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公开(公告)号：KR1020160045171A
公开(公告)日：2016-04-27
申请号：KR1020140139700
申请日：2014-10-16
Applicant: 주식회사 퀀타매트릭스
CPC classification number: C12Q1/18 , C12M1/14 , C12M1/16 , C12M1/18 , C12M23/10 , C12M23/12 , C12M23/20 , C12M23/22 , C12M25/14 , C12M29/04 , C12M29/26 , C12M41/46 , C12Q1/02 , C12Q1/04 , G01N2800/26 , C12M1/34 , G01N33/15
Abstract: 본발명은고정화제를이용한단일세포추적을위한신규한생리활성검사용구조물및 이를포함하는생리활성검사시스템에관한것이다. 또한, 본발명은상기검사용구조물을이용한생리활성검사, 약물감수성검사, 항생제스크리닝, 및진단방법에관한것이다. 본발명에서제공하는생리활성검사용구조물은박테리아특히, 결핵균에대한약물감수성검사, 약물스크리닝및 진단을매우빠르고간편하게수행할 수있다. 특히, 본발명에따른검사용구조물을이용하는경우접종효과와무관하게, 또는인간의객담을농축과정없이전처리만으로도 DST 및진단이가능한바, 종래개발된결핵진단또는 DST 시스템에비하여월등히빠르고정확하며, 간편하게검사를수행할수 있다. 또한, 본발명에따른상기구조물은결핵진단과약물감수성검사를동시에수행할수 있도록하는바, 본발명에서제공하는기술은종래기술을효과적으로대체할수 있다.
Abstract translation: 本发明涉及：使用胶凝剂的跟踪单细胞的新型生物活性测试结构; 和包含该活性测试系统的生物活性测试系统。 此外，本发明涉及使用测试结构测试生物活性，测试药物敏感性，抗生素筛选和诊断的方法。 本发明提供的生物活性测试结构可以非常快速且简单地对细菌，特别是结核分枝杆菌进行药物敏感性试验，药物筛选和诊断。 特别是，无论接种效果如何，DST和诊断均可实现，或仅通过不用浓缩人痰的步骤进行预处理，因此与常规开发的结核病诊断或DST系统相比，可以显着快速准确地进行测试。 此外，根据本发明的结构允许同时进行结核病诊断和药物敏感性试验，因此本发明提供的技术可以有效地代替常规技术。
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12.发明公开다양한 종류의 항생제 및 농도에서 반응하는 미생물 세포의 모양 및 성장 변화 분석을 이용한 신속한 항균제 감수성 검사 방법 및 이를 위한 자동화된 세포 이미지 분석 시스템 有权使用各种抗微生物剂的不同浓度的微生物细胞形态学和生长变化进行快速的抗微生物检测和使用其的自动化细胞图像分析系统
公开(公告)号：KR1020160043827A
公开(公告)日：2016-04-22
申请号：KR1020140138535
申请日：2014-10-14
Applicant: 주식회사 퀀타매트릭스
Abstract: 본발명은다양한종류의항생제및 농도에서반응하는미생물세포의모양및 성장변화분석을이용한신속한항균제감수성검사방법및 이를위한자동화된세포이미지분석시스템에관한것이다. 구체적으로, 본발명에따른다양한종류의항생제및 농도에서반응하는미생물세포의모양및 성장변화분석을이용한신속한항균제감수성검사방법은 CLSI(Clinical and Laboratory Standards Institute)의표준방법에비해최대 6-7 배의빠른속도로정확한결과를판정할수 있다.
Abstract translation: 本发明涉及使用对不同浓度的反应的微生物细胞的形状和生长的变化分析以及各种类型的抗生素快速测试对抗微生物剂的敏感性的方法，以及用于自动化细胞图像分析系统 一样。 更具体地，根据本发明，使用对不同浓度的反应的各种类型的抗生素的微生物细胞的形状和生长的变化分析来快速测试对抗微生物剂的敏感性的方法可以确定在 与临床和实验室标准研究所（CLSI）的标准方法相比，最大速度提高了六到七倍。
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公开(公告)号：KR101446526B1
公开(公告)日：2014-10-08
申请号：KR1020140053582
申请日：2014-05-02
Applicant: 주식회사 퀀타매트릭스 , 서울대학교산학협력단
Abstract: Provided is a cell culture testing device based on microfludic multi-well units, the device comprising a plurality of array structures of arranged microfludic multi-well units wherein the microfludic multi-well unit has an injection unit in which a first fluid is injected; a receiving unit for receiving a second fluid; a fine fluid channel in which the first fluid flows; and an air discharging unit which is allowed to easily inject the first fluid.
Abstract translation: 本发明提供了一种基于微量多孔单元的细胞培养试验装置，该装置包括多个排列的微分多孔单元的阵列结构，其中微量多孔单元具有喷射单元，喷射单元中注入第一流体; 用于接收第二流体的接收单元; 第一流体流过的细流体通道; 以及允许容易地注入第一流体的排气单元。
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Patent Agency Ranking14.发明授权고형화제를 이용한 세균 고정, 약물 확산, 세균 단일 세포 추적과 이를 기반으로 한 빠른 약물 검사 시스템 有权基于细菌固定，抗生素扩散和使用胶凝剂的单细胞生长跟踪的快速抗生素敏感性测试（RAST）系统
公开(公告)号：KR101461662B1
公开(公告)日：2014-12-04
申请号：KR1020130043014
申请日：2013-04-18
Applicant: 주식회사 퀀타매트릭스 , 서울대학교산학협력단
CPC classification number: C12Q1/18 , B29C45/0001 , B29L2031/752 , C12N11/04
Abstract: 고형화제를함유한액상매질과생물학적물질의혼합용액을박막형성용구조물에제공하는단계; 상기혼합용액을고화시켜상기생물학적물질이고정된고체박막을형성하는단계; 생리활성물질을상기고체박막에공급하여상기생리활성물질이상기고체박막내부로확산되도록하는단계; 및상기생리활성물질에대한상기생물학적물질의반응을관찰하는단계를포함하는검사방법이제공된다.
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公开(公告)号：KR101243631B1
公开(公告)日：2013-03-15
申请号：KR1020120073974
申请日：2012-07-06
Applicant: 주식회사 퀀타매트릭스
Inventor： 정용균
CPC classification number: C12Q1/24 , C12M25/00 , C12M33/02 , C12N11/02 , C12N11/06 , C12N11/08 , C12N11/14
Abstract: PURPOSE: A microstructure for capturing and releasing microorganisms is provided to capture low-concentration unknown bacteria. CONSTITUTION: A microstructure for capturing and releasing microorganisms has a microstructure with a surface on which one or more microorganisms are attached, and a mannose-binding lectin is applied on the microstructure. The microstructure further comprises a carboxyl group. [Reference numerals] (AA) Microstructure; (BB) Bacteria
Abstract translation: 目的：捕获和释放微生物的微观结构用于捕获低浓度未知细菌。 构成：用于捕获和释放微生物的微结构具有其上附着有一种或多种微生物的表面的微结构，并且在微结构上施加甘露糖结合凝集素。 微结构还包含羧基。 （附图标记）（AA）微结构; （BB）细菌
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17.发明公开고형화제를 이용한 세균 고정, 약물 확산, 세균 단일 세포 추적과 이를 기반으로 한 빠른 약물 검사 시스템 有权基于细菌固定，抗生素扩散和使用凝胶剂的单细胞生长跟踪的快速抗生素不稳定性测试（RAST）系统
公开(公告)号：KR1020130089619A
公开(公告)日：2013-08-12
申请号：KR1020130043014
申请日：2013-04-18
Applicant: 주식회사 퀀타매트릭스 , 서울대학교산학협력단
CPC classification number: C12Q1/18 , B29C45/0001 , B29L2031/752 , C12N11/04
Abstract: PURPOSE: A RAST system is provided to sharply reduce an amount of cells and drugs which are necessary for a doping test and obtain a doping test result within 2 hours by rapidly tracking the difference in growth of a single cell. CONSTITUTION: A biological activity test structure is equipped with a solid film which is manufactured by gelling liquid medium containing hardening agents. The biological activity test structure comprises: a light-transmissive body portion; at least one micro well which is formed in the light-transmissive body portion; and the thin solid film which is equipped in the micro well and fixes biological material. The biological activity test structure is combinable with multi-well plates. At least one micro well of the light-transmissive body portion is corresponded to at least one well of the multi-well plates when the biological activity test structure is bonded with the multi-well plates. [Reference numerals] (AA) Start; (BB) End; (S1) Supplying a mixture solution of liquid medium and biological materials to a thin film formation substrate; (S2) Forming a solid thin film to which biological materials are fixed by solidifying the mixture solution; (S3) Permeating physiologically active materials into a solid thin film; (S4) Observing biological materials against physiologically active materials
Abstract translation: 目的：提供RAST系统，以大幅度减少掺杂测试所需的细胞和药物的量，并通过快速跟踪单细胞生长差异在2小时内获得掺杂测试结果。 构成：生物活性试验结构配备有通过凝胶化含有硬化剂的液体介质制造的固体膜。 生物活性测试结构包括：透光体部分; 形成在所述透光性主体部中的至少一个微孔; 以及装在微孔中并固定生物材料的薄的固体膜。 生物活性测试结构可与多孔板组合。 当生物活性测试结构与多孔板结合时，透光体部分的至少一个微孔对应于多孔板的至少一个孔。 （附图标记）（AA）开始; （BB）结束; （S1）将液体介质和生物材料的混合溶液供给到薄膜形成基板; （S2）通过固化混合溶液形成固体生物材料固体的薄膜; （S3）将生理活性物质渗透成固体薄膜; （S4）观察针对生理活性物质的生物材料
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18.发明授权고형화제를 이용한 세균 고정, 약물 확산, 세균 단일 세포 추적과 이를 기반으로 한 빠른 약물 검사 시스템 有权基于细菌固定，抗生素扩散和使用凝胶剂的单细胞生长跟踪的快速抗生素不稳定性测试（RAST）系统
公开(公告)号：KR101290648B1
公开(公告)日：2013-07-29
申请号：KR1020120115938
申请日：2012-10-18
Applicant: 주식회사 퀀타매트릭스 , 서울대학교산학협력단
CPC classification number: C12Q1/18 , B29C45/0001 , B29L2031/752 , C12N11/04
Abstract: PURPOSE: A test method using fixation of a biological substance and diffusion of a physiologically active substance is provided to largely reduce the amount of a drug and cells for a drug test, and to quickly trace single cell growth. CONSTITUTION: A physiological activity test method is performed by observing response of a biological substance with respect to a physiologically active substance. The method comprises the steps of: providing a mixture solution of the biological substance and a liquid medium containing a solidifying agent to a substrate for thin film formation (S1); solidifying the mixture solution and forming a biological substance-fixed solid thin film (S2); supplying the physiologically active substance to the solid thin film to diffuse the physiologically active substance into the solid thin film (S3); and determining minimum inhibitory concentration (MIC) of the physiologically active substance based on a result obtained by imaging individual response of single cells of the biological substance with respect to the physiologically active substance. [Reference numerals] (AA) Start; (BB) End; (S1) Provide a mixture solution of a biological substance and a liquid medium containing a solidifying agent to a substrate; (S2) Form a biological substance-fixed solid thin film by solidifying the mixture solution; (S3) Diffuse a physiologically active substance into the solid thin film; (S4) Observe the reaction of the biological substance with respect to the physiologically active substance
Abstract translation: 目的：提供一种使用生物体固定和生理活性物质扩散的试验方法，以大大减少用于药物试验的药物和细胞的量，并快速追踪单细胞生长。 构成：通过观察生物物质相对于生理活性物质的反应来进行生理活性试验方法。 该方法包括以下步骤：将生物物质和含有固化剂的液体介质的混合溶液提供到用于薄膜形成的基底（S1）; 固化混合溶液并形成生物物质固定的固体薄膜（S2）; 将生理活性物质供给固体薄膜以将生理活性物质扩散到固体薄膜中（S3）; 以及基于通过成像生物物质的单细胞对生理活性物质的个体反应而获得的结果来确定生理活性物质的最小抑菌浓度（MIC）。 （附图标记）（AA）开始; （BB）结束; （S1）向基材提供生物物质和含有固化剂的液体介质的混合溶液; （S2）通过固化混合溶液形成生物物质固定的固体薄膜; （S3）将生理活性物质扩散到固体薄膜中; （S4）观察生物物质相对于生理活性物质的反应
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