公开(公告)号：WO2007084625A9

公开(公告)日：2007-09-13

申请号：PCT/US2007001350

申请日：2007-01-19

Applicant: SINAI SCHOOL MEDICINE ,  ZHOU MING-MING ,  SACHCHIDANAND D PHIL ,  ZENG LEI ,  MANFREDI JAMES J ,  RESNICK-SILVERMAN LOIS ,  AARONSON STUART

Inventor： ZHOU MING-MING ,  SACHCHIDANAND D PHIL ,  ZENG LEI ,  MANFREDI JAMES J ,  RESNICK-SILVERMAN LOIS ,  AARONSON STUART

IPC: A61K31/473 ,  A61K31/403

CPC classification number: C07C317/40 ,  C07C233/05 ,  C07C233/07 ,  C07C233/18 ,  C07C233/25 ,  C07C233/54 ,  C07C323/52 ,  C07D209/12 ,  C07D209/38 ,  C07D209/88 ,  C07D215/08 ,  C07D221/08

Abstract: The present invention features compounds and pharmaceutical compositions comprising the same that are useful for modulating p53 activity. The invention further provides methods for inhibiting the biological activity of p53 and for treating diseases such as, for instance, cancer, cell death caused all or in part by cancer treatments such as chemotherapy or radiation thereapy, neuron cell death, stroke, Alzheimer's Disease and Parkinson's Disease.

Abstract translation: 本发明的特征在于包含其可用于调节p53活性的化合物和药物组合物。 本发明还提供了抑制p53的生物学活性和治疗诸如癌症，全部或部分地由癌症治疗如化学疗法或放射治疗，神经元细胞死亡，中风，阿尔茨海默氏病等引起的细胞死亡的疾病的方法，以及 帕金森病

公开(公告)号：WO2023082277A1

公开(公告)日：2023-05-19

申请号：PCT/CN2021/130742

申请日：2021-11-15

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  DOW SILICONES CORPORATION ,  WANG, Tao ,  CHEN, Hongyu ,  WENG, Xilun ,  ZHANG, Kainan ,  MING, Ming ,  MIAO, Wenke ,  OUYANG, Wuye ,  LIU, Andong

Inventor： WANG, Tao ,  CHEN, Hongyu ,  WENG, Xilun ,  ZHANG, Kainan ,  MING, Ming ,  MIAO, Wenke ,  OUYANG, Wuye ,  LIU, Andong

IPC: C08L77/00 ,  C08L51/04 ,  C08L83/04

Abstract: Toughened polyamide composition including: (a) at least one polyamide; (b) at least one toughener component; and (c) at least one siloxane-based component having a viscosity of 1 mm 2/s—100,000 mm 2/s providing toughened polyamide composition with good impact strength; process for producing the toughened polyamide composition; and articles made from the toughened polyamide composition.

公开(公告)号：WO2020107305A1

公开(公告)日：2020-06-04

申请号：PCT/CN2018/118094

申请日：2018-11-29

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  LI, Haiying ,  FENG, Shaoguang ,  LIU, Andong ,  YANG, Xiuhan ,  ZOU, Jian ,  MING, Ming ,  GONG, Yonghua ,  ZHAI, Xuemei

Inventor： LI, Haiying ,  FENG, Shaoguang ,  LIU, Andong ,  YANG, Xiuhan ,  ZOU, Jian ,  MING, Ming ,  GONG, Yonghua ,  ZHAI, Xuemei

IPC: C08L23/12 ,  C08J9/00 ,  C08G101/00 ,  C07C69/72 ,  C08K3/34

Abstract: A thermoplastic polyolefin composition comprises: (A) a polypropylene polymer; (B) an elastomer component; (C) an additive component; and (D) a scavenger component comprising a polyacetoacetate compound having the Formula (I) defined herein and an inorganic porous material. The present disclosure also relates to an article made from the thermoplastic polyolefin composition.

公开(公告)号：WO2009124137A3

公开(公告)日：2010-01-07

申请号：PCT/US2009039187

申请日：2009-04-01

Applicant: SINAI SCHOOL MEDICINE ,  ZHOU MING-MING ,  MUJTABA SHIRAZ

Inventor： ZHOU MING-MING ,  MUJTABA SHIRAZ

IPC: A61K38/00

CPC classification number: C12N9/1007 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C07K2319/09 ,  C12N2710/00022 ,  C12N2710/10343 ,  C12N2740/15043 ,  C12Y201/01043

Abstract: The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine mehtyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3- K27) thereby suppressing the transcription of the gene.

Abstract translation: 本发明涉及通过甲基化一种或多种基因的染色质组蛋白蛋白来抑制一种或多种基因的转录表达的方法。 具体地，病毒SET结构域组蛋白赖氨酸甲酰转移酶（vSET或vSET样蛋白）使基因的组蛋白3（H3-K27）的赖氨酸27甲基化，从而抑制基因的转录。

公开(公告)号：WO2008094315A2

公开(公告)日：2008-08-07

申请号：PCT/US2007/079273

申请日：2007-09-24

Applicant: FEDERAL-MOGUL CORPORATION ,  CHEN, Ming-ming

Inventor： CHEN, Ming-ming

CPC classification number: C09K21/12 ,  B33Y70/00

Abstract: A halogen-free flame-retardant compound and method of forming a continuous material therefrom includes compounding poly(ethylene terephthalate) (PET) with fire- retardant ingredients melamine cyanurate (MC) and melamine polyphosphate (MPP). The compound is then formed into pellets and/or extruded as a thin film or sheet, and also as a filament or yarn, including monofilaments and multifilaments.

Abstract translation: 无卤阻燃化合物及其连续材料的形成方法包括将聚对苯二甲酸乙二酯（PET）与阻燃剂三聚氰胺氰尿酸酯（MC）和多聚磷酸三聚氰胺（MPP）混合。 然后将化合物形成为颗粒和/或作为薄膜或片材挤出，以及作为包括单丝和复丝的细丝或纱线。

公开(公告)号：WO2007117883A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/064351

申请日：2007-03-20

Applicant: FEDERAL-MOGUL CORPORATION ,  CHEN, Ming-Ming

Inventor： CHEN, Ming-Ming

IPC: B32B1/08

CPC classification number: H02G3/0406 ,  D02G3/441 ,  D03D1/0035 ,  D03D1/0058 ,  H01C1/02 ,  H01C1/028 ,  H01C1/06 ,  H02G3/0481 ,  Y10T428/1362

Abstract: A fabric sleeve and hybrid yarn filament used in construction of the sleeve for protecting elongate members against at least one of EMI, RFI or ESD, and methods of construction of the sleeve and hybrid yarn filament. The sleeve includes at least one interlaced hybrid yarn filament having a non-conductive filament and at least one conductive wire filament overlying an outer surface of the non-conductive filament. The hybrid yarn filament is arranged in electrical communication with itself or other hybrid yarn filaments to provide uniform shielding against EMI, RFI, and/or ESD.

Abstract translation: 用于构造套筒的织物套筒和混合纱丝线，用于保护细长构件免受EMI，RFI或ESD中的至少一种，以及构造套筒和混合纱线细丝的方法。 所述套筒包括至少一个具有非导电细丝的交织的混合纱线丝和覆盖在所述非导电丝的外表面上的至少一根导丝丝。 混合纱线细丝布置成与其自身或其它混合纱线电连通，以提供均匀的屏蔽EMI，RFI和/或ESD。

公开(公告)号：WO2006083692A3

公开(公告)日：2007-01-11

申请号：PCT/US2006002840

申请日：2006-01-27

Applicant: MOUNT SINAI SCHOOOL OF MEDICIN ,  ZHOU MING-MING ,  ZENG LEI ,  WANG ZHIYONG

Inventor： ZHOU MING-MING ,  ZENG LEI ,  WANG ZHIYONG

IPC: A61K31/35 ,  A61K31/135 ,  A61K31/16 ,  A61K31/195 ,  A61K31/24 ,  A61K31/275 ,  C07C205/06 ,  C07C205/12 ,  C07C205/37 ,  C07C211/27 ,  C07C211/29 ,  C07C217/56 ,  C07C217/60 ,  C07C217/62 ,  C07C255/58 ,  C07D311/12 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18

CPC classification number: C07C215/16 ,  C07C211/29 ,  C07C211/53 ,  C07C217/20 ,  C07C229/18 ,  C07C229/42 ,  C07C255/58 ,  C07D311/08 ,  C07D311/16 ,  C07D311/18

Abstract: The present invention features compounds of the following general formula (I) wherein R 1 is selected from the group consisting of hydrogen, lower alkyl, aryl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, phenyl, SO 2 , NH 2 , NO 2 , SO 2 , CH 2 , CH 2 CH 3 , OCH 3 , OCOCH 3 , CH 2 COCH 3 , and OH, CN and halogen; R 2 is selected from the group consisting of hydrogen; lower alkyl, aryl, phenyl, aralkyl; substituted aralkyl, heteroaryl; substituted heteroaryl, SO 2 NH 2 NH 3 + N

Abstract translation: 本发明的特征在于以下通式（I）的化合物，其中R 1选自氢，低级烷基，芳基，芳烷基; 取代的芳烷基，杂芳基; 取代的杂芳基，苯基，SO 2，NH 2，NO 2，SO 2，CH 2 CH 2，CH 3，OCH 3，OCOCH 3，CH 2， CO，SO 3，OH，CN和卤素; R 2选自氢; 低级烷基，芳基，苯基，芳烷基; 取代的芳烷基，杂芳基; 取代的杂芳基，SO 2 NH 2 NH 3，N，N，N，N，

公开(公告)号：WO2023082273A1

公开(公告)日：2023-05-19

申请号：PCT/CN2021/130728

申请日：2021-11-15

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  DOW SILICONES CORPORATION ,  WANG, Tao ,  CHEN, Hongyu ,  WENG, Xilun ,  ZHANG, Kainan ,  MING, Ming ,  MIAO, Wenke ,  OUYANG, Wuye

Inventor： WANG, Tao ,  CHEN, Hongyu ,  WENG, Xilun ,  ZHANG, Kainan ,  MING, Ming ,  MIAO, Wenke ,  OUYANG, Wuye

IPC: C08L77/00 ,  C08L77/02 ,  C08L51/06 ,  C08K5/17

Abstract: A toughened polyamide composition including a blend of: (A) at least one polyamide; (B) at least one impact modifier; and (C) at least one organic amine; a process for producing the toughened polyamide composition; and articles made from the toughened polyamide compositions.

公开(公告)号：WO2022160351A1

公开(公告)日：2022-08-04

申请号：PCT/CN2021/074724

申请日：2021-02-01

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  WENG, Xilun ,  CHEN, Hongyu ,  MING, Ming ,  GONG, Yonghua ,  OUYANG, Wuye ,  DU, Libo ,  REN, Shijie

Inventor： WENG, Xilun ,  CHEN, Hongyu ,  MING, Ming ,  GONG, Yonghua ,  OUYANG, Wuye ,  DU, Libo ,  REN, Shijie

IPC: C08L77/00 ,  C08L23/08 ,  C08L23/26

Abstract: A nylon composition comprising a blend, wherein the blend includes: (a) at least one polyamide; and (b) at least one modifier, wherein the modifier includes a substantially linear functionalized ethylene/alpha-olefin copolymer having at least one side chain furan moiety crosslinked with at least one maleimide structure; a process for making the composition; and an article made from the composition.

公开(公告)号：WO2020107304A1

公开(公告)日：2020-06-04

申请号：PCT/CN2018/118093

申请日：2018-11-29

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  LI, Haiying ,  LIU, Andong ,  FENG, Shaoguang ,  YANG, Xiuhan ,  ZOU, Jian ,  MING, Ming ,  GONG, Yonghua ,  ZHAI, Xuemei

Inventor： LI, Haiying ,  LIU, Andong ,  FENG, Shaoguang ,  YANG, Xiuhan ,  ZOU, Jian ,  MING, Ming ,  GONG, Yonghua ,  ZHAI, Xuemei

IPC: C08L23/12 ,  A62D3/30

Abstract: A thermoplastic polyolefin composition comprises: (A) a polypropylene polymer; (B) an elastomer component; (C) an additive component; and (D) a scavenger component comprising a polyacetoacetate compound having the Formula (I) defined herein and calcium carbonate. And an article is made from the thermoplastic polyolefin composition.