公开(公告)号：KR1020120088009A

公开(公告)日：2012-08-08

申请号：KR1020100089651

申请日：2010-09-13

Applicant: 서울대학교산학협력단

Inventor： 노재규 ,  이상건 ,  김만호 ,  주건 ,  정근화 ,  이순태

IPC: A61K38/16 ,  A61K31/7105 ,  A61K31/711 ,  A61P25/28

CPC classification number: A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: PURPOSE: A pharmaceutical composition targeting specific miNRA for preventing or treating neurodegenerative diseases is provided to enhance BDNF and IGF-1 level and to enhance synapse regeneration. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative diseases contains: pharmaceutically effective amount of antisense oligonucleotides having a sequence which is complementary to 2-7th nucleotide sequence; and a pharmaceutically acceptable carrier. The antisense oligonucleotide is a DNA or RNA molecule. A kit for diagnosing Alzheimer's disease contains a nuelcotide sequence of miR-424*, miR-18b*, miR-135a*, miR-1228, miR-320, miR-296-5p, miR-557, miR-338-5p, miR-206, miR-92a, miR-1238, miR-513a-5p, miR-423-5p, miR-188-5p, miR-140-3p, miR-575, miR-640, miR-1237, miR-191* or miR-134, complementary sequence or sequence thereof.

Abstract translation: 目的：提供靶向特异性miNRA以预防或治疗神经变性疾病的药物组合物，以增强BDNF和IGF-1水平并增强突触再生。 构成：用于预防和治疗神经变性疾病的药物组合物含有：药学有效量的具有与第2-7个核苷酸序列互补的序列的反义寡核苷酸; 和药学上可接受的载体。 反义寡核苷酸是DNA或RNA分子。 用于诊断阿尔茨海默病的试剂盒含有miR-424 *，miR-18b *，miR-135a *，miR-1228，miR-320，miR-296-5p，miR-557，miR-338-5p， miR-206，miR-92a，miR-1238，miR-513a-5p，miR-423-5p，miR-188-5p，miR-140-3p，miR-575，miR-640， 191 *或miR-134，其互补序列或序列。