公开(公告)号：WO2006091720A3

公开(公告)日：2006-08-31

申请号：PCT/US2006/006387

申请日：2006-02-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ALKAN, Sefik ,  KIEPER, William C. ,  VASILAKOS, John P. ,  BONK, Jason D. ,  GRIESGRABER, George W. ,  LIPSON, Kenneth E. ,  LIU, Jie J. ,  MENDOZA, James D. ,  STOERMER, Doris ,  WIGHTMAN, Paul D. ,  JING, Naiyong ,  SCHULTZ, William J.

Inventor： ALKAN, Sefik ,  KIEPER, William C. ,  VASILAKOS, John P. ,  BONK, Jason D. ,  GRIESGRABER, George W. ,  LIPSON, Kenneth E. ,  LIU, Jie J. ,  MENDOZA, James D. ,  STOERMER, Doris ,  WIGHTMAN, Paul D. ,  JING, Naiyong ,  SCHULTZ, William J.

IPC: A61K31/4745 ,  A61K31/4748 ,  A61K31/437 ,  A61K31/4738

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

公开(公告)号：WO2006028545A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/021445

申请日：2005-06-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

Inventor： STOERMER, Doris ,  DELLARIA, Joseph, F., Jr. ,  AMOS, David, T. ,  ZIMMERMANN, Bernhard, M. ,  DRESSEL, Luke, T. ,  BONK, Jason, D. ,  RADMER, Matthew, R.

IPC: A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，[1,5]萘啶，[1,5]四氢萘啶），含有化合物 公开了制备这些化合物的方法，以及这些化合物作为免疫调节剂的用途，用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。