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公开(公告)号：US06575742B2
公开(公告)日：2003-06-10
申请号：US10092146
申请日：2002-03-06
Applicant: Hee Moon Kyung , Hyo Sang Park , Sung Min Bae
Inventor： Hee Moon Kyung , Hyo Sang Park , Sung Min Bae
IPC: A61C300
CPC classification number: A61C8/00 , A61C8/0096
Abstract: An osteogenic support device for an orthodontic treatment comprises a platform, lower and upper projections extending downwardly and upwardly from the platform. The upper projection is substantially tapered from the platform toward a cap. The upper protection has a through opening substantially perpendicular to an axis of the lower projection. A first end of the elastic wire is hooked between the cap and the platform, and a second end of the elastic wire is hooked with an orthodontic wire which links each bracket attached on teeth of the orthodontic patient.
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12.发明申请Protein Complex Using An Immunoglobulin Fragment and Method For The Preparation Thereof 审中-公开使用免疫球蛋白片段的蛋白质复合物及其制备方法公开(公告)号：US20100255014A1
公开(公告)日：2010-10-07
申请号：US12757635
申请日：2010-04-09
Applicant: Young Min KIM , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
Inventor： Young Min KIM , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
CPC classification number: A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
Abstract: Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
Abstract translation: 公开了具有改善的体内持续时间和稳定性的蛋白质缀合物及其用途。 蛋白质缀合物包括生理活性多肽，非肽聚合物和免疫球蛋白Fc片段。 由于三种成分共价连接，因此蛋白质缀合物延长了生理活性多肽的体内持续时间和增强的稳定性。 蛋白质缀合物以较高的水平保持体内活性，并显着增加生理活性多肽的血清半衰期，具有诱导不良免疫反应的风险较小。 因此，蛋白质缀合物可用于开发各种多肽药物的长效制剂。
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13.发明申请INSULINOTROPIC PEPTIDE DERIVATIVE WHEREIN ITS N-TERMINAL AMINO ACID IS MODIFIED 有权胰岛素衍生物其N-末端氨基酸被修饰公开(公告)号：US20100204451A1
公开(公告)日：2010-08-12
申请号：US12669372
申请日：2008-07-16
Applicant: Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
Inventor： Sung Youb Jung , Chang Ki Lim , Dae Hae Song , Sung Min Bae , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee
IPC: C07K14/00
CPC classification number: C07K14/46 , A61K38/26 , C07K14/57563 , C07K14/605
Abstract: The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising the same. The insulinotropic peptide derivatives according to the present invention exhibit therapeutic effects, which are not observed in native and other insulinotropic peptide analogs. Therefore, the insulinotropic peptide derivatives and the pharmaceutical composition comprising the same according to the present invention can be effectively provided for the treatment of the diseases.
Abstract translation: 本发明涉及具有高活性的N-末端氨基酸修饰的促胰岛素肽以及包含其的药物组合物。 根据本发明的促胰岛素肽衍生物显示出在天然和其他促胰岛素肽类似物中未观察到的治疗效果。 因此，可以有效地提供促胰岛素肽衍生物和包含其的本发明的药物组合物用于治疗疾病。
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14.发明申请Physiologically Active Polypeptide Conjugate Having Prolonged In Vivo Half-Life 有权延长体内半衰期的生理活性多肽缀合物公开(公告)号：US20100105869A1
公开(公告)日：2010-04-29
申请号：US12603757
申请日：2009-10-22
Applicant: Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
Inventor： Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
IPC: C07K16/00 , C07K14/555
CPC classification number: C07K16/00 , A61K47/60 , A61K47/643 , A61K47/6811 , A61K47/6883
Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
Abstract translation: 具有延长的生理活性的体内半衰期的蛋白质缀合物，其包含i）生理活性多肽，ii）非肽聚合物和iii）免疫球蛋白，可用于开发多肽药物，因为 增强血液中的体内稳定性和延长的半衰期，同时降低诱导免疫反应的可能性。
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公开(公告)号：US20090238838A1
公开(公告)日：2009-09-24
申请号：US11947697
申请日：2007-11-29
Applicant: Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
Inventor： Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
CPC classification number: C07K19/00 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K2319/30
Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
Abstract translation: 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和载体物质及其用途。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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Patent Agency Ranking
公开(公告)号：US09867777B2
公开(公告)日：2018-01-16
申请号：US13574039
申请日：2011-01-18
Applicant: Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
Inventor： Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
CPC classification number: A61K9/0019 , A61K38/193 , A61K47/12 , A61K47/26 , A61K47/6813 , A61K47/6835 , C07K14/535
Abstract: Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.
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公开(公告)号：US20140195443A1
公开(公告)日：2014-07-10
申请号：US14116060
申请日：2011-12-30
Applicant: Nak Kyu Lee , Hye Jin Lee , Jung Han Song , Jeanho Park , Sung Min Bae , Hyoung Wook Lee , Chul Young Kim
Inventor： Nak Kyu Lee , Hye Jin Lee , Jung Han Song , Jeanho Park , Sung Min Bae , Hyoung Wook Lee , Chul Young Kim
CPC classification number: G06Q50/184 , G06Q10/00 , G06Q10/06 , G06Q50/10
Abstract: The present invention relates to a system for servicing convergence index, and more particularly, to a system for servicing a convergence index for outputting a convergence index by utilizing patent information and servicing same. According to the system for servicing the convergence index of the present invention, the convergence index can be outputted by using time information related to a patent which is included in a patent group, a patent classification, and an industrial classification that corresponds to the patent classification. The system for servicing the convergence index of the present invention systematically outputs the convergence index by using patent data, which is an objective data, thereby outputting the convergence index which is objective and appropriate.
Abstract translation: 技术领域本发明涉及一种用于服务收敛指数的系统，更具体地，涉及一种通过利用专利信息并对其进行维护来输出收敛指数的收敛指标的系统。 根据本发明的收敛指标的维修系统，可以通过使用与专利组相关的专利的时间信息，专利分类和对应于专利分类的工业分类，输出收敛指数 。 用于维护本发明的收敛指标的系统通过使用作为客观数据的专利数据系统地输出收敛指数，从而输出客观和适当的收敛指数。
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公开(公告)号：US20130028918A1
公开(公告)日：2013-01-31
申请号：US13638786
申请日：2011-04-04
Applicant: Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
Inventor： Dae Hae Song , Jae Hee Shin , Young Jin Park , Dae Seong Im , Sung Min Bae , Se Chang Kwon
IPC: A61K39/395 , A61P3/10 , C07K16/00
CPC classification number: A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
Abstract: The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
Abstract translation: 本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。 本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。
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19.发明申请IMMUNOGLOBULIN FC FRAGMENT MODIFIED BY NON-PEPTIDE POLYMER AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权非肽聚合物修饰的免疫球蛋白FC片段和包含其的药物组合物公开(公告)号：US20090053246A1
公开(公告)日：2009-02-26
申请号：US11910962
申请日：2005-04-28
Applicant: Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
Inventor： Young Min Kim , Sung Min Bae , Dae Jin Kim , Dae Hae Song , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee
CPC classification number: A61K47/6835 , A61K47/6811 , A61K47/6813 , C07K2317/52 , C07K2319/30
Abstract: Disclosed are an Fc fragment modified by a non-peptide polymer, a pharmaceutical composition comprising the Fc fragment modified by the non-peptide polymer as a carrier, a complex of the Fc fragment and a drug via a linker and a pharmaceutical composition comprising such a complex. The Fc fragment modified by a non-peptide peptide according to the present invention lacks immunogenicity and effector functions. Due to these properties, the Fc fragment maintains the in vivo activity of a drug conjugated thereto in high levels, remarkably increases the serum half-life of the drug, and remarkably reduces the risk of inducing immune responses.
Abstract translation: 公开了由非肽聚合物修饰的Fc片段，包含由作为载体的非肽聚合物修饰的Fc片段的药物组合物，Fc片段的复合物和通过接头的药物和包含这样的 复杂。 由本发明的非肽肽修饰的Fc片段缺乏免疫原性和效应子功能。 由于这些性质，Fc片段以高水平维持与其结合的药物的体内活性，显着增加了药物的血清半衰期，并显着降低了诱导免疫应答的风险。
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公开(公告)号：US20080124347A1
公开(公告)日：2008-05-29
申请号：US11747153
申请日：2007-05-10
Applicant: Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
Inventor： Young Min Kim , Dae Jin Kim , Sung Min Bae , Chang Ki Lim , Se Chang Kwon , Gwan Sun Lee , Dae Hae Song , Young Hoon Kim
CPC classification number: A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
Abstract: The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and a carrier substance, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
Abstract translation: 本发明涉及具有改善的功效和稳定性的体内持续时间的促胰岛素肽缀合物，其包含彼此共价连接的促胰岛素肽，非肽聚合物和载体物质及其用途。 本发明的促胰岛素肽缀合物具有保持较高的体内活性，并且血液半衰期显着增加，因此可以理想地用于开发各种肽药物的长效制剂。
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