公开(公告)号：WO2002064791A3

公开(公告)日：2002-08-22

申请号：PCT/US2001/048369

申请日：2001-12-10

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGEL, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGEL, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclose therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.

公开(公告)号：WO2002059313A2

公开(公告)日：2002-08-01

申请号：PCT/US2001/049394

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  LI, Li ,  BALLINGER, Robert, A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  CASMAN, Stacie, J. ,  VERNET, Corine, A., M. ,  SHENOY, Suresh, G. ,  GUSEV, Vladimir ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  SMITHSON, Glennda ,  STONE, David, J. ,  SCIORE, Paul ,  MACDOUGALL, John, R. ,  GUNTHER, Erik ,  PEYMAN, John, A. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  MILLET, Isabelle

Inventor： LI, Li ,  BALLINGER, Robert, A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  CASMAN, Stacie, J. ,  VERNET, Corine, A., M. ,  SHENOY, Suresh, G. ,  GUSEV, Vladimir ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  SMITHSON, Glennda ,  STONE, David, J. ,  SCIORE, Paul ,  MACDOUGALL, John, R. ,  GUNTHER, Erik ,  PEYMAN, John, A. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  MILLET, Isabelle

IPC: C12N15/12

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002053742A3

公开(公告)日：2002-07-11

申请号：PCT/US2002/000375

申请日：2002-01-07

Applicant: CURAGEN CORPORATION ,  KEKUDA, Ramesh ,  ALSOBROOK, John, P., II ,  TCHERNEV, Velizar, T. ,  LIU, Xiaohong ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GROSSE, William, M. ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  VERNET, Corine, A., M. ,  LI, Li ,  GORMAN, Linda ,  EDINGER, Schlomit ,  SCIORE, Paul ,  ELLERMAN, Karen ,  MALYANKAR, Uriel ,  ROTHENBERG, Mark ,  STONE, David ,  BOLDOG, Ferenc ,  GUO, Xiaojia ,  SHENOY, Suresh ,  ANDERSON, David ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J. ,  MILLER, Charles, E. ,  EISEN, Andrew

Inventor： KEKUDA, Ramesh ,  ALSOBROOK, John, P., II ,  TCHERNEV, Velizar, T. ,  LIU, Xiaohong ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GROSSE, William, M. ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  VERNET, Corine, A., M. ,  LI, Li ,  GORMAN, Linda ,  EDINGER, Schlomit ,  SCIORE, Paul ,  ELLERMAN, Karen ,  MALYANKAR, Uriel ,  ROTHENBERG, Mark ,  STONE, David ,  BOLDOG, Ferenc ,  GUO, Xiaojia ,  SHENOY, Suresh ,  ANDERSON, David ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J. ,  MILLER, Charles, E. ,  EISEN, Andrew

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.

公开(公告)号：WO0164879A3

公开(公告)日：2002-05-10

申请号：PCT/US0106474

申请日：2001-02-28

Applicant: CURAGEN CORP ,  PADIGARU MURALIDHARA ,  MAJUMDER KUMUD ,  BURGESS CATHERINE E ,  VERNET CORINE A M ,  FERNANDES ELMA ,  SHIMKETS RICHARD A ,  TCHERNEV VELIZAR T ,  MISHRA VISHNU ,  CASMAN STACIE ,  SPYTEK KIMBERLY A ,  ZERHUSEN BRYAN

Inventor： PADIGARU MURALIDHARA ,  MAJUMDER KUMUD ,  BURGESS CATHERINE E ,  VERNET CORINE A M ,  FERNANDES ELMA ,  SHIMKETS RICHARD A ,  TCHERNEV VELIZAR T ,  MISHRA VISHNU ,  CASMAN STACIE ,  SPYTEK KIMBERLY A ,  ZERHUSEN BRYAN

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P1/04 ,  A61P1/14 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P7/00 ,  A61P7/06 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/10 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P31/04 ,  A61P31/10 ,  A61P31/18 ,  A61P33/02 ,  A61P35/00 ,  A61P37/00 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K31/70 ,  A61K38/17 ,  G01N33/68

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K39/00

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, of fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽和免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的片段的衍生物，变体，突变体。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO0166747A8

公开(公告)日：2002-02-21

申请号：PCT/US0107160

申请日：2001-03-05

Applicant: CURAGEN CORP ,  VERNET CORINE A M ,  FERNANDES ELMA ,  SHIMKETS RICHARD A ,  HERRMANN JOHN L ,  MAJUMDER KUMUD ,  MACDOUGALL JOHN ,  MISHRA VISHNU ,  MEZES PETER S ,  RASTELLI LUCA

Inventor： VERNET CORINE A M ,  FERNANDES ELMA ,  SHIMKETS RICHARD A ,  HERRMANN JOHN L ,  MAJUMDER KUMUD ,  MACDOUGALL JOHN ,  MISHRA VISHNU ,  MEZES PETER S ,  RASTELLI LUCA

IPC: G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P7/04 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P19/08 ,  A61P25/00 ,  A61P27/16 ,  A61P31/00 ,  A61P31/20 ,  A61P33/06 ,  A61P33/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/08 ,  C07K14/47 ,  C07K14/54 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  A61K31/70 ,  A61K38/17 ,  C07K16/28 ,  G01N33/68

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K14/54 ,  C07K14/70571 ,  Y10T436/143333

Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeuctic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人类核酸和蛋白质中的任何一种相关的疾病的治疗，诊断和研究方法。

公开(公告)号：WO03023008A8

公开(公告)日：2005-10-27

申请号：PCT/US0228596

申请日：2002-09-09

Applicant: CURAGEN CORP ,  ZHONG MEI ,  LI LI ,  GORMAN LINDA ,  SPYTEK KIMBERLY A ,  KEKUDA RAMESH ,  TAUPIER RAYMOND J JR ,  ANDERSON DAVID W ,  VERNET CORINE A M ,  CATTERTON ELINA ,  MILLER CHARLES E ,  SHENOY SURESH G ,  PATTURAJAN MEERA ,  PENA CAROL E A ,  TCHERNEV VELIZAR T ,  PADIGARU MURALIDHARA ,  GUSEV VLADIMIR Y ,  MALYANKAR URIEL M ,  BURGESS CATHERINE E ,  GERLACH VALERIE L ,  CASMAN STACIE J ,  RIEGER DANIEL K ,  GROSSE WILLIAM M ,  SMITHSON GLENNDA ,  PEYMAN JOHN A ,  STARLING GARY ,  ROTHENBERG MARK E ,  LAROCHELLE WILLIAM J ,  SHIMKETS RICHARD A ,  CRABTREE JULIE ,  RASTELLI LUCA ,  VOSS EDWARD Z ,  BOLDOG FERENC L ,  EDINGER SHLOMIT R ,  MILLET ISABELLE ,  MACDOUGALL JOHN R ,  ELLERMAN KAREN ,  CHAPOVAL ANDREI

Inventor： TCHERNEV VELIZAR T ,  GUSEV VLADIMIR Y ,  MILLET ISABELLE ,  CATTERTON ELINA ,  STARLING GARY ,  VERNET CORINE A M ,  GORMAN LINDA ,  PADIGARU MURALIDHARA ,  LI LI ,  MACDOUGALL JOHN R ,  ROTHENBERG MARK E ,  PEYMAN JOHN A ,  MILLER CHARLES E ,  EDINGER SHLOMIT R ,  PATTURAJAN MEERA ,  VOSS EDWARD Z ,  SHENOY SURESH G ,  BOLDOG FERENC L ,  RASTELLI LUCA ,  CASMAN STACIE J ,  SMITHSON GLENNDA ,  LAROCHELLE WILLIAM J ,  KEKUDA RAMESH ,  TAUPIER RAYMOND J JR ,  SHIMKETS RICHARD A ,  CRABTREE JULIE ,  ZHONG MEI ,  ANDERSON DAVID W ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  CHAPOVAL ANDREI ,  SPYTEK KIMBERLY A ,  RIEGER DANIEL K ,  MALYANKAR URIEL M ,  BURGESS CATHERINE E ,  GERLACH VALERIE L ,  PENA CAROL E A

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/04 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  C12N20060101 ,  C12N1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/06 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53

CPC classification number: C07K14/47

公开(公告)号：WO2003085096A2

公开(公告)日：2003-10-16

申请号：PCT/US2003/009929

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C12N

CPC classification number: A61K38/04 ,  A61K38/17 ,  C07H21/02 ,  C07K14/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/00 ,  C12N15/00 ,  C12P21/02 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0214368A3

公开(公告)日：2003-09-25

申请号：PCT/US0125624

申请日：2001-08-16

Applicant: CURAGEN CORP ,  ZERHUSEN BRYAN D ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A ,  SPADERNA STEVEN K ,  GANGOLII ESHA A ,  RASTELLI LUCA ,  BURGESS CATHERINE E ,  MAJUMDER KUMUD ,  SHIMKETS RICHARD ,  MISHRA VISHNU ,  VERNET CORINE A M ,  SZEKERES EDWARD S ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LIU XIAOHONG ,  GERLACH VALERIE L ,  ELLERMAN KAREN ,  SMITHSON GLENNDA ,  PEYMAN JOHN ,  STONE DAVID ,  MACDOUGALL JOHN

Inventor： ZERHUSEN BRYAN D ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A ,  SPADERNA STEVEN K ,  GANGOLII ESHA A ,  RASTELLI LUCA ,  BURGESS CATHERINE E ,  MAJUMDER KUMUD ,  SHIMKETS RICHARD ,  MISHRA VISHNU ,  VERNET CORINE A M ,  SZEKERES EDWARD S ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LIU XIAOHONG ,  GERLACH VALERIE L ,  ELLERMAN KAREN ,  SMITHSON GLENNDA ,  PEYMAN JOHN ,  STONE DAVID ,  MACDOUGALL JOHN

IPC: A61K38/00 ,  A61K48/00 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/68 ,  A61K39/00 ,  C07K16/18 ,  C12N9/64 ,  C12N15/11 ,  C12N15/63 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/6886

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research method for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003076578A3

公开(公告)日：2003-09-18

申请号：PCT/US2003/006794

申请日：2003-03-06

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHAUDHURI, Amitabha ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  LI, Li ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John ,  QIAN, Xiazhong ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SUKUMARAN, Sujatha ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHAUDHURI, Amitabha ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  LI, Li ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel, M. ,  MEZES, Peter, S. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John ,  QIAN, Xiazhong ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SUKUMARAN, Sujatha ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

IPC: C07K14/435 ,  C07H21/04 ,  C12P21/02 ,  C12N15/00 ,  C12N5/00 ,  C12N1/21

Abstract: The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.

公开(公告)号：WO02079398A3

公开(公告)日：2003-08-21

申请号：PCT/US0207355

申请日：2002-03-08

Applicant: CURAGEN CORP ,  KEKUDA RAMESH ,  TCHERNEV VELIZAR T ,  LIU XIAOHONG ,  SPYTEK KIMBERLY A ,  PATTURAJAN MEERA ,  BURGESS CATHERINE E ,  VERNET CORINE A M ,  LI LI ,  GORMAN LINDA

Inventor： KEKUDA RAMESH ,  TCHERNEV VELIZAR T ,  LIU XIAOHONG ,  SPYTEK KIMBERLY A ,  PATTURAJAN MEERA ,  BURGESS CATHERINE E ,  VERNET CORINE A M ,  LI LI ,  GORMAN LINDA

IPC: A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12N15/63 ,  A61K38/16 ,  C07K14/00

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Diclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclodes therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文中所述的是编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体突变体或片段。 本发明进一步揭示用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。