公开(公告)号：EP3792283A1

公开(公告)日：2021-03-17

申请号：EP19197510.1

申请日：2019-09-16

Applicant: Lava Therapeutics B.V.

Inventor： ROOVERS, Robertus Cornelis ,  HORBACH, Gerard Joseph Maria Jean ,  RIEDL, Thilo Alexander ,  VAN DER VLIET, Johannes Jelle ,  PARREN, Paul Willem Henri Ida

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

Abstract: The invention relates to methods for the treatment of cancer. In particular, the invention relates to methods for the treatment of cancer, comprising administration of a high dose of an antibody capable of binding a human Vγ9Vδ2 T cell receptor.

公开(公告)号：EP3250608A1

公开(公告)日：2017-12-06

申请号：EP16715360.0

申请日：2016-01-27

Applicant: Lava Therapeutics B.V.

Inventor： VAN DER VLIET, Johannes Jelle ,  DE GRUIJL, Tanja Denise ,  VERHEUL, Hendrik Marinus Willem ,  DE BRUIN, Renée Cornelia Gerarda ,  LAMERIS, Roland

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K16/2833 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/75

Abstract: The invention relates to compounds, in particular polypeptides that specifically bind to the non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The invention in particular relates to such compounds and polypeptides comprising or consisting of at least one single domain antibody, and wherein at least one single domain antibody specifically binds to CD1d. Also provided is for methods and use employing such compounds, polypeptides and/or single-domain antibodies.

公开(公告)号：EP3853255A1

公开(公告)日：2021-07-28

申请号：EP19828845.8

申请日：2019-09-19

Applicant: Lava Therapeutics B.V.

Inventor： DE WEERDT, Iris ,  KATER, Arnon Philip ,  PARREN, Paul Willem Henri Ida ,  DE GRUIJL, Tanja Denise ,  VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04