公开(公告)号：KR1020090059339A

公开(公告)日：2009-06-11

申请号：KR1020070126151

申请日：2007-12-06

Applicant: 한국생명공학연구원 ,  강원대학교산학협력단

Inventor： 남기환 ,  강용국 ,  김장환 ,  이창희 ,  김은경 ,  손미영 ,  김형진 ,  오구택 ,  김환묵 ,  원영석 ,  문옥성 ,  이철호

IPC: C07D487/22

Abstract: A composition which promotes the differentiation from a stem cell to cardiac myocyte is provided to induce the differentiation or improve cardiac function. A compound which promotes the differentiation from a stem cell to cardiac myocyte is denoted by the chemical formula 1. The derivative of the compound is denoted by the chemical formula 2. A method for inducing from the stem cell to cardiac myocyte comprises a step of culturing the stem cell in the presence of the compound of the derivative. In the chemical formula, R1 is selected from hydrogen, alkyl, alkoxy, hydroxy, halike, nitro, cyano, alkoxycarbonyl, amino group and substituted or non-substituted aryl group or heteroaryl group.

Abstract translation: 提供促进从干细胞向心肌细胞分化的组合物以诱导分化或改善心脏功能。 促进从干细胞向心肌细胞分化的化合物由化学式1表示。化合物的衍生物由化学式2表示。从干细胞诱导心肌细胞的方法包括培养的步骤 该干细胞在衍生物的化合物存在下。 在化学式中，R 1选自氢，烷基，烷氧基，羟基，卤代，硝基，氰基，烷氧基羰基，氨基和取代或未取代的芳基或杂芳基。