公开(公告)号：TW201610414A

公开(公告)日：2016-03-16

申请号：TW104124254

申请日：2015-07-27

Applicant: 國立大學法人德島大學 ,  TOKUSHIMA UNIVERSITY ,  富士金股份有限公司 ,  FUJIKIN INCORPORATED

Inventor： 出口祥啓 ,  DEGUCHI, YOSHIHIRO ,  永瀬正明 ,  NAGASE, MASAAKI ,  池田信一 ,  IKEDA, NOBUKAZU ,  山路道雄 ,  YAMAJI, MICHIO ,  薬師神忠幸 ,  YAKUSHIJIN, TADAYUKI

IPC: G01N21/31

CPC classification number: G01N21/27 ,  G01N21/05 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/08

Abstract: [課題] 提供一種內嵌型濃度測量裝置，可以將光入射部附近的氣體滯留部縮小或是消除，將朝有機金屬材料的光入射部的堆積減少。 [技術內容] 具備：形成有氣體流路(5)的測量單元本體(15)、及與測量單元本體(15)連接且具備窗材(4)的光入射部(3)、及與測量單元本體(15)連接且具備窗材(6)的受光部(8)，氣體流路(5)，是具備：在光入射部(3)的窗材(4)及受光部(8)的窗材(6)之間形成直線狀而成為光路的光路用氣體流路部(5a)、及從形成於測量單元本體(15)的氣體流入口(5B1)連通至光路用氣體流路部(5a)的第一連通部(5B)、及從形成於測量單元本體(15)的氣體流出口(5C)連通至光路用氣體流路部(5a)的第二連通部(5C)，第一連通部(5B)是從氣體流入口(5B1)朝向光入射部(3)的窗材(4)傾斜延伸。

Abstract in simplified Chinese: [课题] 提供一种内嵌型浓度测量设备，可以将光入射部附近的气体滞留部缩小或是消除，将朝有机金属材料的光入射部的堆积减少。 [技术内容] 具备：形成有气体流路(5)的测量单元本体(15)、及与测量单元本体(15)连接且具备窗材(4)的光入射部(3)、及与测量单元本体(15)连接且具备窗材(6)的受光部(8)，气体流路(5)，是具备：在光入射部(3)的窗材(4)及受光部(8)的窗材(6)之间形成直线状而成为光路的光路用气体流路部(5a)、及从形成于测量单元本体(15)的气体流入口(5B1)连通至光路用气体流路部(5a)的第一连通部(5B)、及从形成于测量单元本体(15)的气体流出口(5C)连通至光路用气体流路部(5a)的第二连通部(5C)，第一连通部(5B)是从气体流入口(5B1)朝向光入射部(3)的窗材(4)倾斜延伸。

公开(公告)号：TWI681181B

公开(公告)日：2020-01-01

申请号：TW104124254

申请日：2015-07-27

Applicant: 國立大學法人德島大學 ,  TOKUSHIMA UNIVERSITY ,  日商富士金股份有限公司 ,  FUJIKIN INCORPORATED

Inventor： 出口祥啓 ,  DEGUCHI, YOSHIHIRO ,  永瀬正明 ,  NAGASE, MASAAKI ,  池田信一 ,  IKEDA, NOBUKAZU ,  山路道雄 ,  YAMAJI, MICHIO ,  薬師神忠幸 ,  YAKUSHIJIN, TADAYUKI

IPC: G01N21/31

公开(公告)号：US20240327828A1

公开(公告)日：2024-10-03

申请号：US18743751

申请日：2024-06-14

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10

CPC classification number: C12N15/111 ,  C12N9/22 ,  C12N15/102 ,  C12N2310/20

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.

公开(公告)号：US12064460B2

公开(公告)日：2024-08-20

申请号：US16964142

申请日：2019-01-25

Applicant: TOKUSHIMA UNIVERSITY ,  JICHI MEDICAL UNIVERSITY ,  GENE THERAPY RESEARCH INSTITUTION CO., LTD.

Inventor： Kohji Itoh ,  Daisuke Tsuji ,  Shinichi Muramatsu ,  Katsuhito Asai

IPC: A61K35/76 ,  A61P25/28 ,  C12N7/00

CPC classification number: A61K35/76 ,  A61P25/28 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.

公开(公告)号：US20230221298A1

公开(公告)日：2023-07-13

申请号：US18009429

申请日：2021-06-10

Applicant: Tokushima University

Inventor： Hideharu ABE ,  Koichi UTE

IPC: G01N33/493 ,  G01N33/68 ,  G01N33/53 ,  B01J20/26 ,  B01J20/28

CPC classification number: G01N33/493 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28004 ,  G01N33/5308 ,  G01N33/6803 ,  B01J2220/68

Abstract: Provided is a method for simply obtaining a desired size fraction from an aqueous sample containing particles. The method includes the following steps: (1) bringing the aqueous sample containing particles into contact with a superabsorbent polymer to obtain a superabsorbent polymer gel containing a portion of the particles, and (2) mixing the superabsorbent polymer gel with a salt to recover a portion of the particles.

公开(公告)号：US20230124208A1

公开(公告)日：2023-04-20

申请号：US17905486

申请日：2021-03-04

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Kouji NISHINO ,  Nobukazu IKEDA

IPC: G01N21/27 ,  G01N21/3504 ,  G01N21/31

Abstract: A concentration measurement method performed in a concentration measurement device including an electric unit having a light source and a photodetector, a fluid unit having a measurement cell through which a gas flows, and a processing circuit for calculating a concentration of the gas based on an intensity of a light passing through the measurement cell. The concentration measurement method includes a step of determining an absorption coefficient of the measurement gas using a reference absorption coefficient determined in association with the reference gas and a correction factor associated with the measurement gas, and a step of obtaining a concentration of the measurement gas flowing in the measurement cell using the absorption coefficient of the measurement gas. When the absorption peak wavelength of the measurement gas is longer than the peak wavelength of the light source, a reference gas having a longer absorption peak wavelength than the peak wavelength of the light source is used, and when the absorption peak wavelength of the measurement gas is shorter than the peak wavelength of the light source, a reference gas having a shorter absorption peak wavelength than the peak wavelength of the light source is used.

公开(公告)号：US10976240B2

公开(公告)日：2021-04-13

申请号：US15748264

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Michio Yamaji ,  Nobukazu Ikeda ,  Kouji Nishino ,  Masayoshi Kawashima ,  Kazuteru Tanaka

IPC: G01N21/94 ,  G01N21/31 ,  G01N21/33 ,  G01N21/27 ,  G01J3/10 ,  G01J3/42 ,  G01N21/59 ,  G01N21/15 ,  G01N21/55 ,  G01N21/88

Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.

公开(公告)号：US10384998B2

公开(公告)日：2019-08-20

申请号：US16202914

申请日：2018-11-28

Applicant: Mitsubishi Chemical Corporation ,  TOKUSHIMA UNIVERSITY

Inventor： Yuki Kato ,  Wataru Ninomiya ,  Shigeru Sugiyama

IPC: C07C45/00 ,  B01J29/00 ,  C07C45/51 ,  B01J29/04 ,  C07C47/02

Abstract: To provide a method for producing propionaldehyde directly from glycerol with high yield, gasified glycerol is brought into contact with a silica-type regular mesoporous body. More specifically, gasified glycerol is supplied to a catalyst layer containing a regular mesoporous body while heating the catalyst layer at a temperature ranging from 200 to 800° C. in such a manner that a W/F value can fall within the range from 0.001 to 1000 g·min/ml inclusive wherein W represents an amount (g) of a catalyst and F represents a supply rate (ml/min) of supplied glycerol.

公开(公告)号：US10302563B2

公开(公告)日：2019-05-28

申请号：US14913296

申请日：2014-08-21

Applicant: Tokushima University

Inventor： Yoshihiro Deguchi ,  Takahiro Kamimoto

IPC: G01N21/61 ,  G01N21/3504 ,  G01J3/427 ,  G01N21/31 ,  G01N21/39 ,  G01J5/00 ,  G01J3/433 ,  G01J5/60 ,  G01K11/18 ,  G01K11/00

Abstract: A gas analyzing apparatus includes first and second laser sources that output first and second laser lights, a laser controller that controls the first and second laser sources to vary wavelengths of the first and second laser lights in the respective predetermined wavelength ranges, an optical multiplexer that multiplexes the first and second laser lights to transmit the multiplexed laser light to a target gas, an optical receiver that receives the laser light transmitted through the target gas, and an analyzer that analyzes a temperature and/or a concentration of the target gas based on an electric signal output from the optical receiver. While varying the wavelengths of the laser lights, the laser controller controls amplitudes of the first and second laser lights to differ from each other and varies intensities of the first and second laser lights in the opposite direction.

公开(公告)号：US20190135722A1

公开(公告)日：2019-05-09

申请号：US16202914

申请日：2018-11-28

Applicant: Mitsubishi Chemical Corporation ,  TOKUSHIMA UNIVERSITY

Inventor： Yuki Kato ,  Wataru Ninomiya ,  Shigeru Sugiyama

IPC: C07C45/51 ,  B01J29/04

CPC classification number: C07C45/511 ,  B01J29/035 ,  B01J29/041 ,  B01J35/10 ,  C07C45/52 ,  C07C47/02

Abstract: To provide a method for producing propionaldehyde directly from glycerol with high yield, gasified glycerol is brought into contact with a silica-type regular mesoporous body. More specifically, gasified glycerol is supplied to a catalyst layer containing a regular mesoporous body while heating the catalyst layer at a temperature ranging from 200 to 800° C. in such a manner that a W/F value can fall within the range from 0.001 to 1000 g·min/ml inclusive wherein W represents an amount (g) of a catalyst and F represents a supply rate (ml/min) of supplied glycerol.