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公开(公告)号：AU2006202170B2
公开(公告)日：2009-10-08
申请号：AU2006202170
申请日：2006-05-23
Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY US DEPARTMENT OF HEALTH
Inventor： WHITEHEAD STEPHEN S , KREMPL CHRISTINE D , MURPHY BRIAN R , BUCHHOLZ URSULA , COLLINS PETER L
IPC: C12N15/09 , C12N15/86 , A61K39/00 , A61K39/12 , A61P11/00 , C07K14/14 , C12N7/00 , C12N7/04 , C12R1/93
Abstract: Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
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12.发明专利
公开(公告)号：AU2003239356B2
公开(公告)日：2009-06-25
申请号：AU2003239356
申请日：2003-05-06
Inventor： DIMITROV DIMITER S , ZHANG MEI-YUN
Abstract: The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
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13.发明专利
公开(公告)号：AU2002353822B2
公开(公告)日：2008-11-06
申请号：AU2002353822
申请日：2002-10-15
Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVIC
Inventor： LIU KE , ROSENBERG STEVEN A
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公开(公告)号：AU2008226462A1
公开(公告)日：2008-09-18
申请号：AU2008226462
申请日：2008-03-10
Inventor： MITCHELL JAMES B , CHERUKURI MURALI KRISHNA , GHOSH MANIK , ROUAULT TRACEY
IPC: A61K31/445 , A61P25/16 , A61P25/28
Abstract: A method of treating or preventing neurodegeneration in a mammal comprising administering to the mammal an effective amount of a stable nitroxide radical, such as Tempo1, as well as related methods.
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15.发明专利
公开(公告)号：AU2008203034A1
公开(公告)日：2008-07-31
申请号：AU2008203034
申请日：2008-07-09
Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SER
Inventor： BUKREYEV ALEXANDER A , WHITEHEAD STEPHEN S , TENG MICHAEL N , MURPHY BRIAN R , JUHASZ KATALIN , COLLINS PETER L
IPC: C12N7/04 , A61K39/155 , C12N7/01 , C12N15/45
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Patent Agency Ranking
公开(公告)号：AU2002352913B2
公开(公告)日：2008-05-29
申请号：AU2002352913
申请日：2002-11-26
Inventor： TSANG KWONG-YOK , SCHLOM JEFFREY
IPC: G01N33/50 , A61K31/7088 , A61K35/12 , A61K35/14 , A61K35/76 , A61K38/00 , A61K38/21 , A61K39/39 , A61K48/00 , A61P13/08 , A61P35/00 , C07K7/06 , C07K14/47 , C07K16/18 , C12N5/08 , C12N5/10 , C12N9/64 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
Abstract: This invention relates to isolated peptides comprising agonist epitopes of prostate-specific antigen (PSA). In various aspects, the invention relates to peptides comprising agonist epitopes of the PSA-3 cytotoxic T lymphocyte epitope, and nucleic acids encoding peptides that comprise PSA-3 agonist epitopes. Also related are probes, primers, and vectors comprising these nucleic acids, as well as host cells comprising these vectors, and antibodies that bind to the PSA-3 agonist peptides. This invention further relates to diagnostic reagents and methods utilizing the disclosed nucleic acids or antibodies. The invention also relates to pharmaceutical compositions comprising the nucleic acids, host cells, and peptides of the invention, as well as methods of treatment or prevention of prostate cancer employing such compositions, for example, for peptide-mediated, cell-mediated, and vector-mediated immunotherapies.
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17.发明专利
公开(公告)号：AU2004205289B2
公开(公告)日：2008-04-17
申请号：AU2004205289
申请日：2004-08-27
Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SER
Inventor： MURPHY BRIAN R , WHITEHEAD STEPHEN S , JUHASZ KATALIN , COLLINS PETER L , BUKREYEV ALEXANDER A , TENG MICHAEL N
IPC: C12N7/04 , A61K39/155 , C12N7/01 , C12N15/45
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公开(公告)号：AU2007277142A1
公开(公告)日：2008-01-31
申请号：AU2007277142
申请日：2007-07-25
Applicant: BRITISH COLUMBIA CANCER AGENCY BCCA , CATALAN INST OF ONCOLOGY , GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY , POWELL JOHN I , RIKSHOSPITALET RADIUMHOSPITALET MEDICAL CENTER , ST BARTHOLOMEWS HOSPITAL , UNIV OF ARIZONA CANCER CENTER , UNIV OF BARCELONA , UNIV OF NEBRASKA MEDICAL CENTER , UNIV OF ROCHESTER MEDICAL CENTER , UNIV OF WURZBURG
Inventor： ARMITAGE JAMES , WRIGHT GEORGE , FISHER RICHARD I , GROGAN THOMAS , BEA SILVIA M , SALAVERRIA ITZIAR , MULLER-HERMELINK HANS-KONRAD , FU KAI , JAFFE ELAINE , CHAN WING C , ZETTL ANDREAS , MILLER THOMAS , RIMSZA LISA , HOLTE HARALD , WILSON WYNDHAM , OTT GERMAN , DELABIE JAN , STAUDT LOUIS M , GASCOYNE RANDY , CAMPO ELIAS , CONNORS JOSEPH , SMELAND ERLEND , KVALOY STEIN , VOSE JULIE , MORENO VICTOR , DAVE SANDEEP , TAN BRUCE , WEISENBURGER DENNIS , ROSENWALD ANDREAS , LOPEZ-GUILLERMO ARMANDO , LISTER T ANDREW , MONTSERRAT EMILI , GREINER TIMOTHY C
Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
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19.发明专利
公开(公告)号：AU2006213981A1
公开(公告)日：2006-10-19
申请号：AU2006213981
申请日：2006-09-14
Applicant: ORTHO MCNEIL PHARM INC , THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY
Inventor： KAFRISSEN MICHAEL E
IPC: A61K31/00 , A61K45/00 , A61K31/505 , A61K31/519 , A61K31/565 , A61K31/57 , A61P5/24 , A61P9/00 , A61P15/00 , A61P35/00 , A61P43/00
Abstract: This invention provides folic acid-containing pharmaceutical compositions comprising either an oral contraceptive or a hormone replacement composition. This invention also provides methods of administering folic acid to a subject using the instant pharmaceutical compositions. Finally, this invention provides a drug delivery system useful for administering the instant pharmaceutical compositions.
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公开(公告)号：AU2005291957A1
公开(公告)日：2006-04-13
申请号：AU2005291957
申请日：2005-09-30
Inventor： LIU FA , BURKE JR TERRENCE R , OISHI SHINYA , SHI ZHEN-DAN
IPC: A61K38/12 , A61K31/675 , A61P35/00 , C07F9/553 , C07K5/12
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