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公开(公告)号：KR1020080054955A
公开(公告)日：2008-06-19
申请号：KR1020060127701
申请日：2006-12-14
Applicant: 고려대학교 산학협력단
Abstract: A polydiacetylene sensor chip comprising protein is provided to detect rapidly protein-protein or protein-cell reaction without labeling of the subject to be analyzed, and reduce the amount of polydiacetylene and subject to be analyzed. A polydiacetylene sensor chip comprises a substrate, a vesicle bound to the substrate and having polymerized diacetylene represented by the formula(1): A-(L1)d-(CH2)e-C=C-C=C-(CH2)f-(L2)g-B, and a probe protein bound to the vesicle, wherein a sum d and g is 0, 1 or 2; a sum of e and f is an integer from 2 to 50; e and f are each independently an integer of 1 or more; A and B are each independently methyl group, amine group, carboxyl group, hydroxyl group, maleimide group, biotin group, hydroxysuccinimide group, benzoic acid group or ester group; and L1 and L2 are each independently alkyl group having carbon number of 2 or more, at least one ethylene oxide group, amine group, amide group, ester group or carbonyl group.
Abstract translation: 提供了包含蛋白质的聚二乙炔传感器芯片，用于快速检测蛋白质 - 蛋白质或蛋白质 - 细胞反应，而不需要分析对象的标记，并减少聚二乙炔的量并进行分析。 聚二乙炔传感器芯片包括基底，与基底结合并具有由式（1）表示的聚合的二乙炔的囊泡：A-（L1）d-（CH2）eC = CC = C-（CH2）f-（L2） gB和与小泡结合的探针蛋白，其中和d和g为0,1或2; e和f之和为2至50的整数; e和f各自独立地为1或更大的整数; A和B各自独立地为甲基，胺基，羧基，羟基，马来酰亚胺基，生物素基，羟基琥珀酰亚胺基，苯甲酸基或酯基; 且L1和L2各自独立地为碳数为2以上的烷基，至少一个环氧乙烷基，胺基，酰胺基，酯基或羰基。
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公开(公告)号：KR101852440B1
公开(公告)日：2018-04-27
申请号：KR1020100115854
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , C12N5/071 , A61K31/7105 , C12Q1/68
Abstract: 본발명은서열번호 1의염기서열을포함하는 7 내지 25 개의연속염기서열을포함하는 DUOX 2의 miRNA 분자또는그 모방체(mimic)를유효성분으로포함하는피부세포분화조절용조성물을개시한다. 또한본 발명은서열번호 3의염기서열을포함하는 7 내지 25 개의연속염기서열을포함하는 DUOX 2의 miRNA 저해제를유효성분으로포함하는피부세포분화조절용조성물을개시한다.
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13.发明授权꽃가루, 집먼지 진드기 또는 황사에 의한 피부 유해반응을 스크리닝하는 방법 및 이를 조절하는 피부 외용제 조성물 有权筛选花粉粉尘螨或黄沙尘的皮肤有害反应的方法以及皮肤外用应用控制反应的组成
公开(公告)号：KR101601865B1
公开(公告)日：2016-03-09
申请号：KR1020080119483
申请日：2008-11-28
Applicant: (주)아모레퍼시픽
Abstract: 본발명은꽃가루, 집먼지진드기또는황사와같은환경유해인자에의하여발현량이변화하는유전자를스크리닝함으로써피부자극을유도하는데관여하는물질또는이를억제하는물질, 피부자극을완화시키는물질을스크리닝하는방법, 및고련피와관동화추출물중 1종이상을유효성분으로함유하여꽃가루, 집먼지진드기또는황사에의한피부유해영향을완화하며독소를해독하고배출하는피부외용제조성물에관한것이다.
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公开(公告)号：KR1020120088896A
公开(公告)日：2012-08-09
申请号：KR1020100115854
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , C12N5/071 , A61K31/7105 , C12Q1/68
CPC classification number: C12N15/113 , A61K31/7105 , C12N5/0625 , C12Q1/68 , C12Q2600/158 , C12Q2600/178
Abstract: PURPOSE: A composition containing miRNA molecule or mimic of DUOX2 for controlling skin cell differentiation is provided to regulate DUOX2, filagrin, loricrin, keratin 1, and keratin 10 genes. CONSTITUTION: A composition for controlling skin cell differentiation contains miRNA molecule or mimic of DUOX2 having 7-25 bases with a base sequence of sequence number 1. The miRNA molecule or mimic targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition promotes skin cell differentiation. A miRNA inhibitor of DUOX2 targets 1358th to 1364th nucleic acids of DUOX2 mRNA 3'-UTR. The composition suppresses skin cell differentiation. The skin cell is keratinocytes.
Abstract translation: 目的：提供含有miRNA分子或模拟DUOX2用于控制皮肤细胞分化的组合物，用于调节DUOX2，丝胶蛋白，氯氰菊酯，角蛋白1和角蛋白10基因。 构成：用于控制皮肤细胞分化的组合物包含miRNA分子或具有7-25个碱基的DUOX2的模拟物，其碱基序列为序列号1. miRNA分子或模拟物靶向DUOX2 mRNA 3'-UTR的第1358至第1364位核酸。 该组合物促进皮肤细胞分化。 DUOX2的miRNA抑制剂靶向DUOX2 mRNA 3'-UTR的1358至1364位核酸。 该组合物抑制皮肤细胞分化。 皮肤细胞是角质细胞。
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公开(公告)号：KR1020100025070A
公开(公告)日：2010-03-09
申请号：KR1020080083683
申请日：2008-08-27
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition for suppressing differentiation and growth of adipocytes is provided to treat or prevent circulatory system disease or ischemic heart disease. CONSTITUTION: A composition for suppressing differentiation or growth of adipocytes contains 0.00001 to 15 weight% of chemerin. The adipocyte is human bone marrow mesenchymal stem cell. A pharmaceutical composition is used in the form of oral administration formulation or injection. The oral administration formulation is formulated in capsule, tablet, suspension, syrup or powder. A functional health food composition for preventing or treating diabetes, hyperlipidemia, hypercholesterolemia, circulatory system diseases contains 0.00001-10 weight% of chemerin. The health food is used in the form of caramel, chocolate, diet bar or snack. A cosmetic composition for treating obesity contains 0.00001-10 weight% of chemerin as an active ingredient. The cosmetic composition is used in the form of massage cream, body lotion, body cream, body oil, or body essence.
Abstract translation: 目的：提供一种抑制脂肪细胞分化和生长的组合物，用于治疗或预防循环系统疾病或缺血性心脏病。 构成：用于抑制脂肪细胞分化或生长的组合物含有0.00001〜15重量％的凯美宾。 脂肪细胞是人骨髓间充质干细胞。 药物组合物以口服给药制剂或注射剂的形式使用。 口服给药制剂配制成胶囊，片剂，悬浮液，糖浆或粉剂。 用于预防或治疗糖尿病，高脂血症，高胆固醇血症，循环系统疾病的功能保健食品组合物含有0.00001-10重量％的凯美瑞。 保健食品以焦糖，巧克力，饮食酒吧或小吃的形式使用。 用于治疗肥胖的化妆品组合物含有0.00001-10重量％的作为活性成分的凯美瑞。 化妆品组合物以按摩霜，身体乳液，身体霜，身体油或身体精华的形式使用。
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Patent Agency Ranking
公开(公告)号：KR1020170117840A
公开(公告)日：2017-10-24
申请号：KR1020160045790
申请日：2016-04-14
Applicant: (주)아모레퍼시픽
Abstract: 본발명은맞춤형피부진단및 관리시스템에관한것으로서, 본발명의일 실시예에따른맞춤형피부진단및 관리시스템은, 피부상태측정부에서피부상태를측정하여, 탄력, 보습, 색소, 항산화및 민감도로이루어진군 중에서선택된하나이상의카테고리별피부상태정보를산출하는피부상태측정제어부; 데이터베이스또는유전자측정부로부터의피험자의유전자정보에기초하여상기카테고리별피부상태변화예측정보를산출하는피부상태예측제어부; 및상기피부상태측정제어부및 피부상태예측제어부로부터의피부상태정보및 피부상태변화예측정보에기초하여, 현재의피부상태및 변화추이에대한피부진단정보및 이에대한피부관리정보를산출하여제공하는피부진단및 관리정보제공부를포함한다.
Abstract translation: 本发明涉及一种个性化皮肤诊断和管理系统，定制的皮肤诊断和控制系统在根据本发明的一个实施例中，通过在皮肤状态测量部，弹性，保湿，颜色，抗氧化剂和灵敏度测量皮肤状态 皮肤状态测量控制单元，用于计算从由以下组成的组中选择的至少一个类别的皮肤状态信息; 皮肤状态预测控制单元，用于基于来自数据库或基因测量单元的对象的基因信息，计算每个类别的皮肤状态变化预测信息; 和皮肤诊断，基于该皮肤状态测量控制和皮肤状况预测控制robuteoui皮肤状况的信息，以及皮肤状况改变预测信息，通过计算在此为当前皮肤状态和趋势的皮肤诊断和皮肤护理信息提供 和管理信息提供单元。
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公开(公告)号：KR101785347B1
公开(公告)日：2017-10-17
申请号：KR1020100115853
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158
Abstract: 본발명은피부세포에시험물질을처리하는단계; 및상기단계의시험물질을처리한피부세포에서 DUOX 1 유전자의상대적발현정도를확인하는단계를포함하는피부세포분화촉진물질스크리닝방법을개시한다. 또한피부세포에서의 DUOX 1 유전자상대적발현정도를확인할수 있는장치를포함하는피부세포분화촉진물질스크리닝키트를개시한다. 그리고 DUOX 1 유전자의발현을증가시키는물질을유효성분으로포함하는피부세포분화촉진, 피부보습, 피부장벽기능강화또는아토피증상경감또는치료용조성물을개시한다.
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公开(公告)号：KR1020120088895A
公开(公告)日：2012-08-09
申请号：KR1020100115853
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , A61K8/00 , G01N33/15
Abstract: PURPOSE: A method and a kit for screening a material which promotes skin cell differentiation is provided to quickly and simply screen the material. CONSTITUTION: A method for screening a material which promotes skin cell differentiation comprises: a step of treating a test material to skin cells; a step of identifying relative expression level of DUOX1(dual oxidase 1) gene(Genebank Accession No.: NM_017434) in the skin cells; and a step of determining a material which enhances the expression level is the material which promotes skin cell differentiation. The skin cells are keratinocytes. A composition for skin moisturizing, skin barrier function strengthening, or atopic dermatitis relief contains the material as an active ingredient.
Abstract translation: 目的：提供一种用于筛选促进皮肤细胞分化的材料的方法和试剂盒，以快速简便地筛选材料。 构成：筛选促进皮肤细胞分化的材料的方法包括：将测试材料处理至皮肤细胞的步骤; 识别皮肤细胞中DUOX1（双重氧化酶1）基因（Genebank登录号：NM_017434）的相对表达水平的步骤; 并且确定增强表达水平的材料的步骤是促进皮肤细胞分化的材料。 皮肤细胞是角质形成细胞。 用于皮肤保湿，皮肤屏障功能增强或特应性皮炎缓解的组合物含有作为活性成分的材料。
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公开(公告)号：KR1020110056820A
公开(公告)日：2011-05-31
申请号：KR1020090113295
申请日：2009-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q17/04 , A61K8/37 , A61K8/4946
Abstract: PURPOSE: A composition containing octyl salicylate or phenylbenaimidazole sulfonic acid is provided to effectively block UVC and UVB. CONSTITUTION: A composition for blocking UVC contains one or more selected from the group consisting of octyl salicylate or phenylbenzimidazole sulfonic acid as an active ingredient. The composition is used in the form of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, foundation, oil-in-water, or water-in-oil. The maximum absorbance is in the wavelength of 200-290 nm.
Abstract translation: 目的：提供含有辛基水杨酸酯或苯乙咪唑磺酸的组合物，以有效阻断UVC和UVB。 构成：用于封闭UVC的组合物含有选自水杨酸辛酯或苯基苯并咪唑磺酸作为活性成分的一种或多种。 该组合物以溶液，悬浮液，乳液，糊剂，凝胶，霜剂，洗剂，粉末，肥皂，含表面活性剂的清洁剂，油，粉底液，水包油或油包水的形式使用。 最大吸光度为200-290nm波长。
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