公开(公告)号：US20240268948A1

公开(公告)日：2024-08-15

申请号：US18567531

申请日：2022-06-07

Applicant: UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  HOSPICES CIVILS DE LYON

Inventor： Benoit COSSET

IPC: A61F2/07 ,  A61F2/06 ,  A61F2/89

CPC classification number: A61F2/07 ,  A61F2/89 ,  A61F2002/061

Abstract: A fenestrated endoprosthesis of the thoracic aorta including a first mesh of stents, a main tubular endoprosthesis made of fabric, the main tubular endoprosthesis being rigidly attached to the first mesh, and having an arcuate central portion configured to be received in the aortic arch of a patient, the arcuate central portion extending between a first and a second end, each configured to be received respectively in a portion of the ascending or descending aorta, respectively. The fenestrated endoprosthesis further includes a flange also made of fabric and associated with a second mesh of stents, the flange having a substantially frustoconical shape and having a base, the base of the flange being mounted on an opening made in the upper face of the arcuate central portion, the flange being configured to be received at the base of the supra-aortic trunks of the patient.

公开(公告)号：US20240216547A1

公开(公告)日：2024-07-04

申请号：US18558054

申请日：2022-04-28

Applicant: UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG ,  CENTRE HOSPITALIER UNIVERSITAIRE

Inventor： Philippe GAIN ,  Gilles THURET ,  Emilie COURRIER ,  Zhiguo HE ,  Gilles ULRICH ,  Antoinette DE NICOLA ,  Corantin MAURIN ,  Corentin MARET

IPC: A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0043 ,  A61K49/0073 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The invention relates to fluorescein derivative compounds and the use thereof as fluorescent markers. Said markers can be used in particular in biology and in medicine, particularly in the field of ophthalmology. The non-fluorescent fluorescein derivatives are activated in the cell, thereby allowing the detection of living cells as well as the quantification of cell viability by fluorescence, without being toxic to cells.

公开(公告)号：US20240018715A1

公开(公告)日：2024-01-18

申请号：US18032044

申请日：2021-10-15

Applicant: Centre National de la Recherche Scientifique (CNRS) ,  Universite Jean Monnet Saint Etienne ,  La Tannerie Vegetale ,  Université Claude Bernard Lyon 1

Inventor： Fanny DELEAGE ,  Yvan CHALAMET

IPC: D06N3/00 ,  C14C3/26

CPC classification number: D06N3/0061 ,  C14C3/26

Abstract: The present disclosure relates to a method for the preparation, from a mixture comprising (i) plant proteins, (ii) one or more plant tanning agents, (iii) one or more plasticizers, of a biobased material that may resemble animal leather.

公开(公告)号：US20230134190A1

公开(公告)日：2023-05-04

申请号：US17951231

申请日：2022-09-23

Applicant: KERANOVA ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： Fabrizio ROMANO ,  Aurelien BERNARD ,  Cyril MAUCLAIR ,  Emmanuel BAUBEAU

IPC: A61F9/008

Abstract: The present invention relates to an apparatus for cutting-out including a device for treating a L.A.S.E.R. beam generated by a femtosecond laser (1), and positioned downstream from said femtosecond laser, the treatment device comprising: a shaping system (3) positioned on the trajectory of said beam, for modulating the phase of the wave front of the L.A.S.E.R. beam according to a modulation set value calculated for distributing the energy of the L.A.S.E.R. beam in at least two impact points forming a pattern in its focal plane, an optical focusing system (5) downstream from the shaping system, the optical focusing system comprising a concentrator module for focusing the phase-modulated L.A.S.E.R. beam in a focusing plane and a depth-positioning module for displacing the focusing plane into a plurality of cutting-out planes, a sweeping optical scanner (4) positioned between the concentrator module and the depth-positioning module for displacing the pattern in the cutting-out plane in a plurality of positions.

公开(公告)号：US20220162239A1

公开(公告)日：2022-05-26

申请号：US17432510

申请日：2020-02-21

Applicant: UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： JACQUES BODENNEC ,  AMOR BELMEGUENAÏ ,  SELENA BODENNEC ,  LAURENT BEZIN ,  BÉATRICE GEORGES ,  VICTOR BLOT

IPC: C07F9/40 ,  A61P25/08 ,  C07F9/38

Abstract: The present invention relates to structured molecular vectors of formula (I), compounds of formula (II) and pharmaceutical compositions comprising such compounds. The invention also relates to such pharmaceutical compositions for use for preventing and/or treating a disease chosen among an inflammatory disease or a disease associated with a cognitive disorder. The invention further relates to such pharmaceutical compositions for use for preventing cognitive decline or restoring cognitive functions altered in brain injuries and/or in traumatic brain injuries and/or in a neuroinflammatory disease, and/or in a neurodegenerative disease.

公开(公告)号：US11229201B2

公开(公告)日：2022-01-25

申请号：US16772653

申请日：2018-12-14

Applicant: UNIVERSITE JEAN MONNET ,  CENTRE HOSPITALIER UNIVERSITAIRE

Inventor： Philippe Gain ,  Gilles Thuret ,  Pascal Herbepin

IPC: A01N1/02

Abstract: The invention relates to a medical device for preservation of corneal tissue (3) that has been obtained beforehand by sampling, the device comprising a base (11), at least one side wall (12), and means for receiving and blocking the corneal tissue (3), characterized in that the device additionally comprises an applanation lid (13) for covering an opening of the device opposite the transparent base (11), the applanation lid (13) comprising: a transparent window (131), and a support (132) between the window (131) and the side wall (12), the support (132) comprising means for moving the window (131) in translation with respect to the side wall (12) of the device.

公开(公告)号：US10980600B2

公开(公告)日：2021-04-20

申请号：US16343369

申请日：2017-09-18

Applicant: INSTITUT MINES-TÉLÉCOM ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT-ETIENNE

Inventor： David Perrin ,  Stéphane Avril ,  Pierre Badel ,  Jean-Noël Albertini

IPC: A61B34/10 ,  G06T7/12 ,  A61F2/07 ,  G06T7/00 ,  A61B90/00 ,  A61B17/00 ,  A61F2/06

Abstract: The method of assisting the production of an implantable unfurlable made to measure device comprises: three-dimensional reconstruction of a complex surface of the cavity in which the device will be implanted; Production of a first finite element mesh of this complex surface; Choosing of generic components of the device; Production of a second finite element mesh of these assembled generic components; Determination of the morphosis parameters for morphosing from the first mesh to a mesh of a set of simple linked volumes which is representative of the part of the cavity, and then deformation of the first mesh by this morphosis; Simulation of a deformation of the second mesh, by inverse morphosis dependent on the determined parameters, to the complex surface, simulating unfurling of the device; Determination of dimensioning of points of interest by projection onto the second deformed mesh; and Generation of a production blueprint plan of the device.

公开(公告)号：US20200237956A1

公开(公告)日：2020-07-30

申请号：US16845422

申请日：2020-04-10

Applicant: Bioxis Pharmaceuticals ,  Universite Jean Monnet ,  Institut National des Sciences Appliquees de Lyon ,  Universite Claude Bernard Lyon 1 ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： Florence Dupasquier ,  Laurent David ,  Thierry Delair

IPC: A61L27/20 ,  A61K8/73 ,  A61Q19/08 ,  A61L24/08 ,  A61L31/04 ,  A61L27/54 ,  A61L27/58

Abstract: The present invention relates to a homogeneous aqueous solution of injectable chitosan containing a chitosan having a degree of acetylation lower than 20%, said solution containing between 0.1 and 3.5% by weight of chitosan, said solution presenting a pH lower than 6.2, and said aqueous solution being capable of forming crystalline particles of chitosan after injection. The present invention also relates to compounds containing such a homogeneous aqueous solution of chitosan. The invention also relates to such compounds for their use as dermatological or cosmetic compounds, or for their use as a medical device, advantageously as a bioresorbable implant.

公开(公告)号：US20190282734A1

公开(公告)日：2019-09-19

申请号：US16301908

申请日：2017-05-19

Applicant: UNIVERSITE CLAUDE BERNARD LYON I ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET, SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

Inventor： Alexandra MONTEMBAULT ,  Laurent DAVID ,  Thierry DELAIR ,  Solene TADIER ,  Laurent GREMILLARD ,  Annelise FAIVRE ,  Florence DESPETIS

IPC: A61L27/46 ,  A61L27/20 ,  A61L27/10

Abstract: The invention relates to a product intended for the preparation of an injectable composition containing, separated from one another, at least one first and one second composition(s), and in which: —the first composition, referred to as A, is an aqueous solution of chitosan with a pH in the range extending from 3 to 7, and —the second composition, referred to as B1, corresponds to particles of one or more bioactive glass(es), said product not containing glycerophosphate; and also a process for preparing an injectable composition, the corresponding injectable compositions and devices for packaging a product according to the invention.

公开(公告)号：US10358541B2

公开(公告)日：2019-07-23

申请号：US15537132

申请日：2015-12-21

Applicant: ELKEM SILICONES FRANCE SAS ,  Institut National des Sciences Appliquées LYON ,  Université Claude Bernard Lyon 1 ,  Centre national de la recherche scientifique ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： François Ganachaud ,  Etienne Fleury ,  Daniel Portinha De Almeida ,  Aymeric Genest ,  Emmanuel Pouget

IPC: C08K3/36 ,  A61Q19/00 ,  C08G85/00 ,  C08K5/09 ,  C08K5/10 ,  C08G77/388 ,  A61K8/898 ,  C08G77/38 ,  C08G77/26

Abstract: The present invention concerns an organopolysiloxane (A) able to be obtained by the reaction, at a temperature of between 10° C. and 75° C., between—at least one compound (C) chosen from the organic compounds comprising at least one alkene or alkyne functional group, at least one of the substituents of which is an acid functional group and the organic compounds comprising at least one acid functional group and at least one alkene or alkyne functional group, at least one of the substituents of which is an electron-withdrawing group; and—at least one organopolysiloxane (B) chosen from the organopolysiloxanes comprising siloxyl units (I.1) and (I.2) of the following formulae: (I) The present invention also concerns compositions comprising said organopolysiloxanes (A) and the uses thereof. ( I ) Y a ⁢ Z b 1 ⁢ SiO 4 - ( a + b ) 2 ; ( I ⁢ .1 ) Z c 2 ⁢ SiO 4 - c 2 ( I ⁢ .2 )