公开(公告)号：WO1993016378A1

公开(公告)日：1993-08-19

申请号：PCT/DK1993000039

申请日：1993-02-04

Applicant: RADIOMETER A/S ,  JAGNER, Lars-Eric, Daniel ,  BITSCH, Nils, Langergaard

Inventor： RADIOMETER A/S

IPC: G01N27/403

CPC classification number: G01N27/42

Abstract: The present method is a method of electrochemical stripping analysis comprising an electrolysis step and a stripping step. In the method is used an electrode device comprising an electrode body carrying a working electrode, a reference electrode, and a counter electrode. The electrode device comprises a measuring area located at an outer surface of the device, into which area the working electrode opens and wherein at least one contact point for the reference electrode and the counter electrode is located. The electrode device is adapted for dipping into a sample solution contained in a sample container. The measuring area of the electrode device has a surface character appropriate for retaining an aqueous sample residue at said surface after removal of the electrode device from the sample solution. Said residue is of sufficient size to maintain electric contact between the working electrode and the contact point for the reference electrode and the counter electrode and is preferably of sufficient size to completely cover the working electrode. Thus, during displacement from one solution to another, the working electrode is protected from damage caused by an uncontrolled electrode potential, from drying out, and from formation of contaminations. By means of the present method it is possible to perform the electrolysis step of the analysis in the sample and perform the stripping step in another more appropriate solution.

Abstract translation: 本方法是一种电化学汽提分析方法，包括电解步骤和汽提步骤。 在该方法中，使用包括承载工作电极，参考电极和对电极的电极体的电极装置。 所述电极装置包括位于所述装置的外表面的测量区域，所述工作电极打开所述区域，并且其中位于所述参考电极和所述对电极的至少一个接触点。 电极装置适于浸入容纳在样品容器中的样品溶液中。 电极装置的测量面积具有适合于在从样品溶液中除去电极装置之后在所述表面保留含水样品残留物的表面特性。 所述残留物具有足够的尺寸以保持工作电极与参比电极和对电极的接触点之间的电接触，并且优选具有足够的尺寸以完全覆盖工作电极。 因此，在从一种溶液移位到另一种溶液的过程中，保护工作电极免受由不受控制的电极电位引起的损坏，从干燥出来以及形成污染物。 通过本方法，可以在样品中进行分析的电解步骤，并在另一个更合适的溶液中进行汽提步骤。

公开(公告)号：WO1992004438A1

公开(公告)日：1992-03-19

申请号：PCT/DK1991000248

申请日：1991-08-27

Applicant: RADIOMETER A/S ,  EISENHARDT, Anne, Rosengaard ,  CHRISTENSEN, Anne-Marie

Inventor： RADIOMETER A/S

IPC: C12M01/40

CPC classification number: C12Q1/001

Abstract: The biosensor comprises a working electrode, a reference electrode, and a membrane comprising a substrate-limiting layer and an enzyme layer. At the substrate-limiting layer is provided a protection layer having hydrophilic properties corresponding to the properties of regenerated cellulose or being more hydrophilic than regenerated cellulose. Particularly, the substrate-limiting layer is constituted by a polyurethane layer and the protection layer is constituted by a cellophane layer.

Abstract translation: 生物传感器包括工作电极，参比电极和包含底物限制层和酶层的膜。 在基底限制层上提供了具有与再生纤维素的性质相对应的亲水性或比再生纤维素更亲水的保护层。 特别地，基板限制层由聚氨酯层构成，保护层由玻璃纸层构成。

公开(公告)号：WO1991000520A1

公开(公告)日：1991-01-10

申请号：PCT/DK1990000147

申请日：1990-06-13

Applicant: RADIOMETER A/S ,  ANDERSEN, Joergen ,  HVIDTFELDT, Kristian, Jacob ,  SINNERUP, Ib, Olaf

Inventor： RADIOMETER A/S

IPC: G01N35/00

CPC classification number: G01N35/1002 ,  G01N35/1079 ,  G01N2035/1006

Abstract: New apparatus for measuring parameters such as pH, pCO2, pO2, and Hb content of physiological fluids, especially blood, is described. The apparatus comprises novel means for suspending reagent vessels (34, 35, 40, 45, 50) having shoulders (51, 52) and containing calibrating solutions, rinsing solutions etc., as well as for suspending a liquid waste vessel (26) by suspending the vessels between rods (53, 54) fed to the analyser. The reagent vessels are provided with caps (55, 58) at the top and include liquid reagent conduit extending from the outlet aperture of the cap down into the liquid. When the vessel is mounted on the anaylser a fixed inlet tube extending horizontally outwardly from the analyser penetrates a seal across the outlet aperture and connects with the liquid reagent conduit.

Abstract translation: 描述了用于测量诸如生理液体，特别是血液的pH，pCO 2，pO 2和H b含量的参数的新装置。 该装置包括用于悬挂具有肩部（51,52）并包含校准溶液，漂洗溶液等的试剂容器（34,35,40,45,50）的新颖装置，以及用于将液体废物容器（26）悬浮在 将容器悬挂在馈送到分析器的杆（53,54）之间。 试剂容器在顶部设置有帽（55,58），并且包括从帽的出口孔向下延伸到液体中的液体试剂导管。 当容器安装在分析器上时，从分析仪水平向外延伸的固定入口管穿过出口孔并穿过液体试剂导管连接。

公开(公告)号：WO1989004967A1

公开(公告)日：1989-06-01

申请号：PCT/DK1988000191

申请日：1988-11-24

Applicant: RADIOMETER A/S ,  PETERSSON, Bo, Arne

Inventor： RADIOMETER A/S

IPC: G01N35/08

CPC classification number: C12Q1/006 ,  C12Q1/005 ,  C12Q1/58

Abstract: A method and an apparatus for chemical analysis of samples of varying matrices is disclosed. The samples are transported in series by a carrier fluid. At a test location is provided a fluid elemement the chemical composition of which is maintained essentially constant in consequence of the exposure of the fluid element to the carrier fluid prior to and subsequent to the exposure of the fluid element to each individual sample.

Abstract translation: 公开了用于变化矩阵样本的化学分析的方法和装置。 样品通过载体流体串联输送。 在测试位置处提供了流体元件，其流体元件的化学成分在流体元件暴露于每个单个样品之前和之后由于将流体元件暴露于载体流体而基本上保持不变。

公开(公告)号：WO1988001376A1

公开(公告)日：1988-02-25

申请号：PCT/GB1987000573

申请日：1987-08-14

Applicant: RADIOMETER A/S ,  BUCKLEY, Brendan, M.

Inventor： RADIOMETER A/S

IPC: G01N21/55

CPC classification number: G01N21/552

Abstract: A method for determining the level of an analyte in a sample of whole blood uses the technique of internal reflection spectroscopy and an apparatus suitable for the technique. The method is of particular use to detect the attenuation of the totally reflected light by absorption of the evanescent wave, e.g., by haemoglobins. In the apparatus (1) incident light is directed via a light guide (7) to the reflection element (3) and the attenuated totally reflected light is directed out of the element to a photodetector (12) by a light guide (11). In the whole blood in the cuvette (18) the cells are removed from the interface (8) by gravity to leave blood cell free plasma (4) adjacent the interface (8). Thus analytes present in the plasma can be detected. The extent of haemolysis can be estimated.

Abstract translation: 用于确定全血样品中分析物水平的方法使用内反射光谱技术和适合该技术的装置。 该方法特别用于通过例如通过血红蛋白的ev逝波的吸收来检测全反射光的衰减。 在装置（1）中，入射光通过导光体（7）被引导到反射元件（3），衰减的全反射光通过光导（11）被引导到光电检测器（12）。 在比色皿（18）中的全血中，细胞通过重力从界面（8）中移除，以在界面（8）附近留下不含血液的等离子体（4）。 因此可以检测出存在于血浆中的分析物。 可以估计溶血的程度。

公开(公告)号：WO1987003093A1

公开(公告)日：1987-05-21

申请号：PCT/DK1986000126

申请日：1986-11-17

Applicant: RADIOMETER A/S ,  WEBER, Anders

Inventor： RADIOMETER A/S

IPC: G01N33/53

CPC classification number: G01N21/7703 ,  G01N33/5438

Abstract: Sensor (1) for determining the concentration of a biochemical species. The sensor (1) works according to a competitive principle and the response-giving active part (2) of the sensor comprises the two partners in an affinity pair immobilized on two parts of substrate. One of these partners consists of the biochemical species or a competitor hereto.

Abstract translation: 用于确定生物化学物质浓度的传感器（1）。 传感器（1）根据竞争原理工作，并且传感器的响应给定活动部分（2）包括固定在两个基片上的亲和力对中的两个对象。 其中一个合作伙伴包括生化物种或其竞争对手。

公开(公告)号：WO1984004815A1

公开(公告)日：1984-12-06

申请号：PCT/DK1984000048

申请日：1984-05-24

Applicant: RADIOMETER A/S ,  KLITGAARD, Peter, Christian ,  PEDERSEN, Knud, Gronlund

Inventor： RADIOMETER A/S

IPC: G01N27/46

CPC classification number: A61B5/1477 ,  A61B5/04004 ,  A61B5/0448 ,  A61B5/14542 ,  A61B5/4362 ,  A61B2562/0215 ,  A61B2562/0217

Abstract: An electrode assembly for transcutaneously measuring a blood gas parameter and for measuring a bioelectrical signal comprises two separate electrode devices (10, 40), one of which (10) further comprises an electrochemical measuring electrode system. The electrochemical measuring electrode system comprises a reference electrode of a potentiometric electrode system and an anode of a polarographic electrode system constituted by a single metallic body (13), a pH-electrode (31, 32) of the potentiometric electrode system, and a noble metal cathode (33, 34) of the polarographic electrode system. The bioelectrical signal sensing electrode of the electrode device (10) is further constituted by the metallic body (13). A first part of the metallic body (13) is covered by an electrolyte solution (28) which communicates electrolytically therewith and further the pH-glass electrode and the noble metal cathode, and a second part of which is not covered by the electrolyte solution but adapted to electrically conductively communicate with a skin surface part of a test person or a patient through an electrically conductive contact liquid (19). The membrane separates the first and the second part of the metallic body from one another. The second electrode (40) comprises a bioelectrical signal sensing electrode (41), which is adapted to electrically conductively communicate with a skin surface part of a test person or patient through an electrically conductive contact liquid (20). By means of the electrode assembly coincident measuring results of the blood gas partial pressures of oxygen and carbon dioxide and of a bioelectrical signal such as the ECG (electrocardiography), the RR (Respiration rate) or the heart rate of the test person or patient is obtainable.

公开(公告)号：WO1983003304A1

公开(公告)日：1983-09-29

申请号：PCT/DK1983000035

申请日：1983-03-15

Applicant: RADIOMETER A/S ,  FOG, Agner ,  ATLUNG, Sven, Helge, Knud

Inventor： RADIOMETER A/S

IPC: G01N27/30

CPC classification number: G01N27/36

Abstract: An ion selective electrode device, in particular a pH-sensitive electrode device, employing an intercalation electrode (3) as contact material between an ion selective element (2) and an electrical connection (9). An intercalation electrode comprising an equilibrium mixture of two phases, at least one of the phases working as an intercalation electrode, is disclosed. The electrode device may be constructed as a solid state electrode device showing advantageous electrode properties.

Abstract translation: 离子选择性电极装置，特别是pH敏感电极装置，其使用插层电极（3）作为离子选择元件（2）和电连接（9）之间的接触材料。 公开了一种嵌入电极，其包括两相的平衡混合物，至少一个相作为插层电极工作。 电极装置可以构成为显示有利的电极特性的固态电极装置。

公开(公告)号：WO1983001510A1

公开(公告)日：1983-04-28

申请号：PCT/DK1982000093

申请日：1982-10-12

Applicant: RADIOMETER A/S ,  BAUMBACH, Per, Lennart ,  POULSEN, Jorgen

Inventor： RADIOMETER A/S

IPC: G01N27/46

CPC classification number: G01K1/16 ,  A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01K1/165 ,  G01K1/20

Abstract: Selon les principes de mesure transcutanée d'un paramètre du sang, tel que la pression partielle d'un gaz sanguin, un dispositif à électrode de mesure électrochimique (1) est appliqué sur la surface (2) de la peau d'une personne. Le dispositif à électrode comprend un corps (10), p.ex. un substrat à film épais, thermo-régulé à une température prédéterminée à l'aide d'un thermostat et, de plus, il comprend un moyen détecteur (11) associé à une membrane (14) retenant une solution d'un électrolyte dans un réservoir d'électrolyte (15). De plus, le dispositif à électrode possède une chemise comprenant un corps métallique annulaire (16), un corps métallique (4) et un substrat à film épais (8) qui est thermo-régulé à l'aide d'un thermostat à la même température que celle du corps (10) du dispositif à électrode. Lorsque le corps est amené en contact de la surface de la peau, une partie de la surface annulaire de la chemise est également amenée en contact de la surface de la peau de sorte qu'une chemise de chauffage virtuelle est établie dans la peau sous la partie de surface annulaire de manière à diriger sensiblement tout le flux de chaleur depuis le corps vers les tissus se trouvant directement sous la surface de la peau. En mesurant l'énergie électrique fournie pour thermo-réguler le corps à la température prédéterminée à l'aide du thermostat, l'écoulement de sang capillaire local dans les tissus (2) sous la peau est mesuré, et le paramètre du sang en question est mesuré à l'aide des moyens détecteurs (11). Dans un mode alternatif de fonctionnement, le dispositif à électrode est adapté pour mesurer des températures du corps en profondeur en thermo-régulant la chemise à l'aide d'un thermostat à une température telle que la température enregistrée par un détecteur de température du corps et la température enregistrée par un détecteur de température de la chemise soient identiques et, par conséquent, soient identiques à la température en profondeur du corps.

公开(公告)号：WO1994002065A1

公开(公告)日：1994-02-03

申请号：PCT/DK1993000237

申请日：1993-07-12

Applicant: RADIOMETER A/S

Inventor： RADIOMETER A/S ,  PEDERSEN, Knud, Gronlund

IPC: A61B05/00

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491

Abstract: The sensor (1) comprises a sensor body (3) thermostatable by means of a first thermostating system (14, 15) and having an outer surface (3a, 40a) for application to the human body (28) in heat conductive relationship therewith, said outer surface (3a, 40a) forming the measuring surface of the sensor (1). The sensor (1) further comprises analyte sensing means (7, 8) arranged in said sensor body (3) and being thermostated through said body (3) by means of the first thermostating system (14, 15). The sensor (1) further comprises means (16, 41) arranged in the sensor body (3) in heat insulated relationship therewith while in heat conductive relationship with a delimited surface part of the sensor measuring surface (3a, 40a). The means (16, 41) is thermostatable by means of a second thermostating system. The delimited surface part is located within the outer periphery of the sensor measuring surface (3a, 40a). When using the sensor (1) the heat flux (34) from the measuring surface surrounding said delimited surface part provides a heat shield in the tissue, said heat shield surrounding the heat flux (35) from the delimited surface part. Thus, the heat flux (35) from the delimited surface part will be guided substantially unidirectionally to the tissue (28) located directly beneath the delimited surface part and absorbed therein.

Abstract translation: 传感器（1）包括通过第一恒温系统（14,15）可热控制的传感器主体（3），并且具有用于与人体（28）导热关系的外表面（3a，40a） 所述外表面（3a，40a）形成所述传感器（1）的测量表面。 所述传感器（1）还包括布置在所述传感器主体（3）中并通过所述主体（3）通过所述第一恒温系统（14,15）恒温的分析物感测装置（7,8）。 传感器（1）还包括与热传导关系的传感器本体（3）中布置的与传感器测量表面（3a，40a）的限定表面部分的导热关系的装置（16,41）。 装置（16,41）通过第二恒温系统是可热的。 限定的表面部分位于传感器测量表面（3a，40a）的外周边内。 当使用传感器（1）时，来自围绕所述限定表面部分的测量表面的热通量（34）在组织中提供热屏蔽，所述热屏蔽围绕来自限定的表面部分的热通量（35）。 因此，来自限定的表面部分的热通量（35）将被基本上单向地引导到位于界定的表面部分正下方并被吸收的组织（28）。