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公开(公告)号：KR100903766B1
公开(公告)日：2009-06-19
申请号：KR1020070138301
申请日：2007-12-27
Applicant: 주식회사 유영제약 , 인제대학교 산학협력단 , 강재선
CPC classification number: A23K10/12 , A23K10/18 , A23K20/195 , A23K50/80 , C12R1/07
Abstract: A fish feed additive containing fermented soybean by Bacillus polyfermenticus KJS-2 is provided to prevent the infection of parrot fish due to Irido virus by inoculating Bacillus polyfermenticus KJS-2 to beans and fermenting the beans. A fish feed additive contains lactic acid bacteria-fermented soybeans by Bacillus polyfermenticus KJS-2. The fish feed additive shows the prevention effects against Irido virus. The fish feed additive secures a mortality reducing effect. The fish feed additive shows a feed luring effect and a weight gaining effect for cultured fish. The fish feed additive is in a freeze-dry state when in use. The content of fish feed additive is 0.15-15g per kg of feed. The fish feed additive contains 1x10^6~1x10^8cfu of Bacillus polyfermenticus KJS-2 per g of feed.
Abstract translation: 提供了一种通过芽孢杆菌KJS-2含有发酵大豆的鱼饲料添加剂，用于通过将芽孢杆菌KJS-2接种到豆中并发酵豆来防止由于Irido病毒感染鹦鹉鱼。 鱼饲料添加剂含有乳杆菌细菌发酵大豆，由芽孢杆菌多毛霉KJS-2。 鱼饲料添加剂显示对Irido病毒的预防作用。 鱼饲料添加剂确保降低死亡率。 鱼饲料添加剂显示饲料诱导效果和养殖鱼类的增重效果。 鱼饲料添加剂在使用时处于冷冻干燥状态。 鱼饲料添加剂的含量为每公斤饲料0.15-15g。 鱼饲料添加剂每g饲料含有1×10 -6〜1×10 8 kfu的芽孢杆菌KJS-2。
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公开(公告)号：KR100893779B1
公开(公告)日：2009-04-20
申请号：KR1020070045441
申请日：2007-05-10
Applicant: 인제대학교 산학협력단 , 강재선 , 한국생명건강 (주)
IPC: A61K36/232 , A61P39/06
Abstract: 본 발명은 유해 활성산소(free radical) 소거 효과가 있는 참당귀 추출물의 추출방법에 관한 것이다.
유해 활성산소(free radical) 소거효과가 있는 참당귀 추출물은 그 주성분이 데커신과 데커시놀 안젤레이트가 90% 이상으로 구성된 액체 농축물이며, 본 발명은 참당귀 추출물은 인체에 투여 가능한 형태로 물과 에탄올로만 추출하였고, 또한 고 순도를 위하여 온도와 용해도 차이를 이용한 정제방법을 이용한 것이다.
Angelica gigas Nakai, Decursin, Decursinol angelate, antioxidant, free radical-
公开(公告)号：KR1020080099636A
公开(公告)日：2008-11-13
申请号：KR1020070045441
申请日：2007-05-10
Applicant: 인제대학교 산학협력단 , 강재선 , 한국생명건강 (주)
IPC: A61K36/232 , A61P39/06
Abstract: A method of extracting an angelica gigas extract is provided to extracting a high pure material of purity 90% or high by using an ethanol having practicality. A method of an angelica gigas extract is manufactured by extracting Angelica gigas Nakai extraction concentrate as a main component such as decursin, decursinol and decursinol angelate by using an ethanol and water as a solvent and a difference of temperature and solubility. The Angelica gigas Nakai extraction concentrate is manufactured by containing the decursin, the decursinol angelate and the decursinol and removes a free radical.
Abstract translation: 提取当归姜提取物的方法是通过使用具有实用性的乙醇提取纯度高达90％以上的高纯度材料。 通过使用乙醇和水作为溶剂和温度和溶解度的差异，以当归的前提素，前胡萝卜醇和前胡萝卜醇为主要成分提取当归佳果提取浓缩物作为当归的提取物的方法。 当归黑加萃取浓缩物是通过含有前胡素，当归酸和胡萝卜素去除自由基来制造的。
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15.发明公开신규 미생물 트라우스토카이트리움 에스피.케이제이에스-1, 바실러스 폴리퍼멘티쿠스 케이제이에스-2 및 이들과 바실러스 리케니포르미스를 포함하고 있는 사료첨가제 및 사료 有权新分离的THRAUSTOCHYTRA SP。 KJS-1，BACILLUS POLYFERMENKUS KJS-2和饲料添加剂，用于包括枸杞子的培养鱼。 KJS-1，BACILLUS POLYFERMENTICUS KJS-2和BACILLUS LICHENIFORMIS，饲料中含有饲料添加剂
公开(公告)号：KR1020080030733A
公开(公告)日：2008-04-07
申请号：KR1020060096935
申请日：2006-10-02
Applicant: 인제대학교 산학협력단 , 강재선 , 주식회사 유영제약
IPC: C12N1/20
CPC classification number: C12P7/6472 , C12P7/6427
Abstract: Novel microorganisms producing DHA(docosahexanoic acid) are provided to supply DHA as an essential nutrient of fishes to fishes through feed additives, and inhibit death of fishes by inhibiting growth of fungi and bacteria, so that income of farmers is enhanced. Novel microorganisms highly producing DHA, Thraustochytrium sp. KJS-1(KCCM 10667P) and Bacillus polyfermenticus KJS-2(KCCM 10769P), are isolated from the sea. The feed additives for cultivating fishes contain freeze-dried, cultivated products of Thraustochytrium sp. KJS-1(KCCM 10667P), Bacillus polyfermenticus KJS-2(KCCM 10769P) and Bacillus licheniformis in a weight ratio of 5:1:2.6. The feed for cultivating fishes contains 1.8% of the feed additives. Further, a bacteria number in culture freezing dried material of the Bacillus polyfermenticus KJS-2 and the Bacillus Licheniformis is 1x10^10 colony per gram.
Abstract translation: 提供生产DHA（二十二碳六烯酸）的新型微生物，通过饲料添加剂提供DHA作为鱼类的重要营养元素，通过抑制真菌和细菌的生长来抑制鱼类死亡，从而提高农民收入。 高效生产DHA，Thraustochytrium sp。 从海洋中分离KJS-1（KCCM 10667P）和芽孢杆菌KJS-2（KCCM 10769P）。 用于培养鱼类的饲料添加剂含有冷冻干燥的Thraustochytrium sp。 KJS-1（KCCM 10667P），多发性芽孢杆菌KJS-2（KCCM 10769P）和地衣芽孢杆菌，重量比为5:1:2.6。 饲养鱼类的饲料含有1.8％的饲料添加剂。 此外，芽孢杆菌多发性裂殖酵母KJS-2和地衣芽孢杆菌的培养物冷冻干燥物质中的细菌数为1×10 ^ 10菌落/克。
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Patent Agency Ranking
公开(公告)号：KR100895908B1
公开(公告)日：2009-05-04
申请号：KR1020070026285
申请日：2007-03-16
Applicant: 일동홀딩스(주) , 인제대학교 산학협력단 , 강재선
CPC classification number: C12P17/08 , C07D313/00 , C12R1/07
Abstract: 본 발명은 신규한 바실러스 균주인 바실러스 폴리퍼멘티쿠스 KJS-2(
Bacillus
polyfermenticus KJS-2)(KCCM10769P)에서 생산되는 마크로락틴 에이 (Macrolactin A)의 항균물질로서의 용도에 관한 것이다.
본 발명이 제공하는 바실러스 폴리퍼멘티쿠스 KJS-2 (
Bacillus polyfermenticus KJS-2)에서 생산되는 마크로락틴 에이(Macrolactin A)는 각종 미생물과 진균에 대해 넓은 항균 스펙트럼을 보여주고 있으며, 특히, 다제내성균인 반코마이신 내성 장구균(Vancomycin-resistant
enterococci
, VRE)및 메치실린 내성 황색포도상구균(Methicillin-resistant
Staphylococcus
Aureus , MRSA)을 억제하는데 탁월한 효과가 있음이 확인되었다.
따라서 본 발명은 바실러스 폴리퍼멘티쿠스 KJS-2(
Bacillus
polyfermenticus KJS-2)가 생산하는 항균물질 마크로락틴 에이(Macrolactin A)는 반코마이신 내성 장구균(VRE) 및 메치실린 내성 황색포도상구균(MRSA)을 억제하는 뛰어난 항균제제를 제공할 수 있으므로 의약 산업상 매우 유용한 발명이다.-
公开(公告)号：KR1020080084479A
公开(公告)日：2008-09-19
申请号：KR1020070026285
申请日：2007-03-16
Applicant: 일동홀딩스(주) , 인제대학교 산학협력단 , 강재선
CPC classification number: C12P17/08 , C07D313/00 , C12R1/07
Abstract: An antibacterial macrolactin A produced from Bacillus polyfermenticus KJS-2 is provided to improve range of antibacterial spectrum against various microorganisms and fungi, especially vancomycin-resistant Enterococci(VRE) and methicillin-resistant Staphylococcus aureus(MRSA). An antibacterial macrolactin A produced from Bacillus polyfermenticus KJS-2(KCCM 10769P) has MIC(minimum inhibitory concentration)>90 of 15.63-31.25 mug/ml and 7.81-31.25 mug/ml against vancomycin-resistant Enterococci(VRE) and methicillin-resistant Staphylococcus aureus(MRSA), respectively, and is isolated by culturing Bacillus polyfermenticus KJS-2(KCCM 10769P) in TSB(tryptone soy broth) agar medium, extracting the cultured medium with ethyl acetate, subjecting the extract to LC(liquid chromatography)/Mass to obtain a fraction showing improved antibacterial activity, and purifying the fraction with preparative silica gel RP-18.
Abstract translation: 提供了一种由芽孢杆菌KJS-2生产的抗菌性大黄精乳素A，以改善各种微生物和真菌，特别是万古霉素耐药性肠球菌（VRE）和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌谱范围。 由芽孢杆菌KJS-2（KCCM 10769P）产生的抗菌性大多数内生素A具有对万古霉素耐药性肠球菌（VRE）和耐甲氧西林抗性的15.63-31.25μg/ ml和7.81-31.25μg/ ml的MIC（最小抑制浓度）> 90 通过在TSB（胰蛋白胨大豆肉汤）琼脂培养基中培养芽胞杆菌KJS-2（KCCM 10769P），用乙酸乙酯萃取培养的培养基，将提取物进行LC（液相色谱）/质谱分析，分离出金黄色葡萄球菌（MRSA） 质量以获得显示出改善的抗菌活性的级分，并用制备型硅胶RP-18纯化该级分。
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18.发明授权바실러스 폴리퍼멘티쿠스 케이제이에스-2균주가 생산하는항 헬리코박터 파일로리의 효능을 갖는 마크로락틴 에이 有权抗生素PYLORI MACROLACTIN一种生产的BACILLUS POLYFERMENTICUS KJS-2
公开(公告)号：KR100856884B1
公开(公告)日：2008-09-05
申请号：KR1020070026706
申请日：2007-03-19
Applicant: 주식회사 유영제약 , 인제대학교 산학협력단 , 강재선
CPC classification number: C12P17/08 , A61K31/335 , C07D313/00
Abstract: A macrolactin A produced from Bacillus polyfermenticus KJS-2 is provided to inhibit growth of various microorganisms and fungi, especially Helicobacter pylori by increasing antibiotic spectrum range, so that the macrolactin A is useful to treat chronic gastritis, stomach ulcer and recurrent ulcer caused by Helicobacter pylori. An antibacterial composition comprises macrolactin A which is produced by culturing Bacillus polyfermenticus KJS-2(KCCM10769P) and purified by extracting the cultured medium of Bacillus polyfermenticus KJS-2(KCCM10769P) with ethylacetate, wherein the effective concentration of macrolactin A is 20 mug/ml or more.
Abstract translation: 通过增加抗生素的光谱范围，提供了由芽孢杆菌KJS-2生产的大量的内含乳素A，以通过增加抗生素的光谱范围来抑制各种微生物和真菌，特别是幽门螺杆菌的生长，从而使大黄乳球菌素A可用于治疗由幽门螺杆菌引起的慢性胃炎，胃溃疡和复发性溃疡 幽门螺旋杆菌。 抗菌组合物包括通过培养多发性芽胞杆菌KJS-2（KCCM10769P）产生并通过用乙酸乙酯萃取芽孢杆菌KJS-2（KCCM10769P）培养的培养基进行纯化，其中有效浓度为约20ug / ml 或者更多。
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19.发明公开신규 미생물 트라우스토카이트리움 에스피.케이제이에스-1, 바실러스 폴리퍼멘티쿠스 케이제이에스-2및 이들과 바실러스 리케니포르미스를 포함하고 있는사료첨가제 및 사료 有权新分离的THRAUSTOCHYTRA SP。 KJS-1，BACILLUS POLYFERMENKUS KJS-2和饲料添加剂，用于包括三叶草SP的活化鱼。 KJS-1，BACILLUS POLYFERMENTICUS KJS-2和BACILLUS LICHENIFORMIS，饲料中含有饲料添加剂
公开(公告)号：KR1020080030984A
公开(公告)日：2008-04-07
申请号：KR1020080024451
申请日：2008-03-17
Applicant: 인제대학교 산학협력단 , 강재선 , 주식회사 유영제약
CPC classification number: C12N1/20 , A23K10/16 , A23K20/195 , C12R1/07
Abstract: Novel microorganisms producing DHA(docosahexanoic acid) are provided to improve quality of cultivated fishes by supplying DHA as an essential nutrient of fishes to fishes and inhibiting death of fishes, and clean the cultivation tank by inhibiting growth of fungi. The novel microorganisms producing DHA, Thraustochytrium sp. KJS-1(KCCM 10667P) and Bacillus polyfermenticus KJS-2(KCCM 10769P) are selected from microorganisms producing unsaturated fatty acid, isolated from the South coast region. The feed additives for cultivating fishes contain Thraustochytrium sp. KJS-1(KCCM 10667P) and Bacillus polyfermenticus KJS-2(KCCM 10769P), and Bacillus licheniformis.
Abstract translation: 提供生产DHA（二十二碳六烯酸）的新型微生物，通过提供DHA作为鱼类的必需营养物质和鱼类的死亡，并通过抑制真菌的生长来清洁培养罐来提高培养鱼的质量。 产生DHA，Thraustochytrium sp。的新型微生物 KJS-1（KCCM 10667P）和芽孢杆菌KJS-2（KCCM 10769P）选自从南海岸地区分离的产生不饱和脂肪酸的微生物。 用于培养鱼类的饲料添加剂含有Thraustochytrium sp。 KJS-1（KCCM 10667P）和多发芽孢杆菌KJS-2（KCCM 10769P）和地衣芽孢杆菌。
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公开(公告)号：KR1020040080854A
公开(公告)日：2004-09-20
申请号：KR1020030016220
申请日：2003-03-14
IPC: A23L1/30
Abstract: PURPOSE: Provided are foods and pharmaceutical compositions containing Angelica gigas extract which are effective for alleviation of nephrotoxicity and diabetic hypertension. CONSTITUTION: The foods and pharmaceutical compositions containing Angelica gigas extract are characterized in that they are prepared by extracting and concentrating decursin and decursinol angelate contained in the Angelica gigas, Nakai to be formulated into an oral administration form such as tablet, capsule, liquid medicine and powdered form.
Abstract translation: 目的：提供含有当归猕猴提取物的食品和药物组合物，其有效缓解肾毒性和糖尿病高血压。 构成：含有当归提取物的食品和药物组合物的特征在于它们是通过提取和浓缩当归所含的当归的前胡素和当归酸，制成口服给药形式如片剂，胶囊，液体药物和 粉状
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