公开(公告)号：US20220195473A1

公开(公告)日：2022-06-23

申请号：US17691933

申请日：2022-03-10

Applicant: National Research Council of Canada ,  University of Saskatchewan

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12P17/06 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US20220154209A1

公开(公告)日：2022-05-19

申请号：US17392164

申请日：2021-08-02

Applicant: University of Saskatchewan

Inventor： Suresh K. TIKOO ,  Xin ZHAO

IPC: C12N15/86 ,  A61K35/761 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12

Abstract: The present application provided defective bovine adenovirus (BAV) vectors that lack pV function. Cell lines and methods of preparing such vectors are provided. In addition, the invention provides methods of treating a disease or disorder with a defective BAV lacking pV function as well as vaccine comprising a defective BAV lacking pV function.

公开(公告)号：US11124575B2

公开(公告)日：2021-09-21

申请号：US16487673

申请日：2018-02-22

Applicant: University of Saskatchewan ,  The Governing Council of the University of Toronto

Inventor： Sachdev Sidhu ,  Shane Miersch ,  Clarence Ronald Geyer

IPC: C07K16/28 ,  A61K47/68 ,  A61K49/00 ,  G01N33/68

Abstract: An Epidermal Growth Factor Receptor (EGFR, HER1, ErbB1)-binding agent has a heavy chain and a light chain, wherein the dimerization loop from EGFR's Domain II is grafted within complementarity determining region 3 (CDR3) of the heavy chain, and the binding agent is affinity matured. The graft directs the binding agent to bind EGFR at its dimerization region, to thereby inhibit EGFR dimerization and activation. In another embodiment, an EGFR-binding agent is panned out of Library F, a Fab library. The binding agents are for detecting and/or quantifying EGFR expression, for targeting EGFR-expressing cells, and for decreasing levels of EGFR in EGFR-expressing cells.

公开(公告)号：US20210244807A1

公开(公告)日：2021-08-12

申请号：US17156477

申请日：2021-01-22

Applicant: University of Saskatchewan ,  Kenya Agriculture and Livestock Research Organization (KALRO) ,  International Livestock Research Institute (ILRI)

Inventor： Andrew POTTER ,  Volker GERDTS ,  Jose PEREZ-CASAL ,  Yejun WANG ,  Hezron WESONGA ,  Reuben SOI ,  Jan NAESSENS ,  Joerg JORES

IPC: A61K39/02 ,  C07K14/30 ,  A61P31/04 ,  C12N15/62

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

公开(公告)号：US20210228511A1

公开(公告)日：2021-07-29

申请号：US17156167

申请日：2021-01-22

Applicant: University of Saskatchewan

Inventor： Juan P. Ianowski ,  Julian S. Tam ,  Xiaojie Luan ,  Veronica A. Campanucci

IPC: A61K31/165 ,  A61K33/14 ,  A61K9/00 ,  A61K31/05

Abstract: The present application relates to a method of increasing the volume of an airway surface liquid (ASL) layer and/or increasing mucociliary clearance in a subject. For example, the application relates the use of one or more neuronal agonists such as menthol and/or capsaicin, in combination with hypertonic saline (HTS) or isotonic saline (ITS) for increasing the volume of airway surface liquid (ASL) and/or increasing mucociliary clearance or for treatment of a disease, disorder or condition treatable by increasing the volume of an ASL layer and/or increasing mucociliary clearance. For example, the disease, disorder or condition is cystic fibrosis or a non-cystic fibrosis respiratory disease, disorder or condition such as non-cystic fibrosis bronchiectasis.

公开(公告)号：US20210219410A1

公开(公告)日：2021-07-15

申请号：US17250302

申请日：2019-07-04

Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Sylvain FOURMAUX ,  Jean-Claude KIEFFER ,  Emil HALLIN

IPC: H05G2/00 ,  G01N23/041 ,  G01N33/00

Abstract: A X-ray source, comprising a laser, of a pulse duration of at most 40 fs, instantaneous power of at least about 80TW, a pulse repetition rate of at least 1 Hz; an optical compressor spectrally shaping the laser beam; focusing optics in the range between f#10 and f#15; and a gas target of electron density after ionization by the laser beam in a range between 1018 cm3 and 1019 cm−3; wherein the focusing optics focuses the laser beam in the gas target, and interaction of the focused laser beam with the gas target generates an X-ray beam, with a focused laser amplitude a0, given by a0=0.855 [IL (1018W/cm2)λL,2 (μm)]1/2, where IL is the on-target laser intensity and λL is the laser wavelength, of at least 2 and a P/Pc ratio value of at least 20, with P being the beam power and Pc a critical power given by Pc=17 (nc/n) GW where n is the electron density and nc is a critical electron density at which the plasma acts as a mirror reflecting the laser beam.

公开(公告)号：US20210060049A1

公开(公告)日：2021-03-04

申请号：US17046164

申请日：2019-05-31

Applicant: University of Saskatchewan

Inventor： Meena Kishor Sakharkar ,  Jian Yang

IPC: A61K31/7048 ,  A61K31/192 ,  A61P31/04

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of tulathromycin and gallic acid for the treatment of a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection or a disease, disorder or condition arising from a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection.

公开(公告)号：US10859581B2

公开(公告)日：2020-12-08

申请号：US15319436

申请日：2015-06-12

Applicant: University of Saskatchewan

Inventor： Changiz Taghibiglou

IPC: G01N33/68 ,  A61K39/395 ,  C07K14/47 ,  A61K39/00 ,  A61B5/15

Abstract: The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of PrPC. The disclosure also provides kits for measuring the amount of PrPC in a blood sample.

公开(公告)号：US20200325508A1

公开(公告)日：2020-10-15

申请号：US16917362

申请日：2020-06-30

Applicant: National Research Council of Canada ,  University of Saskatchewan

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12P17/06 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US20200164066A1

公开(公告)日：2020-05-28

申请号：US16630744

申请日：2018-07-17

Applicant: University of Saskatchewan

Inventor： Susantha Gomis ,  Shelly Popowich ,  Kalhari Venukala Bandara Goonewardene ,  Suresh Tikoo ,  Marianna Foldvari

IPC: A61K39/39 ,  A23K20/153 ,  A23K50/75 ,  C12N15/117

Abstract: This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.