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公开(公告)号：KR1020170062868A
公开(公告)日：2017-06-08
申请号：KR1020150168593
申请日：2015-11-30
Applicant: (주)아모레퍼시픽
IPC: A61K48/00 , A61K31/713 , A61K9/127 , A61K9/00 , G01N33/50
Abstract: 본명세서는 ENTPD4의발현또는활성억제제를유효성분으로포함하는흑색종예방또는치료용조성물에관한것으로, 상기 ENTPD4의발현또는활성억제제는 ENTPD4 유전자의적어도일부에결합하는올리고뉴클레오티드이며, 구체적으로 siRNA, shRNA 및 miRNA 중어느하나이상일수 있으며, 또한, 본명세서는시험물질에대한흑색종예방및 치료물질을스크리닝하는방법을제공한다.
Abstract translation: 本文涉及用于黑素瘤预防或治疗，其包括用于所述ENTPD4表达或活性抑制剂作为活性成分的，表达或活性抑制剂用于ENTPD4的组合物是结合ENTPD4基因的至少一部分的寡核苷酸，具体地，siRNA的， shRNA和miRNA，并且本公开还提供了用于筛选用于测试剂的黑素瘤预防剂和治疗剂的方法。
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公开(公告)号：KR1020140057054A
公开(公告)日：2014-05-12
申请号：KR1020120123693
申请日：2012-11-02
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K48/00 , A61K31/7105 , G01N33/15
Abstract: Disclosed are isolated miRNA nucleic acid molecules comprising SEQ ID No. 1 or SEQ ID No. 2; a fragment or an analog thereof having hybridization ability of the miRNA to regulate expression of one or more of keratin 1 and keratin 10; or a skin external application composition comprising the same. In one aspect of the present invention, disclosed is a method of screening a keratogenesis regulatory substance using the miRNA nucleic acid molecules, or the fragment or the analog thereof.
Abstract translation: 公开了包含SEQ ID No.1或SEQ ID No.2的分离的miRNA核酸分子; 其具有miRNA调节角蛋白1和角蛋白10中的一种或多种的表达的杂交能力的片段或类似物; 或包含其的皮肤外用施用组合物。 在本发明的一个方面，公开了使用miRNA核酸分子或其片段或类似物筛选角化生成调节物质的方法。
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公开(公告)号：KR1020130000039A
公开(公告)日：2013-01-02
申请号：KR1020110060484
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61Q7/00 , A61Q19/00 , C12Q1/68
CPC classification number: C12N15/1136 , A61Q7/00 , A61Q19/00 , C12Q1/6813 , C12Q2600/148 , C12Q2600/158 , C12Q2600/178
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules is provided to regulate the expression of tyrosinase-related proteins, PAX3, and melan-A. CONSTITUTION: A composition for regulating the expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected from bases of sequence number 1 and is selected among oligonucleic acid molecules with 15-23 continuous base sequences. The composition is a cosmetic or pharmaceutical composition for generating black hair or preventing grey hair. The pigmentation-related gene expresses PAX3, tyrosinase-related protein 1, or melan-A. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA或反义核酸分子的组合物，以调节酪氨酸酶相关蛋白（PAX3）和黑色素A的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基，并且选自具有15-23个连续碱基序列的寡核酸分子。 该组合物是用于产生黑发或防止灰白头发的化妆品或药物组合物。 色素沉着相关基因表达PAX3，酪氨酸酶相关蛋白1或黑色素A。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR1020130000038A
公开(公告)日：2013-01-02
申请号：KR1020110060483
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/11 , A61K31/7105 , A61P17/14 , A61Q19/02
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules for preventing grey hair or improving a skin whitening effect is provided to regulate the expression of genes expressing tyrosinase, tyrosinase-related proteins, and melan-A. CONSTITUTION: A composition for regulating the expression of pigmentation-related genes contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among base sequences of sequence number 1, and contains 15-22 continuous base sequences including ugaaaug. The pigmentation-related genes express tyrosinase, tyrosinase-related protein 1, or melan-A. A method for screening a material which regulates the expression of the pigmentation-related genes among test materials comprises: a step of transfectioning the miRNA of sequence number 1 or antisense nucleic acid molecules of sequence number 2 into cells; a step of treating the test materials to the cells; and a step of identifying if the test materials promote or suppress the expression of the pigmentation-related genes. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有用于预防灰白发或改善皮肤美白效果的miRNA或反义核酸分子的组合物，以调控表达酪氨酸酶，酪氨酸酶相关蛋白和黑色素A的基因的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基序列，并且包含15-22个连续碱基序列，包括ugaaaug。 色素沉着相关基因表达酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A。 用于筛选调节试验材料中色素沉着相关基因表达的材料的方法包括：将序列号1的miRNA或序列号2的反义核酸分子转染入细胞的步骤; 将测试材料处理到细胞的步骤; 以及鉴定测试物质是否促进或抑制色素沉着相关基因表达的步骤。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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Patent Agency Ranking
公开(公告)号：KR1020110129275A
公开(公告)日：2011-12-01
申请号：KR1020100048820
申请日：2010-05-25
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K36/185 , A61Q19/00 , C12N5/077
Abstract: PURPOSE: A composition for promoting the differentiation of human mesenchymal stem cells to adipocytes, containing Sterculiae scaphigerae semen extract, is provided to enhance the volume and elasticity of skin. CONSTITUTION: An external use skin composition for promoting the differentiation of adipocytes contains 0.0001-30 wt% of Sterculiae scaphigerae semen extract as an active ingredient. The mesenchymal stem cell is derived from humans. A pharmaceutical composition for promoting the differentiation into adipocytes contains Sterculiae scaphigerae semen extract as an active ingredient. The dose of the extract is 0.001mg/kg/day-2000mg/kg/day.
Abstract translation: 目的：提供一种用于促进人类间充质干细胞分化为脂肪细胞的组合物，其含有Sterculiae scaphigerae精液提取物，以增强皮肤的体积和弹性。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的白e精液提取物作为活性成分。 间充质干细胞来源于人类。 用于促进分化成脂肪细胞的药物组合物含有仙人掌精液提取物作为活性成分。 提取物的剂量为0.001mg / kg /天-2000mg / kg /天。
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公开(公告)号：KR101871920B1
公开(公告)日：2018-07-02
申请号：KR1020170098819
申请日：2017-08-04
Applicant: (주)아모레퍼시픽
IPC: A61K8/60 , C12N15/113 , A61Q19/02
Abstract: 본발명의서열번호 1의 miRNA는 has-miR-1248의모방체로서, has-miR-1248의발현에대한촉진제로사용되어색소형성유전자인티로시나아제, 티로시나아제관련단백질 1, 멜란-A의발현을억제하여피부미백효과를제공할수 있으며, 서열번호 2의 miRNA는상기서열번호 1의 miRNA에대한안티센스핵산분자로서 has-miR-1248의발현에대한억제제로사용되어색소형성유전자인티로시나아제, 티로시나아제관련단백질 1, 멜란-A의발현을촉진시켜백모방지또는흑모생성효능을제공할수 있다. 또한, 본발명의서열번호 1의 miRNA는 has-miR-1248의발현에대한촉진제로사용되어진피세포재생조절유전자인트로포미오신 3과아그레칸의발현을억제하여우수한진피세포재생효과를제공할수 있다.
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公开(公告)号：KR101849102B1
公开(公告)日：2018-04-17
申请号：KR1020110060483
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/11 , A61K31/7105 , A61P17/14 , A61Q19/02
Abstract: 본발명은서열번호 1의 miRNA 또는서열번호 2인안티센스핵산분자를유효성분으로포함하는백모방지및 흑모생성또는피부미백효과조성물을제공한다. 또한, 본발명은시험물질에대한색소형성유전자의발현조절물질을스크리닝하는방법으로서, 서열번호 1의 miRNA 또는서열번호 2인안티센스핵산분자를세포에트랜스펙션시키는단계; 상기세포에시험물질을처리하는단계; 및상기시험물질이색소형성유전자의발현을촉진하는지또는억제하는지여부를확인하는단계;를포함하는것을특징으로하는색소형성유전자의발현조절물질스크리닝방법을제공한다.
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公开(公告)号：KR102027451B1
公开(公告)日：2019-10-02
申请号：KR1020120123693
申请日：2012-11-02
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K31/7105 , G01N33/50
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