公开(公告)号：US20050286108A1

公开(公告)日：2005-12-29

申请号：US11123224

申请日：2005-05-06

Applicant: Chris Xu ,  James Howe

Inventor： Chris Xu ,  James Howe

IPC: G02F1/01 ,  G02F1/23

CPC classification number: G02F1/01 ,  G02F2201/205

Abstract: A programmable, ultrafast optical delay line based on reversible frequency conversion uses a time-prism pair and no moving parts. A first electro-optic phase modulator acting as a first time-prism shifts the frequency of an incoming pulse train. The pulse train passes through a dispersion element, such as a dispersive fiber, which delays the pulse train by an amount that is directly proportional to the magnitude of the frequency shift, which in turn is proportional to the magnitude of the phase modulator drive voltage. A second electro-optic phase modulator is driven π out of phase to the first modulator and restores the frequency of the delayed pulse train to the original frequency of the incoming pulse train. To reduce pulse broadening effects and enhance performance further, soliton propagation inducing elements can be employed between the time-prisms.

Abstract translation: 基于可逆频率转换的可编程，超快速光学延迟线使用时间棱镜对，无移动部件。 作为第一时间棱镜的第一电光相位调制器移动输入脉冲串的频率。 脉冲串通过诸如分散光纤的色散元件，其将脉冲串延迟与频移幅度成正比的量，该量与调相器驱动电压的大小成正比。 第二电光相位调制器被驱动到相位到第一调制器，并将延迟的脉冲串的频率恢复到输入脉冲序列的原始频率。 为了减少脉冲展宽效应并进一步提高性能，可以在时间棱镜之间采用孤子传播诱导元件。

公开(公告)号：US5655520A

公开(公告)日：1997-08-12

申请号：US110549

申请日：1993-08-23

Applicant: Harvey James Howe ,  Craig Jonathan Madden ,  Richard Raphzel Rosenthal

Inventor： Harvey James Howe ,  Craig Jonathan Madden ,  Richard Raphzel Rosenthal

IPC: A61M11/06 ,  A61M15/00 ,  A61M16/16 ,  A61M16/20 ,  G05D7/01 ,  A61M16/10 ,  F16K11/00 ,  G05D11/02

CPC classification number: G05D7/012 ,  A61M15/002 ,  A61M15/0086 ,  A61M11/06 ,  A61M15/009 ,  A61M16/16 ,  A61M16/20

Abstract: A nebulizer is improved by placing a flexible valve in the ambient air inlet tube. Inhalation suction and Venturi effect shut down the flexible valve in proportion to the strength of the inhalation. Thus, the same output flow rate is obtained even with variable strength inhalations. Medications can be properly administered by controlled inhalation flow rates. In an alternate embodiment a metered dose inhaler (MDI) is outfitted with a similar flexible valve. Once again the patient is forced to inhale at a constant flow rate, thus causing the medication to seep deeply into the lungs. In both embodiments the flexible valve is preferably shaped in a duck billed fashion with air flow flowing toward the narrow end of the duck bill.

Abstract translation: 通过将柔性阀放置在环境空气入口管中来改善雾化器。 吸入吸入和文丘里效应按照吸入强度的比例关闭柔性阀。 因此，即使使用可变强度吸入也可获得相同的输出流量。 药物可以通过受控的吸入流量适当地施用。 在替代实施例中，计量剂量吸入器（MDI）配备有类似的柔性阀。 再次，患者被迫以恒定的流速吸入，从而导致药物深入肺部渗入。 在两个实施例中，柔性阀优选地以鸭嘴形式形成，气流朝向鸭帐单的窄端流动。

公开(公告)号：US09550010B2

公开(公告)日：2017-01-24

申请号：US13173701

申请日：2011-06-30

Applicant: Olaf Schulz ,  James Howe ,  Rick Swaim ,  Bryan Huber ,  Joel Batts ,  David Harness ,  Ryan Belaney

Inventor： Olaf Schulz ,  James Howe ,  Rick Swaim ,  Bryan Huber ,  Joel Batts ,  David Harness ,  Ryan Belaney

IPC: A61L24/00 ,  A61L27/12 ,  A61L27/58 ,  A61L24/02 ,  A61B17/17 ,  A61B17/16

CPC classification number: A61B17/16 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/17 ,  A61B2217/005 ,  A61B2217/007 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/12 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/02 ,  A61M1/0035 ,  A61M1/0058

Abstract: Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.

Abstract translation: 提供了治疗退行性骨患者的方法和制造方法。 这些方法可用于改善退行性骨（例如骨质疏松或骨质疏松性骨）的局部区域中的骨质量，例如通过将BMD改善为与BMD年龄基本相似的平均健康个体的BMD。 所述方法可以包括在退行性骨的局部区域中形成空隙并用引起新的，健康的天然骨材料的产生的骨再生材料填充空隙。 制品可以包括由可用于改善骨质量的本发明方法中的各种材料形成的套件。