公开(公告)号：WO1979000521A1

公开(公告)日：1979-08-09

申请号：PCT/GB1979000014

申请日：1979-01-17

Applicant: NAT RES DEV CORP ,  CRISP S ,  WILSON A

Inventor： NAT RES DEV CORP

IPC: C08L33/02

CPC classification number: C04B28/28 ,  A61K6/0835 ,  A61L15/12 ,  A61L27/446 ,  C08K3/00 ,  C08L33/02

Abstract: Compositions which are hardenable in the presence of water to form a poly (carboxylate) cement contain a metal salt which accelerates the setting of the composition.

Abstract translation: 在水存在下可硬化以形成聚（羧酸盐）水泥的组合物含有加速组合物凝固的金属盐。

公开(公告)号：WO2006137084A2

公开(公告)日：2006-12-28

申请号：PCT/IN2006000210

申请日：2006-06-21

Applicant: NAT RES DEV ,  VARADACHARI CHANDRIKA

Inventor： VARADACHARI CHANDRIKA

IPC: C05B11/10 ,  C01B25/40 ,  C05D9/02

CPC classification number: C05D9/02 ,  C05B11/10 ,  C05B13/04

Abstract: A process for the preparation of water insoluble bio-release micronutrient fertilizers, containing iron and manganese with either zinc and/or copper, comprising (a) heating orthophosphoric acid at a temperature of 130°C-150°C with a mixture of (i) source of iron oxide, (ii) manganese dioxide or pyrolusite, and (iii) either or both compounds of zinc or copper selected from zinc ash or zinc oxide and cupric oxide, or cupric sulphate or cupric chloride and (iii) a basic compound such as oxide or carbonate of magnesium or calcium, to produce a multi-metallic polyphosphate; (b) neutralisation of the polyphosphate with a basic compound followed by drying and pulverisation to obtain a solid powdery material.

Abstract translation: 一种用于制备含有锌和/或铜的铁和锰的水不溶性生物释放微量营养素肥料的方法，包括（a）在130℃-150℃的温度下加热正磷酸和（i ）氧化铁源，（ii）二氧化锰或软锰矿，以及（iii）选自锌灰或氧化锌和氧化铜，或硫酸铜或氯化铜的锌或铜的一种或两种化合物，和（iii）碱性化合物 例如镁或钙的氧化物或碳酸盐，以产生多金属多磷酸盐; （b）用碱性化合物中和多磷酸盐，然后干燥和粉碎，得到固体粉状物质。

公开(公告)号：WO8704427A3

公开(公告)日：1987-12-03

申请号：PCT/GB8700019

申请日：1987-01-15

Applicant: NAT RES DEV

Inventor： JONES ROBERT LESLIE ,  WILSON NORMAN HAPPER

IPC: C07C69/03 ,  C07B61/00 ,  C07C51/00 ,  C07C51/353 ,  C07C59/125 ,  C07C59/205 ,  C07C59/80 ,  C07C67/00 ,  C07C67/347 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C235/82 ,  C07C325/00 ,  C07C327/24 ,  C07C405/00 ,  C07D493/08 ,  C07C69/708

CPC classification number: C07D493/08 ,  C07C59/80 ,  C07C405/0091

Abstract: A process for the preparation of a compound of formula (I), wherein X and X' each represents hydrogen or together represent a bridging group -CH2-, -CH2-CH2- or -O-; R1 is a 6-carboxyhex-2-enyl group or a modification thereof in which the group is altered by one, or an appropriate combination of two or more, of the following: (a) alteration of the position of the double bond, with the proviso that in the modified group the double bond is not in the alpha-beta position relative to the ring; (b) reduction of the double bond; (c) alteration of the chain length through a decrease of one or two methylene groups or an increase of one to six methylene groups; (d) replacement of one or two methylene groups each separately by an oxygen or sulphur atom, with the proviso that in the modified group no oxygen or sulphur atom is in an alpha position relative to either a doubly bonded carbon atom or to the carboxy group or a derivative thereof and that at least 2 carbon atomes separate any pair of oxygen and/or sulphur atoms; and (e) formation of an amide, ester or salt derivative of the carboxy group; R2 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by an aromatic group directly or through an oxygen or sulphur atom; and R3, R4, R5 and R6 are each hydrogen, or R3 and R4 together and/or R5 and R6 together represent the second bond of a carbon-carbon double bond; comprises effecting a Diels Alder reaction between a diene of formula (II) and a dienophile of formula (III), wherein X, X' and R2 are as defined for (I); Y is R1 or a precursor therefor in which a double bond is present and/or the terminal group is in different form, either being a free carboxy group rather than the carboxy group derivative present in R1 or being a carboxy group derivative rather than the free carboxy group present in R1; and R and R' are either each hydrogen or together represent the third bond of a carbon-carbon triple bond; and where appropriate thereafter, in either order, reducing the double bond or bonds in the ring of the Diels Alder adduct and/or converting the group Y to the group R1. The compounds prepared by this process are of value as intermediates for the preparation of biologically active compounds.

Abstract translation: 制备式（I）化合物的方法，其中X和X'各自代表氢或一起代表桥基-CH 2 - ， - CH 2 -CH 2 - 或-O-; R1是6-羧基己-2-烯基或其修饰，其中该基团被以下的一个或两个或更多个的适当组合改变：（a）改变双键的位置，与 条件是在修饰基团中双键不在相对于环的α-β位; （b）减少双键; （c）通过减少一个或两个亚甲基或增加一个至六个亚甲基而改变链长; （d）分别用氧或硫原子分别置换一个或两个亚甲基，条件是在修饰基团中氧或硫原子相对于双键碳原子或羧基处于α位 或其衍生物，并且至少2个碳原子分离任何一对氧原子和/或硫原子; 和（e）形成羧基的酰胺，酯或盐衍生物; R2是直接或通过氧或硫原子被芳基取代的脂族烃基或脂族烃基; 并且R3，R4，R5和R6各自为氢，或者R3和R4一起和/或R5和R6一起表示碳 - 碳双键的第二键; 包括在式（II）的二烯与式（III）的亲二烯体之间进行狄尔斯阿尔德反应，其中X，X'和R2如对（I）所定义; Y是R 1或其中存在双键的前体和/或末端基团是不同形式，或者是游离羧基而不是存在于R 1中的羧基衍生物或者是羧基衍生物而不是游离的 存在于R1中的羧基; 并且R和R'各自为氢或一起表示碳 - 碳三键的第三键; 然后以任意次序，减少Diels Alder加合物的环中的双键或键和/或将基团Y转化为基团R1。 通过该方法制备的化合物作为制备生物活性化合物的中间体是有价值的。

公开(公告)号：WO1982003411A1

公开(公告)日：1982-10-14

申请号：PCT/GB1982000095

申请日：1982-03-24

Applicant: NAT RES DEV CORP ,  HOSELITZ KURT

Inventor： NAT RES DEV CORP

IPC: C22C38/02

CPC classification number: C22C45/02 ,  H01F1/15308

Abstract: An alloy of composition (by mole) around Fe80B15Si5 with additions of up to 4 mole % Ag or Cu or up to 2% Zn or mixtures thereof when rapidly cooled solidifies to a non-crystalline glass structure, which is ductile and magnetically "soft", i.e. offering a reasonable saturation magnetisation yet with low losses. Exemplary glassy alloy: Fe79.5B15Si5Cu0.5.

Abstract translation: 在Fe80B15Si5周围的组合物（摩尔）的合金，当加速高达4摩尔％的Ag或Cu或至多2％的Zn或其混合物时，迅速冷却固化成非结晶玻璃结构，其为延性和磁性“软” ，即提供合理的饱和磁化，但具有低损耗。 示例性玻璃态合金：Fe79.5B15Si5Cu0.5。

公开(公告)号：WO1982003090A1

公开(公告)日：1982-09-16

申请号：PCT/GB1982000068

申请日：1982-03-03

Applicant: NAT RES DEV CORP ,  JAMES RICHARD

Inventor： NAT RES DEV CORP

IPC: C12Q01/34

CPC classification number: C12Q1/04 ,  C12Q1/18 ,  C12Q1/34 ,  G01N33/04 ,  G01N2333/986 ,  G01N2415/00

Abstract: Procede d'identification de beta-lactamases en controlant specifiquement les reactions de concurrence entre un substrat chromogene, par exemple la nitrocefine, et divers substrats en concurrence, de preference certains des beta-lactames les plus recents, par exemple la cefoxitine, le moxalactame, MK 0787 etc. Une etude detaillee de ces reactions par l'inventeur a revele des variations accentuees auxquelles on ne s'attendait pas dans la reactivite (affinite) de ces enzymes pour les differents beta-lactames. Sur cette base l'invention fournit un test d'analyse pour l'identification des beta-lactamases'inconnues'basee sur la comparaison de leur comportement dans la reaction de concurrence avec des donnees d'affinite sur des beta-lactamases connues. Le substrat chromogene et une selection des beta-lactames les plus utiles sont fournis sous forme de 'kit'. Il peut contenir des melanges prepares des beta-lactames et du substrat chromogene. Le test d'analyse peut s'effectuer visuellement en utilisant des plaques de micro-titrage et un simple systeme de comptage ou plus quantitativement par analyse spectro-photometrique. Il peut etre utilise pour l'identification rapide des beta-lactamases dans un laboratoire d'hopital ou pour l'identification des bacteries gram-negatives basees sur les beta-lactamases qu'elles produisent.

公开(公告)号：WO1981001657A1

公开(公告)日：1981-06-25

申请号：PCT/GB1980000215

申请日：1980-12-12

Applicant: NAT RES DEV CORP ,  TURNER R ,  HOLMAN R

Inventor： NAT RES DEV CORP

IPC: A61M05/28

CPC classification number: A61M5/283 ,  A61M5/3202

Abstract: A syringe is provided comprising a barrel (10) open at one end, a piston (20) sealably located in the barrel and being partly formed by a membrane (23), a plunger (30) slidable into the barrel to engage and move the piston, and a needle (40) projecting through the plunger into and out of the barrel. A material to be dispensed is located between the barrel and piston, and plunger movement causes the needle to pierce the membrane and also causes the piston to move to eject material through the needle. Preferably a protective cap (50) is connected with the barrel to cover the plunger/needle projection. Typically the dispensed material is pharmaceutical and it can be maintained sterile by suitable sealing of the piston and/or cap with the barrel. The plunger can interlock with the piston to allow withdrawal movement useful in intravenous injection. Also the barrel closed end can include another membrane (62) allowing mixture of another material, such as a solvent or diluent liquid.

Abstract translation: 提供了一种注射器，其包括在一端开口的筒体（10），可密封地定位在筒体中并由薄膜（23）部分地形成的活塞（20），可滑入筒体中的活塞（30） 活塞以及通过柱塞伸入和移出筒体的针（40）。 要分配的材料位于筒体和活塞之间，并且柱塞移动导致针刺穿膜并且还使活塞移动以通过针喷射材料。 优选地，保护盖（50）与筒连接以覆盖柱塞/针突起。 通常，所分配的材料是药物，并且可以通过活塞和/或盖与筒的适当密封来保持无菌。 柱塞可以与活塞互锁，以允许静脉注射中有用的抽出运动。 筒封闭端也可以包括允许混合其它材料例如溶剂或稀释液的另一膜（62）。

公开(公告)号：WO1980002671A1

公开(公告)日：1980-12-11

申请号：PCT/GB1980000099

申请日：1980-06-06

Applicant: NAT RES DEV CORP ,  WARD I ,  GIBSON A ,  COATES P

Inventor： NAT RES DEV CORP

IPC: B29C17/02

CPC classification number: B29C67/00 ,  B29C47/00 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0038 ,  B29C47/0057 ,  B29C47/02 ,  B29C55/30 ,  B29K2023/00 ,  B29K2027/12 ,  B29K2059/00 ,  B29K2061/00 ,  B29L2023/22

Abstract: Oriented thermoplastics having enhanced properties such as Young's modulus, resistance to creep, resistance to gas transport are prepared by drawing the thermoplastic in the solid phase through a die so that its plastic strain is progressively increased during start-up.

公开(公告)号：WO1980000504A1

公开(公告)日：1980-03-20

申请号：PCT/GB1979000138

申请日：1979-08-10

Applicant: NAT RES DEV CORP ,  HOLLAND L

Inventor： NAT RES DEV CORP

IPC: G05D05/03

CPC classification number: C23C14/546 ,  C23C14/547 ,  G01B7/06 ,  G01B7/066 ,  G01B11/0683 ,  G01B21/08 ,  G05D5/03

Abstract: In apparatus for sensing and controlling the deposition of a thin film on to a substrate (12) from a gas or vapour phase, the optical reflectance or transmittance is sensed, the resonant frequency of a crystal (14) also exposed to the deposition is sensed, and the quotient of the change in each signal over a predetermined time interval is determined. The deposition can be terminated at a suitable thickness, for example a reflectance or transmittance maximum or minimum. Instead of an optical property, the electrical resistivity of the film may be sensed and used in the same way.

公开(公告)号：WO1979000320A1

公开(公告)日：1979-06-14

申请号：PCT/GB1978000043

申请日：1978-11-24

Applicant: NAT RES DEV CORP ,  MCKELVIE J ,  WALKER C

Inventor： NAT RES DEV CORP

IPC: G01B09/02

CPC classification number: G01B11/165 ,  G01B2290/30

Abstract: A surface on which there is a regular periodic pattern, often a relief pattern (12), is deformed, and in-plane deformation is sensed by illuminating the deformed pattern with a beam (12) of coherent light so that light is reflected as one zero order beam and a plurality of diffracted beams, and combining two of the beams (16, 18) so that they interfere in a manner related to the deformation along the direction of intersection of the surface plane with the plane in which the two interfering beams lie. The magnitude and direction of in-plane deformation in one or more directions and the magnitude and direction of the maximum in-plane stress or strain, can be determined automatically.

公开(公告)号：WO9100729A3

公开(公告)日：1991-06-13

申请号：PCT/GB9001079

申请日：1990-07-13

Applicant: NAT RES DEV

Inventor： CREIGHTON ANDREW MALCOLM

IPC: A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P39/02 ,  C07D241/08

CPC classification number: A61K31/535 ,  A61K31/495 ,  A61K31/70 ,  C07D241/08 ,  A61K31/165 ,  A61K2300/00

Abstract: Compounds of formula (II), wherein n is 0, 1 or 2, R1, R2, R3 and R4 are each separately selected from hydrogen, unsubstituted acyclic aliphatic hydrocarbon groups having a maximum of six carbon atoms and C1-6 alkyl groups substituted by a hydroxy group or a C1-6 alkoxy group, or one of R1 and R2 and one of R3 and R4 is hydrogen and the others are a trimethylene, tetramethylene or pentamethylene bridging group, and R5 is hydrogen or an unsubstituted acyclic aliphatic hydrocarbon group having a maximum of six carbon atoms, but with the provisos that (a) when n is 0 the combinations R1 = R2 = R3 = R4 = R5 = H and R1 = R2 = R3 = R5 = H, R4 = methyl are excluded, and (b) when n is 0, R1, R3 and R5 are each hydrogen, and each of R2 and R4 is other than hydrogen the compound is in other than the meso or erythro configuration, or a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of use in therapy, particularly as cardioprotective agents.