PROCESS OF MAKING α-AMINOOXYKETONE/α-AMINOOXYALDEHYDE AND α-HYDROXYKETONE/α-HYDROXYALDEHYDE COMPOUNDS AND A PROCESS OF MAKING REACTION PRODUCTS FROM CYCLYC α,ß-UNSATURATED KETONE SUBSTRATES AND NITROSO SUBSTRATES
    12.
    发明申请
    PROCESS OF MAKING α-AMINOOXYKETONE/α-AMINOOXYALDEHYDE AND α-HYDROXYKETONE/α-HYDROXYALDEHYDE COMPOUNDS AND A PROCESS OF MAKING REACTION PRODUCTS FROM CYCLYC α,ß-UNSATURATED KETONE SUBSTRATES AND NITROSO SUBSTRATES 审中-公开
    制备α-氨基戊酮/α-氨基戊二醛和α-羟基酮/α-羟基甲醛化合物的方法和制备来自环己烷α,β-不饱和酮基材和硝基底物的反应产物的方法

    公开(公告)号:WO2005090294A2

    公开(公告)日:2005-09-29

    申请号:PCT/US2005/005426

    申请日:2005-02-18

    Abstract: The present invention is directed to a process of making α-aminooxyketone and α-­hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of formula (IV), wherein X 1 -X 3 represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the α-aminooxyketone compound formed to the α-hydroxyketone compound. The present invention results in α-aminooxyketone and α-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol / Michael reaction. The substrates of this reaction are generally cyclic α,ß-unsaturated ketone substrate and a nitroso substrate. This methodology generally involves reacting the cyclic α,ß-unsaturated ketone substrate and the nitroso substrate in the presence of a proline-based catalyst, to provide a heterocyclic product.

    Abstract translation: 本发明涉及制备α-氨基氧基酮和α-羟基酮化合物的方法。 合成途径通常包括在式(IV)催化剂存在下使醛或酮底物和亚硝基底物反应,其中X 1 -X 3独立地表示氮,碳,氧或硫,Z表示 具有或不具有取代基的4至10元环,以及任选的将形成的α-氨基氧基酮化合物转化成α-羟基酮化合物的另外步骤。 本发明产生具有高对映选择性和高纯度的α-氨基氧基酮和α-羟基酮化合物。 本发明还涉及催化不对称的O-亚硝基醛醇/迈克尔反应。 该反应的底物通常为环状α,β-不饱和酮底物和亚硝基。 该方法通常包括在脯氨酸催化剂存在下使环状α,β-不饱和酮底物和亚硝基底物反应,得到杂环产物。

    NOVEL COPOLYMER OF METHACRYLIC ESTER, COMPOSITION, OPTICAL ELEMENT AND ELECTRIC MEMBER
    17.
    发明申请
    NOVEL COPOLYMER OF METHACRYLIC ESTER, COMPOSITION, OPTICAL ELEMENT AND ELECTRIC MEMBER 审中-公开
    甲基丙烯酸酯,组合物,光学元件和电子部件的新型共聚物

    公开(公告)号:WO2007129418A1

    公开(公告)日:2007-11-15

    申请号:PCT/JP2006/320360

    申请日:2006-10-05

    CPC classification number: C08F220/18 C08F220/24 Y10T428/105

    Abstract: ABSTRACT A copolymer of (meth)acrylic ester represented by a general formula (1) including a following repeating unit A and repeating unit B. In the general formula (1), R1 and R2 each independently represent hydrogen atom or methyl group; R3 represents an alkyl group having 1 to 4 carbon atoms; Y represents an atomic group forming an aromatic ring; x represents 1 to n, n represents the number of fluorine atoms which can be contained in the aromatic ring; and a and b each independently represent an integer of 1 or more.

    Abstract translation: 摘要:由通式(1)表示的(甲基)丙烯酸酯的共聚物,其包含以下重复单元A和重复单元B.在通式(1)中,R 1和R 2各自独立地表示氢原子或甲基。 R3表示碳原子数1〜4的烷基。 Y表示形成芳环的原子团; x表示1〜n,n表示可以包含在芳香环中的氟原子数; a和b各自独立地表示1以上的整数。

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