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公开(公告)号：KR1020170035771A
公开(公告)日：2017-03-31
申请号：KR1020160104381
申请日：2016-08-17
Applicant: (주)아모레퍼시픽
IPC: A61K36/258 , A61K8/97 , A23L1/30 , A61Q19/02
CPC classification number: A61K8/97 , A61K36/258 , A61Q19/02
Abstract: 본명세서에는인삼유래의엑소좀유사베지클을포함하는미백용조성물및 상기인삼유래의엑소좀유사베지클을제조하는방법이개시된다. 상기인삼유래의엑소좀유사베지클은 20 내지 500 nm의직경을가진것일수 있고, 인삼뿌리에서분리된것일수 있다. 상기조성물은인삼유래의엑소좀유사베지클을유효성분으로포함함으로써, 멜라닌생성을효과적으로억제하여기미, 주근깨, 흑색점, 모반, 흑색종등 피부색소침착질환을예방, 개선또는치료하는효과가있다.
Abstract translation: 在本说明书中，公开了包含人参来源的外泌体样囊泡的增白组合物和来自人参的外泌体样囊泡的制备方法。 源自人参的外泌体样囊泡可以具有20-500nm的直径，并且可以从人参根分离。 该组合物是有效的斑，雀斑，黑点，痣，黑色素瘤，皮肤色素沉着疾病的预防，改善或治疗由包括较大的比特外人参起源相似贝塞尔作为有效的活性成分抑制黑色素生成 。
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公开(公告)号：KR1020140145479A
公开(公告)日：2014-12-23
申请号：KR1020130067976
申请日：2013-06-13
Applicant: (주)아모레퍼시픽
IPC: A61K31/7034 , A61K8/73 , A61P17/00 , A61Q19/02
CPC classification number: A61K31/7034 , A61K8/602 , A61Q19/02
Abstract: 본 발명은 아카르보스(Acarbose)를 유효성분으로 함유하는 조성물에 관한 것으로, 보다 구체적으로는 아카르보스를 유효성분으로 함유하여 피부의 멜라닌 생성을 억제함으로써 피부 미백 효과를 나타내는 피부 미백용 조성물에 관한 것이다.
Abstract translation: 本发明涉及含有阿卡波糖作为活性成分的组合物，更具体地说，涉及含有阿卡波糖作为有效成分的皮肤美白组合物，以抑制皮肤中黑色素的产生，从而呈现皮肤美白效果。
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公开(公告)号：KR1020140052569A
公开(公告)日：2014-05-07
申请号：KR1020120118765
申请日：2012-10-25
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition comprising cellobiose as an active ingredient, and more specifically, to a skin external application composition for skin whitening which contains cellobiose as an active ingredient thereby inhibiting melanin production of skin and accordingly having a skin whitening effect.
Abstract translation: 本发明涉及包含纤维二糖作为活性成分的组合物，更具体地说，涉及含有纤维二糖作为活性成分的皮肤外用施用组合物，从而抑制皮肤的黑色素生成并因此具有皮肤美白效果。
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公开(公告)号：KR1020130000039A
公开(公告)日：2013-01-02
申请号：KR1020110060484
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61Q7/00 , A61Q19/00 , C12Q1/68
CPC classification number: C12N15/1136 , A61Q7/00 , A61Q19/00 , C12Q1/6813 , C12Q2600/148 , C12Q2600/158 , C12Q2600/178
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules is provided to regulate the expression of tyrosinase-related proteins, PAX3, and melan-A. CONSTITUTION: A composition for regulating the expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected from bases of sequence number 1 and is selected among oligonucleic acid molecules with 15-23 continuous base sequences. The composition is a cosmetic or pharmaceutical composition for generating black hair or preventing grey hair. The pigmentation-related gene expresses PAX3, tyrosinase-related protein 1, or melan-A. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA或反义核酸分子的组合物，以调节酪氨酸酶相关蛋白（PAX3）和黑色素A的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基，并且选自具有15-23个连续碱基序列的寡核酸分子。 该组合物是用于产生黑发或防止灰白头发的化妆品或药物组合物。 色素沉着相关基因表达PAX3，酪氨酸酶相关蛋白1或黑色素A。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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Patent Agency Ranking
公开(公告)号：KR101800243B1
公开(公告)日：2017-12-20
申请号：KR1020110060484
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61Q7/00 , A61Q19/00 , C12Q1/68
Abstract: 본발명은서열번호 1의 miRNA 또는서열번호 2인안티센스핵산분자를유효성분으로포함하는백모방지및 흑모생성또는피부미백효과조성물을제공한다. 또한, 본발명은시험물질에대한색소형성유전자의발현조절물질을스크리닝하는방법으로서, 서열번호 1의 miRNA 또는서열번호 2인안티센스핵산분자를세포에트랜스펙션시키는단계; 상기세포에시험물질을처리하는단계; 및상기시험물질이색소형성유전자의발현을촉진하는지또는억제하는지여부를확인하는단계;를포함하는것을특징으로하는색소형성유전자의발현조절물질스크리닝방법을제공한다.
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公开(公告)号：KR1020170003000A
公开(公告)日：2017-01-09
申请号：KR1020150093049
申请日：2015-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K31/4178 , A61K31/18 , A61K8/49 , A61K8/46 , A61K8/42 , A61K9/20 , A61K9/48 , A61K47/38 , A61Q19/02 , G01N33/50
CPC classification number: A61K8/494 , A61K8/42 , A61K8/46 , A61K8/49 , A61K9/20 , A61K9/48 , A61K31/18 , A61K31/4178 , A61K47/38 , A61Q19/02 , G01N33/50 , G01N33/5044
Abstract: 본명세서에는멜라닌형성세포에서분비되는엑소좀의분비제어를통해피부미백에효능이있는피부미백용조성물및 피부미백효능물질을스크리닝하는방법이개시된다. 상기피부미백용조성물은멜라닌형성세포에서분비되는엑소좀의분비량을억제시킴으로써멜라닌형성세포의세포사멸을증가시킬수 있고, 이러한멜라닌형성세포의세포사멸로인해결과적으로멜라닌생성을저해하여미백효능이발휘되는효과가있다.
Abstract translation: 在本说明书中公开的是：通过控制从黑素细胞分泌的外来体的分泌而具有皮肤美白效果的皮肤美白组合物; 以及用于筛选具有皮肤美白效果的材料的方法。 皮肤美白组合物可以通过抑制从黑素细胞分泌的外来体的分泌量来促进黑素细胞的凋亡，从而通过黑素细胞的凋亡抑制黑色素的产生，从而呈现皮肤美白效果。
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公开(公告)号：KR1020140027782A
公开(公告)日：2014-03-07
申请号：KR1020120093805
申请日：2012-08-27
Applicant: (주)아모레퍼시픽
Abstract: Novel melanoblast is disclosed in the present invention. A production method of the novel melanoblast is also disclosed in the present invention. Specifically, the present invention provides the novel melanoblast which has different gene expression, melanin content, tyrosinase activity, and protein expression compare to existing melanocyte. The present invention also provides the production method of the novel melanoblast for producing melanoblast from the culturing of keratinocyte. [Reference numerals] (AA) After the separation of cultured epithelial cells; (BB) In a PMA- medium; (CC) In a PMA+ medium
Abstract translation: 本发明公开了新型黑素细胞。 本发明还公开了新型黑色素细胞的制造方法。 具体地说，本发明提供与现有黑素细胞相比，具有不同基因表达，黑色素含量，酪氨酸酶活性和蛋白质表达的新型黑素细胞。 本发明还提供了用于从培养角化细胞产生黑素细胞的新型黑素细胞的制备方法。 （附图标记）（AA）培养的上皮细胞分离后; （BB）在PMA-介质中; （CC）在PMA +培养基中
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公开(公告)号：KR1020130131628A
公开(公告)日：2013-12-04
申请号：KR1020120055319
申请日：2012-05-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/4926 , A61K9/0014 , A61K31/445 , A61Q19/02
Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2
Abstract translation: 本发明涉及一种用于皮肤美白的组合物，其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成，从而表现出美白效果。 （AA）比较例1（BB）实施例1（CC）实施例2
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公开(公告)号：KR1020130128907A
公开(公告)日：2013-11-27
申请号：KR1020120053095
申请日：2012-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/133 , A23L29/035 , A23L29/045 , A23V2200/318 , A61K8/41 , A61Q19/02
Abstract: The present invention relates to a whitening composition which suppresses or prevents melanogenesis and, particularly, to a composition containing valiolamine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明涉及抑制或预防黑素生成的增白组合物，特别涉及包含化学式1的缬草烯胺衍生物或其药学上可接受的盐作为活性成分的组合物。
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