公开(公告)号：KR1020140038324A

公开(公告)日：2014-03-28

申请号：KR1020130111137

申请日：2013-09-16

Applicant: (주)셀트리온

Inventor： 박영준 ,  정진교 ,  최영미 ,  이민섭 ,  최준헌 ,  조은주 ,  송현남 ,  박성준 ,  이종협 ,  홍승서

IPC: C07D207/12 ,  A61K31/4015 ,  A61P35/00

CPC classification number: C07K7/06 ,  A61K31/40 ,  A61K31/421 ,  A61K31/426 ,  A61K38/00 ,  C07D207/12 ,  C07D401/12 ,  C07D409/12 ,  C07K5/0205 ,  C07K5/06052

Abstract: The present invention provides a dolastatin-10 derivative having excellent anticancer activity, a method for manufacturing the same, and an anticancer drug composition comprising the same as an active ingredient. The dolastatin-10 derivative of the present invention is a novel synthetic compound which can be used for treating a tumor, slowing growth of tumors, and preventing an increase in number of tumors. For example, the dolastatin-10 derivative is effective to inhibit or prevent the growth of tumor in permalignant and malignant cells.

Abstract translation: 本发明提供具有优异的抗癌活性的多拉司他汀-10衍生物，其制造方法和包含该组合物作为活性成分的抗癌药物组合物。 本发明的多拉司他汀-10衍生物是可用于治疗肿瘤，减缓肿瘤生长和防止肿瘤数量增加的新型合成化合物。 例如，多拉司他汀-10衍生物可有效抑制或阻止去角质和恶性细胞中肿瘤的生长。