Abstract:
PURPOSE: A pharmaceutical composition for preventing or treating diseases related to abnormal suppression of regulatory T cell activation is provided to activate regulatory T cells and suppress Th1/Th17 differentiation by a polypeptide, thereby preventing or treating autoimmune diseases, allergic diseases, or neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating diseases related to abnormal suppression of regulatory T cell activation contains a polypeptide containing bee venom-phospholipase A2 (PLA2) amino acid sequence without a leader sequence. The polypeptide has an amino acid sequence of sequence number 2. The polypeptide additionally has an amino acid sequence of sequence number 4 at N-terminal of bee venom-PLA2 amino acid sequence, an amino acid sequence of sequence number 5 at C-terminal, or the amino acid sequences of the sequence numbers 4 and 5. [Reference numerals] (AA) CD4+ Foxp3+(%) in a cell; (BB) Comparative group; (CC) F type-RPLA2; (DD) B type-RPLA2; (EE) C type-RPLA2
Abstract:
본 발명은 자초, 백굴채 및 계지를 필수적으로 함유하는 추출물로부터 소염진통 작용 및 항염증 작용을 갖는 관절염 예방 및 개선을 위한 건강기능식품에 관한 것이다. 본 발명은 자초, 백굴채 및 계지를 필수적으로 함께 투여함으로써 위장장애, 위염, 위궤양 등의 부작용을 나타내지 않을 뿐만 아니라, 소염진통 작용 및 항염증 작용에 있어서 획기적인 상승작용을 나타냄으로써 상기 생약재를 단독으로 사용할 때 보다 효과적으로 소염진통 작용 및 항염증 작용을 갖는 관절염 예방 및 개선을 위한 건강기능식품에 유용하게 사용될 수 있다. 자초, 백굴채, 계지, 염증, 관절염, 소염진통, 통증
Abstract:
An herb medicine composition is provided to show anti-cancer effect by lowering the activity and decreasing the expression amount of VEGF and bFGB, which are expressed when inducing angiogenesis, and HIF-1alpha gene protein, which is expressed in the low oxygen state. The herb medicine composition for preventing and treating cancer comprises 10-15 grams of Astragalus membranaceus, 10-15 grams of ginseng, 15-20 grams of Patrinia villosa, 10-14 grams of Angelicae Gigantis Radix, 10-14 grams of Pericarpium Zanthoxyli, 25-30 grams of Benincase hispida cogniaux, 25-30 grams of Phaseolus angularis, 10-15 grams of Bletilla striata Reichb. fil., 10-15 grams of Tulipa edulis, and 10-15 grams of glue. The administration amount of the herb medicine composition is in the range of 10-100 mg/kg.