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11.发明专利
公开(公告)号：JPS62278454A
公开(公告)日：1987-12-03
申请号：JP11719587
申请日：1987-05-15
Applicant: MILES LAB
Inventor： HERUMUTO ENGERUMAN , KAARU HAINTSU HIRUDENBURANTO , GIYUNTAA YUNKAASU
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公开(公告)号：JPS6250782B2
公开(公告)日：1987-10-27
申请号：JP11624579
申请日：1979-09-12
Applicant: MILES LAB
Inventor： ROBAATO BAUAA
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13.发明专利
公开(公告)号：JPS62215400A
公开(公告)日：1987-09-22
申请号：JP4899587
申请日：1987-03-05
Applicant: MILES LAB
Inventor： HERUBERUTO HIYUUGURU , OIGEN SHIYUNAABERU
IPC: C07D279/02 , C07D231/56 , C07D275/04 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/493 , G01N33/50 , G01N33/52
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公开(公告)号：JPS6240662B2
公开(公告)日：1987-08-29
申请号：JP14521577
申请日：1977-12-05
Applicant: MILES LAB
IPC: G01N33/536 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/542 , G01N33/543
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15.发明专利
公开(公告)号：JPS62171682A
公开(公告)日：1987-07-28
申请号：JP515087
申请日：1987-01-14
Applicant: MILES LAB
Inventor： HAABAATO JIYON HABERA , JIYON DEBITSUDO HANFURIIZU
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Patent Agency Ranking
公开(公告)号：JPS62138434A
公开(公告)日：1987-06-22
申请号：JP28444586
申请日：1986-12-01
Applicant: MILES LAB
Inventor： MAIKERU EI SHIIRAA , PAMERA KEI SASAGAWA , RONARUDO EICHI HAIN
Abstract: There is disclosed an improved method for separating one of alpha-1-proteinase inhibitor (also known as alpha-1 anti-trypsin) and antithrombin-III from an aqueous solution of plasma proteins containing the same, such as from Cohn Fraction IV-1, Cohn Fraction IV, reworks of Cohn Fraction IV and IV-1, Cohn Effluent II & III and Cohn Effluent I. The method includes the steps of first holding an aqueous solution of plasma proteins containing one of alpha-1-proteinase inhibitor and antithrombin-III in a relatively large volume of buffer solution as solvent and at a pH adjusted to be relatively basic when compared to conditions heretofore known, and at a temperature in the range of from 2 - 50° C for a period of about 0·2- 24 hours. Following the above treatment, alpha-1- proteinase inhibitor and antithrombin-III are obtained by applying conventional techniques to the resulting solution. Accordingly, the solution is then mixed with a polyalkylene glycol, e.g. polyethylene glycol, in the range of from as low as 8% to as high as 23% (w/v) based on volume of solution to selectively precipitate unwanted proteins. The alpha-1- proteinase inhibitor is then separated from the supernatant solution by adsorption on an anion exchange resin or by precipitation by further addition of a polyalkylene glycol, e.g. polyethylene glycol. The method of the invention provides an improvement in the yield of alpha-1-proteinase inhibitor.
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公开(公告)号：JPS62134563A
公开(公告)日：1987-06-17
申请号：JP28610886
申请日：1986-12-02
Applicant: MILES LAB
Inventor： ANGERA EE MIHAERUSU
IPC: C12Q1/00 , C07K5/083 , C12Q1/04 , C12Q1/06 , C12Q1/37 , G01N33/52 , G01N33/569 , G01N33/579
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公开(公告)号：JPS6283899A
公开(公告)日：1987-04-17
申请号：JP17898286
申请日：1986-07-31
Applicant: MILES LAB
IPC: G01N33/577 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K14/41 , C07K16/00 , C07K16/12 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/569
Abstract: Monoclonal antibodies specific to serotypic determinants on the flagella of a microorganism and found to be useful in inhibiting motility.
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19.发明专利
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公开(公告)号：JPS6215000A
公开(公告)日：1987-01-23
申请号：JP15810086
申请日：1986-07-07
Applicant: MILES LAB
Inventor： KUU HIYUUN CHIYUN , GEIRII RII DEBISU , FURANSHISU HENRII BAAHOFU
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