公开(公告)号：WO1989007656A2

公开(公告)日：1989-08-24

申请号：PCT/GB1989000140

申请日：1989-02-13

Applicant: SERVASE LIMITED ,  WORMAN, Colin, Peter ,  HABIB, Nagy, Adly ,  APOSTOLOV, Kosta ,  BARKER, William, Roland ,  WOOD, Christopher, Barry

Inventor： SERVASE LIMITED

IPC: C12Q01/38

CPC classification number: C12Q1/37 ,  C12Q2334/00 ,  C12Q2334/70

Abstract: The involvement of serine esterase activity in a number of clinical conditions is disclosed. A rapid test for serine esterase activity is disclosed, this test involving (a) fixing the sample which is to be tested, e.g. in formalin; and (b) contacting the fixed sample with a solution containing N-alpha benzyloxy carbonyl-L-lysine thiobenzyl ester and a chromogen (e.g. Fast Blue BB). The use of this test as a diagnostic indicator or monitor of the progress of therapeutic treatment is disclosed. Techniques for the treatment of diseases, particularly auto-immune diseases, are also suggested.

公开(公告)号：WO2011161474A1

公开(公告)日：2011-12-29

申请号：PCT/GB2011/051204

申请日：2011-06-24

Applicant: EMCISION LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61B18/14 ,  A61B17/34

CPC classification number: A61B18/1492 ,  A61B17/320068 ,  A61B17/3478 ,  A61B18/1477 ,  A61B2017/00296 ,  A61B2018/00613 ,  A61B2018/00821 ,  A61B2018/1425 ,  A61B2018/1869 ,  A61B2090/3784 ,  A61B2090/3925 ,  A61B2218/001 ,  A61N5/1001 ,  A61N7/00 ,  A61N2007/025

Abstract: Apparatus and methods suitable for causing tissue ablation at a specified therapeutic site in the body of a patient. The apparatus comprises an ablation device having a distal end and a proximal end and a central lumen extending along its length, the distal end comprising at least one energy delivery element suitable for causing tissue ablation. A penetrating member having a distal end and a proximal end, the distal end comprising a sharp tip suitable for piercing tissue and creating a channel for the device in the tissue, is coaxially positioned within the central lumen of the ablation device and is capable of being advanced distally out of the central lumen of the device and retracted back to within the central lumen of the device. The apparatus may further comprise an endoscope for delivery of the device to the site of treatment.

Abstract translation: 适合于在患者体内的特定治疗部位引起组织消融的装置和方法。 该装置包括具有远端和近端以及沿其长度延伸的中心腔的消融装置，远端包括适于引起组织消融的至少一个能量输送元件。 具有远端和近端的穿透构件，所述远端包括适于刺穿组织并且为所述组织中的装置创建通道的尖端，其同轴地位于所述消融装置的中心腔内，并且能够被 从装置的中央腔向前远端延伸并缩回到装置的中央腔内。 该装置还可以包括用于将装置输送到治疗部位的内窥镜。

公开(公告)号：WO2008084244A3

公开(公告)日：2008-10-02

申请号：PCT/GB2008000093

申请日：2008-01-11

Applicant: EMCISION LTD ,  HABIB NAGY

Inventor： HABIB NAGY

IPC: A61B18/04 ,  A61B18/14 ,  A61F2/95

CPC classification number: A61B18/1477 ,  A61B18/1492 ,  A61B2018/143 ,  A61F2002/9522 ,  A61F2002/9528 ,  A61F2002/9534

Abstract: A device for treating diseased tissue includes a plurality of needles (21) connected to a central shaft (22) via a hub (23), the connection of each needle to the hub including a hinge mechanism so that the needles can open out once the hub is pushed out of a catheter. RF power can be applied so that tissue can be treated via electrodes defined by the needles.

Abstract translation: 用于治疗患病组织的装置包括经由毂（23）连接到中心轴（22）的多个针（21），每个针与包括铰链机构的毂的连接使得针一旦 轮毂被推出导管。 可以施加RF功率，以便可以通过由针定义的电极来处理组织。

公开(公告)号：WO2008084252A2

公开(公告)日：2008-07-17

申请号：PCT/GB2008000102

申请日：2008-01-11

Applicant: EMCISION LTD ,  HABIB NAGY

Inventor： HABIB NAGY

IPC: A61F2/95

CPC classification number: A61B18/1477 ,  A61B18/1492 ,  A61B2018/143 ,  A61F2002/9522 ,  A61F2002/9528 ,  A61F2002/9534

Abstract: A removable stent (10) has guide member pairs (16) and loops (20), the guide member pairs being used to align arms of a framework (28) which may expand or collapse the stent. The stent can be retained inside an outer sheath (30) of a catheter (32) with a collapsible filter net (34). Magnetic stents and stents with springs (170) and hinges (156) are also provided.

Abstract translation: 可拆卸支架（10）具有引导构件对（16）和环（20），引导构件对用于对准可扩张或折叠支架的框架（28）的臂。 支架可以用可折叠过滤网（34）保持在导管（32）的外护套（30）内。 还提供了具有弹簧（170）和铰链（156）的磁性支架和支架。

公开(公告)号：WO2007135431A2

公开(公告)日：2007-11-29

申请号：PCT/GB2007001914

申请日：2007-05-23

Applicant: EMCISION LTD ,  HABIB NAGY

Inventor： HABIB NAGY

IPC: A61B17/08 ,  A61B18/18

CPC classification number: A61B18/1492 ,  A61B17/12013 ,  A61B17/2202 ,  A61B18/24 ,  A61B2017/00867 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/2272 ,  C08L2201/12

Abstract: A device is provided that is suitable for percutaneous insertion into a hollow vessel, such as a blood vessel, within the body of a patient for purpose of causing endoluminal closure of the vessel at a specified therapeutic site in the body of a patient. The device suitably is in the form of a catheter that is slidably mounted on a guidewire. The catheter may comprise one or more heating modules, as well as one or more extendable structures located on the device and optionally on the associated guidewire, that lead thermal ablation of the vessel walls and subsequent collapse of the vessel. The catheter can function alone or in cooperation with an associated guidewire to induce sealing of the vessel. Methods of using the catheter to treat lesions such as tumours or haemorrhages are also described.

Abstract translation: 提供了一种适于经皮插入患者体内的中空血管（例如血管）的装置，目的是在患者体内的特定治疗部位引起血管内腔封闭。 该装置适合于可滑动地安装在导丝上的导管的形式。 导管可以包括一个或多个加热模块，以及位于装置上并且任选地在相关联的导丝上的一个或多个可延伸结构，其引导血管壁的热消融并随后容器破裂。 导管可以单独地或与相关联的导丝协作起作用以引起血管密封。 还描述了使用导管治疗诸如肿瘤或出血的病变的方法。

公开(公告)号：WO2005113781A2

公开(公告)日：2005-12-01

申请号：PCT/GB2005/002016

申请日：2005-05-23

Applicant: GOT-A-GENE AB ,  HABIB, Nagy ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  BOULANGER, Pierre ,  LINDHOLM, Leif ,  MAGNUSSON, Maria ,  HONG, Saw See ,  ROSA-CALATRAVA, Manuel

Inventor： BOULANGER, Pierre ,  LINDHOLM, Leif ,  MAGNUSSON, Maria ,  HONG, Saw See ,  ROSA-CALATRAVA, Manuel

IPC: C12N15/86

CPC classification number: C07K14/005 ,  A61K47/64 ,  A61K2039/5256 ,  C07K2319/33 ,  C07K2319/50 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10345 ,  C12N2810/50

Abstract: The present invention relates to a vector comprising a nucleic acid molecule and a peptide or peptide derivative, said peptide or peptide derivative comprising a peptide of general Formula (I ) R 1 - R 2 - R 3 - R 4 - R 5 - R 6 (I ) wherein: R 1 is arginine or lysine; R 2 is glutamine or asparagine; R 3 is methionine; R 4 is serine Or threonine; R 5 is histidine, tryptophan, arginine or lysine; and R 6 is valine, leucine or isoleucine; or a functionally active fragment thereof and a vector comprising a nucleic acid molecule and a peptide or peptide derivative, said peptide or peptide derivative comprising a peptide of general Formula (III) R 1 - R 2 - R 3 - R 4 - R 5 - R 6 - R 7 - R 8 - R 9 - R 10 (III) wherein: R 1 is threonine; R 2 is alanine; R 3 is tyrosine; R 4 is Serine; R 5 is serine R 6 is tyrosine R 7 is any amino acid, R 8 is any amino acid; R 9 is glycine; and R 10 is glycine or a functionally active fragment thereof and uses thereof in gene cancer

Abstract translation: 本发明涉及包含核酸分子和肽或肽衍生物的载体，所述肽或肽衍生物包含通式（I）的肽R 1 - ，R 2 - ，R 4 - ，R 5 - R6（I）其中：R1是精氨酸或赖氨酸; R2是谷氨酰胺或天冬酰胺; R3是甲硫氨酸; R4是丝氨酸或苏氨酸; R5是组氨酸，色氨酸，精氨酸或赖氨酸; R6是缬氨酸，亮氨酸或异亮氨酸; 或其功能活性片段和包含核酸分子和肽或肽衍生物的载体，所述肽或肽衍生物包含通式（III）的肽R 1 -R 2 R 3 - R 5 - （R 6）其中：R 1是苏氨酸; R2是丙氨酸; R3是酪氨酸; R4是丝氨酸; R5是丝氨酸R6是酪氨酸，R7是任何氨基酸，R8是任何氨基酸; R9是甘氨酸; 并且R10是甘氨酸或其功能活性片段及其在基因癌中的用途

公开(公告)号：WO2005030071A1

公开(公告)日：2005-04-07

申请号：PCT/GB2004/004111

申请日：2004-09-28

Applicant: EMCISION LIMITED ,  HABIB, Nagy ,  DICKINSON, Robert, Julian ,  PACEY, Andrew, Robert

Inventor： HABIB, Nagy ,  DICKINSON, Robert, Julian ,  PACEY, Andrew, Robert

IPC: A61B18/14

CPC classification number: A61B18/1477 ,  A61B2018/0016 ,  A61B2018/143

Abstract: A surgical organ resection device comprising a plurality of elongate electrodes (4) for insertion into organ tissue, the electrodes being capable of operating in a bipolar manner, and an input for receiving a drive signal for driving the electrode, the elongate electrodes being arranged in a two-dimensional array and/or the device being arranged such that, in use, subsets of the elongate electrodes are driven in turn.

Abstract translation: 一种手术器官切除装置，包括用于插入器官组织的多个细长电极（4），所述电极能够以双极方式操作，以及用于接收用于驱动电极的驱动信号的输入端，所述细长电极被布置在 二维阵列和/或设备被布置成使得在使用中依次驱动细长电极的子集。

公开(公告)号：WO8704926A3

公开(公告)日：1988-05-19

申请号：PCT/GB8700111

申请日：1987-02-16

Applicant: HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

Inventor： HABIB NAGY ADLY ,  WOOD CHRISTOPHER BARRY ,  APOSTOLOV KOSTA ,  BARKER WILLIAM ROLAND

IPC: C07C57/02 ,  A61K31/20 ,  A61K31/23 ,  A61P31/12 ,  A61P35/00 ,  C07C51/00 ,  C07C53/126 ,  C07C53/19 ,  C07C57/12 ,  C07C67/00

CPC classification number: A61K31/23 ,  A61K31/20

Abstract: Use of certain fatty acids in effecting modifications to the lipid structure of cell membranes. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with elevation of the saturation index of cell membranes, including nervous disorders including multiple sclerosis and schizophrenia; and to the use of the active materials of the invention in the treatment thereof. The active principles in the present invention are mono-unsaturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. oleic acid, or pharmaceutically acceptable derivatives thereof.

公开(公告)号：WO2011055143A3

公开(公告)日：2011-10-06

申请号：PCT/GB2010051845

申请日：2010-11-04

Applicant: EMCISION LTD ,  HABIB NAGY

Inventor： HABIB NAGY

IPC: A61B18/14 ,  A61B17/22 ,  A61B18/18

CPC classification number: A61B17/22 ,  A61B17/2202 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/245 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2090/3788 ,  A61F2/013 ,  C08L2201/12

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localised ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract translation: 提供了适用于重塑至少部分地被质量块堵塞的中空容器的内表面的装置和方法。 该装置包括具有远端和近端的细长本体，远端包括位于本体远端的尖端部分以及位于远端内的尖端部分附近的至少一个加热元件。 所述至少一个加热元件被构造成在尺寸上比在远端的尺寸更大并且因此朝远端逐渐变细。 此外，至少一个加热元件被布置成使得它可以从装置的主体向外展开并且由此在中空容器上施加扩张力。 该至少一个加热元件能够输送足够的能量来重塑内表面，并且如果必要的话引起中空容器的局部消融而不引起中空容器的闭合。

公开(公告)号：WO2011055143A2

公开(公告)日：2011-05-12

申请号：PCT/GB2010/051845

申请日：2010-11-04

Applicant: EMCISION LIMITED ,  HABIB, Nagy

Inventor： HABIB, Nagy

IPC: A61B18/14 ,  A61B17/22 ,  A61B18/18

CPC classification number: A61B17/22 ,  A61B17/2202 ,  A61B18/082 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/245 ,  A61B90/06 ,  A61B2017/00022 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22061 ,  A61B2017/22079 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00821 ,  A61B2018/00898 ,  A61B2018/126 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2090/3788 ,  A61F2/013 ,  C08L2201/12

Abstract: A device and method suitable for remodelling the internal surface of a hollow vessel at least partially occluded by a mass is provided. The device comprises an elongate body having a distal end and a proximal end, the distal end comprising a tip portion located at the distal terminus of the body, and at least one heating element located proximally to the tip portion within the distal end. The at least one heating element is configured to be greater in dimension proximally than distally and thereby tapers towards the distal end. Furthermore, the at least one heating element is arranged so that it can be deployed outwardly from the body of the device and in so doing exert an expansion force on the hollow vessel. The at least one heating element is capable of delivering sufficient energy to remodel the internal surface, and if necessary caused localised ablation, of the hollow vessel without inducing closure of the hollow vessel.

Abstract translation: 提供了一种适于重塑至少部分被块体封闭的中空容器的内表面的装置和方法。 所述装置包括具有远端和近端的细长主体，所述远端包括位于所述主体的远端的尖端部分，以及位于所述远端内的所述尖端部分的近侧的至少一个加热元件。 所述至少一个加热元件被配置为在远端比近端更大的尺寸，从而朝向远端逐渐变细。 此外，至少一个加热元件被布置成使得其可以从装置的主体向外展开，并且这样对中空容器施加膨胀力。 所述至少一个加热元件能够输送足够的能量来重建内表面，并且如果需要引起中空容器的局部消融，而不引起中空容器的封闭。