公开(公告)号：US20080119494A1

公开(公告)日：2008-05-22

申请号：US12021546

申请日：2008-01-29

Applicant: Janel Young ,  Scott Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

Inventor： Janel Young ,  Scott Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

IPC: A61K31/519 ,  A61P41/00

CPC classification number: A61K9/1647

Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

Abstract translation: 本发明包括用于抑制经受外科手术的体腔中的组织表面之间的术后粘连形成的方法，该方法包括将Pemirolast或其类似物以体积的数量直接施用于体腔内的组织表面 并且在有效抑制粘连形成的条件下，以及适用于局部，非全身给药的体内和直接经受外科手术的体腔内组织的输送载体和组合物。

公开(公告)号：US20070298075A1

公开(公告)日：2007-12-27

申请号：US11759327

申请日：2007-06-07

Applicant: Maureen Borgia ,  Hassan Chaouk ,  Han Cui ,  Walter Laredo ,  Zhigang Li ,  Aruna Nathan ,  Michael Trezza

Inventor： Maureen Borgia ,  Hassan Chaouk ,  Han Cui ,  Walter Laredo ,  Zhigang Li ,  Aruna Nathan ,  Michael Trezza

IPC: A61F2/00 ,  A61F13/00

CPC classification number: A61F9/00772 ,  A61F9/0017 ,  A61M31/002

Abstract: The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.

Abstract translation: 本发明提供了用于将活性剂递送到眼睛的泪液和鼻泪管中的一种或两种的泪点塞。 本发明的塞子具有主体，容纳在主体内的储存器，以及可选地是围兜。 储存器具有至少一个开口并且包含聚合材料和至少一种活性剂。

公开(公告)号：US20150346101A1

公开(公告)日：2015-12-03

申请号：US14366266

申请日：2013-08-08

Applicant: Weiqian ZHAO ,  Han CUI ,  Lirong QIU ,  Yun WANG

Inventor： Weiqian ZHAO ,  Han CUI ,  Lirong QIU ,  Yun WANG

IPC: G01N21/65 ,  G01N21/47

CPC classification number: G01N21/47 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/063

Abstract: The present invention belongs to a technical field of optical microscopic imaging and spectral measurement, and discloses a laser differential confocal mapping-spectrum microscopic imaging method and device. The core concept of the present invention is to combine the differential confocal detection and the spectrum detection techniques and use a dichroic beam splitting system (13) to separate the Rayleigh light for geometric position detection from the Raman scattering light for spectrum detection, by mean of the property that the zero-cross point of the differential confocal curve (43) accurately corresponds to the focus of the objective, the spectral information at focus of the excitation spot being accurately captured by the zero trigger to accomplish the spectrum detection with high spatial resolution. Therefore, the present invention provides a method and device that may be able to accomplish the spectrum detection with high spatial resolution to a micro-area of a sample.

Abstract translation: 本发明属于光学显微成像和光谱测量的技术领域，并且公开了一种激光微分共焦映射光谱显微成像方法和装置。 本发明的核心概念是组合差分共聚焦检测和光谱检测技术，并使用二向色分束系统（13）将用于几何位置检测的瑞利光与用于光谱检测的拉曼散射光分离，通过 差分共聚焦点曲线（43）的零交叉点准确地对应于物镜的焦点，激发点焦点处的光谱信息被零点触发精确地捕获，完成高空间分辨率的光谱检测 。 因此，本发明提供了一种能够以高空间分辨率对样品的微区进行光谱检测的方法和装置。

公开(公告)号：US08277831B2

公开(公告)日：2012-10-02

申请号：US10780452

申请日：2004-02-17

Applicant: Janel E. Young ,  Scott A. Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

Inventor： Janel E. Young ,  Scott A. Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

IPC: A61F2/02

CPC classification number: A61K9/1647

Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

Abstract translation: 本发明包括用于抑制经受外科手术的体腔中的组织表面之间的术后粘连形成的方法，该方法包括将Pemirolast或其类似物以体积的数量直接施用于体腔内的组织表面 并且在有效抑制粘连形成的条件下，以及适用于局部，非全身给药的体内和直接经受外科手术的体腔内组织的输送载体和组合物。

公开(公告)号：US20070141160A1

公开(公告)日：2007-06-21

申请号：US11300822

申请日：2005-12-15

Applicant: Laura Brown ,  Han Cui ,  Zhangwen Wu

Inventor： Laura Brown ,  Han Cui ,  Zhangwen Wu

IPC: A61K9/14

CPC classification number: A61K9/0019 ,  A61K9/1641

Abstract: A method of treatment of osteoarthritis is described, where a therapeutically effective amount of a composition having biodegradable microparticles in an aqueous vehicle is delivered into the intra-articular space of a joint. In one aspect, the microparticle-containing composition is injected into the synovial fluid-containing portion of an affected joint.

Abstract translation: 描述了治疗骨关节炎的方法，其中在水性载体中具有可生物降解的微粒的组合物的治疗有效量被递送到关节的关节内空间。 一方面，将含有微粒的组合物注入受影响的关节的含滑液的部分。

公开(公告)号：US07220433B2

公开(公告)日：2007-05-22

申请号：US10608507

申请日：2003-06-27

Applicant: Han Cui ,  Joel Rosenblatt ,  Ram L. Kataria ,  Chuanbin Wu

Inventor： Han Cui ,  Joel Rosenblatt ,  Ram L. Kataria ,  Chuanbin Wu

IPC: A61K9/16

CPC classification number: A61K9/5073 ,  A61K47/34

Abstract: The present invention is directed to parenterally-administrable microparticles for providing sustained-release of a therapeutic agent in the body, where the microparticles include a polymeric core containing a therapeutically effective amount of a therapeutic agent disposed therein, a first film encapsulating the core, the first film prepared from a first biodegradable polymer soluble in an appropriate solvent therefore, and a second film encapsulating the core and the first film, the second film prepared from a biodegradable polymer soluble in an appropriate solvent therefore, wherein the first film is insoluble in the solvent used to prepare the second film, and to parenterally-administrable compositions containing such microparticles dispersed in a suitable carrier therefore.

Abstract translation: 本发明涉及用于在体内提供治疗剂持续释放的肠胃外给药微粒，其中微粒包括含有治疗有效量的治疗剂的聚合物芯，其中包含核心的第一膜， 因此，由可溶于适当溶剂的第一可生物降解聚合物制备的第一膜以及包封芯和第一膜的第二膜，由可溶于适当溶剂的可生物降解的聚合物制备的第二膜，其中第一膜不溶于 因此用于制备第二膜的溶剂，以及含有分散在合适载体中的这种微粒的肠胃外给药组合物。

公开(公告)号：US07101566B2

公开(公告)日：2006-09-05

申请号：US10183260

申请日：2002-06-28

Applicant: Joel Rosenblatt ,  Han Cui ,  Ram L. Kataria ,  Chuanbin Wu

Inventor： Joel Rosenblatt ,  Han Cui ,  Ram L. Kataria ,  Chuanbin Wu

IPC: A61F13/00 ,  A61F2/00 ,  A61K9/14 ,  A61K9/19

CPC classification number: A61K9/5031 ,  A61K47/34

Abstract: The present invention is directed to sustained release microparticle formulation for parenteral administration of biologically active substances, especially drugs. More specifically it relates to coated drug containing microparticles, wherein the coating is a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

Abstract translation: 本发明涉及用于肠胃外给药生物活性物质，特别是药物的持续释放微粒制剂。 更具体地说，它涉及含有包衣药物的微粒，其中涂层是合成的，生物可吸收的生物相容性聚合物蜡，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，聚合物蜡的熔点较低 如通过差示扫描量热法测定的。

公开(公告)号：US20060122150A1

公开(公告)日：2006-06-08

申请号：US11239725

申请日：2005-09-30

Applicant: Dennis Argentieri ,  Demetrius Carter ,  Laura Brown ,  Jeffrey Geesin ,  John Siekierka ,  Han Cui

Inventor： Dennis Argentieri ,  Demetrius Carter ,  Laura Brown ,  Jeffrey Geesin ,  John Siekierka ,  Han Cui

IPC: A61K31/728

CPC classification number: A61K31/728 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/38 ,  A61K31/40 ,  A61K31/415 ,  A61K47/36

Abstract: A pharmaceutical composition for use in treating a joint-capsule arthropathy comprising an effective amount of one or more of a locally administered, optionally encapsulated therapeutic agent in admixture with a hyaluronic acid delivery vehicle and a method for use thereof in treating a joint-capsule arthropathy by intra-articular injection.

Abstract translation: 一种用于治疗关节囊性关节病的药物组合物，其包含与透明质酸递送载体混合的有效量的一种或多种局部施用的，任选包封的治疗剂及其用于治疗关节囊性关节病的方法 通过关节内注射。

公开(公告)号：US20050106229A1

公开(公告)日：2005-05-19

申请号：US10714719

申请日：2003-11-17

Applicant: Janel Young ,  Scott Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

Inventor： Janel Young ,  Scott Wadsworth ,  Kevin Cooper ,  Joel Rosenblatt ,  Han Cui

IPC: A61K9/127 ,  A61K9/50 ,  A61K31/196

CPC classification number: A61K31/196 ,  A61K9/127 ,  A61K9/5031

Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Tranilast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

Abstract translation: 本发明包括用于抑制经受外科手术的体腔中的组织表面之间的术后粘连形成的方法，该方法包括以体积的量向管腔内的组织表面直接给予Tranilast或其类似物 并且在有效抑制粘连形成的条件下，以及适用于局部，非全身给药的体内和直接经受外科手术的体腔内组织的输送载体和组合物。