公开(公告)号：US10228308B2

公开(公告)日：2019-03-12

申请号：US15319717

申请日：2015-06-19

Applicant: SpinChip Diagnostics AS

Inventor： Stig Morten Borch ,  Torgeir Hamsund ,  Jostein Geir Holtlund ,  Anja Gulliksen

IPC: G01N1/10 ,  G01N33/543 ,  B01L3/00 ,  B03D3/00 ,  G01N35/04

Abstract: A method for transferring beads in a fluidic chip having an internal fluid circuit through which various reactants, including beads, may be moved by use of centrifugal force includes providing beads having a density equal to, or lower than, m1 in a section of the fluid circuit, where the section includes at least a first outlet. The method includes providing a first liquid medium having a density d2 to the section, such that d2>m1, and applying a centrifugal force such that the beads migrate in an opposite direction of the centrifugal force.

公开(公告)号：WO2019091650A1

公开(公告)日：2019-05-16

申请号：PCT/EP2018/075435

申请日：2018-09-20

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： TRONRUD, Ole, Christian ,  STENMARK, Sebastian ,  JAHREN, Rolf ,  HAMSUND, Torgeir ,  BORCH, Stig, Morten

IPC: B04B5/02 ,  B04B7/00

CPC classification number: B04B5/02 ,  B04B7/00

Abstract: The present invention provides a centrifuge apparatus (1) for a processing cartridge (2), comprising a rotary plate (3) being rotatable around its centre axis (C1) and comprising at least one cartridge holder (15), wherein the rotary plate (3) has an upper face (4) and a lower face (5), and the cartridge holder is rotatable around its centre axis (C2) and arranged off-centre the centre axis (C1) of the rotary plate and comprises an inner side wall (7) surrounding a through-going passage (6), wherein the through-going passage is able to accommodate the processing cartridge and extends from the upper face to the lower face of the rotary plate; and the inner side wall comprises a resilient locking assembly (8,25) for interaction with at least one cooperating first abutting surface (9) on the processing cartridge (2), such that the processing cartridge may be inserted into the through-going passage and releasably secured by the locking assembly; and at least one stopping element (10) for interaction with at least one cooperating second abutting surface (11) on the processing cartridge, the at least one stopping element being arranged to retain the processing cartridge at a desired vertical level (L) when the cartridge is releasably secured.

公开(公告)号：WO2015193478A1

公开(公告)日：2015-12-23

申请号：PCT/EP2015/063824

申请日：2015-06-19

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： BORCH, Stig, Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein, Geir ,  GULLIKSEN, Anja

IPC: G01N33/543

CPC classification number: G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

Abstract: The present invention provides a method of transferring beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing beads (8) having a density equal to, or lower than, ml in a section (7, 15) of the fluid circuit, the section comprising at least a first outlet (16, 13); providing a first liquid medium to the section, the liquid medium having a density d2, such that d2>ml; and applying a centrifugal force such that the beads migrate in the opposite direction of the centrifugal force.

Abstract translation: 本发明提供了一种在包含内部流体回路的流体芯片中转移珠子的方法，通过该内部流体回路可以通过离心力将各种反应物（其中至少一个反应物是珠子）移动到其中，该方法包括以下步骤： 在所述流体回路的部分（7,15）中提供密度等于或小于ml的珠（8），所述部分至少包括第一出口（16,13）; 向该部分提供第一液体介质，液体介质具有密度d2，使得d2> ml; 并施加离心力使得珠沿离心力的相反方向迁移。

公开(公告)号：WO2022135848A1

公开(公告)日：2022-06-30

申请号：PCT/EP2021/083512

申请日：2021-11-30

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： STENMARK, Sebastian ,  BORCH, Stig, Morten ,  HAMSUND, Torgeir ,  MEYER, Erik, L. ,  JAHREN, Rolf ,  KRISTIANSEN, Håvard ,  STAAL, Odd, Martin ,  HILL, Steven ,  PAUS, Didrik ,  KAVLI, Ole-Andreas

IPC: B01L3/00

Abstract: The present invention provides a processing cartridge (1) comprising a main cartridge section (2) and an actuating cartridge section (3), the main cartridge section (2) comprises a liquid reservoir chamber (4), a liquid container (5), a container piercing element (6) and a resilient container holding element (9), wherein the actuating cartridge section (3) is configured to dock with the main cartridge section (2) and comprises an actuating member (10) configured to interact with the liquid container (5) during docking; the liquid container, the piercing element (6) and the container holding element (9) are arranged in the liquid reservoir chamber (4), the liquid container is filled with a suitable processing liquid and features a pierceable dispensing side (16), and the container piercing element faces the dispensing side; the liquid container (5) is held in a first position by the container holding element, wherein the dispensing side is separated from the container piercing element; and the actuating member (10) is configured to move the liquid container from the first position to a second position during docking of the cartridge actuating section, and in the second position the dispensing side (16) is pierced by the container piercing element.

公开(公告)号：WO2015193474A1

公开(公告)日：2015-12-23

申请号：PCT/EP2015/063817

申请日：2015-06-19

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： BORCH, Stig, Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein, Geir ,  GULLIKSEN, Anja

IPC: G01N33/543

CPC classification number: G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

Abstract: The present invention provides a method of separating beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing at least a first set of beads (8a) having a density ml and a second set of beads (8b) having a density m2 in a section (7, 15, 18) of the fluid circuit, the section comprising at least a first outlet (16, 13, 17); providing a first liquid medium in the section, the liquid medium having a density d3, such that ml

Abstract translation: 本发明提供了一种在流体芯片中分离珠粒的方法，该流体碎片包括内部流体回路，通过该内部流体回路可以通过使用离心力使至少一个反应物为珠粒的各种反应物移动，该方法包括以下步骤： 提供具有密度ml的至少第一组珠子（8a）和在所述流体回路的部分（7,15,18）中具有密度m2的第二组珠粒（8b），所述部分包括至少第一 出口（16,13,17）; 在该部分中提供第一液体介质，液体介质具有密度d3，使得ml

公开(公告)号：WO2019091880A1

公开(公告)日：2019-05-16

申请号：PCT/EP2018/080079

申请日：2018-11-05

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： TRONRUD, Ole, Christian ,  JAHREN, Rolf ,  STENMARK, Sebastian ,  BORCH, Stig, Morten

IPC: B04B5/02 ,  G01N35/00 ,  B01L3/00 ,  B04B13/00

Abstract: A method and apparatus for controlling a position of a target point on a processing result 10 relative to a focus point of a focusing sensor system 20 for determining properties of the processing result 10 which is located inside a cartridge 35, and where the focusing sensor system 20 is stationary at a set position relative to a disc 40 rotatable about a first axis 45 by a first motor connected to a controller, and where the cartridge 35 is rotatable about a second axis 50 by a second motor connected to a controller, and where the cartridge 35 is smaller than the disc 40 and placed in and off-centre of the disc 40. The method comprises the steps of determining a point within the cartridge 35 as an initial focus point 55 of the focusing sensor system 20; controlling rotation of the cartridge 35 and disc 40 such that the focus point of the focusing sensor system 20 corresponds to the initial focus point 55; checking whether the initial focus point 55 of the focusing sensor system 20 corresponds to the target point on the processing result 10, and adjusting rotation of the cartridge 35 and disc 40 such that focus point of the focusing sensor system 20 corresponds to the target point on the processing result 10, and examining signals received from the focusing sensor system 20 for determining properties of the processing result 10 at the target point. The apparatus comprises means for performing said method.

公开(公告)号：WO2015193471A1

公开(公告)日：2015-12-23

申请号：PCT/EP2015/063811

申请日：2015-06-19

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： BORCH, Stig, Morten ,  HAMSUND, Torgeir ,  HOLTLUND, Jostein, Geir ,  GULLIKSEN, Anja

IPC: G01N33/543

CPC classification number: G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

Abstract: The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d > m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

Abstract translation: 本发明提供了一种分析含有待定性和/或定量测定的分析物的样品的方法，其包括结合步骤和洗涤步骤，其中所述结合步骤包括：使所述分析物与密度为m1的珠相互作用; 获得包含具有密度m2的可量化珠子络合物的填充珠粒的结构; 洗涤步骤包括：将填充的珠子分散在密度d> m2和m1的液体介质中; 并分离包含可量化珠子络合物的液体介质和珠粒。

公开(公告)号：DK3158332T3

公开(公告)日：2018-02-05

申请号：DK15730158

申请日：2015-06-19

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： BORCH STIG MORTEN ,  HAMSUND TORGEIR ,  GULLIKSEN ANJA ,  HOLTLUND JOSTEIN GEIR

IPC: G01N33/543

公开(公告)号：NO20230762A1

公开(公告)日：2025-01-07

申请号：NO20230762

申请日：2023-07-06

Applicant: SPINCHIP DIAGNOSTICS AS

Inventor： STENMARK SEBASTIAN ,  PAUS DIDRIK ,  MACKENZIE JENNY

IPC: A61B5/15 ,  G01N35/10

Abstract: The invention concerns a sample transfer device for transferring a liquid sample from a sealed test container, the sample transfer device comprising a longitudinal center axis defining an axial direction, a circumferential direction, and a radial direction, a base extending in the radial direction and comprising a base top side facing in the axial direction and a base bottom side facing opposite the axial direction, the base further comprising a neck portion extending in the axial direction from the base top side, and a base protrusion extending from the base bottom side, wherein the neck portion comprises a cup with a cup top rim defining an opening to the cup distal from the base, and a cup bottom defining the bottom of the cup arranged proximal to the base, wherein the base protrusion comprises a cannula extending from the base protrusion in a direction substantially opposite or opposite of the axial direction, and wherein the cannula is in fluid connection with the cup bottom via a fluid conduit, wherein the inner diameter of the cup is larger than the inner diameter of the fluid conduit and configured for retaining a liquid sample within the cup when in use.

公开(公告)号：BR112012016286B1

公开(公告)日：2019-10-22

申请号：BR112012016286

申请日：2010-12-28

Applicant: SPINCHIP DIAGNOSTICS AS ,  STIFTELSEN SINTEF

Inventor： STIG MORTEN BORCH

IPC: B01L3/00

Abstract: patente de invenção: " cartucho para processamento de amostra e método de processar e/ou analisar uma amostra sob força centrífuga". a presente invenção refere-se a um cartucho para processamento de amostra (10) para realizar processamento sob força centrífuga que atua em no mínimo duas direções, quando a orientação do cartucho em relação à força centrífuga é mudada; o cartucho compreendendo uma primeira cavidade (18) adaptada para conter uma amostra, uma segunda cavidade (22) em comunicação direta com a primeira cavidade, no qual a primeira e segunda cavidades são arranjadas de tal modo que a amostra na primeira cavidade é movida a partir dela para a segunda cavidade quando uma força centrífuga que atua sobre o cartucho é mudada de uma primeira direção (30) para uma segunda direção (36), a primeira cavidade é alongada perpendicular à força centrífuga que atua na primeira direção e a segunda cavidade é mais rasa do que a primeira cavidade e mais estendida na direção da força centrífuga que atua na segunda direção do que a primeira cavidade é estendida na direção da força centrífuga que atua na primeira direção. a presente invenção também refere-se a um método de processar e/ou analisar uma amostra sob força centrífuga.