
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公开(公告)号：JP2013137034A
公开(公告)日：2013-07-11
申请号：JP2013057279
申请日：2013-03-19
Applicant: Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
Inventor： MORRISSEY MARTIN
IPC: F04B43/02
CPC classification number: F04B43/082 , Y10T137/86035
Abstract: PROBLEM TO BE SOLVED: To provide an assembly for a pump, a pump and a pumping system which includes a disposable flexible bladder and disposable conduits with the pump through which the fluid to be pumped is passed in a manner such that the pump components are never exposed to the fluid.SOLUTION: The pump is provided having the disposable bladder and the disposable conduits together with check valves that control a fluid flow through the bladder and conduits when the bladder is alternately compressed and expanded. The use of disposable conduits and bladder eliminates the need for hygienically regenerating the pump between uses. The pump can be utilized in a fluid delivery system such as tangential flow filtration.
Abstract translation: 要解决的问题：提供一种用于泵，泵和泵送系统的组件，其包括一次性柔性气囊和具有泵的一次性管道，待泵送的流体通过该泵通过，使得泵组件从不 暴露于流体。解决方案：提供具有一次性气囊和一次性管道的泵以及止回阀，当止动阀交替地压缩和膨胀时，该止回阀控制通过气囊和导管的流体流动。 使用一次性管道和膀胱消除了在使用之间卫生地再生泵的需要。 泵可用于流体输送系统，例如切向流过滤。
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公开(公告)号：JP2013066744A
公开(公告)日：2013-04-18
申请号：JP2012267247
申请日：2012-12-06
Applicant: Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
Inventor： PROULX STEPHEN P , CIANCIOLO JOSEPH , PEREIRA BRIAN , VIGNA JAMES
IPC: A61M39/02
CPC classification number: F16L37/0987 , A61M39/12 , A61M2039/1027 , F16L33/22 , F16L2201/60 , Y10T24/14
Abstract: PROBLEM TO BE SOLVED: To provide a connector for connecting a flexible conduit with a second conduit having a barbed outer surface.SOLUTION: The connector accommodates the end of the flexible conduit and the end of the second conduit in a manner which prevents removal of the flexible conduit and the second conduit from the connector. Optionally, the connector has a ring that may be used to apply additional pressure and security to the outer surface of the flexible conduit. Additionally, the connector may have a wireless enabled communication and optionally, memory device such as a RFID tag attached or affixed to it.
Abstract translation: 要解决的问题：提供一种用于将柔性导管连接到具有带倒钩的外表面的第二导管的连接器。
解决方案：连接器以防止柔性导管和第二导管从连接器移除的方式容纳柔性导管的端部和第二导管的端部。 可选地，连接器具有可用于向柔性导管的外表面施加附加压力和安全性的环。 另外，连接器可以具有无线使能通信，并且可选地，可以附接或附加到其上的诸如RFID标签的存储设备。 版权所有（C）2013，JPO＆INPIT
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公开(公告)号：JP2012111781A
公开(公告)日：2012-06-14
申请号：JP2012054079
申请日：2012-03-12
Applicant: Emd Millipore Corp , イーエムディー ミリポア コーポレイション
Inventor： SIWAK MARTIN
IPC: B01D61/16 , C07K1/34 , B01D15/00 , B01D15/12 , B01D15/38 , B01D29/01 , B01D29/11 , B01D29/21 , B01D29/41 , B01D39/14 , B01D39/18 , B01D61/14 , B01D69/14 , B01J20/28 , C07K1/14 , C12M3/06 , C12N9/00 , C12P21/00 , C12P21/06
CPC classification number: B01D15/125 , B01D15/3804 , B01D15/3809 , B01D29/41 , B01D39/083 , B01D39/086 , B01D39/1607 , B01D39/18 , B01D39/20 , B01D61/142 , B01D61/16 , B01D69/141 , B01D2239/0407 , B01D2239/0428 , B01D2239/065 , B01D2239/0654 , B01D2239/0695 , B01D2311/04 , B01J20/28014 , B01J20/28028 , C12P21/00 , B01D2311/2649 , B01D2311/2626
Abstract: PROBLEM TO BE SOLVED: To provide a novel means for reducing NSB to a lower level before the liquid ever reaches the purification step.SOLUTION: The present invention relates to a prefilter used for purification systems such as affinity chromatography columns and ultrafiltration systems. The prefilter, positioned upstream of the system inlet, reduces the amount of non-specific binding (NSB) chemical species that enter the system, thereby extending the yield, capacity and lifetime of the system. Suitable agents include but are not limited to: hydrophobic entities; lipophilic entities; activated carbon; charged cation or anion entities; ligands; particles such as fumed silica, glass, controlled pore glass or derivitized version of each; silica or silicates; and combinations thereof. The material(s) can be incorporated into a variety of media such as fibers, beads, membranes and the like and then incorporated into a variety of device designs including lenticular pads, depth filters, bead containing columns, spiral wound devices, TFF devices and the like.
Abstract translation: 要解决的问题：提供一种在液体达到净化步骤之前将NSB还原到较低水平的新方法。 解决方案：本发明涉及用于纯化系统如亲和层析柱和超滤系统的预过滤器。 位于系统入口上游的预过滤器减少进入系统的非特异性结合（NSB）化学物质的量，从而延长系统的产量，容量和寿命。 合适的试剂包括但不限于：疏水性实体; 亲脂性实体; 活性炭; 带电阳离子或阴离子实体; 配体; 颗粒如煅制二氧化硅，玻璃，受控孔玻璃或每种的衍生版本; 二氧化硅或硅酸盐; 及其组合。 这些材料可以结合到各种介质如纤维，珠粒，膜等中，然后结合到各种装置设计中，包括透镜衬垫，深度过滤器，包含珠的柱，螺旋缠绕装置，TFF装置和 类似。 版权所有（C）2012，JPO＆INPIT
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