公开(公告)号：US10202459B2

公开(公告)日：2019-02-12

申请号：US15363103

申请日：2016-11-29

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY OF ULSAN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PHAROSGEN

Inventor： Youngro Byun ,  In San Kim ,  Ahmed Al-Hilal Taslim ,  Sang-Yoon Kim ,  Ye Ji Jang

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K31/727 ,  G01N33/574 ,  G01N33/68 ,  C07K14/705 ,  C12N15/113 ,  A61K47/54

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：US20170260278A1

公开(公告)日：2017-09-14

申请号：US15450272

申请日：2017-03-06

Applicant: SEOUL NATIONAL UNIVERSITY ,  UNIVERSITY OF ULSAN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PHAROSGEN

Inventor： Youngro Byun ,  In San Kim ,  Ahmed Al-Hilal Taslim ,  Sang-Yoon Kim ,  Ye Ji Jang

IPC: C07K16/28

CPC classification number: C07K16/2872 ,  A01K2217/075 ,  A01K2227/105 ,  A61K47/55 ,  A61K47/554 ,  A61K47/61 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/30 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3515 ,  C12Q1/68 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

公开(公告)号：EP3049399A2

公开(公告)日：2016-08-03

申请号：EP15839131.8

申请日：2015-07-10

Applicant: Pharosgen

Inventor： KIM, Sang Yoon ,  BYUN, Young Ro ,  CHUNG, Seung Woo

IPC: C07D309/10 ,  A61K47/48 ,  A61K31/4015 ,  A61K38/08 ,  A61K31/7042 ,  A61P35/00

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.

Abstract translation: 描述了在通过胱天蛋白酶激活时释放化学治疗剂的前药缀合物，以及使用这种前药缀合物诱导凋亡，扩增凋亡和治疗癌症的方法。

公开(公告)号：EP3049399A4

公开(公告)日：2017-10-25

申请号：EP15839131

申请日：2015-07-10

Applicant: PHAROSGEN

Inventor： KIM SANG YOON ,  BYUN YOUNG RO ,  CHUNG SEUNG WOO

IPC: C07D309/10 ,  A61B18/02 ,  A61K31/337 ,  A61K31/4015 ,  A61K31/65 ,  A61K31/7042 ,  A61K38/08 ,  A61K38/14 ,  A61K45/06 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  A61K47/65 ,  A61N7/02 ,  A61P35/00

CPC classification number: A61K47/551 ,  A61B18/02 ,  A61K31/337 ,  A61K31/65 ,  A61K38/14 ,  A61K45/06 ,  A61K47/48338 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  A61K47/61 ,  A61K47/643 ,  A61K47/65 ,  A61N1/403 ,  A61N5/062 ,  A61N7/02 ,  A61N2005/067 ,  A61N2007/0004

Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.