-
公开(公告)号：KR1020080062092A
公开(公告)日：2008-07-03
申请号：KR1020060137422
申请日：2006-12-29
Applicant: (주)차바이오텍
IPC: C08B37/08
CPC classification number: C08B37/0072 , A61K31/728
Abstract: A method for preparing hyaluronic acid derivatives is provided to produce three-dimensionally porous hyaluronic acid derivatives having characteristics usable as a cell delivery carrier through wet spinning. A method for preparing hyaluronic acid derivatives includes a step of producing the derivatives of hyaluronic acid or salts thereof having excellent biocompatibility and biodegradability usable as a cell delivery carrier of a cell treatment agent comprising stem cells through wet spinning. The biocompatible hyaluronic acid threads by wet spinning are produced by using a proper mixture solution of dimethylsulfoxide and distilled water as a solvent of a spinning solution for the hyaluronic acid or salt thereof, and using ethanol, dimethylformamide, or a mixture solution thereof as a solidifying solvent.
Abstract translation: 提供了一种制备透明质酸衍生物的方法，以制备具有通过湿纺丝可用作细胞递送载体的特征的三维多孔透明质酸衍生物。 制备透明质酸衍生物的方法包括制备具有优异生物相容性和生物降解性的透明质酸衍生物或其盐作为包含干细胞的细胞处理剂通过湿法纺丝的细胞递送载体的步骤。 通过使用二甲基亚砜和蒸馏水的合适的混合溶液作为透明质酸或其盐的纺丝溶液的溶剂，通过使用乙醇，二甲基甲酰胺或其混合溶液作为凝固剂，制备湿纺丝的生物相容性透明质酸线 溶剂。
-
公开(公告)号：KR101340478B1
公开(公告)日：2013-12-11
申请号：KR1020110094598
申请日：2011-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
Abstract: 본 발명은 누에 실샘 초미세분말유래 수용성 세리신을 이용한 화장료 조성물 에 관한 것이다.
본 발명의 누에 실샘 초미세분말유래 수용성 세리신을 이용한 화장료 조성물은, 누에를 동결건조하여 실샘을 분리하고 그 분리된 실샘을 물로 용해한 후, 원심분리하여 얻은 상등액에, 알칼리를 첨가한 후 가수분해한 다음 중화 및 탈염과정을 거쳐 얻은 세리신을 포함한다.
본 발명에 의해, 인체 무해하면서 항산화능, 피부세포증식능, 피부 친화력 등이 우수한 누에 실샘 초미세분말유래 수용성 세리신을 이용한 화장료 조성물이 제공된다.-
13.发明授权
公开(公告)号：KR101298012B1
公开(公告)日：2013-08-26
申请号：KR1020110010942
申请日：2011-02-08
Applicant: (주)차바이오텍
IPC: A61K39/00 , C07K16/32 , C12N5/0783
CPC classification number: A61K39/0011 , A61K2039/505 , A61K2039/5158 , C07K16/32 , C07K2317/24 , C12N5/0646
Abstract: 본 발명은 면역글로불린 G 존재하에서 단핵구 세포를 배양함으로써 인터페론-γ 생성능이 현저하게 증가된 NK 세포를 포함하는 림프구에 항-HER2/neu 항체를 결합시킴으로써, 유방암, 난소암 등의 HER2/neu 항원을 발현하는 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 암세포 표적지향을 위한 약학 조성물을 제공한다.
-
公开(公告)号：KR1020130030968A
公开(公告)日：2013-03-28
申请号：KR1020110094598
申请日：2011-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
Abstract: PURPOSE: A cosmetic composition using water soluble sericin which is derived from silkworm grand ultrafine powder is provided to ensure excellent antioxidation, skin cell proliferation ability, and skin affinity. CONSTITUTION: A cosmetic composition contains 0.001-50 wt% of water soluble sericin which is derived from silkworm grand ultrafine powder. A method for preparing sericin comprises: a step of freeze-drying silkworm and isolating silkworm grand; a step of dissolving the silkworm grand in water and centrifuging to collect a supernatant; a step of adding alkali to the supernatant and hydrolyzing; and a step of neutralizing and desalting.
Abstract translation: 目的：提供使用由蚕丝超细粉衍生的水溶性丝胶蛋白的化妆品组合物，以确保优异的抗氧化，皮肤细胞增殖能力和皮肤亲和力。 构成：化妆品组合物含有0.001-50重量％的来自蚕质超细粉末的水溶性丝胶蛋白。 一种制备丝胶蛋白的方法，包括：将蚕冷冻干燥并隔离蚕茧的步骤; 将蚕桑溶解在水中并离心收集上清液的步骤; 向上清液中加入碱水解水解步骤; 和中和和脱盐的一步。
-
公开(公告)号：KR1020110138765A
公开(公告)日：2011-12-28
申请号：KR1020100058843
申请日：2010-06-22
Applicant: (주)차바이오텍
CPC classification number: A61L27/3625 , A61L27/20 , A61L27/60 , C08B37/003 , C12N5/0653
Abstract: PURPOSE: A composite filler is provided to not disassembled in the skin tissue for long time and generate a collagen tissue by SVF cell originated from human adipose tissue. CONSTITUTION: A composite filler comprises a human adipose tissue-derived stromal vascular cell and hyaluronic acid derivative. The hyaluronic acid derivative is cross-linked hyaluronic acid derivative by using 1,4-butanediol diglycidyl ether. The content of the human adipose tissue-derived stromal vascular cell is 106/ml - 108/ml.
Abstract translation: 目的：提供复合填料长期在皮肤组织中不分解，并由源自人类脂肪组织的SVF细胞产生胶原组织。 构成：复合填料包含人脂肪组织来源的基质血管细胞和透明质酸衍生物。 透明质酸衍生物是使用1,4-丁二醇二缩水甘油醚的交联透明质酸衍生物。 人脂肪组织来源的基质血管细胞的含量为106 / ml-108 / ml。
-
Patent Agency Ranking
公开(公告)号：KR1020100089391A
公开(公告)日：2010-08-12
申请号：KR1020090008608
申请日：2009-02-03
Applicant: (주)차바이오텍
Abstract: PURPOSE: A novel transformation system in Sebekia benihana is provided to express homo or hetero protein or polypeptide and to transform physiologically active material. CONSTITUTION: A method for transforming Sebekia benihana strain comprises: a step of culturing Sebekia benihana for 3-7 days to form spore; a step of performing heat shock at 40-60 °C fkor 15-25 minutes and inducing germination of mycelium; a step of cooling at room temperature; a step of preparing transformed E.coli with an expression vector; a step of mixing the mycelium and E.coli and culturing for 16-18 hours; a step of selecting Sebekia benihana.
Abstract translation: 目的：提供Sebekia benihana中的新型转化系统，以表达同源或杂蛋白或多肽并转化生理活性物质。 构成：转化Sebekia benihana菌株的方法包括：培养Sebekia benihana 3-7天形成孢子的步骤; 在40-60°F，15〜25分钟内进行热休克并诱导菌丝体发芽的步骤; 在室温下冷却的步骤; 用表达载体制备转化的大肠杆菌的步骤; 将菌丝体与大肠杆菌混合并培养16-18小时的步骤; 选择Sebekia benihana的一个步骤。
-
公开(公告)号：KR101462004B1
公开(公告)日：2014-11-19
申请号：KR1020120075754
申请日：2012-07-11
Applicant: (주)차바이오메드 , 의료법인 성광의료재단 , (주)차바이오텍
CPC classification number: C12N5/0607 , A61K8/985 , A61K35/51 , A61K2800/10 , A61Q19/00 , C12N5/0018 , C12N5/0605 , C12N2502/025 , C12N2509/00
Abstract: 본 발명은 탯줄로부터 유용성분을 효과적으로 추출하는 방법을 제공한다. 본 발명은 유용성분을 포함하는 탯줄 추출물을 제공한다. 본 발명의 탯줄 추출물은 동물 유래의 일반 세포 및 줄기세포 배양을 위한 혈청 대체물로 사용할 수 있다. 또한, 본 발명의 탯줄 추출물은 조직 수복용 필러, 드레싱 및 피부상태 개선용 화장료 조성물에 이용할 수 있다. 또한, 탯줄 추출물을 이용하여 탯줄, 지방 등의 조직 유래 줄기세포 분리 및 배양용 배지 조성물 그리고 이를 이용한 조직 유래 줄기세포 분리 및 배양 방법에 관한 것이다.
-
公开(公告)号：KR1020140039370A
公开(公告)日：2014-04-02
申请号：KR1020120104477
申请日：2012-09-20
Applicant: 대한민국(농촌진흥청장) , (주)차바이오텍
CPC classification number: A61K8/987 , A61K8/64 , A61K2800/80 , A61Q19/00
Abstract: The present invention relates to a cosmetic composition including a hydrolysate from a silkworm silk gland. A cosmetic composition of the present invention is characterized in including a hydrolysate from a silkworm silk gland, and more specifically, the hydrolysate is prepared by separating a gland from a silkworm, dissolving the separated gland into water, centrifuging and obtaining a supernatant, adding an alkaline compound to conduct hydrolysis, neutralizing and desalting. According to the present invention, provided is a cosmetic composition comprising a hydrolysate from a silkworm silk gland which is harmless to humans and having good antioxidant activity, dermal fibroblast proliferating properties, skin affinity, etc.
Abstract translation: 本发明涉及包含来自蚕丝腺的水解产物的化妆品组合物。 本发明的化妆品组合物的特征在于包括来自蚕丝腺的水解产物，更具体地说，通过从蚕分离腺体，将分离的腺液溶解在水中，离心并得到上清液，加入 碱性化合物进行水解，中和脱盐。 根据本发明，提供了一种化妆品组合物，其包含来自对人类无害且具有良好抗氧化活性，真皮成纤维细胞增殖性质，皮肤亲和性等的蚕丝腺的水解产物。
-
公开(公告)号：KR1020140008749A
公开(公告)日：2014-01-22
申请号：KR1020120075754
申请日：2012-07-11
Applicant: (주)차바이오메드 , 의료법인 성광의료재단 , (주)차바이오텍
CPC classification number: C12N5/0607 , A61K8/985 , A61K35/51 , A61K2800/10 , A61Q19/00 , C12N5/0018 , C12N5/0605 , C12N2502/025 , C12N2509/00
Abstract: The present invention provides a method for effectively extracting useful components from an umbilical cord. The present invention provides an umbilical cord extract including the useful components. The umbilical cord extract according to the present invention can be used as a serum substitute for cultivating ordinary cells and stem cells derived from an animal. Also, the umbilical cord extract according to the present invention, can be used for a filler for tissue repair, dressing, and improving skin condition. In addition, the present invention relates to a medium composition for isolating and culturing stem cells derived from a tissue, such as an umbilical cord, fatty tissues and the like, and a method for isolating and culturing stem cells derived from the tissue using the same.
Abstract translation: 本发明提供了一种从脐带有效提取有用成分的方法。 本发明提供了包含有用成分的脐带提取物。 根据本发明的脐带提取物可用作培养来自动物的普通细胞和干细胞的血清替代物。 此外，根据本发明的脐带提取物可用于组织修复，敷料和改善皮肤状况的填料。 此外，本发明涉及用于分离和培养源自组织如脐带，脂肪组织等的干细胞的培养基组合物，以及使用该组合物分离和培养源于组织的干细胞的方法 。
-
20.发明公开포유류의 탯줄유래 줄기세포 분리 또는 배양용 배지 조성물, 그리고 이를 이용한 포유류의 탯줄유래 줄기세포 분리 또는 배양 방법 无效用于分离或培养MAMMALIAN脐带血干细胞的介质，以及分离或培养MAMMALIAN脐带干细胞的方法
公开(公告)号：KR1020130008178A
公开(公告)日：2013-01-22
申请号：KR1020110068761
申请日：2011-07-12
Applicant: (주)차바이오텍 , (주)차바이오메드 , 의료법인 성광의료재단
Abstract: PURPOSE: A medium composition for isolating and culturing mammalian umbilical cord-derived stem cells is provided to quickly obtain a large amount of stem cells with excellent proliferation and differentiation abilities. CONSTITUTION: A medium composition for isolating or culturing mammalian umbilical cord-derived stem cells contains an umbilical cord extract without serum. Mammal includes human, pig, horse, cow, mouse, rat, hamster, rabbit, goat, or sheep. A method for preparing the umbilical cord extract comprises: a step of adding cut umbilical cord to a buffer solution and stirring; and a step of collecting supernatant from the mixed solution. A method for preparing the stem cells from the mammalian umbilical cord comprises: a step of culturing a blood-removed umbilical cord tissue in a container which is coated with a cell adhesion protein and contains the medium composition; and a step of treating the tissue with a medium containing stem cell lysis enzyme and isolating the stem cells. The cell adhesion protein includes mammalian umbilical cord-derived collagen, gelatin, fibronectin, laminin, or poly-D-lysine.
Abstract translation: 目的：提供用于分离和培养哺乳动物脐带血干细胞的培养基组合物，以快速获得大量具有优异增殖和分化能力的干细胞。 构成：用于分离或培养哺乳动物脐带源干细胞的培养基组合物含有不含血清的脐带提取物。 哺乳动物包括人，猪，马，牛，老鼠，大鼠，仓鼠，兔，山羊或绵羊。 制备脐带提取物的方法包括：将切割的脐带加入缓冲溶液并搅拌的步骤; 以及从混合溶液中收集上清液的步骤。 用于从哺乳动物脐带制备干细胞的方法包括：在包被细胞粘附蛋白并容纳培养基组合物的容器中培养除血的脐带组织的步骤; 以及用含有干细胞裂解酶的培养基处理组织并分离干细胞的步骤。 细胞粘附蛋白包括哺乳动物脐带胶原，明胶，纤连蛋白，层粘连蛋白或聚-D-赖氨酸。
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.027 seconds)
