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公开(公告)号：KR102227605B1
公开(公告)日：2021-03-16
申请号：KR1020200107235
申请日：2020-08-25
Applicant: (주)제이엘케이 , 가톨릭대학교 산학협력단
Abstract: 본발명에따르면, 인공지능기반으로말초동맥질환을진단하는장치가제공될수 있다. 상기인공지능기반의말초동맥협착진단장치는말초동맥이포함된진단영역의혈관조영영상을기반으로하는말초동맥영상을입력하는데이터입력부와, 미리정해진시간단위를기준으로획득된상기말초동맥영상의모션변화에기초하여학습기반서브말초동맥영상을구성하는보간영상학습모델을구비하며, 상기보간영상학습모델을사용하여상기말초동맥영상에대응되는서브말초동맥영상을생성하는말초동맥영상보간부와, 상기데이터입력부및 말초동맥영상보간부에서제공되는정보를확인하여유의한말초동맥질환을분석하는말초동맥영상분석부를포함할수 있다.
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12.发明公开ｍｉＲ－７, ｍｉＲ－１８ａ 또는 ｍｉＲ－１８ｂ를 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 약학적 조성물 审中-实审包含用于预防或治疗代谢性疾病的miR-7 miR-18a或miR-18b的药物组合物
公开(公告)号：KR1020160139849A
公开(公告)日：2016-12-07
申请号：KR1020150075656
申请日：2015-05-29
Applicant: 가톨릭대학교 산학협력단
IPC: A61K48/00 , A61K31/713 , A61K31/7088
Abstract: 본발명은 miRNA의대사성질환예방또는치료용약학적조성물로서의용도에관한것이다. 본발명에서는 miRNA를이용한대사성질환의후보물질을개발하였고, LXRβ의표적부위에 specific binding을통하여 RNA 수준및 단백질수준에서도효과적으로 down regulation한다는것을규명하였다. 따라서, 본발명에서발굴한 miRNA, 즉 miR-7, miR-18a 또는 miR-18b은죽상동맥경화, 지방간, 당뇨, 고지혈증, 고혈압, 협심증및 심근경색등의대사성질환의치료등에유용하게사용될수 있다.
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公开(公告)号：KR101365207B1
公开(公告)日：2014-02-20
申请号：KR1020110129807
申请日：2011-12-06
Applicant: 가톨릭대학교 산학협력단
IPC: C12N5/0784 , A61K35/15
Abstract: 본 발명은 심근염 치료용 면역관용 수지상 세포, 이의 제조방법 및 이의 심근염 치료 용도에 관한 것이다. 보다 구체적으로, 본 발명은 마이오신 및 TNF-α 가 포함된 배지에서 미성숙 수지상 세포를 배양하는 단계를 포함하는 심근염 치료용 면역관용 수지상 세포의 제조방법, 상기 방법에 의해서 제조된 심근염 치료용 면역관용 수지상 세포, 및 이를 포함하는 약학 조성물에 관한 것이다.
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公开(公告)号：KR102217392B1
公开(公告)日：2021-02-22
申请号：KR1020200090039
申请日：2020-07-21
Applicant: (주)제이엘케이 , 가톨릭대학교 산학협력단
Abstract: 본발명에따르면, 유의한관상동맥협착을진단하는장치가제공될수 있다. 상기인공지능기반의관상동맥협착진단장치는관상동맥(coronary artery)이포함된진단영역의혈관조영영상으로부터관상동맥영역을검출하는 CA 검출학습모델을구비하며, 상기 CA 검출학습모델을사용하여상기혈관조영영상에대응되는관상동맥영상을구성하는관상동맥영상검출부와, 미리정해진시간단위를기준으로획득된상기관상동맥영상의모션변화에기초하여학습기반서브관상동맥영상을구성하는보간영상학습모델을구비하며, 상기보간영상학습모델을사용하여상기관상동맥영상에대응되는서브관상동맥영상을생성하는관상동맥영상보간부와, 상기관상동맥영상검출부및 관상동맥영상보간부에서제공되는정보를확인하여유의한관상동맥협착을분석하는관상동맥영상분석부를포함할수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020130063341A
公开(公告)日：2013-06-14
申请号：KR1020110129808
申请日：2011-12-06
Applicant: 가톨릭대학교 산학협력단
IPC: C12N5/0784 , A61K35/15
CPC classification number: A61K35/15 , C12N5/064 , C12N2500/84 , C12N2501/25 , C12N5/0639
Abstract: PURPOSE: A method for preparing immunotolerance dendritic cells is provided to obtain dendritic cells with myocarditis-specific immunotolerance, to suppress inflammation of myocarditis, and to effectively treat myocarditis. CONSTITUTION: A method for preparing immunotolerance dendritic cells for treating myocarditis comprises a step of culturing immature dendritic cells in a medium containing TNF-alpha and a protein extract of mouse heart infected by Coxsackie virus. The protein extract is prepared by homogenizing mouse heart infected by Coxsackie virus and centrifuging. The immature dendritic cells are prepared by culturing a dendritic cell precursor in a medium containing GM-CSF(Granulocyte Macrophage Colony Stimulating Factor) and IL-4. The immunotolerance dendritic cells has high expression level of CD86 and CD40 compared with immature cells.
Abstract translation: 目的：提供免疫耐受性树突状细胞的制备方法，以获得具有心肌炎特异性免疫耐受性的树突状细胞，抑制心肌炎的炎症，并有效治疗心肌炎。 构成：用于制备用于治疗心肌炎的免疫耐受性树突状细胞的方法包括在含有TNF-α的培养基中培养未成熟树突状细胞的步骤和由柯萨奇病毒感染的小鼠心脏的蛋白质提取物。 通过将柯萨奇病毒感染的小鼠心脏匀浆并离心制备蛋白质提取物。 通过在含有GM-CSF（粒细胞巨噬细胞集落刺激因子）和IL-4的培养基中培养树突状细胞前体来制备未成熟树突状细胞。 与未成熟细胞相比，免疫耐受性树突状细胞具有高表达CD86和CD40的表达水平。
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公开(公告)号：KR1020130063340A
公开(公告)日：2013-06-14
申请号：KR1020110129807
申请日：2011-12-06
Applicant: 가톨릭대학교 산학협력단
IPC: C12N5/0784 , A61K35/15
CPC classification number: C12N5/0639 , A61K35/15 , C12N2501/22 , C12N2501/2304 , C12N2501/25
Abstract: PURPOSE: A method for preparing immunotolerance dendritic cells is provided to obtain dendritic cells with immunotolerance which is specific to myocarditis, to suppress inflammation of myocarditis, and to effectively treat myocarditis. CONSTITUTION: A method for preparing immunotolerance dendritic cells for treating myocarditis comprises a step of culturing immature dendritic cells in a medium containing myosin and TNF-alpha. The immature dendritic cells are prepared by culturing a dendritic cell precursor in a medium containing GM-CSF(Granulocyte Macrophage Colony Stimulating Factor) and IL-4. The immunotolerance dendritic cells for treating myocarditis highly expresses CD86 and CD40.
Abstract translation: 目的：提供免疫耐受性树突状细胞的制备方法，以获得具有免疫耐受性的树突状细胞，其具有心肌炎特异性，抑制心肌炎的炎症，并有效治疗心肌炎。 构成：用于制备用于治疗心肌炎的免疫耐受性树突状细胞的方法包括在含有肌球蛋白和TNF-α的培养基中培养未成熟树突状细胞的步骤。 通过在含有GM-CSF（粒细胞巨噬细胞集落刺激因子）和IL-4的培养基中培养树突状细胞前体来制备未成熟树突状细胞。 用于治疗心肌炎的免疫耐受性树突状细胞高度表达CD86和CD40。
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公开(公告)号：KR1020090004374A
公开(公告)日：2009-01-12
申请号：KR1020070129641
申请日：2007-12-13
Applicant: 주식회사 케이티 , 가톨릭대학교 산학협력단
Abstract: A manufacturing method of iron oxide nano particle is provided to manufacture easily iron oxide nano particle at a low temperature by simple reaction, to be applied practically and to heighten effectiveness of the manufacturing process. A manufacturing method of iron oxide nano particle comprises steps of: reacting di-valent iron salt and tri-valent iron salt and into solvent of the chemical formula CnH2n+1 OH and forming an iron oxide nano particle precursor; and forming the iron oxide system nano particle by reacting a precursor with a base. The di-valent iron salt is one or more materials selected from a group consisting of iron(II) acetate, iron(II) nitrate and iron(II) halide. The tri-valent iron salt is one or more materials selected from a group consisting of iron(III) acetate, iron(III) nitrate and iron(III) halide.
Abstract translation: 提供氧化铁纳米颗粒的制造方法，通过简单的反应在低温下容易地制造氧化铁纳米颗粒，实际应用并提高制造工艺的有效性。 氧化铁纳米颗粒的制造方法包括以下步骤：使二价铁盐和三价铁盐与化学式CnH2n + 1OH的溶剂反应并形成氧化铁纳米颗粒前体; 以及通过使前体与碱反应形成氧化铁体系纳米颗粒。 二价铁盐是选自由乙酸铁（II），硝酸铁（II）和卤化铁（II）组成的组中的一种或多种。 三价铁盐是选自乙酸铁（III），硝酸铁（III）和卤化铁（III）的一种或多种材料。
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公开(公告)号：KR100830889B1
公开(公告)日：2008-05-21
申请号：KR1020060129630
申请日：2006-12-18
Applicant: 주식회사 케이티 , 가톨릭대학교 산학협력단
CPC classification number: G01N33/574 , A61K49/1821 , B82Y5/00 , B82Y15/00 , B82Y40/00 , G01N33/54326 , G01N33/54346
Abstract: A nanoparticle conjugated with a cetuximab antibody is provided to obtain a contrast medium for in vitro and in vivo imaging of tissues with colon cancer, and to inhibit growth of colon cancer. A nanoparticle for diagnosis of colon cancer comprises: a core particle formed of a magnetic material; a silica compound shell containing an organic fluorescent material; and a cetuximab antibody bonded to the shell surface by way of an NHS-PEO12-maleimide group. In the nanoparticle, the magnetic core particle is at least one oxide selected from the group consisting of cobalt, iron, manganese, zinc, nickel and copper. Further, the organic fluorescent material is one of an RITC(Rhodamine B isothiocyanate) and an FITC(fluoresceine isothiocyanate).
Abstract translation: 提供与西妥昔单抗抗体缀合的纳米颗粒以获得用于结肠癌组织的体外和体内成像的造影剂，并抑制结肠癌的生长。 用于诊断结肠癌的纳米颗粒包括：由磁性材料形成的核心颗粒; 含有有机荧光材料的二氧化硅复合壳; 和通过NHS-PEO12-马来酰亚胺基团结合到壳表面的西妥昔单抗抗体。 在纳米颗粒中，磁芯颗粒是选自钴，铁，锰，锌，镍和铜中的至少一种氧化物。 此外，有机荧光材料是RITC（异硫氰酸若丹明B）和FITC（异硫氰酸荧光素）之一。
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公开(公告)号：KR102098462B1
公开(公告)日：2020-04-08
申请号：KR1020180029659
申请日：2018-03-14
Applicant: 가톨릭대학교 산학협력단 , 한국기초과학지원연구원
IPC: C07K16/28 , G01N33/574
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