公开(公告)号：JP2012143615A

公开(公告)日：2012-08-02

申请号：JP2012094831

申请日：2012-04-18

Applicant: Research Triangle Inst ,  リサーチ・トライアングル・インスティチュート

Inventor： DAUSCH DAVID ,  VON RAMM OLAF ,  CASTELLUCCI JOHN

IPC: A61B8/12 ,  H04R17/00

Abstract: PROBLEM TO BE SOLVED: To provide methods of generating enhanced flexure mode signals by piezoelectric transducers and ultrasound image diagnostic probes using the same.SOLUTION: A method of generating an enhanced receive signal from a piezoelectric ultrasound transducer is described. The method comprises providing a piezoelectric ultrasound transducer comprising a piezoelectric element operable in flexural mode, receiving an acoustic signal by the piezoelectric element, applying a DC bias to the piezoelectric element prior to receiving the acoustic signal and/or concurrently with receiving the acoustic signal, and generating an enhanced receive signal from the piezoelectric element as a result of receiving the acoustic signal by the piezoelectric element. pMUT-based image diagnostic probes using the above method are also described.

Abstract translation: 要解决的问题：提供通过压电换能器产生增强的弯曲模式信号的方法和使用其的超声图像诊断探针。

解决方案：描述了从压电超声换能器产生增强的接收信号的方法。 该方法包括提供一种压电超声换能器，其包括可弯曲模式操作的压电元件，通过压电元件接收声信号，在接收声信号之前和/或与接收声信号同时向压电元件施加DC偏压， 以及作为由压电元件接收声信号的结果，从压电元件产生增强的接收信号。 还描述了使用上述方法的基于pMUT的图像诊断探针。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2010202671A

公开(公告)日：2010-09-16

申请号：JP2010141878

申请日：2010-06-22

Applicant: Research Triangle Inst ,  リサーチ・トライアングル・インスティチュート

Inventor： COOK CLARENCE EDGAR ,  SLOAN CAROL DELTA ,  THOMAS BRIAN FRAZIER ,  NAVARRO HERNAN A

IPC: A61K31/435 ,  A61K31/473 ,  A61P15/16 ,  A61P31/02 ,  A61P31/04 ,  C07D221/16

CPC classification number: A61K31/435 ,  A61K31/473 ,  Y02P20/582

Abstract: PROBLEM TO BE SOLVED: To provide an oral male contraceptive, in addition, a more effective spermicidal composition required to use in traditional local/external customary birth control. SOLUTION: There are provided: a hexahydroindenopyridine compound that acts as a spermicide and/or a fungicide; a spermicidal and/or fungicidal composition containing the compound; and a method of killing motile sperms or fungi using the compound and the composition. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供口服男性避孕药，另外还需要在传统的本地/外部习惯性避孕中使用更有效的杀精组合物。 解决方案：提供：作为杀精剂和/或杀真菌剂起作用的六氢茚基吡啶化合物; 含有该化合物的杀精和/或杀真菌组合物; 以及使用该化合物和组合物杀死活动精子或真菌的方法。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010120972A

公开(公告)日：2010-06-03

申请号：JP2010040245

申请日：2010-02-25

Applicant: Research Triangle Inst ,  リサーチ・トライアングル・インスティチュート

Inventor： COOK C EDGAR ,  KEPLER JOHN A ,  ZHANG PING-SHENG ,  LEE YUE-WEI ,  TALLENT C RAY

IPC: C07J21/00 ,  A61K31/58 ,  A61K31/585 ,  A61P5/34 ,  A61P5/36 ,  A61P5/38 ,  A61P15/00 ,  A61P15/08 ,  C07J33/00 ,  C07J43/00

CPC classification number: C07J41/0083 ,  A61K31/58 ,  C07J43/006 ,  Y10S514/841 ,  Y10S514/843

Abstract: PROBLEM TO BE SOLVED: To solve a problem that the necessity of an anti-progestin compound exhibiting higher specificity is left. SOLUTION: An cyclic amine-substituted compound such as N-piperidinyl, especially useful when the 4-position of a 11β-aryl portion is substituted, is provided, because we have found that it has the reduced possibility of toxicity, not only holds the total molecular characteristics of dimethylamino analogues, but also exhibits to strongly bind to progestin receptors, and has a latent progesterone or anti-progesterone activity. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：为了解决留下显示更高特异性的抗孕激素化合物的必要性的问题。 解决方案：提供了环状胺取代的化合物如N-哌啶基，当11β-芳基部分的4-位被取代时特别有用，因为我们发现它具有降低的毒性的可能性，而不是 仅保持二甲基氨基类似物的总分子特征，而且还具有强烈结合孕激素受体的表现，并且具有潜在的孕酮或抗孕酮活性。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2009102364A

公开(公告)日：2009-05-14

申请号：JP2008327662

申请日：2008-12-24

Applicant: Research Triangle Inst ,  リサーチ トライアングル インスティテュート

Inventor： KUHAR MICHAEL J ,  CARROLL FRANK I ,  BOJA JOHN W ,  LEWIN ANITA H ,  ABRAHAM PHILIP

IPC: C07D487/08 ,  A61K31/437 ,  A61K31/46 ,  A61P3/00 ,  A61P25/00 ,  A61P25/24 ,  A61P25/30 ,  A61P25/36 ,  A61P43/00 ,  C07D451/02 ,  C07F7/22

CPC classification number: C07D451/02 ,  C07F7/2212

Abstract: PROBLEM TO BE SOLVED: To provide a novel compound which binds to a cocaine receptor. SOLUTION: The novel compound exhibits a high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compound can be used as an imaging or pharmaceutical agent in the diagnosis and treatment of drug addiction, depression. anorexia, and neurodegenerative diseases. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供结合可卡因受体的新型化合物。 解决方案：新化合物对脑中的可卡因受体表现出高亲和力，特别是多巴胺和血清素转运蛋白位点。 该化合物可用作成像或药剂在药物成瘾，抑郁症的诊断和治疗中。 厌食症和神经退行性疾病。 版权所有（C）2009，JPO＆INPIT