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公开(公告)号：KR101384991B1
公开(公告)日：2014-06-17
申请号：KR1020110071184
申请日：2011-07-18
Applicant: 성균관대학교산학협력단 , 서울대학교산학협력단
CPC classification number: A61K9/0024 , A61K9/0004 , A61K9/0019 , A61K31/337 , A61K31/704 , A61K47/06 , A61K47/34
Abstract: 본 발명은 간동맥 가이딩 카테타링이 가능한 블록공중합체로 이루어진 약물전달체와 상기 약물전달체 내부에 담지된 치료 약물을 포함하며, 상기 약물전달체가 외부에서는 졸상이고, 간동맥에서는 젤 상태로 전이되어 간동맥의 혈액공급을 지연 내지 차단하며, 간동맥에서 젤 상태로 전이되는과정에서 상기 치료 약물이 서서히 방출되는 온도 및 pH 민감성 하이드로젤의 인터벤셔널 인젝션에 기반한 간암치료용 약물전달체를 제공한다.
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Patent Agency Ranking
公开(公告)号：KR101220429B1
公开(公告)日：2013-01-18
申请号：KR1020100093726
申请日：2010-09-28
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 고분자를 이용한 췌장소도 봉입용 캡슐(encapsulated pancreatic islets) 표면의 개질 방법에 관한 것으로서, 구체적으로 췌장소도를 캡슐로 봉입(encapsulation)한 후 다양한 고분자 결합(polymeric grafting)을 이용하여 폴리에틸렌 글리콜(polyethylene glycol, PEG)과 같은 고분자 사슬을 췌장소도 캡슐의 표면에 결합시켜 표면을 개질하는 방법에 관한 것이다. 본 발명의 표면개질 방법에 의해 표면이 변형된 췌장소도는 이식시 면역거부 반응을 최소화할 뿐만 아니라, 섬유아세포에 의한 섬유화도 막을 수 있어 췌장소도의 효율과 생존기간을 연장시킬 수 있다.
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公开(公告)号：KR1020120130606A
公开(公告)日：2012-12-03
申请号：KR1020110048674
申请日：2011-05-23
Applicant: 서울대학교산학협력단
IPC: C12N5/10 , A61K35/39 , C07K14/435
CPC classification number: C12N5/10 , A61K35/39 , C07K14/435
Abstract: PURPOSE: A secretion signal peptide-linked exendin-4 transduced pancreatic islet and a method for treating diabetes using the same are provided to improve insulin secretion ability and to reduce cell necrosis rate. CONSTITUTION: A pancreatic islet cell cluster is transduced with a vector with a gene construct containing genes encoding secretion signal peptide and a gene encoding exendin-4. The pancreatic islet cell cluster is prepared by culturing the pancreatic islet cell cluster for 3-9 days. The surface of the pancreatic islet cell cluster is modified with biocompatible polymers, PEG(polyethylene glycol). A composition for treating diabetes contains the pancreatic islet cell cluster as an active ingredient.
Abstract translation: 目的：提供分泌信号肽连接的毒蜥外泌肽-4转导的胰岛和使用该胰岛素治疗糖尿病的方法，以改善胰岛素分泌能力并降低细胞坏死率。 构成：用含有编码分泌信号肽的基因和编码毒蜥外泌肽-4的基因的基因构建体的载体转导胰岛细胞簇。 通过培养胰岛细胞簇3-9天制备胰岛细胞簇。 胰岛细胞簇的表面用生物相容性聚合物PEG（聚乙二醇）修饰。 用于治疗糖尿病的组合物含有胰岛细胞簇作为活性成分。
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公开(公告)号：KR1020130130942A
公开(公告)日：2013-12-03
申请号：KR1020120054614
申请日：2012-05-23
Applicant: 동국대학교 산학협력단 , 서울대학교산학협력단 , 한국과학기술연구원
CPC classification number: A61K49/04 , A61K49/0428 , B82Y5/00 , G06T11/003
Abstract: The present invention relates to a CT contrast agent for detecting blood clot containing a fibrin target peptide sequence conjugated glycol chitosan-gold nanoparticle. The a CT contrast agent for detecting blood clot enables users to rapidly and repeatedly obtain CT image information of the size and the location of the blood clot in cardio-cerebrovascular thrombosis, and to monitor images of cerebral thrombosis.
Abstract translation: 本发明涉及一种用于检测含有纤维蛋白靶肽序列共轭二醇壳聚糖 - 金纳米粒子的血块的CT造影剂。 用于检测血块的CT造影剂使得用户能够快速且反复地获得心血管血栓形成中血块大小和位置的CT图像信息，并监视脑血栓形成。
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公开(公告)号：KR1020130010402A
公开(公告)日：2013-01-28
申请号：KR1020110071184
申请日：2011-07-18
Applicant: 성균관대학교산학협력단 , 서울대학교산학협력단
CPC classification number: A61K9/0024 , A61K9/0004 , A61K9/0019 , A61K31/337 , A61K31/704 , A61K47/06 , A61K47/34 , A61K9/10 , A61K47/30 , A61K47/50
Abstract: PURPOSE: A drug delivery system for treating liver cancer based on interventional injection of temperature- and pH-sensitive hydrogel is provided to stably support an anticancer agent and to enable deep injection into microvessel. CONSTITUTION: A drug delivery system for treating liver cancer based on interventional injection of temperature- and pH-sensitive hydrogel contains a drug delivery system with a block copolymer and a therapeutic drug supported inside the drug delivery system. The drug delivery system further contains a contrast agent inside. The block copolymer is a poly(beta-amino ester)-based block copolymer, a polyamidoamine-based polymer, a polyaminoester urethane-based block copolymer, or a sulfonamide-based block copolymer. The poly(beta-amino ester)-based block copolymer is poly(beta-amino ester)-polyethylene glycol-poly(beta-amino ester)(PAE-PEG-PAE), PAE-PCLA-PEG-PCLA-PAE, PAE-PCL-PEG-PCL-PAE or PAEPCGA-PEG-PCGA-PAE. [Reference numerals] (AA) Embodiment 14; (BB) Embodiment 15; (CC) Embodiment 16; (DD) Control group
Abstract translation: 目的：提供基于介导性注射温敏和pH敏感性水凝胶治疗肝癌的药物递送系统，以稳定地支持抗癌剂并能够深入注射到微血管中。 构成：基于介导性注射温度和pH敏感性水凝胶治疗肝癌的药物递送系统包含药物递送系统，其具有支持药物递送系统内的嵌段共聚物和治疗药物。 药物输送系统还含有造影剂。 嵌段共聚物是基于聚（β-氨基酯）的嵌段共聚物，基于聚酰胺胺的聚合物，聚氨基酯氨基甲酸酯基嵌段共聚物或磺酰胺类嵌段共聚物。 聚（β-氨基酯）基嵌段共聚物是聚（β-氨基酯） - 聚乙二醇 - 聚（β-氨基酯）（PAE-PEG-PAE），PAE-PCLA-PEG-PCLA-PAE，PAE -PCL-PEG-PCL-PAE或PAEPCGA-PEG-PCGA-PAE。 （附图标记）（AA）实施例14; （BB）实施例15; （CC）实施例16; （DD）对照组
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公开(公告)号：KR1020120032209A
公开(公告)日：2012-04-05
申请号：KR1020100093726
申请日：2010-09-28
Applicant: 서울대학교산학협력단
CPC classification number: A61F2/0077 , A61F2002/0081 , A61L27/20 , A61L27/50 , B01J13/20
Abstract: PURPOSE: A capsule for encapsulating pancreas islet having modified surface and a preparation method thereof are provided to effectively block the attack of an immune cell. CONSTITUTION: A capsule for encapsulating pancreas islet having modified surface is as follows. Pancreas islet is encapsulated in a capsule comprised of alginate. The capsule surface is reformed by biocompatible polymer. In the biocompatible polymer, a functional radical is attached to the side chain or end thereof. The functional radical is selected from a group consisting of an amine radical, hydroxyl radical, a carboxyl radical, and a sulfone radical.
Abstract translation: 目的：提供一种用于包封具有改良表面的胰岛的胶囊及其制备方法，以有效阻断免疫细胞的侵袭。 构成：用于封装具有改性表面的胰岛的胶囊如下。 胰岛被包裹在由藻酸盐组成的胶囊中。 胶囊表面由生物相容性聚合物重整。 在生物相容性聚合物中，功能性基团连接到侧链或其末端。 官能团选自胺基，羟基，羧基和砜基。
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