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公开(公告)号：KR1020150131477A
公开(公告)日：2015-11-25
申请号：KR1020140058102
申请日：2014-05-15
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은설포라판(sulforaphane, SFN) 을유효성분으로함유하는당뇨병의예방및 치료용조성물에관한것으로서, 상기설포라판(sulforaphane, SFN) 은관련유전자발현및 내당성에미치는효과실험에서, 순환아디포넥틴(adiponectin) 수준및 아디포넥틴(adiponectin)의 mRNA 발현을유의적으로증가시키고, 혈당수준을감소시킴을확인함으로서당뇨질환의예방및 치료용조성물및 건강기능식품으로유용하게이용될수 있다.
Abstract translation: 本发明涉及一种用于预防和治疗糖尿病的组合物，其包含萝卜硫素（SFN）作为活性成分，其中，萝卜硫素可用作预防和治疗糖尿病疾病的组合物以及由于显着增加循环脂联素的作用而作为健康功能性食物 脂联素的水平和mRNA表达，并且在相关基因表达和葡萄糖耐量的效应试验中降低血糖水平。
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公开(公告)号：KR101565646B1
公开(公告)日：2015-11-18
申请号：KR1020130089269
申请日：2013-07-29
Applicant: 가톨릭대학교 산학협력단
Inventor： 이주영
Abstract: 본발명은산화인지질억제제를유효성분으로함유하는면역질환예방또는치료용약제학적조성물에관한것으로, 본발명에서는산화인지질이염증조절복합체를활성화시키고, caspase-1을활성화시켜, 인터루킨-1베타(IL-1β)의발현및 분비를증가시킬수 있음을확인하였다. 따라서, 산화인지질억제제는인터루킨-1베타(IL-1β)의과발현또는과분비가문제되는면역질환의치료제로활용가능할것이며, 나아가본 발명은시험관내에서인터루킨-1베타(IL-1β)의발현을유도하는방법과인터루킨-1베타(IL-1β)의과발현또는과분비가문제되는면역질환의치료제를스크리닝하는효과적인방법을제공할수 있을것이다.
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公开(公告)号：KR101514521B1
公开(公告)日：2015-04-22
申请号：KR1020130074069
申请日：2013-06-26
Applicant: 가톨릭대학교 산학협력단
Abstract: 본 발명에 있어서 XL-DNA 및 XS DNA는 TLR9에 결합하여 IFN-β, COX2 발현을 증가시키고, 수지상 세포의 IL-12, TNF-α의 분비를 증가시키며, 수지상 세포 표면에 보조 자극 분자인 CD80, CD86 발현을 증가시키는 등 선천성 면역 세포를 자극하여 후천성 면역 반응을 효과적으로 유도하며, 특히 대장암에 있어서 독소루비신과 병용 투여시 몸무게 감소 등의 부작용 없이 소량으로도 뛰어난 항암 효능을 나타내는바, 항암 약물에 대한 항암 보조제로서 암 질환에 대한 치료 및 예방에 유용하게 사용될 수 있을 것이다.
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公开(公告)号：KR1020140112870A
公开(公告)日：2014-09-24
申请号：KR1020130027501
申请日：2013-03-14
Applicant: 가톨릭대학교 산학협력단
Abstract: The present invention relates to Corynebacterium glutamicum which has increased target substance productivity compared with a mother cell and produced by a recombinant method or mutation, and to a use of the same. If recombinant Corynebacterium glutmicum is used, high intracellular ATP concentration increases such as gene expression, biosynthesis, and material transfer to efficiently produce useful target substances including such a protein and a metabolite.
Abstract translation: 本发明涉及谷氨酸棒杆菌，其与母细胞相比具有提高的目标物质生产力并且通过重组方法或突变产生，并且涉及其使用。 如果使用重组谷氨酸棒杆菌，则高的细胞内ATP浓度增加，例如基因表达，生物合成和材料转移，以有效产生包括这种蛋白质和代谢物的有用靶物质。
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公开(公告)号：KR102027653B1
公开(公告)日：2019-11-04
申请号：KR1020170152755
申请日：2017-11-16
Applicant: 가톨릭대학교 산학협력단
IPC: A61K36/484 , A23L33/105
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Patent Agency Ranking
公开(公告)号：KR101702897B1
公开(公告)日：2017-02-06
申请号：KR1020160046168
申请日：2016-04-15
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/4188 , A61K31/192 , A23L1/30
CPC classification number: A23L33/10 , A61K31/192 , A61K31/4188
Abstract: 본발명은바이오틴이결합된카페인산(BTCA) 화합물을유효성분으로함유하는통풍예방또는치료용약학조성물및 건강식품에관한것으로보다상세하게는, 본발명의바이오틴이결합된카페인산(BTCA) 화합물은요산염(MSU) 결정에의해유도된사이토카인의증가수준을현저하게감소시켰으며, 특히 IL-1β의생성을억제하고 NLRP3 인플라마좀(inflammasome) 활성을저해함으로써, 요산염결정에의해유도되는염증반응을억제하는것을확인하였다. 따라서, 본발명의 BTCA 화합물은 MSU 결정에의해유도되는염증에의해발병되는통풍의예방또는치료용약학조성물및 건강식품으로사용될수 있다.
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公开(公告)号：KR1020140064273A
公开(公告)日：2014-05-28
申请号：KR1020120131434
申请日：2012-11-20
Applicant: 가톨릭대학교 산학협력단
Inventor： 이주영
IPC: A61K31/685 , A61K31/661 , A61P37/00
CPC classification number: A61K31/685 , Y10S514/814 , Y10S514/825 , Y10S514/857 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/894 , Y10S514/903
Abstract: The present invention relates to a pharmaceutical use of phosphatidylcholine which is used to prevent or treat immune diseases caused by abnormality of the immune response, and more specifically, to a composition comprising phosphatidylcholine as an active ingredient for preventing or treating immune diseases. The composition comprising phosphatidylcholine as an active ingredient for preventing or treating immune diseases according to the present invention can be involved in the TLR4 signal transduction system by binding with Cys133 of MD2 to hinder the reaction of LPS and MD2, so that the toll-like receptor-mediated immune diseases can be finally prevented and treated through this mechanism. The composition comprising phosphatidylcholine as an active ingredient of the present invention can be utilized for a health functional food and a cosmetic product, as well as a medicine, and thus is expected to have a very high value when being applied to a food industry, a medicinal industry, and a cosmetic industry.
Abstract translation: 本发明涉及用于预防或治疗由免疫应答异常引起的免疫疾病的磷脂酰胆碱的药物用途，更具体地涉及包含磷脂酰胆碱作为预防或治疗免疫疾病的活性成分的组合物。 根据本发明的包含磷脂酰胆碱作为预防或治疗免疫疾病的活性成分的组合物可以通过与MD2的Cys133结合来阻断LPS和MD2的反应而参与TLR4信号转导系统，使得toll样受体 可以通过这种机制最终预防和治疗介导的免疫疾病。 包含作为本发明的活性成分的磷脂酰胆碱的组合物可以用于保健功能性食品和化妆品以及药物，因此预期在应用于食品工业时具有非常高的价值， 药用工业，化妆品行业。
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公开(公告)号：KR1020140052293A
公开(公告)日：2014-05-07
申请号：KR1020120118246
申请日：2012-10-24
Applicant: 가톨릭대학교 산학협력단
Inventor： 이주영
Abstract: The present invention relates to a novel use of retinol for prevention or treatment of toll-like receptor (TRL)-mediated immune diseases, and provided are a pharmaceutical composition for prevention or treatment of toll-like receptor-mediated immune diseases, a health food, and a cosmetic composition alleviating skin inflammatory diseases, comprising retinol as an active ingredient. Since retinol of the present invention can suppress the expression of various inflammatory mediators (TNF-alpha, IL-6, IL-12, IFN-beta, IP-10, RANTES, iNOS, CXCL9 and IL-27), when toll-like receptor 2 (TLR2), toll-like receptor 3 (TLR3) and toll-like receptor 4 (TLR4) are activated, toll-like receptor-mediated immune diseases can be ultimately alleviated through this mechanism. Accordingly, the composition of the present invention comprising retinol as an active ingredient can be used as medical supplies such as a pharmacological composition as well as health foods and cosmetic products so that the value of the present invention is expected to be enhanced when being used in food industries, medicine industries and cosmetic industries.
Abstract translation: 本发明涉及视黄醇用于预防或治疗类风湿关节受体（TRL）介导的免疫疾病的新用途，并且提供了用于预防或治疗类风湿关节炎免疫疾病的药物组合物，一种保健食品 以及减轻皮肤炎性疾病的化妆品组合物，其包含视黄醇作为活性成分。 由于本发明的视黄醇可以抑制各种炎性介质（TNF-α，IL-6，IL-12，IFN-β，IP-10，RANTES，iNOS，CXCL9和IL-27）的表达， 受体2（TLR2），toll样受体3（TLR3）和toll样受体4（TLR4）被激活，可以通过这种机制最终减轻toll样受体介导的免疫疾病。 因此，作为活性成分的含有视黄醇的本发明的组合物可以用作医药用组合物以及保健食品和化妆品等医疗用品，因此，当使用本发明的值时， 食品工业，医药工业和化妆品行业。
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公开(公告)号：KR102134307B1
公开(公告)日：2020-07-15
申请号：KR1020180128919
申请日：2018-10-26
Applicant: 가톨릭대학교 산학협력단 , 주식회사 제이비케이랩
IPC: A61K47/61 , A61K31/352 , A23L33/105 , A23L33/125
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公开(公告)号：KR101936766B1
公开(公告)日：2019-01-11
申请号：KR1020160148820
申请日：2016-11-09
Applicant: 가톨릭대학교 산학협력단 , 대한민국 (식품의약품안전처장)
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