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公开(公告)号：US20050281715A1
公开(公告)日：2005-12-22
申请号：US10870107
申请日：2004-06-17
Applicant: Merrit Jacobs , Robert Burkovich , David Johnson
Inventor： Merrit Jacobs , Robert Burkovich , David Johnson
CPC classification number: G01N21/13 , G01N21/0303 , G01N21/253 , G01N2021/0357 , G01N2021/0367 , G01N2021/0371 , G01N2201/0438
Abstract: A device and method solves the problems of improving precision, in particular in reducing movement of a cuvette, particularly lateral or side to side movement of a cuvette, during the measurement process. The device, which stabilizes a cuvette during a measurement read in an analyzer having a cuvette path of travel, includes: a fixed support located on a first side of the path of travel and abutting a side of the cuvette at a location that does not interfere with an optical window on the cuvette on which the measurement read takes place; and a movable support located on a second side of the path of travel and biased against a side of the cuvette at a location that does not interfere with the optical window on the cuvette on which the measurement read takes place, and which is opposite the side abutting the fixed support.
Abstract translation: 一种装置和方法解决了在测量过程中提高精度的问题，特别是在减小试管的运动，特别是比色杯的侧向或侧向运动。 在具有运动的比色皿路径的分析器中读取测量期间使测定杯稳定的装置包括：位于行进路径的第一侧的固定支撑件，并且在不干扰的位置处邻接比色杯的一侧 在其上进行测量读取的比色皿上具有光学窗口; 以及可移动支撑件，其位于行进路径的第二侧，并且在不影响在其上进行测量读取的比色皿上的光学窗口的位置处抵靠所述比色皿的侧面偏压，并且与所述侧面相对的位置 抵靠固定支架。
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公开(公告)号：US20050185177A1
公开(公告)日：2005-08-25
申请号：US11047450
申请日：2005-01-31
Applicant: Donald Moran , Michael LaCourt , Davis Freeman , Merrit Jacobs , David Heavner
Inventor： Donald Moran , Michael LaCourt , Davis Freeman , Merrit Jacobs , David Heavner
CPC classification number: G01N21/59
Abstract: A method for measuring the presence or concentration of an analyte in a sample by spectrophotometry: providing an open top cuvette having a sample with an analyte to be measured; providing a light source and a detector for detecting emitted light; taking at least two measurements that includes: (i) directing at least two beams of light from the light source to different locations on the cuvette; (ii) passing the at least two beams through the cuvette at their respective locations and through the sample to be measured; and (iii) measuring at least two respective emitted light beams with the detector; and comparing the at least two emitted light beams to determine if: all the emitted light beams should be disregarded; one or more of the emitted light beams should be disregarded; or the sample absorbances should be averaged. In a preferred embodiment, the method includes taking at least three measurements. In another preferred embodiment, the spectrophotometry is absorption spectrophotometry, and the method is performed on a diagnostic analyzer.
Abstract translation: 通过分光光度法测量样品中分析物的存在或浓度的方法：提供具有待测量待分析物的样品的开放顶部比色皿; 提供光源和用于检测发射光的检测器; 进行至少两个测量，其包括：（i）将来自光源的至少两束光束引导到比色杯上的不同位置; （ii）使所述至少两束光束在其各自的位置通过所述比色皿并通过待测样品; 和（iii）用检测器测量至少两个相应的发射光束; 以及比较所述至少两个发射的光束以确定是否：所有发射的光束应被忽略; 一个或多个发射光束应被忽略; 或样品吸光度应平均。 在优选实施例中，该方法包括进行至少三次测量。 在另一个优选的实施方案中，分光光度法是吸收分光光度法，并且该方法在诊断分析仪上进行。
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公开(公告)号：US08507280B2
公开(公告)日：2013-08-13
申请号：US11838576
申请日：2007-08-14
Applicant: Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Danielson , Terri Fazio
Inventor： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Danielson , Terri Fazio
CPC classification number: B01L3/0275 , B01L3/5082 , B01L2300/041 , G01N35/025 , G01N2035/1058 , G01N2035/1062 , Y10T436/107497 , Y10T436/11 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
Abstract: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
Abstract translation: 公开了一种使临床分析仪上的样品流体的表面张力正常化的方法。 该方法包括将一部分样品流体抽吸到计量尖端中，计量尖端具有下端，样品流体通过该下端吸入，上端; 密封计量尖端的下端，形成样品流体部分的比色皿; 用表面张力归一化剂预处理微尖端，然后将表面张力归一化剂分配到试管中的样品流体中; 使用微尖端将表面张力归一化剂和样品流体混合在比色杯中，以产生样品流体和表面张力归一化剂的混合物，该混合物具有归一化的表面张力; 并在临床分析仪上使用混合物进行测试。
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公开(公告)号：US20090192744A1
公开(公告)日：2009-07-30
申请号：US11930433
申请日：2007-10-31
Applicant: Donald James Moran, JR. , Michael W. LaCourt , Davis Freeman, III , Merrit Jacobs
Inventor： Donald James Moran, JR. , Michael W. LaCourt , Davis Freeman, III , Merrit Jacobs
CPC classification number: G01N21/59
Abstract: A method for measuring the presence or concentration of an analyte in a sample by spectrophotometry: providing an open top cuvette having a sample with an analyte to be measured; providing a light source and a detector for detecting emitted light; taking at least two measurements that includes: (i) directing at least two beams of light from the light source to different locations on the cuvette; (ii) passing the at least two beams through the cuvette at their respective locations and through the sample to be measured; and (iii) measuring at least two respective emitted light beams with the detector; and comparing the at least two emitted light beams to determine if: all the emitted light beams should be disregarded; one or more of the emitted light beams should be disregarded; or the sample absorbances should be averaged. In a preferred embodiment, the method includes taking at least three measurements. In another preferred embodiment, the spectrophotometry is absorption spectrophotometry, and the method is performed on a diagnostic analyzer.
Abstract translation: 通过分光光度法测量样品中分析物的存在或浓度的方法：提供具有待测量待分析物的样品的开放顶部比色皿; 提供光源和用于检测发射光的检测器; 进行至少两个测量，其包括：（i）将来自光源的至少两束光束引导到比色杯上的不同位置; （ii）使所述至少两束光束在其各自的位置通过所述比色皿并通过待测样品; 和（iii）用检测器测量至少两个相应的发射光束; 以及比较所述至少两个发射的光束以确定是否：所有发射的光束应被忽略; 一个或多个发射光束应被忽略; 或样品吸光度应平均。 在优选实施例中，该方法包括进行至少三次测量。 在另一个优选的实施方案中，分光光度法是吸收分光光度法，并且该方法在诊断分析仪上进行。
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公开(公告)号：US20080044908A1
公开(公告)日：2008-02-21
申请号：US11838576
申请日：2007-08-14
Applicant: Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Denisison , Terri Fazio
Inventor： Merrit Jacobs , Ed Graham , Karen Vavra , Chuck Noeson , Susan Denisison , Terri Fazio
IPC: G01N33/48
CPC classification number: B01L3/0275 , B01L3/5082 , B01L2300/041 , G01N35/025 , G01N2035/1058 , G01N2035/1062 , Y10T436/107497 , Y10T436/11 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
Abstract: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the lower end of the metering tip, forming a cuvette for the portion of the sample fluid; pre-treating a micro-tip with a surface tension-normalizing agent, and then dispensing the surface tension-normalizing agent into the sample fluid in the cuvette; mixing the surface tension-normalizing agent and the sample fluid in the cuvette using the micro-tip to create a mixture of the sample fluid and the surface tension-normalizing agent, the mixture having a normalized surface tension; and using the mixture for testing on the clinical analyzer.
Abstract translation: 公开了一种使临床分析仪上的样品流体的表面张力正常化的方法。 该方法包括将一部分样品流体抽吸到计量尖端中，计量尖端具有下端，样品流体通过该下端吸入，上端; 密封计量尖端的下端，形成样品流体部分的比色皿; 用表面张力归一化剂预处理微尖端，然后将表面张力归一化剂分配到试管中的样品流体中; 使用微尖端将表面张力归一化剂和样品流体混合在比色杯中，以产生样品流体和表面张力归一化剂的混合物，该混合物具有归一化的表面张力; 并在临床分析仪上使用混合物进行测试。
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Patent Agency Ranking
公开(公告)号：US07307718B2
公开(公告)日：2007-12-11
申请号：US11047450
申请日：2005-01-31
Applicant: Donald James Moran, Jr. , Michael W. LaCourt , Davis Freeman, III , Merrit Jacobs , David Allen Heavner
Inventor： Donald James Moran, Jr. , Michael W. LaCourt , Davis Freeman, III , Merrit Jacobs , David Allen Heavner
CPC classification number: G01N21/59
Abstract: A method for measuring the presence or concentration of an analyte in a sample by spectrophotometry: providing an open top cuvette having a sample with an analyte to be measured; providing a light source and a detector for detecting emitted light; taking at least two measurements that includes: (i) directing at least two beams of light from the light source to different locations on the cuvette; (ii) passing the at least two beams through the cuvette at their respective locations and through the sample to be measured; and (iii) measuring at least two respective emitted light beams with the detector; and comparing the at least two emitted light beams to determine if: all the emitted light beams should be disregarded; one or more of the emitted light beams should be disregarded; or the sample absorbances should be averaged. In a preferred embodiment, the method includes taking at least three measurements. In another preferred embodiment, the spectrophotometry is absorption spectrophotometry, and the method is performed on a diagnostic analyzer.
Abstract translation: 通过分光光度法测量样品中分析物的存在或浓度的方法：提供具有待测量待分析物的样品的开放顶部比色皿; 提供光源和用于检测发射光的检测器; 进行至少两个测量，其包括：（i）将来自光源的至少两束光束引导到比色杯上的不同位置; （ii）使所述至少两束光束在其各自的位置通过所述比色皿并通过待测样品; 和（iii）用检测器测量至少两个相应的发射光束; 以及比较所述至少两个发射的光束以确定是否：所有发射的光束应被忽略; 一个或多个发射光束应被忽略; 或样品吸光度应平均。 在优选实施例中，该方法包括进行至少三次测量。 在另一个优选的实施方案中，分光光度法是吸收分光光度法，并且该方法在诊断分析仪上进行。
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公开(公告)号：US20070118294A1
公开(公告)日：2007-05-24
申请号：US11285275
申请日：2005-11-22
Applicant: Merrit Jacobs
Inventor： Merrit Jacobs
IPC: G06F19/00
CPC classification number: G01N35/00663 , G01N2035/00673
Abstract: A method for determining the remaining time a fluid in a container can be used. The method includes: determining the amount of fluid in the container; and determining the remaining time based on the amount of fluid in the container. Preferably, the step of determining the remaining time is calculated by using the determined amount of fluid and a predetermined first correlation of remaining time vs. amount of fluid in the container. In a preferred embodiment, the fluid is a reagent in a reagent pack used in a diagnostic analyzer. A method for measuring the presence or concentration of an analyte in a sample on an automated diagnostic analyzer includes: providing a reagent storage container on the analyzer; providing a measurement station for taking a measurement of the sample; determining the amount of reagent remaining in a reagent storage container; calculating the remaining time of the reagent by using the determined amount of reagent and a predetermined first correlation of remaining time vs. amount of fluid in the container; if the time the reagent has been in the reagent container is greater than the remaining time, then discarding the reagent, otherwise adding reagent to the sample; and taking a measurement of the sample to determine the presence or concentration of the analyte.
Abstract translation: 用于确定容器中的流体可以被使用的剩余时间的方法。 该方法包括：确定容器中的流体量; 以及基于容器中的流体量确定剩余时间。 优选地，通过使用确定的流体量和容器中的剩余时间与流体量的预定的第一相关性来计算确定剩余时间的步骤。 在优选的实施方案中，流体是诊断分析仪中使用的试剂包中的试剂。 用于测量自动诊断分析仪上样品中分析物的存在或浓度的方法包括：在分析仪上提供试剂储存容器; 提供用于测量样品的测量站; 确定残留在试剂储存容器中的试剂的量; 通过使用确定量的试剂计算试剂的剩余时间，以及在容器中预先确定剩余时间与流体量的第一相关性; 如果试剂在试剂容器中的时间大于剩余时间，则丢弃试剂，否则加入试剂; 并测量样品以确定分析物的存在或浓度。
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公开(公告)号：US20050196867A1
公开(公告)日：2005-09-08
申请号：US11091283
申请日：2005-03-28
Applicant: Randy Bower , Stuart MacDonald , James Shaw , Mark Simon , Michael Avdenko , Joseph Dambra , David Hyde , Merrit Jacobs , James Riall
Inventor： Randy Bower , Stuart MacDonald , James Shaw , Mark Simon , Michael Avdenko , Joseph Dambra , David Hyde , Merrit Jacobs , James Riall
CPC classification number: G01N35/00594 , G01N35/00603 , G01N35/10 , G01N35/1016 , G01N2035/00653 , G01N2035/1018 , G01N2035/1025 , Y10T436/11 , Y10T436/119163 , Y10T436/2575
Abstract: The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.
Abstract translation: 本发明是用于检测分析仪中用于进行临床测定的失败的方法。 识别分析仪中可能导致测定失败的潜在错误，以及它们的潜在来源。 也确定如此识别的错误源将导致临床上显着的误差的概率。 基于其在可接受限度内检测到这种误差的可能性并且伴随检测失败的错误检测的低概率的选择和实现的这些措施的组合来识别与潜在错误源相对应的可用潜在检测措施。 所选择的每个措施在功能上独立于被选择用于解决误差源的其他措施，并且不受与检测失败相同的固有手段的影响。 还介绍了该方法在临床分析仪中的应用。
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公开(公告)号：US20050185176A1
公开(公告)日：2005-08-25
申请号：US10784505
申请日：2004-02-23
Applicant: Donald Moran , Michael LaCourt , Davis Freeman , Merrit Jacobs
Inventor： Donald Moran , Michael LaCourt , Davis Freeman , Merrit Jacobs
CPC classification number: G01N21/31 , G01N21/64 , G01N2021/157 , G01N2021/6493
Abstract: A method for measuring the presence or concentration of an analyte in a sample by spectrophotometry: providing an open top cuvette having a sample with an analyte to be measured; providing a light source and a detector for detecting emitted light; taking at least two measurements that includes: (i) directing at least two beams of light from the light source to different locations on the cuvette; (ii) passing the at least two beams through the cuvette at their respective locations and through the sample to be measured; and (iii) measuring at least two respective emitted light beams with the detector; and comparing the at least two emitted light beams to determine if: all the emitted light beams should be disregarded; one or more of the emitted light beams should be disregarded; or the sample absorbances should be averaged. In a preferred embodiment, the method includes taking at least three measurements. In another preferred embodiment, the spectrophotometry is absorption spectrophotometry, and the method is performed on a diagnostic analyzer.
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公开(公告)号：US20050079103A1
公开(公告)日：2005-04-14
申请号：US10684599
申请日：2003-10-14
Applicant: Merrit Jacobs
Inventor： Merrit Jacobs
CPC classification number: G01N35/00029 , G01N35/028 , G01N2035/00079 , G01N2035/00108 , G01N2035/0405
Abstract: A moving evaporation control cover for at least one fluid containing receptacle for use in a clinical analyzer includes: a pliable cover capable forming a sealing relationship with the fluid containing receptacle, wherein said cover moves with said receptacle; and one or more rollers in contact with the pliable cover. Preferably, the receptacle is a cuvette for use in a diagnostic or chemical analyzer.
Abstract translation: 用于临床分析仪中使用的用于至少一个流体容纳容器的移动蒸发控制盖包括：能够与流体容纳容器形成密封关系的柔性盖，其中所述盖随所述容器移动; 以及与柔性罩接触的一个或多个辊。 优选地，容器是用于诊断或化学分析仪的试管。
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