APPARATUS AND METHODS FOR DETECTING GENE MUTATION

    公开(公告)号:WO2022224021A1

    公开(公告)日:2022-10-27

    申请号:PCT/IB2021/053355

    申请日:2021-04-23

    Abstract: Methods and apparatuses are disclosed for detecting a presence of a mismatched pair in an oligonucleotide duplex that is attached to a solid substrate using an atomic force microscope. In particular, methods and apparatuses of the invention allow qualitative and quantitative analysis of the presence of a mismatched pair in a sample of oligonucleotide duplex using an atomic force microscope comprising an AFM cantilever that includes a DNA mismatch repair protein. Methods and apparatuses of the invention allow detection of gene mutation without a need for amplification, labeling, or modification of the sample. Such apparatuses and methods can be used in a wide variety of clinical diagnostic applications including detection and/or analysis of biomarkers related to, but not limited to, cancer, trauma, sepsis, aseptic inflammation, myocardial infarction, stroke, transplantation, diabetes, sickle cell disease, as well as other clinical conditions.

    APPARATUS AND METHOD FOR ESTIMATING DIRECTION IN WIRELESS COMMUNICATION SYSTEM

    公开(公告)号:WO2020138972A1

    公开(公告)日:2020-07-02

    申请号:PCT/KR2019/018515

    申请日:2019-12-26

    Abstract: A communication system is provided. The communication system supports higher data rates Beyond 4 th -Generation (4G) communication system such as Long Term Evolution (LTE). A first apparatus in a wireless communication system is provided. The apparatus includes an antenna array, at least one transceiver, and at least one processor. The transceiver is configured to transmit signals by using a beam set, and receive a signal for indicating at least one beam in the beam set from a second apparatus. The processor is configured to determine an auxiliary beam pair, based on the at least one beam. The transceiver is configured to transmit reference signals to the second apparatus by using the auxiliary beam pair, and receive feedback information relating to the auxiliary beam pair from the second apparatus. The at least one processor is configured to determine, based on the feedback information, a communication direction relating to the second apparatus.

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