公开(公告)号：WO0168028A3

公开(公告)日：2002-12-27

申请号：PCT/CA0100321

申请日：2001-03-14

Applicant: ORTHOLOGIC CORP

Inventor： CULHANE JEFFREY J ,  SOLOMON ALEXANDER G ,  KRUGER PAUL ,  MILOSAVLJEVIC DRAGAN ,  COTTERELL DANIEL E C ,  MACPHAIL ANDREW J

IPC: A61H1/02

CPC classification number: A61H1/0277 ,  A61H2001/0203 ,  A61H2001/0207 ,  A61H2201/0173 ,  A61H2201/018

Abstract: A therapeutic mobilization device includes a flexion assembly, a pro/supination assembly and a valgus carrying angle compensation device. The flexion assembly has an arm attachment assembly and an elbow actuator and the elbow actuator defines and axes of rotation. The pro/supination assembly is attached to flexion assembly and has a distal forearm attachment assembly and a pro/supination actuator operably connected thereto. The valgus carrying angle compensation device is operably attached to the flexion assembly and the pro/supination assembly. Preferably the pro/supination assembly is slidably mounted on a housing shaft whereby during flexion the pro/supination assembly is free to move along the housing shaft. Further, preferably the arm attachment assembly includes an attachment ring and an adjustable clamp pivotally attached thereto whereby the attachment ring defines a pro/supination axis and the adjustable clamp pivots orthogonally to the pro/supination axis.

Abstract translation: 治疗动员装置包括屈曲组件，推进组件和外翻角度补偿装置。 弯曲组件具有臂附接组件和弯头致动器，并且弯头致动器限定旋转轴。 推进组件附接到屈曲组件并且具有远程前臂附接组件和可操作地连接到其上的推进/推进致动器。 外翻角度补偿装置可操作地附接到屈曲组件和推进组件。 优选地，推进组件可滑动地安装在壳体轴上，由此在弯曲期间，推进组件可自由地沿壳体轴移动。 此外，优选地，臂附接组件包括附接环和可枢转地附接到其上的可调节夹具，由此附接环限定了主轴/仰角轴线，并且可调节的夹具正转地与前/后轴线枢转。

公开(公告)号：WO2009142679A2

公开(公告)日：2009-11-26

申请号：PCT/US2009/001954

申请日：2009-03-26

Applicant: ORTHOLOGIC CORP. ,  STEER, Randolph, C. ,  SHELLER, Michael, R. ,  WAGSTAFF, John, D.

Inventor： STEER, Randolph, C. ,  SHELLER, Michael, R. ,  WAGSTAFF, John, D.

IPC: A61K38/48 ,  A61K38/10 ,  A61P9/10

CPC classification number: A61K38/4833

Abstract: The present invention includes methods of treating acute myocardial infarction in a subject, comprising administering to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist.

Abstract translation: 本发明包括在受试者中治疗急性心肌梗死的方法，其包括向受试者施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂。

公开(公告)号：WO2008036387A8

公开(公告)日：2008-06-26

申请号：PCT/US2007020445

申请日：2007-09-21

Applicant: ORTHOLOGIC CORP ,  TEXAS A & M UNIV SYS ,  CARNEY DARRELL H ,  OLSZEWSKA-PAZDRAK BARBARA ,  FOSSUM THERESA W

Inventor： CARNEY DARRELL H ,  OLSZEWSKA-PAZDRAK BARBARA ,  FOSSUM THERESA W

IPC: A61K38/36 ,  A61K39/395 ,  A61P3/10 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P15/10 ,  A61P19/02 ,  A61P29/00 ,  A61P39/00

CPC classification number: A61K38/10 ,  A61K38/16 ,  A61K38/18 ,  A61K38/4833 ,  C12N9/6429 ,  C12Y304/21005

Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.

Abstract translation: 内皮功能障碍（ED）与许多疾病和病症有关。 非蛋白水解活化的凝血酶受体的激动剂可用于治疗ED或ED相关疾病和病症的方法中。

公开(公告)号：WO2008036387A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/020445

申请日：2007-09-21

Applicant: ORTHOLOGIC CORP. ,  THE TEXAS A & M UNIVERSITY SYSTEM ,  CARNEY, Darrell, H. ,  OLSZEWSKA-PAZDRAK, Barbara ,  FOSSUM, Theresa, W.

Inventor： CARNEY, Darrell, H. ,  OLSZEWSKA-PAZDRAK, Barbara ,  FOSSUM, Theresa, W.

IPC: A61K38/36 ,  A61K39/395 ,  A61P9/12 ,  A61P9/10 ,  A61P9/04 ,  A61P3/10 ,  A61P15/10 ,  A61P11/06 ,  A61P19/02 ,  A61P13/12 ,  A61P39/00 ,  A61P29/00

CPC classification number: A61K38/10 ,  A61K38/16 ,  A61K38/18 ,  A61K38/4833 ,  C12N9/6429 ,  C12Y304/21005

Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.

Abstract translation: 内皮功能障碍（ED）与许多疾病和病症有关。 非蛋白水解活化的凝血酶受体的激动剂可用于治疗ED或ED相关疾病和病症的方法中。

公开(公告)号：WO2007035406A1

公开(公告)日：2007-03-29

申请号：PCT/US2006/035829

申请日：2006-09-14

Applicant: THE BOARD REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ORTHOLOGIC CORP. ,  FULLER, Gerald, M. ,  CARNEY, Darrell, H. ,  BERGMANN, John, S.

Inventor： FULLER, Gerald, M. ,  CARNEY, Darrell, H. ,  BERGMANN, John, S.

IPC: C07K16/36 ,  C12N5/10 ,  A61K39/395 ,  G01N33/53 ,  A61P35/00 ,  A61P19/00 ,  A61P7/00 ,  C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/75 ,  C12N9/6429 ,  C12Y304/21005

Abstract: Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subj ect in need of such treatment are disclosed.

Abstract translation: 公开了与具有由编码凝血酶或其部分的核苷酸序列的补体编码的氨基酸序列的互补肽结合的抗体和抗原结合片段。 这样的抗体和抗原结合片段可以是凝血酶受体介导事件的激动剂或拮抗剂。 还公开了使用本发明的激动剂抗体和抗原结合片段在需要这种治疗的受试者中激活非蛋白水解活化的凝血酶受体（NPAR）的方法。 此外，公开了使用本发明的拮抗剂抗体和抗原结合片段在需要这种治疗的病人中抑制NPAR活化的方法。

公开(公告)号：WO0168027A3

公开(公告)日：2002-08-08

申请号：PCT/CA0100320

申请日：2001-03-14

Applicant: ORTHOLOGIC CORP

Inventor： SOLOMON ALEXANDER G ,  CULHANE JEFFREY J ,  COTTERELL DANIEL E C

IPC: A61H1/02 ,  G01L1/22

CPC classification number: A61H1/0218 ,  A61H1/02 ,  A61H1/0277 ,  A61H2201/0173 ,  A61H2201/5007

Abstract: A control system is adapted for use in association with a therapeutic motion and splinting device. The therapeutic device has at least one component that is monitored. The system comprises the steps of defining the range of motion, defining the maximum reverse on load, monitoring the reverse on load and moving the device through its range of motion. A first and second maximum limit of range of motion in a first and second direction are respectively defined. A maximum reverse on load is defined and is monitored whereby the deformation of the at least one component is monitored and the load created is interpreted. The device is cycled between a first and second position defined by one of the first maximum limit and the maximum reverse on load and one of the second maximum limit and the maximum reverse on load respectively.

Abstract translation: 控制系统适于与治疗运动和夹板装置相关联使用。 治疗装置具有至少一个被监测的组件。 该系统包括以下步骤：定义运动范围，定义负载上的最大反向运动，监测负载上的反向运动以及通过其运动范围移动设备。 分别限定第一和第二方向上的运动范围的第一和第二最大限制。 定义最大反向负载并进行监控，从而监测至少一个部件的变形并解释产生的负载。 该装置在由第一最大极限和最大反向负载中的一个限定的第一和第二位置之间循环，并且分别是第二最大极限和最大反向负载之一。

公开(公告)号：TWI257307B

公开(公告)日：2006-07-01

申请号：TW090116938

申请日：2001-07-11

Applicant: 歐索羅巨克股份有限公司 ORTHOLOGIC CORP.

Inventor： 達瑞爾H. 卡爾西 CARNEY, DARRELL H.

IPC: A61K ,  A61F ,  A61P

CPC classification number: A61K9/1647 ,  A61K38/4833 ,  A61L27/227

Abstract: 本發明是有關於促進心臟組織修補之方法，包括將一治療有效量之血管生成的凝血衍生的胜，給藥至心臟組織，及/或有關於抑制或減少血管栓塞或再狹窄之方法。本發明也有關於刺激再血管化之方法。在另一具體實施例中，本發明也有關於使用凝血衍生的胜，以製造用於本發明所說明的方法之藥劑。

Abstract in simplified Chinese: 本发明是有关于促进心脏组织修补之方法，包括将一治疗有效量之血管生成的凝血衍生的胜，给药至心脏组织，及/或有关于抑制或减少血管栓塞或再狭窄之方法。本发明也有关于刺激再血管化之方法。在另一具体实施例中，本发明也有关于使用凝血衍生的胜，以制造用于本发明所说明的方法之药剂。

公开(公告)号：TW200829267A

公开(公告)日：2008-07-16

申请号：TW096135320

申请日：2007-09-21

Applicant: 歐索羅巨克股份有限公司 ORTHOLOGIC CORP. ,  德州農工大學體系 THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： 戴瑞爾H 卡尼 CARNEY, DARRELL H. ,  芭芭拉 歐爾茲柴斯卡 帕茲德拉克 OLSZEWSKA-PAZDRAK, BARBARA ,  泰瑞莎W 芙桑 FOSSUM, THERESA W.

IPC: A61K ,  C07K ,  C12N

CPC classification number: A61K38/10 ,  A61K38/16 ,  A61K38/18 ,  A61K38/4833 ,  C12N9/6429 ,  C12Y304/21005

Abstract: 內皮功能不良(Endothe1ia dysfunction,ED)與許多疾病以及病症有關。非-蛋白水解活化性凝血受體之激動劑可用於治療ED或ED-相關的疾病以及病症之方法。

Abstract in simplified Chinese: 内皮功能不良(Endothe1ia dysfunction,ED)与许多疾病以及病症有关。非-蛋白水解活化性凝血受体之激动剂可用于治疗ED或ED-相关的疾病以及病症之方法。

公开(公告)号：EP0843573B1

公开(公告)日：2003-12-10

申请号：EP95937426.5

申请日：1995-10-04

Applicant: ORTHOLOGIC CORP.

Inventor： KAUFMAN, Jonathan, J. ,  CHIABRERA, Allessandro, E.

IPC: A61N1/00 ,  A61N7/00

CPC classification number: A61N7/00 ,  A61B2017/0015 ,  A61B2017/00172 ,  A61F2002/2864

公开(公告)号：EP1265578A2

公开(公告)日：2002-12-18

申请号：EP01913449.3

申请日：2001-03-14

Applicant: Orthologic Corp.

Inventor： SOLOMON, Alexander, G. ,  CULHANE, Jeffrey, J. ,  COTTERELL, Daniel, E., C.

IPC: A61H1/02

CPC classification number: A61H1/0218 ,  A61H1/02 ,  A61H1/0277 ,  A61H2201/0173 ,  A61H2201/5007

Abstract: A control system is adapted for use in association with a therapeutic motion and splinting device. The therapeutic device has at least one component that is monitored. The system comprises the steps of defining the range of motion, defining the maximum reverse on load, monitoring the reverse on load and moving the device through its range of motion. A first and second maximum limit of range of motion in a first and second direction are respectively defined. A maximum reverse on load is defined and is monitored whereby the deformation of the at least one component is monitored and the load created is interpreted. The device is cycled between a first and second position defined by one of the first maximum limit and the maximum reverse on load and one of the second maximum limit and the maximum reverse on load respectively.