公开(公告)号：WO2005106298A1

公开(公告)日：2005-11-10

申请号：PCT/US2005/014027

申请日：2005-04-22

Applicant: MEDTRONIC, INC. ,  OLSEN, James, M. ,  MORRIS, Mary, M. ,  HEGLAND, Michael ,  BLANCO, Justin, A.

Inventor： OLSEN, James, M. ,  MORRIS, Mary, M. ,  HEGLAND, Michael ,  BLANCO, Justin, A.

IPC: F16K1/40

CPC classification number: A61M25/0021 ,  A61M5/14276 ,  A61M5/16813 ,  A61M25/00 ,  A61M25/0029 ,  A61M25/003 ,  A61M25/0043 ,  A61M25/0068 ,  A61M25/0071 ,  A61M25/0075 ,  A61M27/006 ,  A61M2025/0073 ,  A61M2039/1005 ,  A61M2205/15 ,  A61M2206/16

Abstract: Catheter systems including one or more flow restrictors are disclosed. The catheter systems may include two or more delivery branches. The delivery branches may be connected to a supply catheter section using a branching catheter connector that may include one or more flow restrictors. The flow restrictors may include a restrictor body located within a lumen with a channel located between the restrictor body and interior surface of the lumen, the channel restricting flow through the lumen past the flow restrictor. The channel may be defined by a groove formed in the restrictor body and/or the interior surface of the lumen. Methods of providing pressure relief by flowing fluid past a flow restrictor are also disclosed.

Abstract translation: 公开了包括一个或多个限流器的导管系统。 导管系统可以包括两个或更多个输送分支。 输送分支可以使用可包括一个或多个限流器的分支导管连接器连接到供应导管部分。 限流器可以包括位于管腔内的节流体，通道位于限流器主体和内腔内表面之间，通道限制流经管腔的流经限流器。 通道可以由形成在限流器主体中的凹槽和/或内腔的内表面限定。 还公开了通过使流体流过限流器来提供压力释放的方法。

公开(公告)号：WO2009135083A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042439

申请日：2009-04-30

Applicant: MEDTRONIC, INC. ,  BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

Inventor： BURNES, John, E. ,  GARDESKI, Kenneth, C. ,  KLEPFER, Ruth, N. ,  MACAULAY, Patrick, E. ,  MORRIS, Mary, M. ,  SCHEINER, Avram

IPC: A61M25/06 ,  A61B17/34 ,  A61N1/05 ,  A61M25/00

CPC classification number: A61N1/36053 ,  A61M25/09 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/36085 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36128

Abstract: This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient. This disclosure is directed to a system for implantation of an implantable medical lead within a lumen of a blood vessel within a patient for delivery of electrical stimulation to nerve tissue located adjacent to and outside of the blood vessel, the system comprising: a catheter adapted to be positioned within the blood vessel lumen adjacent the nerve tissue; an electrode configured to be advanced toward a wall of the blood vessel lumen; and a sensor configured to detect the relative positions of the nerve tissue outside of the blood vessel and the electrode within the blood vessel lumen.

Abstract translation: 本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。 本公开涉及一种用于在患者体内的血管的腔内植入可植入医疗引线的系统，用于将电刺激递送到位于血管附近和外部的神经组织，所述系统包括：适于 定位在与神经组织相邻的血管腔内; 构造成朝向血管腔的壁前进的电极; 以及传感器，被配置为检测血管外部的神经组织和血管腔内的电极的相对位置。

公开(公告)号：WO2008085528A1

公开(公告)日：2008-07-17

申请号：PCT/US2007/060943

申请日：2007-01-23

Applicant: MEDTRONIC, INC. ,  SKUBITZ, Sean, P. ,  BOLEA, Stephen, L. ,  KAPLAN, Paula, M. ,  MORRIS, Mary, M.

Inventor： SKUBITZ, Sean, P. ,  BOLEA, Stephen, L. ,  KAPLAN, Paula, M. ,  MORRIS, Mary, M.

IPC: A61N1/00

CPC classification number: A61N1/0553 ,  A61N1/0558

Abstract: A medical system for electrical stimulation includes a first column of electrodes, a second column of electrodes, an expandable member disposed between first and second columns, and an expansion mechanism adapted to transmit an externally applied pressure to the expandable member. The pressure expands the expandable member in order to force the first column of electrodes apart from the second column of electrodes. The first and second columns, disposed side-by-side, may be inserted through a percutaneous needle and into a epidural space, alongside a spinal cord; after insertion, the first column may be forced apart from the second column by applying the pressure to the expandable member.

Abstract translation: 用于电刺激的医疗系统包括第一列电极，第二电极列，设置在第一和第二列之间的可扩张构件以及适于将外部施加的压力传递到可扩张构件的膨胀机构。 压力使可膨胀构件膨胀，以迫使第一列电极与第二列电极分开。 并排设置的第一和第二列可以穿过经皮针插入到与脊髓一起的硬膜外腔中; 在插入之后，通过向可膨胀构件施加压力，第一柱可以被迫离开第二柱。

公开(公告)号：WO2007019055A2

公开(公告)日：2007-02-15

申请号：PCT/US2006/028900

申请日：2006-07-26

Applicant: MEDTRONIC, INC. ,  MORRIS, Mary, M. ,  BERGAN, Matthew, A. ,  FERNADES, Brian, C.A. ,  GARDESKI, Kenneth, C. ,  SPEAR, Stanten, C.

Inventor： MORRIS, Mary, M. ,  BERGAN, Matthew, A. ,  FERNADES, Brian, C.A. ,  GARDESKI, Kenneth, C. ,  SPEAR, Stanten, C.

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

CPC classification number: A61L27/50 ,  A61K49/0452 ,  A61K51/1203 ,  A61L27/38 ,  A61L27/3895

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid

Abstract translation: 一种方法涉及选择用于植入哺乳动物中的细胞类型并识别细胞类型的比重或密度。 然后，选择比重或密度在比重或密度范围内的载体液体，所述比重或密度的范围与所选择的细胞类型的比重或密度近似匹配。 还提供了用于将生长细胞递送到哺乳动物组织中的液体，其中载体流体组分的密度与通过载体流体一贯递送的细胞的密度相匹配<！ - SIPO

公开(公告)号：WO2006060514A1

公开(公告)日：2006-06-08

申请号：PCT/US2005/043374

申请日：2005-11-30

Applicant: MEDTRONIC, INC. ,  SIGG, Daniel, C. ,  UJHELYI, Michael, R. ,  MORRIS, Mary, M.

Inventor： SIGG, Daniel, C. ,  UJHELYI, Michael, R. ,  MORRIS, Mary, M.

IPC: A61B5/02 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172

CPC classification number: A61M5/14276 ,  A61B17/00234 ,  A61B17/3417 ,  A61B17/3478 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61M5/1723 ,  A61M2005/1405 ,  A61M2205/3523

Abstract: Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.

Abstract translation: 用于经由血管系统和心房壁，特别是通过上腔静脉和右心房壁，经静脉进入心包腔的方法和系统，以将药理剂，特别是NO-供体药物递送到 心被披露。 输注导管的近端连接器连接至输液泵，并且具有远端输注导管腔端开口的远端导管段布置在心包腔内。 可植入的输液泵可与可植入的局部缺血监测器结合使用，以监测局部缺血状态并触发输送或调节药理剂的定期输送以最佳地治疗局部缺血。 患者可以操作患者激活器，患者在感觉缺血症状时发送由可植入输液泵接收的信号并触发输注推注和/或连续输注。